• Journal of Korean Tunnelling and Underground Space Association
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• v.23 no.3
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• pp.199-209
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• 2021

Alternative methods of rock cutting have been introduced to substitute and to improve the traditional mechanical rock excavation methods (e.g., TBM and roadheader). Undercutting methods have been recently studied in some countries. In undercutting, several additional cutting parameters are involved in its cutting process compared to the traditional rock-cutting. As a fundamental study, this paper introduces the concept of undercutting method with actuated disc, lab-scaled testing system, and testing procedures of undercutting by the system. Also, we present the calculation methods of cutter forces and specific energy, and discuss the results of undercutting tests compared to those of traditional rock-cutting methods.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2005.04a
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• pp.203-206
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• 2005

The objective of study on composite cylinder for alternative fuel vehicle is to develop safe, efficient, and commercially viable, on-board fuel storage system for the fuel cell vehicle or natural gas vehicle that use highly compressed gaseous fuel such as hydrogen or natural gas. This study presents the whole procedure of development and certification of a type 3 composite cylinder of 207bar service pressure and 70 liter water capacity, which includes design/analysis, processing of filament winding, and validation through various testing and evaluation. Design methods of liner configuration and winding patterns are presented. Three dimensional, nonlinear finite element analysis techniques are used to predict burst pressure and failure mode. Design and analysis techniques are verified through burst and cycling tests. The full qualification test methods and results for validation and certification are presented.

• Communications for Statistical Applications and Methods
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• v.13 no.3
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• pp.503-512
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• 2006

In this paper, the Inverse Weibull distribution parameters have been estimated using a new estimation technique based on the non-parametric kernel density function that introduced as an alternative and reliable technique for estimation in life testing models. This technique will require bootstrapping from a set of sample observations for constructing the density functions of pivotal quantities and thus the confidence intervals for the distribution parameters. The performances of this technique have been studied comparing to the conditional inference on the basis of the mean lengths and the covering percentage of the confidence intervals, via Monte Carlo simulations. The simulation results indicated the robustness of the proposed method that yield reasonably accurate inferences even with fewer bootstrap replications and it is easy to be used than the conditional approach. Finally, a numerical example is given to illustrate the densities and the inferential methods developed in this paper.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.05a
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• pp.222-225
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• 2006

Pull-off test is widely used to evaluate bond performance between concrete and FRP composite. However, reliability of experiment result declines due to many difference between test methods of each national standards. This study analyzed problems of various existing test methods for pull-off test and suggested standardized test method. In addition, since tensile strength of concrete is smaller than bond strength of epoxy resin, maximum bond strength of epoxy resin shall be limited within tensile strength of concrete. Alternative testing method, therefore, which decrease FRP adhesion areas than concrete adhesion areas is suggested to widen test range of bond strength in pull-off test. In the experimental results, bond performance can be estimated up to two times of tensile strength of concrete by reducing FRP adhesion areas by 1/3.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.11 no.17
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• pp.67-80
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• 1988

This study is concerned with the comparison of two time homogeneous Poisson processes. Traditionally, the methods of testing equality of Poisson processes were based on the binomial distribution or its normal approximations. The sampling plans used in these methods are to observe the processes concurrently over a predetermined time interval, possibly different for each process. However, when the values of the intensities of the processes are small, inverse type sampling plans are more appropriate since there may be cases where only a few or even no events are observed in the predetermined time interval. This study considers 9 inverse type sampling plans for the comparison of two Poisson processes. For each sampling plans considered, critical regions and the design parameters of the sampling plan are determined to guarantee the significance level and the power at some values of the alternative hypothesis. The Problem of comparing of two Weibull processes are also considered.

• Electronics and Telecommunications Trends
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• v.38 no.1
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• pp.46-54
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• 2023

The announcement of the US Environmental Protection Agency that it will stop conducting or funding experimental studies on mammals by 2035 should prioritize ongoing efforts to develop and use alternative toxicity screening methods to animal testing. Toxicity screening is likely to be further developed considering the combination of human-induced pluripotent-stem-cell-derived organ-on-a-chip and multielectrode array (MEA) technologies. We briefly review the current status of MEA technology and MEA-based neuropharmacological drug screening using various cellular model systems. Highlighting the coronavirus disease pandemic, we shortly comment on the importance of early prediction of toxicity by applying artificial intelligence to the development of rapid screening methods.

