• 대한수의학회지
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• 제29권4호
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• pp.487-492
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• 1989

The capsular serogroupes and drug susceptibility of 111 isolates of Pasteurella multocida from pigs with atrophic rhinitis and pneumonic lesions were investigated. Of the 111 P multocida isolates, 42 were from lung lesions, 47 from nasal turbinate lesions and the remaining 22 from the nasal swabs. P multocida isolates were typed for capsular serogroupes A by hyaluronidase inhibition of capsule and D by acriflavine auto-agglutination. Most isolates(64.9%) were type A, 23.4% were type D and the remaining 11.7% were untypable. Resistance to triple sulfa(97.3%) was most frequent, followed by resistance to tiamulin(71.2%), tylosin(56.8%), streptomycin(36.9%), and neomycin(36.0%). The majority of the organisms were susceptible in order of prevalence to baytril(100%), ampicillin(98.2%), linsmycin(97.3%), colistin(97.3%), cephalothin(94.6%), gentamicin(93.7%), amikacin(92.3%), tetracycline(91.9%), trimethoprim/sulfamethoxazole(91.0%), and kanamycin(90.1%). No differences in drug resistance in relation to capsular serogroupes of P multocida and the origin of lesions were noted. A high prevalence of multiple drug resistance was observed and the most common resistant patterns were Sss, Tm, Ty(12.6%) and Sm, Sss, Tm, Ty(8.1%) patterns.

• 대한수의학회지
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• 제29권4호
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• pp.479-485
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• 1989

The present study was conducted to investigate the incidence of Pasteurella multocida infection in Youngnam swine herds during the period from March 1988 to February 1989 and some properties of the isolated organisms. P multocida was isolated from 22(43.1%) of 51 growing pigs of 4 to 12 weeks of age and from 8(80.0%) of 10 herds. From nasal turbinates of 102 slaughtered pigs, 47(46.1%) pigs were culture positive and pigs from 8(88.9%) of 9 herds were found to be infected with P multocida. From lungs of 101 slaughtered pigs, 42(41.6%) pigs were culture positive and the pigs from 11(91.7%) of 12 herds were found to be infected with P multocida. The majority of biochemical and cultural properties of the P multocida isolates were identical to those of the standard strains. The isolation frequencies of P multocida in relation to pig snout lesion grades of 0 to 5 were 28.6%, 41.6%, 48.0%, 50.0%, 85.7%, and 100%, respectively.

• 대한수의학회지
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• 제20권2호
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• pp.159-165
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• 1980

A total of 98 strains of Bordetella bronckiseptica isolated from pigs affected the infectious atrophic rhinitis(AR) during 1978 were surveyed for drug sensitivity to 26 chemotherapeutic agents, and minimum inhibitory concentration(MIC), incidence rate of resistant strain and resistant patern from the strains which were obtained from the different pig farm in Jeonnam province were examined. The results obtained are summarized as follows. 1. Most of the strains tested were resistant to Ampicillin (AB, PC), spiramycin(SPO, sulfa drugs (SD) (MIC:$400.0{{\mu}g/ml}$) and streptomycin(SM) (MIC:$200.0{{\mu}g/ml}$). Of the 75.0% of strains were also resistant to penicillin(PC) (MIC:$200.0{{\mu}g/ml}$) and of the 14.3 of strains were inhibited to grow to tetracycline(TC), chlortetracycline(CTC), oxytetracyc-line(OTC), erythromycin(EM), tylosin(TS), leucomycin (LM) and chloramphenicol (CP) (MIC:$6.25{{\mu}g/ml}$). On the other hand, most of the strains tested were inhibited to grow to kanamycin(KM), gentamycin(GM) neomycin(NM) (MIC:$25.0{{\mu}g/ml}$) and to colistin(CL) (MIC:$12.5{{\mu}g/ml}$). 2. Incidence rate of resistant strains to main chemotherapeutic agents was 100.0% of sulfa drugs, 96.4% of streptomycin, 85.7% of penicillin, tetracycline, chloramphenicol and erythromycin, 46.4% of gentamycin, 17.9% of colistin and 0.0% of kanamycin and nalidixic acid.

