• Korean Journal of Microbiology
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• v.53 no.4
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• pp.304-308
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• 2017

Researchers have comparatively fewer opportunities to conduct experiments on foot-and-mouth disease virus (FMDV), owing to the limited availability of biosafety level 3 facilities. Bovine rhinovirus (BRV) and human rhinovirus (HRV), which are genetically closely related to FMDV, have been evaluated in this study as model viruses for FMDV. To discover whether BRV and HRV have similar physicochemical properties as FMDV, virus susceptibility tests have been performed in different physical (pH and heat) and chemical (acidic/alkaline solutions and commercial disinfectants) conditions in vitro. Our data revealed that the physicochemical characteristics of BRV and HRV were nearly similar to those of FMDV.

• Journal of Oral Medicine and Pain
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• v.21 no.1
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• pp.133-140
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• 1996

Saliva have many important functions in the maintenance of oral health. Saliva contains protective components, antibacterial enzymes, and other rubricating glycoprotein elements. When the salivary flow decreases of the salivary composition changes, a normally healthy mouth can become susceptible to caries, periodontal disease, and mucositis, and other diseases. Salivary peroxidase system acts as an antimicrobial factor in the oral cavity, having a role in the prevention of dental plaque accumulation, dental caries and gingivitis. Recently, this enzyme system has been introduced by many researchers in the form of toothpaste, mouthwash or moisturizing gel for use in patients with various disease states . The author prescribed the peroxidase system containing gel (Oralbalance) to the 18 Burning Mouth Syndrome (BMS) patients for 1 week and investigated the changes of the subjective symptoms, $HOSCN/OSCN^-$ levels of unstimulated whole saliva, and the salivary flow rates. The obtained results were as follows : 1. The patients reported decrease in all symptoms of BMS after the use of peroxidase system containing gel, particulary, a significantly higher decreases of dry mouth and burning symptoms. 2. Decreased $HOSCN/OSCN^-$ levels of unstimulated whole saliva were detected in the patients with BMS after the use of perosidase system containing gel for 1 week. 3. There was no difference between the flow rates of unstimulated whole saliva before and after uses of peroxidase system containing gel for 1 week.

• Applied Biological Chemistry
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• v.48 no.4
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• pp.301-310
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• 2005

Foot-and-mouth disease (FMD) is a highly contagious disease of mammals and has a great potential for causing severe economic loss in susceptible cloven-hoofed animals, such as cattle, pigs, sheep, goats and buffalo. FMDV, a member of the Aphthovirus genus in the Picornaviridae family, is a non-enveloped icosahedral virus that contains a positive sense RNA of about 8.2 kb in size. The genome carries one open reading frame consisting of 3 regions: capsid protein coding region P1, replication related protein coding region P2, and RNA-dependent RNA polymerase coding region P3. FMDV infects pharynx epithelial cell in the respiratory tract and viral replication is active in lung epithelial cell. Morbidity is extremely high. A FMD outbreak in Korea in 2002 caused severe economic loss. Although intense research is undergoing to develop appropriate drugs to treat FMDV infection, there is no specific therapeutic for controlling FMDV infection. Moreover, there is an increasing demand for the development of vaccine strategies against FMDV infection in many countries. In this report, more effective prevention strategies against FMDV infection were reviewed.

• The Journal of Korean Medical History
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• v.25 no.1
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• pp.81-91
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• 2012

Objectives : "Yayaoyuanfang" is a prescription book, compiled by Xuguozhen in 1267. In "Yayaoyuanfang", there are 13 chapters including "Throat, Mouth and Teeth". Because there are few prescription books focused only on mouth and teeth disease in traditional medicine, "Throat, Mouth and Teeth" in "Yayaoyuanfang" is distinctive. Methods : We try to analyze prescriptions by form, effectiveness and report experiences in "Yayaoyuanfang". Results : There are 95 prescriptions with 77 powder, 5 paste, 5 liquid, 2 granule and 5 other forms. Effectiveness of those are divided into teeth, gum and mouth. Effectiveness for teeth are about pains, weakness, cavity, discoloration and so on. Effectiveness for gum are about pain, swelling, weakness, shrinking, etc. Effectiveness for mouth is about bad breath. Conclusions : "Throat, Mouth and Teeth" in "Yayaoyuanfang" has professional prscriptions for throat, mouth and teeth with several form and effectiveness.

• Korean Journal of Veterinary Service
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• v.40 no.3
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• pp.177-185
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• 2017

In this study, we evaluated the efficacy of a commercial vaccine stress-relieving agent (Anti VS-2 injection) to reduce the adverse effects of foot-and-mouth disease (FMD) vaccination site in 120 pigs on two tested pig farms. The results showed that incidence of pig with abnormal meat, size of abnormal meat and weight of discarded abnormal meat are significantly decreased in Anti VS-2 injection-supplemented FMD vaccinated pig groups (n=60) compared to the non-supplemented FMD vaccinated pig groups (n=60) (P<0.05). And the average economic loss by discard of abnormal meat were estimated 99,382 won or 21,514 won in the non-supplemented FMD vaccinated groups or in the Anti VS-2 injection-supplemented FMD vaccinated groups, respectively, showing that the cost saving effect was 78% (77,869 won). In conclusion, it is expected to reduce the incidence and severity of abnormal meat in the FMD vaccinated pigs and to contribute not only to the reduced economic loss of pig farmers but also to the promotion of food hygiene when the Anti VS-2 injection is mixed with FMD vaccine.

