Complementary and alternative medicine has gained popularity and respectability in recent years in the United States. Since aging is often associated with chronic health conditions that commonly lead to physical and psychosocial disabilities (e.g., depression, functional and/or cognitive disabilities, and decreased quality of life), older adults often seek options to maintain health and treat chronic conditions as an adjunct to conventional medical care. Herbal products, the most commonly used among various complementary and alternative medicines (CAM), should be used with caution due to potential herbal-drug interactions (related to polypharmacy) and herbal-disease interactions (related to comorbidities). Five of the most common chronic conditions in older adults are chronic pain, cardiovascular problems, hypertension, diabetes, and chronic lung problems. A high rate of falls or risk of falling is also a problem unique to this older population. For these conditions, only a few types of CAM (e.g., acupuncture, qi gong, tai chi) were tested, with promising results. However, in spite of evidence supporting the use of certain types of CAM to alleviate some common chronic conditions, findings are limited in terms of other types of CAM tested and both short and long-term effects. More rigorous clinical trials of various CAM types are thus warranted to advance scientific knowledge and establish evidence-based practices to care for the growing number of older adults who deserve to have a better quality of life.
Alternative splicing (AS) is an important mechanism of producing transcriptome diversity and microarray techniques are being used increasingly to monitor the splice variants. There exist three types of microarrays interrogating AS events-junction, exon, and tiling arrays. Junction probes have the advantage of monitoring the splice site directly. Johnson et al., performed a genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays (Science 302:2141-2144, 2003), which monitored splicing at every known exon-exon junctions for more than 10,000 multi-exon human genes in 52 tissues and cell lines. Here, we describe an algorithm to deduce the relative concentration of isoforms from the junction array data. Non-negative Matrix Factorization (NMF) is applied to obtain the transcript structure inferred from the expression data. Then we choose the transcript models consistent with the ECgene model of alternative splicing which is based on mRNA and EST alignment. The probe-transcript matrix is constructed using the NMF-consistent ECgene transcripts, and the isoform abundance is deduced from the non-negative least squares (NNLS) fitting of experimental data. Our method can be easily extended to other types of microarrays with exon or junction probes.
The Journal of the Korean life insurance medical association
/
v.24
/
pp.97-117
/
2005
Internally Korean insurance market is that whole life products' growth are becoming slowdown that's why new insurance products have appeared on the market in consideration of consumer's needs recently. Externally domestic insurance market competitions has drifted from insurance industry to whole financial industry since bankasurance started. Life insurance companies should open up a new market to survive from severe competitions. Worksite marketing can be an alternative. An insurer make arrangements with an employer about an insurance terms which an insurer offers in Worksite marketing. Then eligible individuals enroll in the plans at their own discretion and pay 100 percent of the premium for coverage through payroll deductions. An employer doesn't need to pay extra money for additional benefit but can raise employee's loyalty and satisfaction of company through worksite marketing. An employee can be covered at discounted premium rate and less strict underwriting guidelines to an insurer compared to individual insurance. In developed countries specially U.S insurance market, Worksite marketing is getting very popular and growing rapidly due to the advantages. Worksite marketing has both individual insurance characters and group insurance characters. Individual insurance characters are that employees enroll in the plans at their own discretion and pay 100 percent of the premium for coverage. Group insurance characters are that actively at work and participation etc. An insurer have to reflect these two characters on Worksite marketing when an insurance company work out a plan for developing products and underwriting guidelines. When an insurer devise worksite products, one should consider participation level which means percentage of eligible employees participating. Participation is related to anti-selection. As we know underwriting is essential for every kind of insurance, especially underwriting plays major role in worksite marketing. We can see that in the below. Firstly, it has a function in calculation of premium rate. When calculate premium rate for worksite products underwriters have to estimate expected participation level and risk factors. So underwriters and acturies keep in close contact with each other. Secondly, underwriting methods are important. When an insurer underwrite worksite products, there are three kinds of underwriting methods. These are Simplified issue underwriting, Full underwriting and Guaranteed issue underwriting. Simplified issue underwriting typically requires no medical examination, but usually requires supplying satisfactory answers to one or several health and/or lifestyle questions. Full underwriting requires a complete medical history questionnaire that may further require an exam. Guaranteed issue underwriting means that coverage is issued without the employee having to provide evidence of insurability. When insurer set the GI limit are usually based on the type of industry, number of eligible employees, the average amount of coverage and participation level. In addition to insurer should have a clear definition of eligible employee on the insurance provision and application form. It will minimize possibility of trouble claims and anti-selection. An insurer also establish preexisting condition exclusion and special guidelines for late entrants. When an insurer introduce Worksite marketing to Korean insurance market, an insurer has to examine market research to analyze potential market and strategy of sales most of all. Also an insurer should review real situation of the U.S, England and Japanese market etc. There are a lot of new technologies about worksite marketing process that an insurer should learn. When an insurer consider many things which we explained it can be a real alternative.