• 대한수의학회지
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• 제49권2호
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• pp.113-119
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• 2009

Atrophic rhinitis (AR) is the one of important respiratory diseases and causes severe economic losses in pig industry. Severe attempts have been made to reduce the economic losses by preventing the disease. One of the methods is the spraying of antibiotics into nasal cavity of piglets. Recently, the efficacy of the spraying with kanamycin and gentamicin was reduced in the Korean swine industry. Therefore, the preventive methods have been required to be changed based on the antimicrobial susceptibility profiles of causative agents of swine AR. Based on the current situations of this disease, Bordetella (B.) bronchiseptica and Pasteurella (P.) multocida 4D were isolated from pigs with clinical signs of AR. The isolation rates of B. bronchiseptica and P. multocida 4D were 58.5% and 32.9%, respectively. In the antimicrobial susceptibility test, the bacteria were resistant to kanamycin and gentamicin which have been used as the spraying agents, but they were susceptible to amikacin. A new spraying agent was developed using amikacin using ${\beta}$-glucan and yakbaltag as supplementary agents. Field efficacy of the agent was carried out with different schedule. The results from this study suggested that the newly developed spraying agents might be helpful to prevent AR in swine.

• 한방안이비인후피부과학회지
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• 제29권2호
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• pp.106-111
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• 2016

Objective : The aim of this study is to report the effect of Hani-maehwa laser(fractional mode) treatment on acne scar. Methods : The patient with atrophic facial acne scars was treated with 5 sessions of laser therapy at 4-week intervals. The therapeutic response to treatment was assessed at 3 months after last laser session. The treatment effect was evaluated by standardized photography, anti aging, skin brightness and flatness. That was measured by micro fluorescence measurement camera(ECO SKIN, Cuvitz Inc.) in 16(left zygoma) and 26(right zygoma) spot. And side effects were also checked. Results : Atrophic facial acne scars have improved markedly. Anti aging, skin brightness and flatness were improved. Especially anti aging and flatness were noticeably improved. Adverse effects were not reported.Conclusions : Korean medicine cautery method applies to high level laser(CO₂ Hani-maehwa laser). These are different designs but same principle. It can be considered that laser therapy is effective method for treating acne scars.

• The Journal of Korean Physical Therapy
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• 제3권1호
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• pp.175-188
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• 1991

A study was performed to investigate the effect of electrical stimulation on disused rat soleus muscle, of male rat. The animal's hindlimbs were immobilized 4weeks by plaster of paris, and stimulated with E. S. T for 4weeks (20min/day) The changes on soleus were examined with histochemical, histological, and morphometric method. The results are summarized as follows. 1. Disued atrophy group from immobilization, which margin of sarcolemma and myofibril in sarcoplasm were not cleared, also degenerated from necrosis with phagocytosis. 2. The numbers of nuclear were much increased and accumulation of nuclear were finded, and relatively muscular atrophic changed. 3. Increased inflammatory cyte, also finded neutrophil and macrophage. 4. Relatively atrophic changed from severe fibrosis by incleased connectivetissue. 5. The glycogen granules were much decreased in E. S. T group. It means that electrical stimulation effected the muscle exercise. 6, The activity of the NADH-TR reaction of E. S. T. Tgroup were white muscle group are transformed into red muscle fiber than normal group. 7. These results indicate that the electrical stimulation effected to soleus also prevention and delayed muscular atrophy.

• 대한한방내과학회지
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• 제37권2호
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• pp.283-292
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• 2016

Objective: Acne scarring is the most common sequela after dermal inflammation caused by acne. Many methods are currently used to treat acne scarring; doctors using traditional Korean medicine have also attempted to treat acne scarring in a new way that was developed from traditional methods. This study examines the effectiveness of re-cell therapy.Method: Eleven patients with various types of acne scars were treated by re-cell therapy. We used the global acne scarring classification (GASC) and ECCA (from the French “echelle d’evaluation clinique des cicatrices d’acne”), both of which are generally used to measure and grade the degree of acne scarring.Results: As a result of the treatment, the conditions of all patients were conspicuously improved in both scales. The GASC scores of the patients changed from grade 19.6±10.4 to grade 4.9±3.3 (p=0.001), and the ECCA scores changed from grade 120.9±28.7 to grade 41.8±18.3.Conclusion: Re-cell therapy showed effectiveness in treating acne scarring and could be applied in clinical cases.

• 대한물리의학회지
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• 제5권2호
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• pp.273-280
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• 2010

Purpose : The purpose of this experiment was to evaluate the pre-application effect of low frequency electrical stimulation(LFES) on VEGF expression of atrophic muscle and to determine the optimal pre-application period of LFES for prevent muscle atropy Methods : Twenty-five adult sprague-dawley rats were randomly assigned to weight bearing group, hindlimb suspension for 14 days group, hindlimb suspension with pre-application of LFES for 14 days group, hindlimb suspension with pre-application of LFES for 11 dsys group and, hindlimb suspension with pre-application LFES for 7 dsys group. 16Hz of Biphasic pulse current was applied to gastrocnemius for 15min per days. Results : VEGF were decreased expression in HSG groups, whereas VEGF were significantly increased in HS+ES14G, HS+ES11G, HS+ES7G groups Conclusion : LFES during the hindlimb suspension showed a positive effect in VEGF induction and early application is strongly encourage VEGF induction. This indicated that pre-application of LFES could prevent muscle atrophy.