• Journal of Sasang Constitutional Medicine
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• v.33 no.3
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• pp.87-94
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• 2021

Objectives The purpose of this study is to examine the meaning of the Soeumin's Softness and Non-softness in the mouth(口中和, 口中不和). Methods We examined The Existing Doctors's using of the Softness and Non-softness in the mouth, and considered Jema Lee's using of the Softness and Non-softness in the mouth. Afterward, we considered the meaning of the Soeumin's Softness and Non-softness in the mouth in 『Donguisusebowon(東醫壽世保元)』. Results and Conclusion 1. Junggyeong Jang used the Softness in the mouth, and he didn't use the Non-softness in the mouth in 『Sanghanlun(傷寒論)』. 2. The Next Generation Doctors used the Softness in the mouth, and they didn't use the Non-softness in the mouth. Especially, Dongwon Lee used the Softness in the mouth as the Knowing the taste of food, and used the Non-softness in the mouth as the Non-knowing the taste of food. 3. Jema Lee used the Softness and Non-softness in the mouth as urgent indicator of the Soeumbyeong diarrhea in 『Gabobon(甲午本)』, and used the Softness and Non-softness in the mouth as classification indicator of the Taeeumbyeong and Soeumbyeong in 『Sinchuckbon(辛丑本)』. 4. The Non-softness in the mouth is Jema Lee's specific term. It means dry of mouth, thirsty and the Non-knowing the taste of food. 5. The change from the Non-softness to Softness in the mouth is recovery indicator of the Soeumin's disease. It is the basis for setting the Drinking water(能飮水) as the Soeumin's igiljeung(二吉證).

• Journal of Veterinary Clinics
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• v.28 no.1
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• pp.113-121
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• 2011

Foot-and-mouth disease (FMD) is a severe vesicular disease of cloven-hoofed animals including domesticated ruminants and pigs. Acute clinical signs may be mild in sheep and goats but are associated with lameness in pigs and mouth lesions with vesicles in cattle. The required condition for a successful pathogen appears to be the ability to counteract both the host innate and adaptive immune response. FMD virus (FMDV) inhibits the induction of antiviral molecules and interferes with the secretory pathway in the infected cell. The surface expression of Major Histocompatibility Complex (MHC) class I molecules is reduced in infected cells. Thus, the ability of the host to recognize and eliminate virus infected cells is decreased. Furthermore, FMDV infection results in a rapid, but transient lymphopenia, reducing the number of T and B cells, and affecting T cell function. The virus appears to premature apoptosis-mediated cell death because it has a very short replication cycle and is able to rapidly produce large amounts of virus. FMDV engages the host protective response at multiple steps to ensure its effective replication and pathogenesis. This review describes the recent pathological and immunological studies to overcome the powerful abilities of FMDV to counteract defense mechanism of host.

• Journal of Microbiology and Biotechnology
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• v.30 no.1
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• pp.38-43
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• 2020

Hand, foot, and mouth disease (HFMD) is caused by enterovirus 71 (EV71) in infants and children under six years of age. HFMD is characterized by fever, mouth ulcers, and vesicular rashes on the palms and feet. EV71 also causes severe neurological manifestations, such as brainstem encephalitis and aseptic meningitis. Recently, frequent outbreaks of EV71 have occurred in the Asia-Pacific region, but currently, no effective antiviral drugs have been developed to treat the disease. In this study, we investigated the antiviral effect of salvianolic acid B (SalB) on EV71. SalB is a major component of the Salvia miltiorrhiza root and has been shown to be an effective treatment for subarachnoid hemorrhages and myocardial infarctions. HeLa cells were cultured in 12-well plates and treated with SalB (100 or 10 ㎍/ml) and 10⁶ PFU/ml of EV71. SalB treatment (100 ㎍/ml) significantly decreased the cleavage of the eukaryotic eIF4G1 protein and reduced the expression of the EV71 capsid protein VP1. In addition, SalB treatment showed a dramatic decrease in viral infection, measured by immunofluorescence staining. The Akt signaling pathway, a key component of cell survival and proliferation, was significantly increased in EV71-infected HeLa cells treated with 100 ㎍/ml SalB. RT-PCR results showed that the mRNA for anti-apoptotic protein Bcl-2 and the cell cycle regulator Cyclin-D1 were significantly increased by SalB treatment. These results indicate that SalB activates Akt/PKB signaling and inhibits apoptosis in infected HeLa cells. Taken together, these results suggest that SalB could be used to develop a new therapeutic drug for EV71-induced HFMD.

• Journal of dental hygiene science
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• v.10 no.4
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• pp.233-239
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• 2010

The study of the elderly and poor oral status interpersonal relationships and smooth social life limited to give is the social alienation and isolation, promoting to having problems with a sense of the elderly subjective oral health status and social efficacy affects whether analyzed. 1. Subjective oral health status authoring feel healthy food disorders, toothache, periodontal problems, tmj pain, dry mouth, bad breath symptoms such as 'sometimes' 'often' than a 'no' if you appear to be a highly subjective and social efficacy Efficacy of oral health status and social influence were more (p<0.01). 2. Subjective oral health status of the seven kinds of sub-variable that oral health status, food authoring disorders, toothache, gum disease, jaw joint or more, dry mouth, bad breath instantly and look at the relationship between social efficacy oral health status, ability of mastication, pain in oral, gum disease, tmj pain, dry mouth, presence of halitosis than positive (+) was correlated.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2005.11a
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• pp.26-46
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• 2005