• Sijohaknonchong
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• v.30
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• pp.21-52
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• 2009

This study observed what roles and identity the Taoist Hermits have when they appear in Korean Verse, SiJo, which was preoccupied by the illustrious-officials in Choseon Dynasty. This study has found that languages of Taoist Hermit frequently appear in SiJo, through the historical study documents focusing on only the mountain wizards in terma of the genre, SiJo. Of those terms used by Taoist Hermit, most prominent was 'JeokSongJa', which was expressed as that sought by the illustrious-officials-they were using the sentence, 'I will follow JeokSongJa' to the extent that it is an idiom. This suggests that the illustrious officials in ChoSeon Dynasty meant if one was going to be entitled to become a Taoist Hermit, he should seek 'JeokSongJa' first. We can see those illustrious officials were using the words with a ideological tone, affected by then 'JangRyang' or 'BeomRyo' who were devoting themselves to finding 'JeokSongJa' with a belief that they could become a Taoist Hermit and live forever, which had been handed down as a legend or a myth. Meanwhile, Li Po is a profile who can not considered, separately in the history of Korean Literature. Li Po recited poems, as a great poet and a hard drinker, who were incited in SiJo of those illustrious officials as a intimate person. In contrast, among those who were accepted as a negative profile, were a Chinese Emperor JinSi and HanMuje. These two emperors, who were looking for a herb of eternal youth and Mt. BongRae, figures who had lost their positions in the real political circle. In addition, they couldn't make their dreams to get perennial youth and long life come true, which stimulated the illustrious officials of that time to recite those poems indicating there is no ideal Utopia so it's better be satisfied with the reality living up to the realistic idea of Confucianism. In this sense, those two emperors are negative. There are also women Taoist Hermits present in SiJo, including MaGo nymphs, SeoWangMo, MuSanShinNyo, and Hang-A. MaGo nymphs were grandmothers who superintend the longevity, often incited as a beautiful woman; SeoWangMo was a Toast Hermit who had an elixir of life; MuSanShinNyo is a beautiful woman who was representing the attachment of cloud friendship; and Hang-A is expressed as a goddess who betrayed her husband and as a result staying lonely in the moon palace. These women goddesses were characterized by their beautiful appearances, generous and delicate personalities. widely incited in romantic poems.

• Journal of the Korean Geosynthetics Society
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• v.6 no.3
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• pp.17-23
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• 2007

To construct an ideal geosynthetic reinforced soil retaining wall (GRS-RW), the facing of the wall should be flexible enough to accommodate a large deformation of the supporting ground and to develop the large tensile force in reinforcements during wall construction as long as the stability is ensured, but should be rigid enough to be stiff and stable as well as durable and aesthetically acceptable for a long life time when the wall is in service. Facing conditions during the construction and service of the wall are quite different. So it is difficult to be satisfied all these conditions with the current construction method which is mainly used in reinforced wall construction in Korea. Most of this contradiction could be solved by the staged construction procedure. According to the results of cases and references analyses, stage construction procedures make it possible to accommodate large deformation of the supporting ground and backfill without losing the stability of the wall, and to derive the tensile strength of reinforcement causing deformation of the facing. When the facing is a full-height rigid one, it also appeared almost impossible to occur a local shear failure of the active zone, and pull-out failure of reinforcements. Therefore, GRS-RWs having a full-height rigid facing have been constructed by the staged construction procedures that matched well with the theory of reinforced soil, which had outstanding stability and durability, and thus could be used for railways and bridge abutments in Korea in the future.

• KIEAE Journal
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• v.8 no.6
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• pp.3-10
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• 2008

Since fire was founded in the world, human races have invented various heating methods. Ondol is traditional heating method in Korea. It is very the important work to trace the history and characteristics of Ondol which originated and was developed in the Korean peninsula. Especially, the study on Ondol will contribute to improving the present heating methods and predicting future ones. In this paper, we shall study through the analysis of documents such as oriental documents, the document of Choseon dynasty, European documents and American documents. In order to discover the origins of Ondol as one of the excellent heating method all over the world, This study aims at identifying the history and characteristics of Ondol in the Korean peninsula, through document analysis. Results of this study are as follows. 1) The first document about Ondol is Sookyongjoo(水經注), Chinese ancient geography book. Contents recorded in the book include the description related to Ondol at Kwankyesa temple which was located at the border land between Gogooryo(ancient Korea) and the northeast of China. 2) Ondol was popular heating method in Gogooryo(ancient Korea) and it was used in not only Gogooryo but also Silla Kingdom and Beakje Kingdom. Thereafter, it was also used widely in Goryo dynasty and Choseon dynasty. Thereby we know that Ondol has been used as a heating method for a long time in the Korean peninsula. 3) Ondol was covered with a floor paper since the beginning of Choseon dynasty. the paper made room clean and impacted on Korean life style. Because the floor was clean and warm, Koreans thus took off shoes and sat on the floor. 4) Ondol was spreaded to Jeju island in Korea before 16th century but wasn't used widely there. The reason was that Ondol was rare high class heating system and the weather was warm in Jeju island. 5) The overspreading of Ondol caused that poor people built roughly Ondol in the last of Choseon dynasty. So, the quality of Ondol gradually became lower and lower. 6) A westerner was impressed by the novelty of Ondol and Frank Lloyd Wright had played an important role to update and spread Ondol widely all over the world. Hailing Ondol as the ideal heating system, Frank Lloyd Wright began incorporating it in his buildings back in the U.S. and even invented a modified ondol system, using hot water running through pipes instead of the hot exhaust through flues.

