• Journal of Korean Medical classics
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• v.19 no.1 s.32
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• pp.155-167
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• 2006

From th Study on A Study on the Thesaurus of Korean medical information for developing search engine, the conclusion is as follow. Knowledge based information system consists of concepts, facts and relation. The final goal of developing the Knowledge based information system is to select, store and control the knowledge and information of Oriental Medicine. Considering limitation of organizing the knowledge system, it is difficult to realize complete basic system and application method. In order to work, it is necessary to combine experts in each part, for example Domain experts, Information and Knowledge engineer. Through the development of knowledge based information system, we can construct EMR(Electronic Medical Record) system in the near future, and it is possible to make semi-expert system. To make Knowledge based information system, we need to establish standards of information that make the distribution of Knowledge and information easily.

• Journal of Integrative Natural Science
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• v.1 no.2
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• pp.122-126
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• 2008

The stress is an unavoidable result and a complex phenomenon in modern society. too, Human activity changes under control of the stress. The stress is a reaction to adrenalin or other stress hormones. It provides the power for fighting and the energy for going away from dangers. Because of the stress, our bodies increase the pulse, the blood pressure and the breath for more blood and more oxygen. So, in this research, we are measuring those which was increased by the stress. Also we will examine the change of HRV and APG on music. After that, in order to reduce the stress, we will design matching system that is based on the sense for music by using Zigbee.

• Proceedings of the Korean Information Science Society Conference
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• 2003.04a
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• pp.106-108
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• 2003

Human Genome Project와 같은 대형 Sequencing 프로젝트와 High-throughput Sequencing 기술의 발전으로 현재 Expressed Sequence Tag (EST)와 같은 대량의 DNA 서열들이 생산되고 있다. 이를 효과적이고 효율적으로 분석해야 할 필요성이 증대되고 있다. 대부분의 실험자들이 서열 분석을 위해 우선적으로 BLAST 검색을 이용하고 있다. 하지만 대량의 서열, 검색 DB의 크기, BLAST 검색 결과의 복잡성에 의해 어려움을 겪고 있다. 이에 빠르고 정리된 결과를 보여줄 수 있는 BLAST 검색 시스템의 필요성이 커지고 있다. 이에 본 논문은 미국 생명공학연구소(NCBI)에서 제공하는 유전자 서열 검색 툴인 BLAST(Basic Logical Alignment Tool)를 클러스터 수퍼 컴퓨터 구축 기술을 기반으로 한 병렬처리와 Gene Ontology를 이용하여 방대한 양의 서열 검색 결과를 요약하는 모형을 제시한다. 이것은 신약개발 및 유전자 발굴 등의 연구기간을 획기적으로 단축시켜 신약 개 발, 농업, 화학, 의료, 환경 등 생명공학 연구에 핵심적인 역할을 할 수 있다. 또한 성능 실험을 통하여 분석결과 대기시간을 최소화하는 병렬처리모형의 효율성을 검증하였다.

• Journal of Intelligence and Information Systems
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• v.16 no.3
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• pp.147-161
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• 2010

As broadcasting and communication are converged recently, communication is jointed to TV. TV viewing has brought about many changes. The IPTV (Internet Protocol Television) provides information service, movie contents, broadcast, etc. through internet with live programs + VOD (Video on demand) jointed. Using communication network, it becomes an issue of new business. In addition, new technical issues have been created by imaging technology for the service, networking technology without video cuts, security technologies to protect copyright, etc. Through this IPTV network, users can watch their desired programs when they want. However, IPTV has difficulties in search approach, menu approach, or finding programs. Menu approach spends a lot of time in approaching programs desired. Search approach can't be found when title, genre, name of actors, etc. are not known. In addition, inserting letters through remote control have problems. However, the bigger problem is that many times users are not usually ware of the services they use. Thus, to resolve difficulties when selecting VOD service in IPTV, a personalized service is recommended, which enhance users' satisfaction and use your time, efficiently. This paper provides appropriate programs which are fit to individuals not to save time in order to solve IPTV's shortcomings through filtering and recommendation-related system. The proposed recommendation system collects TV program information, the user's preferred program genres and detailed genre, channel, watching program, and information on viewing time based on individual records of watching IPTV. To look for these kinds of similarities, similarities can be compared by using ontology for TV programs. The reason to use these is because the distance of program can be measured by the similarity comparison. TV program ontology we are using is one extracted from TV-Anytime metadata which represents semantic nature. Also, ontology expresses the contents and features in figures. Through world net, vocabulary similarity is determined. All the words described on the programs are expanded into upper and lower classes for word similarity decision. The average of described key words was measured. The criterion of distance calculated ties similar programs through K-medoids dividing method. K-medoids dividing method is a dividing way to divide classified groups into ones with similar characteristics. This K-medoids method sets K-unit representative objects. Here, distance from representative object sets temporary distance and colonize it. Through algorithm, when the initial n-unit objects are tried to be divided into K-units. The optimal object must be found through repeated trials after selecting representative object temporarily. Through this course, similar programs must be colonized. Selecting programs through group analysis, weight should be given to the recommendation. The way to provide weight with recommendation is as the follows. When each group recommends programs, similar programs near representative objects will be recommended to users. The formula to calculate the distance is same as measure similar distance. It will be a basic figure which determines the rankings of recommended programs. Weight is used to calculate the number of watching lists. As the more programs are, the higher weight will be loaded. This is defined as cluster weight. Through this, sub-TV programs which are representative of the groups must be selected. The final TV programs ranks must be determined. However, the group-representative TV programs include errors. Therefore, weights must be added to TV program viewing preference. They must determine the finalranks.Based on this, our customers prefer proposed to recommend contents. So, based on the proposed method this paper suggested, experiment was carried out in controlled environment. Through experiment, the superiority of the proposed method is shown, compared to existing ways.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.34 no.3
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• pp.339-346
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• 2016

Semantic search recently been used in the search field. POI is one of the most essential information that make up the geographic information, and many of the geographic information system has POI search function as a basic. In this study, we propose POI semantic search using collective intelligence. For this, we designed and implemented service that constructs empirical information from tag and image, and provides an intuitive spatial navigation experience. For POI search, collective intelligence platform that many users can participate to collect variety information was designed and implemented.

