• Journal of Digital Convergence
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• v.15 no.5
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• pp.505-515
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• 2017

This study examines the verification of algorithm on resilience leisure programs for the productive aging of the new elderly in Korea. The subjects for this study were 525 new elderly who lived in metropolis, medium-sized cities and farming area. The reliability and validity test of the questionnaire were conducted by using SPSS 20.0 program; the results of tree analysis are as follows; First, The influential factor in the resilience leisure programs is subjective health status, desire for activity, interpersonal exchange and household income. The most influential resilience factor of algorithm is interpersonal relationship, self-regulating and affirmative. The structural algorithm of resilience was that low interpersonal relationship group related to the affirmative and high interpersonal relationship group related to the self-regulating.

• Journal of Microbiology and Biotechnology
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• v.34 no.3
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• pp.596-605
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• 2024

Anthocyanins belong to phenolic pigments and are known to have various pharmacological activities. This study aimed to investigate whether anthocyanins could inhibit hydrogen peroxide (H₂O₂)-induced oxidative damage in human retinal pigment epithelial ARPE-19 cells. Our results indicated that anthocyanins suppressed H₂O₂-induced genotoxicity, while inhibiting reactive oxygen species (ROS) production and preserving diminished glutathione. Anthocyanins also suppressed H₂O₂-induced apoptosis by reversing the Bcl-2/Bax ratio and inhibiting caspase-3 activation. Additionally, anthocyanins attenuated the release of cytochrome c into the cytosol, which was achieved by interfering with mitochondrial membrane disruption. Moreover, anthocyanins increased the expression of heme oxygenase-1 (HO-1) as well as its activity, which was correlated with the phosphorylation and nuclear translocation of nuclear factor-erythroid-2 related factor 2 (Nrf2). However, the cytoprotective and anti-apoptotic effects of anthocyanins were significantly attenuated by the HO-1 inhibitor, demonstrating that anthocyanins promoted Nrf2-induced HO-1 activity to prevent ARPE-19 cells from oxidative stress. Therefore, our findings suggest that anthocyanins, as Nrf2 activators, have potent ROS scavenging activity and may have the potential to protect ocular injury caused by oxidative stress.

• Journal of Korean Academy of Nursing
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• v.27 no.3
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• pp.601-613
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• 1997

This project was conducted using a survey method and through interviewing with four persons aged 60 years and over. An interview with an open-ended questionnaire was also used for elderly persons, families, oriental medicine doctor and nurses. topic-related literature review was also done. In total, 382 statements were derived. For content validity, nursing professionals were involved in this study, From that 48 items are developed. The subjects were 340 elderly persons over 60 years old. Data were collected duicing February and March 1997 and analyzed using the SPSS package The result are as follows. 1. Items with low Cronbach Coefficient alpha which means low correlation with total items were removed. 2. Factor analysis was done in order to confirm construct validity and eight factors were obtained from the results. The first factor, 'positive cognition of the aging process', the second factor, 'relationship network' the third factor, 'maintanence of physical functioning, the fourth factor', 'maintanence of peaceful mind' the fifth factor, 'keeping up with daily tasks' the sixth factor, 'continuous adequate body movement' the seventh factor,'involvement of religion in the elderly person's life and the eight factor', 'appropriate resting'. Cronbach Coefficient alpha for the 33 items was .9127 Based on the result, the following is suggested 1. It is anrticipated that the fundamental health of elderly person could be promoted by assessing healthy behaviors of elderly person with this assessment tool. 2. Further studies could be derived from this research. 3. Validity of this assessment tool should be further tested with and a larger sample of elderly person including in-patient elderly persons as well as nursing home residents.