• Journal of Science and Technology Studies
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• v.1 no.1 s.1
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• pp.123-153
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• 2001

This article addresses the 2nd Korean consensus conference on cloning that was held by the Korean National commission for UNESCO in 1999. Though previous perspectives recognized the conference as a new citizen's participatory institution. they do not consider that it contains the ideal of deliberative democracy. This article notes that the citizens participated directly and handled the important social agenda through debate in the consensus conference. The consensus conference is another democratic form derived from preference aggregating democracy in the sense that it basically depends on public judgement of the citizens. This consensus conference has the historical meaning because it is in fact the first experiment of deliberative democracy in Korea. 1) We examine the theoretical foundations of consensus conference. They are social constructionism of science, the tradition of societal debate, and deliberative democracy. 2) We explore what deliberative democracy is. It is different from aggregating preference democracy in the sense that it depends on public judgement rather than private preferences. 3) We investigate the features and meaning of deliberative democracy which has experiment on the conference. In the Consensus Conference it was observed that citizens changed their preferences and went forward to developing their view of community as a result of the process of deliberation. It can be said to confirm the significance of deliberative democracy. However, it is simultaneously an opportunity to clarify some problems of deliberative democracy. First of all, it shows that there were hierarchies within the citizens' panel as well as between the citizens' and the specialists' panels. Secondly, there are difficulties in expressing the value of life in argument or discourse. Also, we need the institutional efforts concerning future generations and nonhuman beings in the respect that cloning relates to them.

• Current Research on Agriculture and Life Sciences
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• v.2
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• pp.15-22
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• 1984

This study was conducted to identify the enzyme treatment time, enzyme concentration and plant growth condition for isolation of potato mesopyll, it was also performed to determine the adquate sucrose molarity on purification of protoplasts and to investigate the incubation time, PEG concentration and DMSO effect for potato-petunia protoplast fusion. The results were summarized as follows: The optimal time of incubation in enzyme solution was 3 - 4 hours and high humidity and low light intensity made plants more effective to protoplast releasing enzymes. Our experimental results showed that the pectolyase Y-23 was an ideal agent for isolation from mesophyll cultured in vitro compared with macerozyme. The enzyme solution with 0.5 % macerozyme and 2 % cellulase was very effective and the purity of healthy protoplast was better in 0.4 and 0.5 M sucrose than in others. It was revealed that the rate of potato-petunia fusion according to the incubation time with PEG was effective at 30 min incubation and percentage of protoplast aggregation was increased by high molecular weight and concentration of PEG. Percentage of potato-petunia protoplast heteroplasmic aggregation was increased by 4 to 16 % in PEG 6000 compared with PEG 4000 and PEG 1500. Addition of 5 to 10 % DMSO to the PEG solution increased to the heteroplasmic aggregation of potato-petunia from 2 to 4 %.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.89-97
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• 2021

The purpose of this study was to examine the awareness of early childhood teachers for early childhood creativity programs using physical computing in an effort to provide future direction for program development. The findings were as follows: First, 43.8 percent of teachers answered they were neutral about the need for these programs, while 40.5 percent replied these programs were necessary. Second, 73.8 percent thought the utilization of physical computing tools would be useful. Third, the largest group thought that the programs should be provided for five-year-olds. Regarding the frequency of programs, once or twice a week were considered most appropriate. Concerning the length of each activity, 20 to 30 minutes was identified as ideal, and study subjects preferred small group activities. In regard to the most effective theme for these programs, tools for daily life were considered best. As for educational content to be included in program planning, scientific inquiry and experiment were viewed as best, followed by the design/ production/utilization of creative works, game and play, and producing and playing musical instruments. Evaluation by a creativity test was chosen as the most desirable evaluation method.

• Journal of Microbiology and Biotechnology
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• v.29 no.4
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• pp.651-657
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• 2019

Although smallpox was eradicated in 1980, it is still considered a potential agent of biowarfare and bioterrorism. Smallpox has the potential for high mortality rates along with a major public health impact, eventually causing public panic and social disruption. Passive administration of neutralizing monoclonal antibodies (mAbs) is an effective intervention for various adverse reactions caused by vaccination and the unpredictable nature of emerging and bioterrorist-related infections. Currently, vaccinia immune globulin (VIG) is manufactured from vaccinia vaccine-boosted plasma; however, this production method is not ideal because of its limited availability, low specific activity, and risk of contamination with blood-borne infectious agents. To overcome the limitations of VIG production from human plasma, we isolated two human single-chain variable fragments (scFvs), (SC34 and SC212), bound to vaccinia virus (VACV), from a scFv phage library constructed from the B cells of VACV vaccine-boosted volunteers. The scFvs were converted to human IgG1 (VC34 and VC212). These two anti-VACV mAbs were produced in Chinese Hamster Ovary (CHO) DG44 cells. The binding affinities of VC34 and VC212 were estimated by competition ELISA to $IC_{50}$ values of $2{\mu}g/ml$ (13.33 nM) and $22{\mu}g/ml$ (146.67 nM), respectively. Only the VC212 mAb was proven to neutralize the VACV, as evidenced by the plaque reduction neutralization test (PRNT) result with a $PRNT_{50}$ of ~0.16 mg/ml (${\sim}1.07{\mu}M$). This VC212 could serve as a valuable starting material for further development of VACV-neutralizing human immunoglobulin for a prophylactic measure against post-vaccination complications and for post-exposure treatment against smallpox.

