• The Journal of Korean Medicine
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• v.22 no.4
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• pp.29-36
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• 2001

Objectives: This study attempted to investigate the allergic histories and the distribution of offending allergens in the general public and further to help their diagnosis and treatment with Oriental Medicine. Methods: Allergic skin tests (AST) were performed and allergic histories were taken of 359 members of the general public who visited the International Exhibition on Oriental Medicine from Sept. 1 to Sept. 5, 2000. The allergen reagents for AST were three (House dust, D. farinae, Dog hair) and the control reagent was histamine solution. Results: 1.50.1 % of the subjects (n=359) were positive to AST. The ratio between males' positivity and females' was 1.06：1. 2. The younger the subjects were, the higher the positivity was. 3. The positive subjects' (n=180) positivity to three allergens was as follows: D. farinae 98.9%, House dust 30.0%, Dog hair 1.7%. 4. The younger the positive subjects were, the higher the positivity to House dust was. In contrast, the positivity to D. farinae was high in all age groups. 5.71.1 % of the positive subjects reacted positively to monotype allergen and 28.9% reacted positively to multiple allergens (2.46：1). The most common monotype allergen was D. farinae (98.4%) and the most common combination of multiple allergens was House dust and D. farinae (94.2%). 6.52.8% of the positive subjects (n=180) and 51.4% of the negative subjects (n=179) represented the history of allergic diseases. There was no relationship between allergic skin test and allergic diseases. Conclusion: To help in diagnosis and treatment with oriental medicine, research to analyze the relationship between allergic skin test and allergic diseases should be continued on the basis of Oriental medical theories.

• Clinical and Experimental Pediatrics
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• v.50 no.5
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• pp.409-415
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• 2007

Allergy skin prick test and intradermal test represent one of the major tools in the diagnosis of IgE-mediated diseases like as atopic asthma, allergic rhinitis, atopic dermatitis, food and drug allergy, and insect bite when properly performed. Skin tests are of particular importance in fields such as allergen standardization, pharmacology, and epidemiology. Even if skin tests seem easy to perform, adequate and proper interpretation requires well-trained physicians who can recognize the numerous factors that may modify the results of skin tests.

• Research in Community and Public Health Nursing
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• v.11 no.1
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• pp.262-277
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• 2000

In order to find out the sex- and age-related prevalence rate of allergic diseases in the community. as well as the causes of those diseases. questionnaires were given to 2.415 subjects (1.206 males and 1.209 females) from May to June. 1998. As a second stage. skin tests were given to 452 of the original subjects between July and August. 1998. Finally. from March to November 1999. the results of the tests were compared with those of other countries to make a comparative analysis of epidemiological research on allergic diseases. The results of this study were as follows: The frequency of allergic symptoms by sex was 50.1% in males and 56.7% in females. respectively, which displayed significant difference between males and females(p<.01). By age, the frequency of allergic symptoms in males was highest for those under the age of 9 at 60.6%, whereas in females the highest frequency was between the ages of 30 to 39 at 75.1 %. The relationship between economic level of the subjects and their frequency of allergic diseases showed significant difference (P<.05). There was a high degree of correlation between family history and the frequency of allergic diseases(P<.01). In allergic symptoms, the highest prevalence in both males and females occurred with urticaria, itch and skin rash (33.6% with males and 38.0% with females). Rhinitis, nasal blocking and sneezing had the second highest frequency in both sexes (11.8% of males and 14.0% of females). With regard to the causes of allergic symptoms among the people with allergies, the rate in males was 30.1% in food. 25.0% in pollen, and among females the rate was 30.7% in food, 26.6% in pollen. The frequency of food allergies by sex was 25.6% in males and 25.8% in females, with little difference between males and females, and by age, males of the ages between 40 to 49 and females of the ages between 30 and 39 showed the highest frequency, 31.8% and 32.6% respectively. Among 585 people with food allergies, the sympoms occurring with the allergy in males were 81.5% with urticaria, itch and skin rash. 5.9% with diarrhea and stomachache, and 5.2% with rhinitis, nasal blocking and sneezing. Among females with food allergies, the symptoms were 82.6% with urticaria, itch, skin rash, 9.1% with diarrhea and stomachache, and 4.7% with rhinitis, nasal blocking and sneezing. The type of food most often causing allergy in males was mackerel (6.6%) and females peaches (7.4%). In respect to a positive rate in the skin test by sex, of the 379 males taking the skin test, 21.4% were positive for allergies, whereas 14.7% of the 346 females tested were positive. Among food items found to cause positive allergic reactions, hops had the highest frequency in males (58.9%) and whole eggs had the greatest effect on females (36.4%). The estimated prevalence of food allergies in terms of skin tests was 5.0% of 1.206 males and 3.6% of 1.209 females. In the estimated frequency of food allergy by age group, males of the ages between 40 and 49 and females of the ages from 30 to 39 had the highest rate (6.5% with males and 4.5% with females). In a comparative analysis of epidemiological research on allergic diseases by country group, allergic diseases occurred in 18-50% of each population studied, and the occurrence of allergic diseases when categorized according to symptoms displayed the following as such: allergic rhinitis (3.8-52%), allergic asthma (1.6-17%), and atopy dermatitis (0.33-20.4%). The prevalence of food-related allergies was 6.6-64.9% and the foods causing allergies frequently included milk, eggs, eggs, peanuts, fish, etc.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.15 no.2
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• pp.210-219
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• 2002

