• Journal of Integrative Natural Science
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• v.8 no.4
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• pp.273-284
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• 2015

Chemoattractant Receptor Homologous molecule expressed on Th2 cells (CRTh2) is a chemoattractant receptor with seven transmembrane helices targeted for inflammatory diseases such as asthma and allergic rhinitis. In this study, pharmacophore based Comparative Molecular Similarity Indices Analysis (CoMSIA) were performed on the series of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acids derivatives. Initially, GASP module was used for generation of pharmacophore models using five highly active compounds from the dataset. Among the generated pharmacophores, the best pharmacophore model was selected based on fitness score and was used as template for the alignment of compounds which was used for CoMSIA analysis. The best predictions were obtained utilizing steric, hydrophobic and H-bond acceptor parameters showing a $q^2$=0.559 and $r^2$=0.730. 15 test set compounds was used to investigate the predictive ability of the CoMSIA model. Contour maps suggested that presence of bulky substituents and H-bond acceptor atoms at $5^{th}$ position of benzene ring will increase the activity of the compounds. The results obtained from this study will be useful to design more potent CRTh2 antagonists.

• Bulletin of the Korean Chemical Society
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• v.28 no.3
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• pp.457-462
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• 2007

Amorphous calcium carbonate (ACC) can readily be prepared using ethanol as the reaction medium and ammonium carbonate as the source of carbon dioxide. Other additives, or any elaborate pH control are not needed to form the initial calcium carbonate precipitate. Ammonia generated from ammonium carbonate maintains the reaction medium in a neutral or weakly basic condition, retarding the crystallization of ACC, while ethanol itself inhibits the dissolution of ACC. The ACC prepared in this way provides a rare opportunity to fabricate molded biomimetic crystals in vitro, but the ACC is too fragile to be fabricated into proper shapes. The malleability of ACC is, however, greatly enhanced by incorporating poly(ethylenimine) (PEI). The ACC/PEI composite can then be fabricated, using a proper mold or template, into mechanically durable biomimetic crystals of definite shape. The ACC in the ACC/PEI composite can further be transformed into vaterite by heating under N2 atmosphere, while the native ACC simply converts into calcite.

• Journal of Integrative Natural Science
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• v.8 no.2
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• pp.89-98
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• 2015

Chemoattractant receptor homologous molecule expressed on Th2 cells (CRTh2) is a G-protein coupled receptor targeted for inflammatory diseases such as asthma, allergic rhinitis and atopic dermatitis. In this study, pharmacophore modeling and comparative molecular field analysis (CoMFA) were performed on the series of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acids derivatives. Five highly active compounds were used for generation of pharmacophore models using GASP module. The best pharmacophore model was selected and used as template for the alignment of compounds which was used for CoMFA analysis. The best predictions obtained for CoMFA was $q^2=0.545$, $r^2=0.756$. The predictive ability of the model was investigated using 15 test set compounds. Contour maps suggested that presence of bulky substituents at $5^{th}$ position of benzene ring connected to suphur atoms attached to imidazol ring will increase the activity of the compounds. The results obtained from this study will be useful to design more potent CRTh2 antagonists.

• Journal of the Korean Home Economics Association
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• v.40 no.7
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• pp.193-210
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• 2002

The purpose of this study is to identify the characteristics of physical setting of adult day care as a place for the elders and adult and to develop an basic understanding of the architectural program and physical setting for adult day care for the cognitively-impaired in the U.S.A. The data was collected from 13 Adult Day Care Centers(ADCC) from 2001 to 2002 by interview and the documents about those facilities. Physical environment should be viewed as an element in the care of individuals with dementia, and that the principles used to plan and design environment should be consistent with the principles used in providing other aspects of care. The results of the study provided the information about the best condition of physical setting of ADCC for the elderly with dementia. Memory Loss Adult Day Center and St. Ann Center for Intergenerational Care have better architectural program than other facilities. It is the hope of this study to provide guideline for design and care professionals with a first draft of a "sense-making" template and to slow own the progression of the disease by the appropriate physical environment.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.27 no.6
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• pp.575-580
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• 2005

Transitional implants were developed to support provisional restorations and to allow for load-free osseointegration of conventional implants while a patient was provided with immediate esthetics and function and are usually placed simultaneously at the time of definitive implant placement. Transitional implants are placed in a non-submerged fashion in a single-stage surgery and are designed to be immediately loaded. They generally are made of commercially pure titanium or titanium alloy and are designed as 1-piece implants composed of root and crown replacement segments. Transitional implants can be used in a wide range of indications, such as basic use as temporary implant, to support and protect the primary implants during the healing phase, single crown in the edentulous anterior region of mandibular, anchorage for orthodontic treatment, support a surgical and radiographic template, and primary implant to extremely atrophied alveolar crests of the mandible and maxilla. This article describes the clinical use of transitional implants to support the provisional complete denture and single crown in the restricted edenturous central incisor region of mandible.