• Journal of Information Processing Systems
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• v.12 no.4
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• pp.688-710
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• 2016

Our approach permits to capitalize the expert's knowledge as business rules by using an agent-based platform. The objective of our approach is to allow experts to manage the daily evolutions of business domains without having to use a technician, and to allow them to be implied, and to participate in the development of the application to accomplish the daily tasks of their work. Therefore, the manipulation of an expert's knowledge generates the need for information security and other associated technologies. The notion of cryptography has emerged as a basic concept in business rules modeling. The purpose of this paper is to present a cryptographic algorithm based approach to integrate the security aspect in business rules modeling. We propose integrating an agent-based approach in the framework. This solution utilizes a security agent with domain ontology. This agent applies an encryption/decryption algorithm to allow for the confidentiality, authenticity, and integrity of the most important rules. To increase the security of these rules, we used hybrid cryptography in order to take advantage of symmetric and asymmetric algorithms. We performed some experiments to find the best encryption algorithm, which provides improvement in terms of response time, space memory, and security.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.24 no.3
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• pp.199-216
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• 2013

In this paper, the 'facility' and its related concepts were analysed, and then ontological conceptual definition for the facility was conducted based on a variety of relationships between those concepts. First, as a facility conception relation, inclusion relation, instance relation, rule relation, attribute relation and part-whole relationships were investigated. Second, facility concepts were prescribed as a physical entity in which many parts were functionally integrated. Third, by strictly separating the basic concept and role concept, reading facility, exhibit facility, etc. were not supposed to make multiple inheritances by putting subordinate concepts as those of role concepts, not those of the concept of facility. Fourth and lastly, an ontology for the facility was made by using OWL DL.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.440-443
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• 2005

The wide spread of internet business recently necessitates recommendation systems which can recommend the most suitable product fur customer demands. Currently the recommendation systems use content-based filtering and/or collaborative filtering methods, which are unable both to explain the reason for the recommendation and to reflect constantly changing requirements of the users. These methods guarantee good efficiency only if there is a lot of information about users. This paper proposes an algorithm called 'demand articulate & integration' which can perceive user's continuously varying intents and recommend proper contents. A method of knowledge classification which can be applicable to this algorithm is also developed in order to disassemble knowledge into basic units and articulate indices. The algorithm provides recommendation outputs that are close to expert's opinion through the tracing of articulate index. As a case study, a knowledge base for heritage information is constructed with the expert guide's knowledge. An intelligent recommendation system that can guide heritage tour as good as the expert guider is developed.

• BMB Reports
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• v.38 no.6
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• pp.650-660
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• 2005

Proteins accumulated in dry, stratified Arabidopsis seeds or young seedlings, totaled 1100 to 1300 depending on the time of sampling, were analyzed by using immobilized pH gradient 2-DE gel electrophoresis. The molecular identities of 437 polypeptides, encoded by 355 independent genes, were determined by MALDI-TOF or TOF-TOF mass spectrometry. In the sum, 293 were present at all stages and 95 were accumulated during the time of radicle protrusion while another 18 appeared in later stages. Further analysis showed that 226 of the identified polypeptides could be located in different metabolic pathways. Proteins involved in carbohydrate, energy and amino acid metabolism constituted to about 1/4, and those involved in metabolism of vitamins and cofactors constituted for about 3% of the total signal intensity in gels prepared from 72 h seedlings. Enzymes related to genetic information processing increased very quickly during early imbibition and reached highest level around 30 h of germination.

• Journal of Microbiology and Biotechnology
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• v.33 no.4
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• pp.449-462
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• 2023

Previously, we confirmed that Mychonastes sp. 246 methanolic extract (ME) markedly reduced the viability of BxPC-3 human pancreatic cancer cells. However, the underlying mechanism ME remained unclear. Hence, we attempted to elucidate the anticancer effect of ME on BxPC-3 human pancreatic cancer cells. First, we investigated the components of ME and their cytotoxicity in normal cells. Then, we confirmed the G1 phase arrest mediated growth inhibitory effect of ME using a cell counting assay and cell cycle analysis. Moreover, we found that the migration-inhibitory effect of ME using a Transwell migration assay. Through RNA sequencing, Gene Ontology-based network analysis, and western blotting, we explored the intracellular mechanisms of ME in BxPC-3 cells. ME modulated the intracellular energy metabolism-related pathway by altering the mRNA levels of IGFBP3 and PPARGC1A in BxPC-3 cells and reduced PI3K and mTOR phosphorylation by upregulating IGFBP3 and 4E-BP1 expression. Finally, we verified that ME reduced the growth of three-dimensional (3D) pancreatic cancer spheroids. Our study demonstrates that ME suppresses pancreatic cancer proliferation through the IGFBP3-PI3K-mTOR signaling pathway. This is the first study on the anticancer effect of the ME against pancreatic cancer, suggesting therapeutic possibilities and the underlying mechanism of ME action.