Background and Objectives The diagnosis of allergic rhinitis includes detailed clinical history, physical examination and the use of either in vivo or vitro tests for relevant allergens. Skin test has been used the most commonly. Recently MAST CLA is used for determination of serum spcecific IgE, This study attempted to find out the distribution of Sasang Constitution and to compare the MAST CLA with skin tests in allergic rhinitis patients. Methods Skin tests, MAST CLA and Sasang Constitution study were performed for 35 allergic rhinitis patients who visited Kyunghee Oriental Medical Center from Sept. 2001 to Nov. 2001. Results 1. The ratio between male and female was 1:1.5. the peak age was the thirties(42.9$\%$) 2. 45.7$\%$ of patients had family history of allergic diseases and allergic rhinitis was the most common. 3. 51.4$\%$ of patients lived in A.P.T. and in preference of cool and warm, 54.3$\%$ of patients prefered both of cool and warm. 4. Among 24 cases who were consulted to dept. of Sasang, 45.8$\%$ was Taeumin. 5. 65.7$\%$ of patients reacted positive to skin test and the common offending allergen was D. pteronyssinus(82.6$\%$). 6. 25.7$\%$ of patients reacted positive to MAST CLA and the common offending allergen was D. farinae(88.9$\%$). 7. Among 22 cases who was performed skin test and MAST CLA the sensivity and specificity of MAST CLA was 27.4$\%$ and 94.9$\%$. There was significant correlations between MAST CLA and skin test(p=0.005, r=0.574, 1, spearman correlation coefficienct).

• Journal of the Korean Applied Science and Technology
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• v.37 no.1
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• pp.66-75
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• 2020

Atopic dermatitis (AD) usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen specially in childhood, association with IgE hyperproduction and precipitation by environmental factors. and wished to examine closely effect that Polygonum multiflorum isolated PM-E and PM-70M orally adminstration used to atopy dermatitis disease patient get in atopy eruption control experimentally. Atopic dermatitis is a chronically relapsing inflammatory skin disease. Animal models induced by relevant allergens play a very important role in the elucidation of the disease. This study was investigated the anti-allergic effect of PM-E and PM-70M on BMAC induced atopic dermatitis in NC/Nga mice. We summerized as the follow. PM-E and PM-70M significantly reduced the skin number of total cell number, CD4⁺ and CD11b⁺/Gr-1 cell compared with positive control and decreased the invasion of CD4⁺ cell in dorsal skin tissue compared with positive control group by using immunohistochemical staining and chemokine such as eotaxin and CCR3 compared with positive control group. PM-E and PM-70M markedly suppressed invasion and edema of leukocytes and mast cell in dorsal skin. Taken together, these findings suggested that PM-E and PM-70M has an anti-allergic activity and this might be useful for the clinical application to treat allergic diseases such as atopic dermatitis.

