Journal of the Korean Society of Physical Medicine (대한물리의학회지)

The Korean Society of Physical Medicine (대한물리의학회)
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Effect of Low Frequency Electrical Stimulation on VEGF Expression of Suspension Induced Atrophic Muscle

뒷다리 현수 유도 위축근에 대한 저빈도 전기자극의 VEGF 발현에 미치는 영향

  • Kang, Jong-Ho (Department of Physical Therapy, Nambu University) ;
  • Han, Jong-Man (Department of Physical Therapy, Chunnam College)
  • 강종호 (남부대학교 물리치료학과) ;
  • 한종만 (전남과학대학 물리치료과)
  • Received : 2010.03.31
  • Accepted : 2010.05.24
  • Published : 2010.05.31
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Abstract

Purpose : The purpose of this experiment was to evaluate the pre-application effect of low frequency electrical stimulation(LFES) on VEGF expression of atrophic muscle and to determine the optimal pre-application period of LFES for prevent muscle atropy Methods : Twenty-five adult sprague-dawley rats were randomly assigned to weight bearing group, hindlimb suspension for 14 days group, hindlimb suspension with pre-application of LFES for 14 days group, hindlimb suspension with pre-application of LFES for 11 dsys group and, hindlimb suspension with pre-application LFES for 7 dsys group. 16Hz of Biphasic pulse current was applied to gastrocnemius for 15min per days. Results : VEGF were decreased expression in HSG groups, whereas VEGF were significantly increased in HS+ES14G, HS+ES11G, HS+ES7G groups Conclusion : LFES during the hindlimb suspension showed a positive effect in VEGF induction and early application is strongly encourage VEGF induction. This indicated that pre-application of LFES could prevent muscle atrophy.

Keywords

References

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