• Journal of Integrative Natural Science
• /
• v.16 no.1
• /
• pp.33-38
• /
• 2023

The follicle stimulating hormone receptor (FSHR) is a glycoprotein hormone, that belongs to the GPCR superfamily. FSHR plays a major role in reproduction. The aberrant activation of FHS receptor leads to infertility and several reproductive disorders. The recently recognized roles of the FSHR in diverse extragonadal tissues is also closely related to Alzheimer's disease and cancers. Analysing the structural characteristics of the receptor is important in understanding the pathophysiology of diseases associated with the receptor. In this present study, homology modelling of FSHR-TM domain was developed using four different templates. Totally 20 models were developed using single template-based approach and selected three based on the validation of RC plot, RMSD, ProSA, QMEAN and ERRAT values. The developed models would be useful for further research on the structural characteristics and binding characteristics of the FSHR-TM domain.

• Journal of Integrative Natural Science
• /
• v.16 no.1
• /
• pp.39-45
• /
• 2023

P2X receptors are ATP-activated ion channels in the plasma membrane. P2X receptors have a role in a diverse range of disorders, making them a valuable therapeutic target. Hence, the present investigation employed homology modelling of the P2X receptor based on the crystal structure of 5SVJ, 6AH4, 5YVE and 5SVL. Twenty models, using both single- and multiple template-based methods, were developed, and the best model was chosen based on the validation result. We observed that a strategy based on multiple templates provided greater accuracy. Future studies involving binding site and docking analysis can make use of the produced structures.

• Journal of Integrative Natural Science
• /
• v.16 no.3
• /
• pp.97-102
• /
• 2023

The gasdermins are a family of recently identified pore-forming effector proteins that cause membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell death. A role in the regulation of cell proliferation and/or differentiation is suggested by the differentiation status-specific expression of gasdermin proteins in epithelial tissues. One of the GSDM protein is Gasdermin A (GSDMA), which decreased in stomach and esophageal cancers, suggesting a tumor suppressor role. GSDMA receptor antagonists have been researched as potential treatments for inflammatory diseases and baldness. GSDMA's significance in a wide range of disorders makes it an important therapeutic target. As a result, homology modelling of the GSDMA receptor was undertaken in the current study using the crystal structures of Mus musculus (GSDMA3), Human gasdermin D (GSDMD), and Murine gasdermin D (murine GSDMD). The best model was chosen based on the validation results after 20 models were developed utilising single template-based approaches. The generated structures can be used for further binding site and docking studies in the future.

• KIPS Transactions on Software and Data Engineering
• /
• v.5 no.2
• /
• pp.69-78
• /
• 2016

Ischemic stroke is a disease that the brain tissues cannot function by reducing blood flow due to thrombosis or embolisms. Due to the nature of the disease, it is most important to identify the status of cerebral vessel and the medical images are necessarily used for its diagnosis. Among many indicators, brain MRI is most widely utilized because experts can effectively obtain the semantic information such as cerebral anatomy aiding the diagnosis with it. However, in case of emergency diseases like ischemic stroke, even though a intelligent system is required for supporting the prompt diagnosis and treatment, the current systems have some difficulties to provide the information of medical images intuitively. In other words, as the current systems have managed the medical images based on the basic meta-data such as image name, ID and so on, they cannot consider semantic information inherent in medical images. Therefore, in this paper, to provide core information like cerebral anatomy contained in brain MRI, we suggest a template-driven medical images mapping method. The key idea of the method is defining the mapping characteristics between anatomic feature and representative images by using template images that can be representative of the whole brain MRI image set and revealing the semantic relations that only medical experts can check between images. With our method, it will be possible to manage the medical images based on semantic.

• BMB Reports
• /
• v.39 no.3
• /
• pp.284-291
• /
• 2006

In this study, the cDNA of a new peptide from the venom of the scorpion, Buthotus saulcyi, was cloned and sequenced. It codes for a 64 residues peptide (Bsaul1) which shares high sequence similarity with depressant insect toxins of scorpions. The differences between them mainly appear in the loop1 which connects the $\beta$-strand1 to the $\alpha$-helix and seems to be functionally important in long chain scorpion neurotoxins. This loop is three amino acids longer in Bsaul1 compared to other depressant toxins. A comparative amino acid sequence analysis done on Bsaul1 and some of $\alpha$-, $\beta$-, excitatory and depressant toxins of scorpions showed that Bsaul1 contains all the residues which are highly conserved among long chain scorpion neurotoxins. Structural model of Bsaul1 was generated using Ts1 (a $\beta$-toxin that competes with the depressant insect toxins for binding to $Na^+$ channels) as template. According to the molecular model of Bsaul1, the folding of the polypeptide chain is being composed of an anti-parallel three-stranded $\beta$-sheet and a stretch of $\alpha$-helix, tightly bound by a set of four disulfide bridges. A striking similarity in the spatial arrangement of some critical residues was shown by superposition of the backbone conformation of Bsaul1 and Ts1.

