• Anatomy and Cell Biology
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• v.50 no.3
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• pp.207-213
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• 2017

Glycogen synthase kinase $(GSK)-3{\beta}$ and related enzymes are associated with various forms of neuroinflammation, including spinal cord injury (SCI). Our aim was to evaluate whether lithium, a non-selective inhibitor of $GSK-3{\beta}$, ameliorated SCI progression, and also to analyze whether lithium affected the expression levels of two representative $GSK-3{\beta}$-associated molecules, nuclear factor erythroid 2-related factor-2 (Nrf-2) and heme oxygenase-1 (HO-1) (a target gene of Nrf-2). Intraperitoneal lithium chloride (80 mg/kg/day for 3 days) significantly improved locomotor function at 8 days post-injury (DPI); this was maintained until 14 DPI (P<0.05). Western blotting showed significantly increased phosphorylation of $GSK-3{\beta}$ (Ser9), Nrf-2, and the Nrf-2 target HO-1 in the spinal cords of lithium-treated animals. Fewer neuropathological changes (e.g., hemorrhage, inflammatory cell infiltration, and tissue loss) were observed in the spinal cords of the lithium-treated group compared with the vehicle-treated group. Microglial activation (evaluated by measuring the immunoreactivity of ionized calcium-binding protein-1) was also significantly reduced in the lithium-treated group. These findings suggest that $GSK-3{\beta}$ becomes activated after SCI, and that a non-specific enzyme inhibitor, lithium, ameliorates rat SCI by increasing phosphorylation of $GSK-3{\beta}$ and the associated molecules Nrf-2 and HO-1.

• Korean Journal of English Language and Linguistics
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• v.1 no.4
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• pp.509-536
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• 2001

The traditional typology of English poetic meters makes a binary division between strong-stress (or accentual) meters and accentual-syllabic (or syllable-stress or syllable-accent) meters. According to this typology, Old and Middle English alliterative poetry was composed in strong-stress meter; the iambic pentameter from Chaucer to Yeats and on to the present has been an accentual-syllabic meter. Intersecting with this literary typology is a linguistic typology that classifies languages of the world as stress-timed or syllable-timed or some mix of the two. English is a clear example of a stress-timed language. Whereas most descriptions of strong-stress meter focus on the counting of stresses, the present study focuses on the patterns of unstressed syllables between the stresses (possibly at isochronous intervals). The implications of this analysis suggest a new typology in which certain forms of English verse follow strict grammatical stress (mainly Old and Middle English, but for reasons different from “strong-stress” expectations) and other forms are shaped by a compromise of grammatical stress and the metrical template. Within this later group, iambic pentameter contrasts with trochaic, anapestic, and dipodic meters in lending itself more readily to modulation. Some of this modulation comes from an easy incorporation into iambic pentameter of elements associated with Old and Middle English meters.

• The Journal of Engineering Research
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• v.6 no.2
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• pp.85-98
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• 2004

The adsorption equilibrium data for the binary gas mixture system from the pure gas adsorption data of carbon dioxide and ethylene on ZSM-5 prepared were predicted. The binary gas mixture adsorption data have been examined against predicted values by two models-the vacancy solution model(VSM) and the statistical thermodynamic model(STM), using parameters obtained from the single component isotherm. The binary gas mixture data for the carbon dioxide-ethylene system were obtained for cation exchanged forms of ZSM-5 for the gas phase carbon dioxide mole fraction of 0.752 at $37^{\circ}C$ and 1 atm. The experimental adsorption phase diagrams were obtained for carbon dioxide-ethylene on sodium form ZSM-5 synthesized. The single component adsorption isotherms for carbon dioxide and ethylene were also obtained for this zeolite. The single component data were used to obtain parameters derived in two models. These parameters were, in turn, used to predict the binary mixture isotherms for this zeolite. Both the vacancy solution and the statistical thermodynamic models give satisfactory predictions of adsorption phase diagrams for the binary gas mixtures of carbon dioxide and ethylene on sodium exchanged ZSM-5. Also the correlation between the experimental data and the predicted values is generally in good agreement. The system appears to show ideal behavior with a relatively constant separation factor. The slight increase in adsorption capacity with an increase in ionic radius is due, in part, to the higher polarizability associated with larger cations.

• Journal of the Korean Mathematical Society
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• v.54 no.2
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• pp.479-491
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• 2017

We investigate the zeros of Epstein zeta functions associated with positive definite quadratic forms with rational coefficients in the vertical strip ${\sigma}_1$ < ${\Re}s$ < ${\sigma}_2$, where 1/2 < ${\sigma}_1$ < ${\sigma}_2$ < 1. When the class number h of the quadratic form is bigger than 1, Voronin gave a lower bound and Lee gave an asymptotic formula for the number of zeros. Recently Gonek and Lee improved their results by providing a new upper bound for the error term when h > 3. In this paper, we consider the cases h = 2, 3 and provide an upper bound for the error term, smaller than the one for the case h > 3.

• Bulletin of the Korean Chemical Society
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• v.16 no.1
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• pp.42-47
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• 1995

Interpolymer complex formation between basic polypeptide poly(L-proline) Form Ⅱ (PLP(Ⅱ)) and acidic polypeptides poly(L-glutamic acid) (PLGA) and poly(L-aspartic acid)(PLAA) has been studied in water-methanol (1:2 v/v) mixed-solvent by viscometry, potentiometry, light scattering and circular dichroism (CD) measurements. It has been found that polymer complexes between PLP(Ⅱ) and PLGA (or PLAA) are formed via hydrogen bonding with a stoichiometric ratio of PLP(Ⅱ)/PLGA (or PLAA)=1:2 (in unit mole ratio) and that PLP(Ⅱ) forms polymer complex more favorably with PLGA than with PLAA. In addition, the minimum (for pH 5.0) and the maximum (for pH 3.2) in reduced viscosity of dilute PLP(Ⅱ)-PLGA mixed solutions are observed at 0.67 unit mole fraction of PLGA (i.e., [PLP(Ⅱ)]/[PLGA]=1/2). These findings could be explained in terms of molecular structure (or conformation) of the complementary polymers associated with the complex formation.

