• Speech Sciences
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• v.9 no.4
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• pp.77-91
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• 2002

This study investigated the use of grammatical morphemes (substantive morphemes and connective endings) of Korean speaking children with and without language impairment (LI). Participants were two children (ages 5;11 and 6;2) with SLI (specific language impairment), two LD (language delay) children (ages 6;3 and 6;5) with 70-84 range on a performance-IQ test, and two children (ages 5;7 and 6;1) with ND (normal development). Spontaneous language samples were elicited by play activities and story generation. A total of 8,059 (M=I,343, ranged 966-1,659) intelligible and nonimitative utterances were analyzed by the KCLA 2.0 (Korean Computerized Language Analysis 2.0) program for substantive morphemes and connective endings. The findings of this study were as follows; (1) The Korean speaking children with LI including SLI demonstrated less uses of grammatical morphemes than ND children. (2) Few differences were found between LI and ND children in the use of the grammatical morpheme types. (3) LI children produced significantly higher percentage of grammatical morpheme errors in spontaneous speech than ND children. (4) Few differences were found between SLI and LD children in degrees of the use and the error of grammatical morphemes.

• Korean Journal of Veterinary Research
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• v.39 no.4
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• pp.673-678
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• 1999

The distribution and relative frequency of insulin-immunoreactive cells in the pancreas was studied during developmental stages (fetus, neonate, 1-month-old, 6-month-old and adult) of the Korean native goat by immunohistochemical methods. The different distribution and relative frequency of glucagon-immunoreactive cells in the pancreas of the Korean native goat was observed during development. Insulin-immunoreactive cells were detected in the exocrine and endocrine portions (pancreatic islets) of the all ages, and in the duct of the 6-month-old. The relative frequencies of these cells were increased in the pancreatic islets with ages but decreased in the exocrine portions. Generally, they were distributed in the interacinar spaces or central zone of the pancreatic islets in all ages. However, the distributions and relative frequencies in the pancreatic islets of the neonate Korean native goat were divided into three patterns : 1) located in the inner zone with numerous frequencies, 2) the peripheral zone of the pancreatic islet with moderate frequencies and 3) the peripheral zone of the pancreatic islet with a few frequencies patterns.

• Korean Journal of Veterinary Research
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• v.47 no.1
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• pp.77-84
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• 2007

Helicobacter pylori (H. pylori) is an important bacterial pathogen that causes chronic gastritisand is associated with gastroduodenal ulcer disease, adenocarcinoma of the distal stomach, and gastricH. pylori infection associated with host agehave not been well-defined in human. To evaluate the difference in host susceptibility to infection in relationto age of acquisition of H. pylori infection, we designed an experiment involving inoculation of H. pyloriATC 43504 at different ages of Mongolian gerbils. H. pylori was inoculated at 5 weeks and 18 monthsof age, as representatives of early and late infection, respectively. Animals were sacrificed 1 week and 4weeks after challenge, and the stomach was removed from each animal for bacterial culture, histologicalexamination, and polymerase chain reaction test. 5 week-old gerbils revealed infection andmaintained continuously its infection until 4 weeks. However, old gerbils did not maintained H. pyloriinfection. These data suggest the insusceptibility of H. pylori in old Mongolian gerbils and the importanceof animal ages for successful animal experimental infection. Also, the results demonstrated that earlyinfection of H. pylori increases its host susceptibility, as compared to the case with later infection, possiblybecause of differences in host gastric mucosal factors and imunologic responses.

• Journal of Preventive Medicine and Public Health
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• v.47 no.5
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• pp.266-272
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• 2014

Objectives: The aim of this study was to investigate the relationship between age at cigarette smoking initiation and smoking level among adolescent current smokers. Methods: In 2007, students from one or two classes of the 10th or 11th grade were randomly selected using the probability proportional to size sampling method. In total, 743 current smokers were included. Multiple logistic regression was used to determine the association between age at smoking initiation and smoking level as either frequent, daily, or heavy smokers. Results: The adjusted odds ratios for each smoking level were significantly higher for younger ages of smoking initiation than those for older ages of initiation were (p for trend <0.001). Compared with the students who started smoking in grades 10 to 11, the adjusted odds ratios for frequent, daily, and heavy smokers increased from 2.24 (95% confidence interval [CI], 1.30 to 3.87) to 3.90 (95% CI, 2.02 to 7.56), from 1.56 (95% CI, 0.92 to 2.62) to 3.17 (95% CI, 1.70 to 5.92), and from 2.56 (95% CI, 1.21 to 5.42) to 5.67 (95% CI, 2.61 to 12.30) with younger ages of smoking initiation. Conclusions: Smoking frequency and amount were closely associated with age at smoking initiation. Therefore, smoking prevention programs should be initiated from the young adolescent period.