• Journal of Animal Reproduction and Biotechnology
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• v.39 no.1
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• pp.2-11
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• 2024

Background: The small intestine plays a crucial role in animals in maintaining homeostasis as well as a series of physiological events such as nutrient uptake and immune function to improve productivity. Research on intestinal organoids has recently garnered interest, aiming to study various functions of the intestinal epithelium as a potential alternative to an in vivo system. These technologies have created new possibilities and opportunities for substituting animals for testing with an in vitro model. Methods: Here, we report the establishment and characterisation of intestinal organoids derived from jejunum tissues of adult pigs. Intestinal crypts, including intestinal stem cells from the jejunum tissue of adult pigs (10 months old), were sequentially isolated and cultivated over several passages without losing their proliferation and differentiation using the scaffold-based and three-dimensional method, which indicated the recapitulating capacity. Results: Porcine jejunum-derived intestinal organoids showed the specific expression of several genes related to intestinal stem cells and the epithelium. Furthermore, they showed high permeability when exposed to FITC-dextran 4 kDa, representing a barrier function similar to that of in vivo tissues. Collectively, these results demonstrate the efficient cultivation and characteristics of porcine jejunum-derived intestinal organoids. Conclusions: In this study, using a 3D culture system, we successfully established porcine jejunum-derived intestinal organoids. They show potential for various applications, such as for nutrient absorption as an in vitro model of the intestinal epithelium fused with organ-on-a-chip technology to improve productivity in animal biotechnology in future studies.

• Clean Technology
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• v.14 no.2
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• pp.103-109
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• 2008

In this study, in order to develop evaluation method of the cleaning efficiency of residual flux which remains on the surface after soldering with solder paste, a specially designed metal tool is used to reduce spread uncertainty of flux while soldering. Using this tool, the measurement of cleaning efficiency of flux after soldering for some typical alternative semi-aqueous cleaners and 1,1,1-TCE by weighing method was conducted. As the test result of cleaning efficiency for each cleaner at several different cleaning times, the precision of the data is confirmed to within about 4% relative standard deviation (RSD) range. So, it is considered that this would be a good evaluation method for evaluating the cleaning efficiency of the residual flux which remains after solder paste soldering in the alternative cleaning. The results of this test method shows that the cleaning efficiency of ST 100SX and Neozal 750H in the cleaning of residual flux was better than other semi-aqueous cleaners, but its cleaning efficiency was clearly inferior to 1,1,1-TCE.

• Physical Therapy Korea
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• v.19 no.3
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• pp.124-131
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• 2012

Most conventional instruments measuring disability rely on total score by simply adding individual item responses, which is dependent on the items chosen to represent the underlying construct (test-dependent) and a test statistic, such as coefficient alpha for the estimate of reliability, varying from sample to sample (sample-dependent). By contrast, item response theory (IRT) method focuses on the psychometric properties of the test items instead of the instrument as a whole. By estimating probability that a respondent will select a particular rating for an item, item difficulty and person ability (or disability) can be placed on same linear continuum. These estimates are invariant regardless of the item used (test-free measurement) and the ability of sample applied (sample-free measurement). These advantages of IRT allow the creation of invariantly calibrated large item banks that precisely discriminate the disability levels of individuals. Computer adaptive testing (CAT) method often requiring a testing algorithm promise a means for administering items in a way that is both efficient and precise. This method permits selectively administering items that are closely matched to the ability level of individuals (measurement precision) and measuring the ability without the loss of precision provided by the full item bank (measurement efficiency). These measurement properties can reasonably be achieved using IRT and CAT method. This article aims to investigate comprehensive overview of the existing disability instrument for back pain and to inform physical therapists of an alternative innovative way overcoming the shortcomings of conventional disability instruments. An understanding of IRT and CAT method will equip physical therapist with skills in interpreting the measurement properties of disability instruments developed using the methods.

• Journal of Genetic Medicine
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• v.15 no.2
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• pp.79-86
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• 2018

Purpose: This study aimed to evaluate the clinical usefulness of non-invasive prenatal testing (NIPT) as an alternative testing of invasive diagnostic testing in pregnancies with ultrasound abnormalities. Materials and Methods: This was a retrospective study of pregnant women with abnormal ultrasound findings before 24 weeks of gestation between April 2016 and March 2017. Abnormal ultrasound findings included isolated increased nuchal translucency, structural anomalies, and soft markers. The NIPT or diagnostic test was conducted and NIPT detected trisomy 21 (T21), T18, T13 and sex chromosomal abnormalities. We analyzed the false positive and residual risks of NIPT based on the ultrasound findings. Results: During the study period, 824 pregnant women had abnormal ultrasound findings. Among the study population, 139 patients (16.9%) underwent NIPT. When NIPT was solely performed in the patients with abnormal ultrasound findings, overall false positive risk was 2.2% and this study found residual risks of NIPT. However, the discordant results of NIPT differed according to the type of abnormal ultrasound findings. Discordant results were significant in the group with structural anomalies with 4.4% false positive rate. However, no discordant results were found in the group with single soft markers. Conclusion: This study found different efficacy of NIPT according to the ultrasound findings. The results emphasize the importance of individualized counseling for prenatal screening or diagnostic test based on the type of abnormal ultrasound.