Journal of The Korean Association For Science Education
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v.19
no.4
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pp.585-594
/
1999
The purpose of this study is to examine the concept of Greenhouse Effect as understood by middle school high school university students using a closed-form questionnaire. Based on results of the questionnaire which was administered to 619, the extent to which alternative concepts were held was quantified and compared the difference of various group based on grade level. gender, text and major. Also, subjects were divided into two groups, one is middle school students and the other is high school university students and common themes within conceptual framework of each group were identified by factor analysis. The result showed that students confused Greenhouse Effect with ozone layer depletion in stratosphere and linked familiar contamination around everyday life. acid rain. radioactive contamination, nuclear arsenal to Greenhouse Effect. These trends were more appreciable in female than male, biology major than any other major and text did not make any significant difference. In addition, the result of factor analysis showed that two groups linked familiar contamination around everyday life to Greenhouse Effect and high school university students understand the consequences of an increase in the Greenhouse Effect more systematically than middle school student, perceived the relation between the origin of an increase in the Greenhouse Effect and human activity but confused Greenhouse Effect with ozone layer depletion in stratosphere.
Elementary preservice teachers' understanding about the insect molt and metamorphosis was examined. Data were collected through the paper-pencil test of 448 junior students at a National University of Education. The instrument used was developed by Son(2003) and modified for the test. The results are as follows: First, Only 3.1$\%$ of students had a scientific concept on the molt periods in the insect life cycle. Students had an alternative conception that molt occurs either only in the larval period (29.9$\%$) or only in the period from pupa to adult (22.3$\%$). The percentage of the students thinking that molt occurs in the period from larva to pupa was low. Second, 98$\%$ of students stated that molt has to do with the larval growth, but 39.1$\%$ of students had an alternative conception that molt occurs after the larval growth at each instar. 25.1$\%$ had a conception that molt is related with the larval growth, but did not show any further understanding. Third, most students understood the correct meaning of metamorphosis. 34..2$\%$ of students had an alternative conception that metamorphosis occurs only in the period changing from pupa to adult, and only a few thought that it occurs in the period from larva to pupa. 24.8$\%$ of students had a scientific concept on the periods in which metamorphosis occurs. Fourth, some students understood the hatching process as molt in the sense that the egg shell is taken off (21.0$\%$), and as metamorphosis in terms of the appearance change from egg to larva (25.0$\%$). Fifth, 35.5$\%$ of students selected bees as an insect of incomplete metamorphosis, and 35.3$\%$ responded 'I have no idea', showing that they had poor understanding about the insect life cycle.