• Investigative Magnetic Resonance Imaging
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• 제7권1호
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• pp.47-55
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• 2003

목적 : 뇌피질 이형성증의 다양한 자기공명영상소견을 유형별로 분류하고 병리적 등급 및 유형과의 연관성을 분석한다. 대상 및 방법 : 수술 후 병리적으로 뇌피질 이형성증이 확진된 97명을 대상으로 하였다. 수술 전 MR 영상을 후향적으로 분석하였으며, 이상 소견의 유무에 따라 MR 양성군과 MR 음성군으로 나누었다. MR 양성군에서는 뇌회와 인접지주막하 공간의 크기, 뇌피질 두께, 피질하백질의 신호 강도, 뇌피질과 백질 경계부의 명확성에 의하여 MR 이상 소견을 분류하였다. 병리적 소견 역시 영상 소견을 모르는 상태에서 후향적으로 분석하였으며, 경도, 중등도, 고도와 비풍선세포형, 풍선세포형으로 나누었다. MR 양성군과 음성군 사이에서 그리고 MR 양성군의 네 가지 유형 내에서 각각 병리적 등급 및 유형의 차이가 있는지 분석하였다. 결과: MR 양성군과 음성군은 각각 39 (40%) 명, 58 (60%) 명이었다. MR 양성군 중 위축형은 13 (33%)명, 피질띠형은 9 (23%)명, 내측 만곡형은 9 (23%)명, 그리고 비특이적 형태는 8 (21%)명이었다. MR 양성군과 음성군 사이에서 병리적 등급은 의미 있는 차이가 없었으나, MR음성군에 비하여 MR 양성군에서 고도의 병리적 등급의 빈도가 높은 경향을 보였으며 또한 풍선 세포형의 빈도 역시 유의하게 높았다. (5% Vs 2l%, p＜0.05). 특히 MR 양성군 중에 내측 만곡형은 고도의 병리적 등급과 풍선세포형의 빈도가 각각 78% (7/9), 56% (5/9)인 반면에, 위축형은 경도의 등급과 비풍선세포형의 빈도가 각각 77% (10/13), 100%(13/13)이었다. 결론: 뇌피질이형성증 환자의 MR 영상에서 반 이하에서만 이상 소견을 발견할 수 있었고, 특히 내측 만곡형은 병리적으로 고도의 등급 및 풍선세포형, 그리고 위축형은 경도의 등급 및 비풍선세포형과 높은 연관성을 보여 주었다.

• Childhood Kidney Diseases
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• 제16권1호
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• pp.32-37
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• 2012

목적: 본 연구는 방광요관역류를 보이는 소아에서 신초음파 이상소견에 대해 알아보고자 하였다. 방법: 2000년 1월부터 2010년 12월까지 일산병원 소아청소년과에 내원하여 요로감염증으로 입원한 후 배뇨성 방광요도조영술을 시행하여 방광요관역류를 진단받은 83명의 소아를 대상으로 총 166 신단위를 후향적으로 분석하였다. 결과: 대상 소아 중 1세 미만의 평균 나이는 $3.1{\pm}2.56$개월이었고, 1세 이상의 평균 나이는 $58.9{\pm}43.01$개월이었다. 신초음파 이상소견을 보이는 신단위에서 방광요관역류가 있는 경우는 73.9%였고, 신초음파 정상소견을 보이는 신단위에서 방광요관역류가 있는 경우는 58.7%였으며 이는 통계적으로 유의한 차이를 보였다($P$=0.049). 로지스틱 회귀분석에서 신초음파 이상소견이 있을 경우 방광요관역류가 있을 확률은 약 2배 증가하였다. 방광요관역류가 있는 신단위에서 신초음파 정상소견을 보이는 경우는 52.8%, 피질음영증가 16.7%, 수신증 17.6%, 요관확장 8.3%, 수신증을 동반한 요관확장 1.9% 등이었다. 이 중 수신증(82.6%), 요관확장(100%), 중복요관(66.6%), 손상된 위축신(100 %)이 있는 경우 방광요관역류의 빈도가 상대적으로 높았다. 결론: 방광요관역류가 있는 신단위에서 신초음파 이상소견으로 방광요관역류의 중증도를 예측하는 것은 가능하지 않으나 방광요관역류의 존재를 예측하는 것은 가능하다. 그러므로 수신증, 요관확장 같은 신초음파 이상소견이 있을 시, 배뇨성 방광요도조영술의 시행이 필요할 것이다.