• Journal of Korean Home Economics Education Association
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• v.23 no.3
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• pp.161-183
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• 2011

This study aims to design, develop the impact of a high school course in practical problem- focused teaching plan which will enable students to deal with an aging society, and prepare well for the aging by looking at issues the elderly face. This study set a target of analyzing the 2007 revised curriculum manual to develop instructor-led teaching and learning plans for 'Successful aging preparation'. Five common subjects were reframed on a practical problem basis through factor analysis of preliminary research regarding aging education for teenagers and the 2007 revised curriculum and textbooks of Technology Home Economics, and Human Development. The practical problem was 'What do we need to do to Successfully live an independent life in aging?', and the subjects studied to answer this question were the aging society and population changes. the nature of the elderly, aging preparation, care of the elderly, and welfare services for the elderly. These five subjects were grouped under the main categories of The Aging Society. Understanding the Elderly, and aging Preparation. The ultimate objective of the lessons was, through critical reasoning, to inquire into the causes of current problems the elderly face so that teenagers can understand aging societies and the elderly, and prepare for a Successful aging. Another objective was to seek reasonable alternatives for teenagers as they prepare for Successful and independent aging, and increase their problem-solving abilities in choosing the best course of action by considering the ripple effect of consequences of each of those alternatives. The practical problem-teaching lesson plans consisted of five classes on practical reasoning instruction. This study suggests that new high school curricula should include lessons on preparation for aging so that students can deal successfully with our aging society.

• Journal of Marine Bioscience and Biotechnology
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• v.13 no.2
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• pp.86-93
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• 2021

A high salt diet contributes to kidney damage by causing hypoxia and oxidative stress. Recently, an increase in dietary salt has been reported to induce an inflammatory phenotype in immune cells, further contributing to kidney damage. However, studies on the exact mechanism and role of a high salt diet on the inflammatory response in the kidneys are still insufficient. In this study, a cisplatin-induced acute kidney injury model using C57BL/6 mice was used to analyze the effect of salt intake on kidney injury. Results showed that high salt administration aggravated kidney edema in mice induced by treatment with cisplatin. Moreover, the indicators of kidney and liver function impairment were significantly increased in the group cotreated with high salt compared with that treated with cisplatin alone. Furthermore, the exacerbation of kidney damage by high salt administration was also associated with a decrease in the number of cells in the immune regulatory system. Additionally, high salt administration further decreased renal perfusion functions along with increased cisplatin-induced damage to proximal tubules. This was accompanied by increased expression of T cell immunoglobulin, mucin domain 1 (a biomarker of kidney injury), and Bax (a pro-apoptotic factor). Moreover, cisplatin-induced expression of proinflammatory mediators and cytokines, including cyclooxygenase-2 and tumor necrosis factor-α in kidney tissue, was further increased by high salt intake. Therefore, these results indicate that the kidney's inflammatory response by high salt treatment can further promote kidney damage caused by various pathological factors.

• Nutrition Research and Practice
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• v.16 no.5
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• pp.549-564
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• 2022

BACKGROUND/OBJECTIVES: Oxidative stress is caused by an imbalance between harmful free radicals and antioxidants. Long-term oxidative stress can lead to an "exhausted" status of antioxidant defense system triggering development of metabolic syndrome and chronic inflammation. Green perilla (Perilla frutescens) is commonly used in Asian cuisines and traditional medicine in southeast Asia. Green perilla possesses numerous beneficial effects including anti-inflammatory and antioxidant functions. To investigate the potentials of green perilla leaf extract (PE) on oxidative stress, we induced oxidative stress by high-fat diet (HFD) in aging mice. MATERIALS/METHODS: C57BL/6J male mice were fed HFD continuously for 53 weeks. Then, mice were divided into three groups for 12 weeks: a normal diet fed reference group (NDcon), high-fat diet fed group (HDcon), and high-fat diet PE treated group (HDPE, 400 mg/kg of body weight). Biochemical analyses of serum and liver tissues were performed to assess metabolic and inflammatory damage and oxidative status. Hepatic gene expression of oxidative stress and inflammation related enzymes were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: PE improved hepatopathology. PE also improved the lipid profiles and antioxidant enzymes, including hepatic glutathione peroxidase (GPx) and superoxide dismutase (SOD) and catalase (CAT) in serum and liver. Hepatic gene expressions of antioxidant and anti-inflammatory related enzymes, such as SOD-1, CAT, interleukin 4 (IL-4) and nuclear factor erythroid 2-related factor (Nrf2) were significantly enhanced by PE. PE also reduced the levels of hydrogen peroxide (H₂O₂) and malondialdehyde (MDA) in the serum and liver; moreover, PE suppressed hepatic gene expression involved in pro-inflammatory response; Cyclooxygenase-2 (COX-2), nitric oxide synthase (NOS), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6). CONCLUSIONS: This research opens opportunities for further investigations of PE as a functional food and possible anti-aging agent due to its attenuative effects against oxidative stress, resulting from HFD and aging in the future.