Journal of the Korean Society of Manufacturing Technology Engineers
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v.19
no.4
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pp.521-528
/
2010
A product system will be improved continually until requirements are satisfied. It is true that considering alternative designs to improve product system is hard work; it is also true that selecting an adequate design idea that represents the needs of stakeholders concerned and meets effectiveness factors properly is not an easy work, either. In the process of driv-ing an idea and designing, which is called Design Phase, there are lots of existing tools for testing the driven idea in DFSS. But, those kinds of tools do not offer the function that helps to select the technically better design idea among alternative design ideas that have the same evaluation level. Moreover it is inappropriate to select adequate alternative design ideas by just verifying only the evaluation table in pugh matrix, since satisfied deviation val-ues are low when there is a too competitive mass product system in a market. Also, for the IT product with short life cycle, faster and more effective testing tool is needed. Therefore, the 'roduct quality index' is suggested in order to select an appropriate candidate design concept for system development that meets requirements by using 'deality concept' pro-vided by TRIZ. According to the result of this research, it is possible to select technically better idea fast and effectively; it is confirmed by applying the approach to the case of LCD BLU (Back Light Unit).
Journal of the Korean Institute of Electrical and Electronic Material Engineers
/
v.31
no.2
/
pp.122-127
/
2018
In an attempt to estimate the life projection of LED packages, IESNA published a paper regarding an LED package measurement test method in 2008, and a life projection technical document in 2011, to be used for LED life estimation. IESNA's publications regarding LED package measurement methods were functional, but they were not internationally standardized before 2017. In order to develop a standardized method, the International Standard chose to use the LM-80 as a measurement method for LED life projection in their publication in 2017. Many projection methods have been discussed by the IEC Technical Committee 34 working group, including the method using an exponential function, which reflects lumen degradation characteristics well. This study is designed to explore alternative LED package life estimation methods using an exponential function with statistical analysis, other than the one suggested by the International Standard.
The purpose of this study is to analyze the life cycle cost of primary cooling system by systematic support cost. Life Cycle Cost(LCC) is the process of making an economic assessment of an item, area, system, or facility by considering all significant costs of ownership over an economic life, expressed in terms of equivalent costs. The essence of life cycle costing is the analysis of equivalent costs of various alternative proposals. In order to select economical primary cooling system in early heat source plan stages, the research investigates cost items and cost characteristics during project process phases such as planning/design, construction, maintenance /management, and demolition/sell phases. The study also analyze the life cycle cost by capacity leading to suggest the most economical primary cooling system by systematic support cost.
Journal of Korean Home Economics Education Association
/
v.24
no.3
/
pp.123-142
/
2012
The purpose of this study is to find out how career education has been positioned in secondary school home economics education, and to clarify the identity of career education as one part of home economics education. Furthermore, this study tries to give alternative teaching-learning strategies for life career education across the life span. It deals with home economics curricular and journals. It also analyses the 21 sorts of home economics textbooks and one career and vocation textbook in secondary school, which are supposed to be based on the newly revised 2007 curriculum. As a research method this study takes a qualitative approach. As follows are the results of this study. First, career education has been positioned as one part of home economics education. Second, both career and vocation education and home economics education have dealt with the contents related to career such as self-understanding, career-exploring, deciding-making related to career, career-designing. However, career and vocation education has focused on 'vacational career', whereas home economics education has focused on 'life career' across the life span. Third, this study proposed three alternative teaching-learning strategies for life career education across the life span.
Kim, H.G.;Kim, T.S.;Park, M.S.;Park, C.H.;Song, U.C.;Park, Y.G.
Proceedings of the KIEE Conference
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1995.11a
/
pp.379-381
/
1995
Many generating stations in korea are 25 years or more old, and are nearing the end of their planned life. Financial conditions and Site, Environment problems have made approval for construction of new stations increasingly difficult, and extending the life of an existing older plant may be a palatable alternative. Therefore, To determine whether generator rewinds are necessary to achieve an extended life, and Methods are required to estimate the proable remaining life of existing winding, here, We are going to estimate insolation condition through Nondestructive diagonostic test and Aging history tests of generator Stator winding and winding conditions through deterioration characteristics due to Heat cycle.
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