• Journal of the Korean Society of Costume
• /
• v.63 no.4
• /
• pp.30-43
• /
• 2013

This study provides suggestions of cultural product design contents by using the cloud-shaped gong in traditional temple culture in order to find a high value-added approach. The research herein is part of cultural design contents projects embedded with the spiritual value and symbolic connotation of temple culture. This would be meaningful to enhance its degree of utilization. This can also be a way to find a strategic alternative to a high value addition of temple stay and dissemination of temple culture. For the research methodology, literature was reviewed over temple stay and Bulgeonsamul. For motive design and development of cultural product design, both Adobe Illustrator CS3 and Adobe Photoshop CS3 were used as computer design program. The template image of cloud-shaped gong for basic motive design was selected from those available at the domestic temples for accurate depiction of its head and body. Finally, samples were adopted from those temples of Gounsa, Songgwangsa, Guinsa, Hwaeomsa, and Naesosa. For each motive, different colors were applied and ten basic motives were practiced in total. By repeating the process for these motives, three types of textile design were prepared. T-shirt designs used a round neckline as basic form, and it was designed for sleeved and sleeveless styles. Apron designs stressed V-neckline and two types were processed: one for the back seam line and the other for side seam line. Pendants were designed with modern and luxurious image so that so that it could be used in various types of accessories. Designs for the bedding applied pattern design of the motives and this was done in a way that gave the images a sense of stability and splendor.

• Journal of Korea Multimedia Society
• /
• v.12 no.5
• /
• pp.633-643
• /
• 2009

We propose a color transfer method that used color contrast based templates to express the visual difference clearly between objects, while remaining the quality of the input image. Our algorithm employs colors of both the input image and template distributed on the $a^{\ast}b^{\ast}$chrominance plane of CIE $L^{\ast}a^{\ast}b^{\ast}$color space. The templates are made by considering the effect of color contrast and have the shape of either a line or a curve represented color distribution of the basic colors based gradation image. These tempates can be modeled on spline curves. We also generate simply new templates with the different basic colors by moving the control points of that curve. The color transfer method using the templates is done through a regressive analysis and color matching. We maintained color coherence of the input image by transforming similarly the color distribution of an input image to the one of templates.

• Journal of the Korea Society of Computer and Information
• /
• v.20 no.4
• /
• pp.33-40
• /
• 2015

This paper presents the design and implementation of the educational remote controlled robot system including remote sensing in the embedded environment. The design of sensing information processing, software design and template design mechanism for the programming practice are introduced. LPC1769 using Cortex-M3 core as CPU, LPCXPRESSO as debugging environment, C language as firmware development language and FreeRTOS as OS are used in development environment. The control command is received via RF communication by the server and the robot system which is operated by driving the various sensors. The educational procedure is from robot demo operation program as hands-on practice and then compiling, loading of the basic robot operation program, already supplied. Thereafter the verification is checked by using the basic robot operation to allow demo operation such as hands-on-training procedure. The original protocol is designed via RF communication between server and robot system, and the satisfied performance result is presented by analyzing the robot sensing data processing.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2014.02a
• /
• pp.429.2-429.2
• /
• 2014

ZnO nanowire is known as synthesizable and good mechanical properties. And, stimuli-responsive polymer is widely used in the application of tunable sensing device. So, we combined these characteristics to make precise tunable sensing devise. In this work, we investigate the dependence of ZnO nanowire alignment and morphology on si substrate using nanosphere template with various conditions via hydrothermal process. Also, pH-temperature dependant tuning ability of nanostructure was studied. The brief experimental scheme is as follow. First, Zno seed layer was coated on a si wafer ($20{\times}20mm$) by spin coater. And then $1.15{\mu}m$ sized close-packed PS nanospheres were formed on a cleaned si substrate by using gas-liquid-solid interfacial self-assembly method. After that, zinc oxide nanowires were synthesized using hydrothermal method. Before the wire growth, to specify the growth site, heat treatment was performed. Finally, NIPAM(N-Isopropylacrylamide) was coated onto as-fabricated nanostructure and irradiated by UV light to form the PNIPAM network. The morphology, structures and optical properties are investigated by FE-SEM(Field Emission Scanning electron Microscopy), XRD(X-ray diffraction), OM(Optical microscopy), and WCA(water contact angle).

• Journal of the military operations research society of Korea
• /
• v.33 no.2
• /
• pp.17-29
• /
• 2007

This work describes a basic process of OMS/MP in guided weapons on board ship. The OMS/MP which provided basic data of ROC & RAM analysis must be prepared by user But data acquisition Quantified by specific operational environment of ship and related preparing instructions which are not established are now insufficient of reliable weapon systems acquisition. The OMS/MP is an important area that become measures of Acceptance Test and doctrine considering future battlespace environment From a development of the OMS/MP template that describe systematically and as quantitative of shipped guided weapons, combat developer oriented product development & reliable weapon system acquisition are ta be accomplished. This research developed OMS/MP preparation templete that presented quantified OMS/MP derivation and RAM target value calculation process which provide optimum weapon systems design concept to research developers