• Journal of Life Science
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• v.29 no.9
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• pp.941-948
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• 2019

Colorectal cancer is a major health problem in industrialized countries. Ziyuglycoside II ($3{\beta}-3-{\alpha}$-1- arabinopyranosyloxy-19-hydroxyurs-12-en-28-oicacid), a triterpenoid saponin isolated from the roots of Sanguisorba officinalis L., possesses antioxidant, antiangiogenic, and anticancer properties. However, the therapeutic function of ziyuglycoside II in colitis-associated colorectal carcinogenesis is undefined. In the present study, the effect of ziyuglycoside II on colitis-associated colon cancer induced in mice using azoxymethane (AOM)/dextran sulfate sodium (DSS) was explored. The AOM model recapitulates many features of human colon cancer, but it lacks an inflammatory component. DSS induces colitis and promotes AOM-induced colon cancer in mice. BALB/c mice were injected with AOM and administered 2% DSS in drinking water. The mice were given ziyuglycoside II (1 or 5 mg/kg) orally three times per week, and colonic tissue was collected at 64 days. Administration of ziyuglycoside II markedly diminished the formation of colonic tumors. Western blot and immunohistological analyses showed that ziyuglycoside II noticeably decreased nuclear factor kappa-B-positive cells and levels of inflammation-related proteins, such as inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-${\alpha}$, and interleukin-6 in colon tissue. It also prompted apoptosis. Ziyuglycoside II treatment augmented cleaved forms of caspase-3, caspase-7, and poly (ADP-ribose) polymerase in colonic tissues. In conclusion, ziyuglycoside II could defend against colitis-associated tumorigenesis in mice by inhibiting inflammation and inducing apoptosis. This shows a promising chemopreventive potential for its use in colitis-associated colon cancer.

• Journal of Chest Surgery
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• v.14 no.1
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• pp.83-86
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• 1981

Eight cases by power tiller accidents experienced for 3 years from Jan. 1978 to Dec. 1980 were studied clinically. The results are as follows: 1. The most of the patients were thirties to fifties, and the incidence rate of male to female 7:1. 2. The common injuries were hemopneumothorax and multiple rib fractures [respectively and the other associated injuries were hepatic and delayed splenic ruptures, and fractures of the another sites. 3. The accident forms were overturning [50.0%], falling down from the power tiller [37.5%], and collision against the power tiller [12.5%]. 4. All of the drivers and 75% of the passengers in the patients were drunken states at the accident time. 5. The common methods of treatment were closed thoracostomy [62.5%], conservative treatment [37.5%], and exploratory laparotomy [25.0%].

• Environmental Mutagens and Carcinogens
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• v.10 no.2
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• pp.93-106
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• 1990

The Drosophila temperature-sensitive mutant shibire (shi) is paralyzed at restrictive temperature by a reversible block in synaptic transmission. To explore the functional relationship among shi gene products, viability and temperature-sensitive paralytic behavior were quantitaively analyzed for four shi alleles, shi$^{ts1}$, shi$^{ts2}$, shi$^{ts4}$, and shi$^{ST139}$, and their heteroallelic combinations. The hemizygous combination of shi alleles over deficiency was not completely lethal. shi$^{ts2}$ exhibited distinctively higher viability than other alleles. A novel behavior, bang sensitivity, was also found in shi/Df(1). This bang-sensitive paralytic behavior was compared with that of the typical bang-sensitive mutant flies. Heterozygotes, shi/+, are more severe in temperature sensitivity than deficiency hemizygotes, Df(1)/+. Heteroallelic combinations of shi were less sensitive to high temperature than homozygotes. Among all allelic combinations, shi$^{ts2}$/shi$^{ts4}$ showed an unexpected extreme reduction in temperature sensitivity. The results of allelic interactions among 4 shi alleles suggest that the shi mutations examined behave as antimorphic alleles and that the gene product of shi are likely to function in multimeric forms.

• Bulletin of the Korean Mathematical Society
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• v.55 no.1
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• pp.227-237
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• 2018

In this paper, we study some geometric structures of a weakly cyclic Z-symmetric manifold (briefly, $[W CZS]_n$). More precisely, we prove that a conformally flat $[W CZS]_n$ satisfying certain conditions is special conformally flat and hence the manifold can be isometrically immersed in an Euclidean manifold $E^n+1$ as a hypersurface if the manifold is simply connected. Also we show that there exists a $[W CZS]_4$ with one parameter family of its associated 1-forms.

• Journal of the Chungcheong Mathematical Society
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• v.30 no.1
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• pp.77-102
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• 2017

As an analogy of $Poincar{\acute{e}}$ series in the space of modular forms, T. Ono associated a module $M_c/P_c$ for ${\gamma}=[c]{\in}H^1(G,R^{\times})$ where finite group G is acting on a ring R. $M_c/P_c$ is regarded as the 0-dimensional twisted Tate cohomology ${\hat{H}}^0(G,R^+)_{\gamma}$. In the case that G is the Galois group of a Galois extension K of a number field k and R is the ring of integers of K, the vanishing properties of $M_c/P_c$ are related to the ramification of K/k. We generalize this to arbitrary n-dimensional twisted cohomology of the ring of integers and obtain the extended version of theorems. Moreover, some explicit examples on quadratic and biquadratic number fields are given.