• The Journal of Pediatrics of Korean Medicine
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• v.34 no.4
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• pp.31-42
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• 2020

Objectives The purpose of this study is to perform a review on recent researches of Hataedock, a traditional method of removing fetal toxin by dropping herbal extracts in the mouth, to appraise its preventive and therapeutic effects of diseases. Methods Studies of Hataedock were extracted from both Chinese and Korean medical journals published within 10 years, from January 2010 to January 2020. Clinical studies and experimental researches were analyzed and categorized to skin disease, allergic rhinitis, intestinal mucosa inflammation and anal fistula for further evaluation. Results Among 194 studies were searched and screened, 22 met designated criteria. Hataedock showed the effectiveness in treating skin disease, allergic rhinitis, intestinal mucosa inflammation and anal fistula by maintaining skin barrier and regulating immune system. Coptis japonica, Glycyrrhiza uralensis, and Fermented Glycine max were mainly used as herbal extracts in Hataedock. Conclusion This study shows the recent research trends of Hataedock and suggests that Hataedock can be considered as a method of treatment or prevention to some of the incurable chronic diseases.

• Journal of Medicine and Life Science
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• v.15 no.1
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• pp.1-5
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• 2018

Allergy is conditions when a hypersensitivity reaction happens with a certain element, called as an allergen, which is commonly not reactive to ordinary individuals. Allergic diseases involve various organs or systems in the body. The purpose of allergy tests is to make a diagnosis of allergic diseases and to identify the affecting allergens. In vivo tests, more relevant in clinical situation, include skin test, patch test and provocation test. In in vitro tests, there are specific IgE test, histamine releasing assay, and lymphocyte activation test, safer and more objective than in vivo tests. In the view point of clinical practice, skin test, provocation test, total IgE test and specific IgE test were reviewed in depth.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.16 no.3
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• pp.210-219
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• 2003

Objectives : This study is to suggest a kind of guide line of dietary therapy in allergic diseases. Methods : We investigated frequency, symptoms and implicating foods of food allergy, and experience, methods, periods, results and necessity of dietary therapy of 49 patients with allergic diseases by using self-report questionnaires. The data were analyzed by SPSS／PC+ program using frequency, Chi-square test(p〈0.05) and Pearson correlation coefficient(p〈0.01). Results : 1. The frequency of food allergy was 49% and skin symptoms were the most common. 2. The most implicating foods were chicken, flour, milk, pork and egg in order. 3. 36.7% of patients had experienced dietary therapy and 47.4% of them had stated mild improvement. 4. Over 80% of patients perceived necessity of dietary therapy and there is significant correlation between necessity of dietary therapy and sum of food allergens(r=368). Conclusions : Dietary therapy is recommended as supplementary therapy in allergic diseases and it needs to be established based on the real conditions and Korean Oriental medical theory.

• The Journal of Pediatrics of Korean Medicine
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• v.29 no.2
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• pp.1-15
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• 2015

Objectives In the theory of Korean Medicine, Cicadae Periostracum (CP) has been used to treat skin diseases such as inflammatory dermatitis, tetanus and pruritus. CP can reduce heat and disperse wind. In prior studies, anti-allergic effect and anti-inflammatory effect of CP were reported. However, there has been no report regarding the correlation of CP and allergic contact dermatitis (ACD). This study was performed to show the effects of CP in ACD induced by 2,4-dinitrochlorobenzene (DNCB) in mice. Methods In this experiment, the effects of CP on biological changes were measured, such as changes in ear and spleen weight, ear and dorsum skin thickness, clinical aspect on the dorsum skin and histological changes. The effect of proliferation rate of splenocytes was also investigated in vitro and vivo study. Results In results, CP application (CPA) group and CP application and administration (CPAA) group were significantly restrained in ear weight gain and increase in ear and dorsum skin thickness compared to the control group. In addition, CPA and CPAA group showed diminished erythema, desquamation, bloodstain, and marks. Also, the histological assessment showed that CP treatement diminished thickness of epidermis, hyperkeratosis, pigmentation and parakeratosis. Conclusions In conclusion, these data suggest that CP can decrease symptoms of ACD.

• Advances in Traditional Medicine
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• v.5 no.2
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• pp.167-171
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• 2005

Sho-Seiryu-To is known to be effective against allergic diseases, but its effect on skin itching has not been reported. We observed the effect of Sho-Seiryu-To on three elderly patients who, desoite using an anti-allergic drug, has severe chronic skin itching with peripheral eosinophilia. All three patients decreased their peripheral eosinophilia and improved their skin condition within eight weeks. We conclude that Sho-Seiryu-To could be capable of treating elderly patients with chronic skin itching and peripheral eosinophilia.