• Journal of Electrical Engineering and Technology
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• v.2 no.1
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• pp.42-49
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• 2007

For electricity markets to function in a truly competitive and efficient manner, it is not enough to focus solely on improving the efficiencies of power supply. To recognize price-responsive load as a reliability resource, the customer must be provided with price signals and an instrument to respond to these signals, preferably automatically. This paper attempts to develop the Windows-based load management system in competitive electricity markets, allowing the user to monitor the current energy consumption or billing information, to analyze the historical data, and to implement the consumption strategy for cost savings with nine possible scenarios adopted. Finally, this modeling framework will serve as a template containing the basic concepts that any load management system should address.

• Journal of Korea Multimedia Society
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• v.12 no.5
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• pp.633-643
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• 2009

We propose a color transfer method that used color contrast based templates to express the visual difference clearly between objects, while remaining the quality of the input image. Our algorithm employs colors of both the input image and template distributed on the $a^{\ast}b^{\ast}$chrominance plane of CIE $L^{\ast}a^{\ast}b^{\ast}$color space. The templates are made by considering the effect of color contrast and have the shape of either a line or a curve represented color distribution of the basic colors based gradation image. These tempates can be modeled on spline curves. We also generate simply new templates with the different basic colors by moving the control points of that curve. The color transfer method using the templates is done through a regressive analysis and color matching. We maintained color coherence of the input image by transforming similarly the color distribution of an input image to the one of templates.

• Journal of the Korea Society of Computer and Information
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• v.20 no.4
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• pp.33-40
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• 2015

This paper presents the design and implementation of the educational remote controlled robot system including remote sensing in the embedded environment. The design of sensing information processing, software design and template design mechanism for the programming practice are introduced. LPC1769 using Cortex-M3 core as CPU, LPCXPRESSO as debugging environment, C language as firmware development language and FreeRTOS as OS are used in development environment. The control command is received via RF communication by the server and the robot system which is operated by driving the various sensors. The educational procedure is from robot demo operation program as hands-on practice and then compiling, loading of the basic robot operation program, already supplied. Thereafter the verification is checked by using the basic robot operation to allow demo operation such as hands-on-training procedure. The original protocol is designed via RF communication between server and robot system, and the satisfied performance result is presented by analyzing the robot sensing data processing.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.429.2-429.2
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• 2014

ZnO nanowire is known as synthesizable and good mechanical properties. And, stimuli-responsive polymer is widely used in the application of tunable sensing device. So, we combined these characteristics to make precise tunable sensing devise. In this work, we investigate the dependence of ZnO nanowire alignment and morphology on si substrate using nanosphere template with various conditions via hydrothermal process. Also, pH-temperature dependant tuning ability of nanostructure was studied. The brief experimental scheme is as follow. First, Zno seed layer was coated on a si wafer ($20{\times}20mm$) by spin coater. And then $1.15{\mu}m$ sized close-packed PS nanospheres were formed on a cleaned si substrate by using gas-liquid-solid interfacial self-assembly method. After that, zinc oxide nanowires were synthesized using hydrothermal method. Before the wire growth, to specify the growth site, heat treatment was performed. Finally, NIPAM(N-Isopropylacrylamide) was coated onto as-fabricated nanostructure and irradiated by UV light to form the PNIPAM network. The morphology, structures and optical properties are investigated by FE-SEM(Field Emission Scanning electron Microscopy), XRD(X-ray diffraction), OM(Optical microscopy), and WCA(water contact angle).

• Journal of the military operations research society of Korea
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• v.33 no.2
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• pp.17-29
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• 2007

This work describes a basic process of OMS/MP in guided weapons on board ship. The OMS/MP which provided basic data of ROC & RAM analysis must be prepared by user But data acquisition Quantified by specific operational environment of ship and related preparing instructions which are not established are now insufficient of reliable weapon systems acquisition. The OMS/MP is an important area that become measures of Acceptance Test and doctrine considering future battlespace environment From a development of the OMS/MP template that describe systematically and as quantitative of shipped guided weapons, combat developer oriented product development & reliable weapon system acquisition are ta be accomplished. This research developed OMS/MP preparation templete that presented quantified OMS/MP derivation and RAM target value calculation process which provide optimum weapon systems design concept to research developers