• Korean Chemical Engineering Research
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• v.57 no.3
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• pp.305-312
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• 2019

The discovery of nitric oxide (NO) as a major signaling molecule in a number of pathophysiological processes - vasodilation, immune response, platelet aggregation, wound repair, and cancer biology - has led to the development of various exogeneous NO delivery systems. However, the development of ideal delivery system for human body application is still left as a challenge due to its high reactivity and short half-life in physiological condition. In this article, an overview of several nano-structures as potential NO delivery system will be presented, along with their recent research results and biomedical applications. Nano-size delivery system has immense advantages compared to others due to its high surface-to-volume ratio and capability for surface modification; thus, it has been proven to be effective in delivering nitric oxide with enhanced performance. Through this novel nano-structure delivery system, we are expecting to achieve sustained release of nitric oxide within adequate range of concentration, which ensures desired drug effects at the target site. Among different nano-structures, in particular, nanoparticle, microemulsion and nanofilm will be reviewed and compared to each other in respect of nitric oxide release profile. The proposed nano-structures for exogeneous NO delivery have a biological significance in that it can be further utilized in diverse biomedical fields as a highly promising therapeutic method.

• Animal Bioscience
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• v.36 no.1
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• pp.29-42
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• 2023

Objective: Pigs, an ideal biomedical model for human diseases, suffer from about 50% early embryonic and fetal death, a major cause of fertility loss worldwide. However, identifying the causal variant remains a huge challenge. This study aimed to detect single nucleotide polymorphisms (SNPs) and candidate genes for the number of mummified (NM) piglets using the imputed whole-genome sequence (WGS) and validate the potential candidate genes. Methods: The imputed WGS was introduced from genotyping-by-sequencing (GBS) using a multi-breed reference population. We performed genome-wide association studies (GWAS) for NM piglets at birth from a Landrace pig populatiGWAS peak located on SSC11: 0.10 to 7.11 Mbp (Top SNP, SSC11:1,889,658 bp; p = 9.98E-13) was identified in cyclin dependent kinase on. A total of 300 Landrace pigs were genotyped by GBS. The whole-genome variants were imputed, and 4,252,858 SNPs were obtained. Various molecular experiments were conducted to determine how the genes affected NM in pigs. Results: A strong GWAS peak located on SSC11: 0.10 to 7.11 Mbp (Top SNP, SSC11:1,889,658 bp; p = 9.98E-13) was identified in cyclin dependent kinase 8 (CDK8) gene, which plays a crucial role in embryonic retardation and lethality. Based on the molecular experiments, we found that Y-box binding protein 1 (YBX1) was a crucial transcription factor for CDK8, which mediated the effect of CDK8 in the proliferation of porcine ovarian granulosa cells via transforming growth factor beta/small mother against decapentaplegic signaling pathway, and, as a consequence, affected embryo quality, indicating that this pathway may be contributing to mummified fetal in pigs. Conclusion: A powerful imputation-based association study was performed to identify genes associated with NM in pigs. CDK8 was suggested as a functional gene for the proliferation of porcine ovarian granulosa cells, but further studies are required to determine causative mutations and the effect of loci on NM in pigs.

• Journal of Korea Entertainment Industry Association
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• v.13 no.3
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• pp.269-278
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• 2019

This study is intended to present the direction of art mask design development and help people's life care by producing an art mask with the motif of the characteristic of abjection concept. It went through the definition and characteristics of abject and abjection focusing on previous research, professional books and art works. The characteristics of abjection based on theoretical research are to express death with dead bodies and skulls, including the dismantling of ideal beauty standards, the expression of fragmented bodies, and the expression of sick and alienated bodies. This researcher produced 6 research works by combining the fascinating abjection, induced by ugly and disgusting abject, to design factors. These works fragmented each part of the facial form by the cutting and dismantling, and made viewers feel the abjection by giving a grotesque deformation. The results obtained through the research works are as follows. First, It was found that the abjection characteristics-applied works was helpful in the treatment of the mental wound of modern people. Second, the production of works based on the abjection characteristics paved the way to expand the scope of art mask design concepts and establish the new design ideas. Third, the application of the motif using the abjection characteristics to the art mask design showed that the use of various objects could express creative designs and secure diversity in using materials. In the future, this researcher hopes that such research will be used as the basic data of the follow-up study on art mask design, and it will help develop art mask designs.