• Natural Product Sciences
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• v.12 no.4
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• pp.210-213
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• 2006

A 4,5-dioxoaporphine type alkaloid, cepharadione B (1), a phenolic acid, protocatechuic acid (2), and flavonols, quercetin (3), afzelin (4), and quercitrin (5), were isolated from the EtOAc-soluble extract of the whole plants of Houttuynia cordata. All the isolates (1-5) were subjected to in vitro bioassays to evaluate advanced glycation end products (AGEs) formation and rat lens aldose reductase (RLAR) inhibitory activity. The three flavonols 3-5 exhibited a significant inhibitory activity on AGEs formation with $IC_{50}$ values of 66.9, 58.9, and $32.3{\mu}M$, respectively. While the two flavonol rhamnosides 4 and 5 showed a remarkable inhibitory activity against RLAR with $IC_{50}$ values of 0.81 and $0.16{\mu}M$, respectively.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.4
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• pp.728-733
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• 2011

This study was designed to analyze the results of stress index by heart rate variability test. The subjects were workers in the automobile manufacturing industry. The subjects consisted of 23,767 workers who had answered about questionnaires of a job position, age, smoking, drinking, exercise state and sex. The stress index(SI) and stress resistance(SR) were examined by SA3000P. We analyzed the differences of SI and SR according to job positions, ages, the state of smoking, drinking, exercise and sex by T-test or ANOVA with SPSS ver. 17.0. Regarding the differences of SI among job positions, the SI was highest in sales positions. Among ages, the SI was highest in 30s. In smoking, the SI was lower in non-smoking group. In drinking, there was no significant differences in SI. In exercise, the SI was lower in exercise group. In sex, there was no significant difference. The case of SR, SR was lowest in sales positions. Among ages, the SR was lowest in 40s. In smoking, the SR was lower in smoking group. In drinking, there was no significant differences in SR. In exercise, there was no significant difference. In sex, the SR was lowest in male. According to these results, we should establish the methods of controlling stress from the perspective of Korean traditional medicine.

• Science of Emotion and Sensibility
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• v.4 no.2
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• pp.39-45
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• 2001

This study was conducted to identify the structure of the sensibility and autonomic nervous responses to odor by ages. 72 participants, 24 each in their teens, twenties, and thirties were given odor stimuli, cederwood, grapefruit, teebaum, peppermint, rose. During the presentation of stimuli, participant were measured blood flow, skin temperature, skin conductance, and ECG and subjective emotion to each odor were evaluated, Five factors, aesthetic, intensity, naturality, uniqueness, and romantism were identified but there were no differences by ages. Emotional factors that predict the preference to certain odors turned out partly different by ages. However, odors that made participants feel sick created more autonomic nervous response than odors that made them feel good.

• Journal of the Korean Society of Food Culture
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• v.14 no.3
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• pp.225-231
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• 1999

Perception and knowledge on the diet among 651 women living in Inchon were surveyed by questionnaires in March through May, 1998. Respondents consisted of middle school girls(12.3%), high school girls(16.4%), and women in twenties(16.4%), thirties(18.9%), forties(15.7%) and fifties and over(20.3%). Ratio of high school graduates was the highest(37.0%) among respondents, and there was a tendency of less education with ages. Seventy-six percent of women practised the diet for the self-satisfaction of a nice figure, 20% for healing diseases, and 3.4% for attracting boy friends' or husbands' attention. The purpose of the diet was significantly different with ages(p<0.01). The diet methods which the respondents perceived effective and wanted to practise were exercise and food therapy. Average score of the knowledge on the diet was 8.27 out of 10, and significantly different with ages and education(p<0.05). Twenties showed the highest score and high school girls, thirties, middle school girls, forties and fifties and over were followed in decreasing order. Also the score was in decreasing order of graduates of college, high, elementary and middle school.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.70.2-70.2
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• 2011

We present a study of the metallicities, ages, and alpha-elements of globular clusters (GCs) in nearby giant elliptical galaxies (gEs) (M87, M49, M60, NGC 5128, NGC 1399, NGC 1407, and NGC 4636) using data in the literature. We used only the data for the GCs derived from the comparison of absorption line indices with the single stellar population model. The metallicity distributions of GCs in these gEs are bimodal, showing the existence of metal-poor and metal-rich populations. All these gEs harbor young GCs with ages less than 5 Gyr as well as old GCs. The mean age of the metal-rich GCs ([Fe/H]>-0.9) is about 3 Gyr younger than that of the metal-poor GCs. The mean values for the alpha-elements of the GCs are smaller than or similar to that of the Milky Way GCs. All the GCs in these gEs show an age-metallicity relation; the larger the metallicities of the GCs are, the younger the GCs are. Old GCs with ages > 10 Gyr have two distinct sub-populations (metal poor and metal rich), while young GCs show a broad metallicity distribution with a single peak. We discuss these results in relation with the formation of GCs in gEs.

• Food Science and Preservation
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• v.24 no.4
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• pp.536-541
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• 2017

Hyperglycemia found in diabetes mellitus causes several physiological abnormalities including the formation of advanced glycation end products (AGEs) and oxidative stress. Accumulation of AGEs and elevation of oxidative stress plays major roles in the development of diabetic complications. Adiponectin secreted from adipocytes is known to improve insulin sensitivity and blood glucose level. Curcumin (CCM), a bioactive component of turmeric, has been reported as a potent antioxidant. Present work aimed to elucidate the roles of CCM in high glucose-induced protein glycation and intracellular events in mature adipocytes. The results demonstrated that CCM inhibited the formation of fluorescent AGEs by approximated 52% at 3 weeks of bovine serum albumin (BSA) glycation with glucose. Correspondingly, CCM decreased the levels of fructosamine and ${\alpha}-dicarbonyl$ compounds during BSA glycation with glucose. These data suggested that CCM might be a new promising anti-glycation agent. Also, CCM reduced high glucose-induced oxidative stress in a dose dependent manner, whereas CCM treatment time-dependently elevated the expression of adiponectin gene in 3T3-L1 adipocytes. The findings from this study suggested the possibility of therapeutic use of CCM for the prevention of diabetic complications and obesity-related diseases.