• Journal of Korean Institute of Industrial Engineers
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• v.36 no.2
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• pp.108-116
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• 2010

The maintenance of a deteriorating system is often imperfect. Previous studies have shown that the imperfect preventive maintenance (PM) can reduce the wear out and aging effects of deteriorating systems to a certain level between the conditions of as good as new and as bad as old. In this paper, we employ the concept of the improvement factor in investigating two optimal PM policies; failure limit policy and periodic PM policy. We redefine the improvement factor model as a function of the cost of PM, using this concept, we derive the conditions of optimal PM policies and formulate expressions to compute the expected cost rate. Based on this information, the determination of the maintenance policies which minimize the cost rate is examined. Numerical examples for the Weibull distribution case are also given.

• Journal of the Korean Society of Clothing and Textiles
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• v.19 no.3
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• pp.463-470
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• 1995

Anthropological measurements concerning 29 items were made on 37 adult males aged from 20 to 60. Factor analysis was applied in all 36 items. The main results are as gallows 1. Neck girth and need base girth are smaller. in the elder croup than the gouger group. 2. These decrease occur in the frontal part of the neck. 3. Neck frontal width decreases with age, but side depth increases. 4. The back part of the body depth at the level of the shoulder increases with age. 5. For the factor analysis, the third factor is a factor of forms, the variations of which has a relation with age.

• Journal of Food Hygiene and Safety
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• v.9 no.1
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• pp.31-36
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• 1994

The acute toxicity of recombinant human epidermal growth factor, DWP-401 was evaluated in SD rats. Male and female rats aging 6 weeks were administered orally or subcutaneously with 0, 0.125, 0.25, 0.5, 1 and 2 mg/kg of DWP-401. No deaths and no toxic symptoms related to the DWP-401 were observed. The body weights of treated animals were not significantly different from the controls. The results of necropsy revealed no abnormal gross findings of the organs in treated animals. LD50 values of DWP-401 for male and female rats were estimated to be over 2 mg/kg, which is approximately 2, 000 times of expected clinical dose.

• The Journal of the Korea Contents Association
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• v.18 no.3
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• pp.509-519
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• 2018

The purpose of this study was to examine the attitude toward own aging among community-residing elderly and the predictors of the attitude focusing on personal resources, social support, and social participation. Data were collected from 198 elders aged 60+ with the cooperation of several social service center for the aged, senior centers, and senior citizen associations in Daejeon Metropolitan City. SPSS 22.0 software was used for descriptive analysis, correlation analysis, and hierarchical regression analysis. The results showed that (1) the research participant elderly's attitude toward own aging indicated fairly negative perception of their own aging; (2) self-esteem and economic status were statistically significant factors indicating the higher levels of self-esteem and economic status predicting the positive attitude of their own aging; (3) emotional support from family was statistically significant factor that predicted the positive attitude of their own aging; (4) the level of social participation was also statistically significantly associated with the positive attitude; (5) In the full model of all independent variables, the significance of emotional support from family and social participation disappeared, but self-esteem and economic status among personal resources remained statistically significant influential factors. Based on the findings, suggestions for social welfare policy and practice to improve community-residing elderly's positive attitude toward their own aging were discussed.