• Proceedings of the Korea Multimedia Society Conference
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• 2000.11a
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• pp.303-306
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• 2000

AIN CS-3를 기반으로 하는 IMT-2000 망은 지능망의 구성요소들과 통합 및 연동을 통하여 기존에 개발되었거나 앞으로 개발될 유선 지능망의 서비스들을 쉽게 수용할 수 있게 된다. 본 논문에서는 IMT-2000 및 IMT-2000과 연동되는 타 네트워크의 상이한 플랫폼 환경의 개발환경 및 향후 유지보수과정에서 발생할 것으로 예측되는 TMN 시스템 내 에이전트의 Q3 인터페이스 구현상의 표준을 이를 수 없다는 층의 문제점을 해결하기 위하여 I-Farmer 모델을 제안하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2007.10a
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• pp.114-115
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• 2007

• Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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• 2003.12a
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• pp.578-584
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• 2003

본 논문에서는 인터넷 기반 P2P 네트워크를 이용한 Grid 컴퓨팅에서의 효율적인 보안 관리 모델을 제시한다. 하나는 P2P 네트워크를 이용한 에러 복구 과정과 다른 하나는 에이전트간 신뢰관계 구성 방안이다. 또한 P2P 네트워크에서 다양한 네트워크 간 보안 통신을 보장하기 위해 SOAP을 이용한 보안 메시지 프로토콜을 제안한다. 제안된 새로운 보안 관리 모델은 P2P 네트워크로 구성된 Grid 컴퓨팅 네트워크의 성능을 향상시킬 것으로 기대된다.

• Natural Product Sciences
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• v.4 no.4
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• pp.226-229
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• 1998

Methanolic extract of Cassia tora leaves was evaluated for its hepatoprotective activity in rats by inducing hepatotoxicity with paracetamol (acute model). The extract at a dose of 400 mg/kg orally exhibited significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin, and alkaline phosphatase (ALP). The effects produced were comparable to that of a standard hepatoprotective agent.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.425.1-425.1
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• 2002

Nanoparticles of polylactic acid (PLA) and polyethylenimine (PEI) as an effective gene delivery agent were prepared and characterized. As a model plamid DNA. PME185/$\beta$-gal. a mammalian expression vector. and fluorescence enhancing protein (pEGHP) were used. The effects of PEI type on the physical properties of nanoparticles and transfection efficiency were examined. (omitted)

• Annual Conference of KIPS
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• 2007.05a
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• pp.201-204
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• 2007

본 논문은 소각재 재활용 모니터링 시스템 구현을 위한 에이전트 기반의 RFID 모델을 설계한다. RFID를 이용한 모니터링 시스템은 상태관리 에이전트, 위치관리 에이전트, 불량관리 에이전트, 상황관리 에이전트 등의 데이터 관리 에이전트를 이용해 데이터를 자동 관리하고, 대용량의 데이터를 처리하기 위해 대용량 데이터 처리 에이전트를 이용한다. 안정적인 소각재 재활용을 위한 에이전트 기반 데이터 모니터링 시스템의 개발은 산업체 전반에 걸쳐있는 기계화, 수작업화 된 공정을 실시간 자동화 공정으로 개발하는 획기적인 방법이 될 것이다.

• The KIPS Transactions:PartC
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• v.15C no.5
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• pp.383-390
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• 2008

The mobile sink is most suitable to guarantee the real time processing to events in ubiquitous environment. However it brings many challenges to wireless sensor networks. In particular, the question of how to transfer the collected data to the mobile sink is an important topic in the aspect of effective management of wireless sensor nodes. In this paper, a new data dissemination model is proposed. Since this method uses the home agent and the access node concepts, it provides reliable and efficient data delivery to mobile sink with minimum overhead. In this proposed method, the information of the mobile sink which is constantly moving is informed only to the home agent node and the access node, instead of all sensor nodes. Thus, the collected data from sensor nodes are transferred to the fixed home agent and it sends these data to the mobile sink. Since the confliction phenomenon between data packets in wireless networks could be reduced, the success ratio of data arriving in the mobile sink is highly enhanced. In our experiments, the proposed method reduces the number of broadcast packets so that it saves the amount of energy consumed for transmitting and receiving the data packets. This effect contributes to prolong the lifetime of the wireless sensor networks operated by batteries.

• Investigative Magnetic Resonance Imaging
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• v.2 no.1
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• pp.73-82
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• 1998

Purpose : A precise NMR technique for measuring the rate of water exchange and cell membrane permeability across the hepatocyte membrane using liver-specific MR contrast agent is described. Materials and Methods : The rat hepatocytes isolated by perfusion of the livers were used for the NMR measurements. All experiments were performed on an IBM field cycling relaxometer operating from 0.02MHz to 60 MHz proton Larmor frequency. spin-echo pulse sequence was empolyed to measure spin-lattice relaxation time, T1. The continuous distribution analysis of water proton T1 data from rat hepatocytes containing low concentrations of the liver specific contrast agent, Gd-EOB-DTPA, modeled by a general two compartment exchange model. Results : The mean residence time of water molecule inside the hepatocyte was approximately 250 msec. The lower limit for the permeability of the hepatocyte membrane was $(1.3{\pm}0.1){\;}{\times}{\;}10^{-3}cm/sec$. The CONTIN analysis, which seeks the natural distribution of relaxation times, reveals direct evidence of the effect of diffusive exchange. the diffusive water exchange is not small in the intracellular space in the case of hepatocytes. Conclusions : Gd-EOB-DTPA, when combined with continuous distribution analysis, provides a robust method to study water exchange and membrane permeability in hepatocytes. Water exchange in hepatocyte is much slower thatn that in red blood cells. Therefore, tissue-specific contrast agent may be used as a functional agent to give physiological information such as cell membrane permeability.

• Journal of the Korean Society of Radiology
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• v.16 no.2
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• pp.103-113
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• 2022

In this paper, a combined ¹⁸F-FDG(fluorodeoxyglucose) and MNP(magnetic nanoparticles) contrast agent was synthesized using N-(p-maleimidophenyl) isocyanate as the crosslinker for use in simultaneous PET-MRI scans. PET-MRI images were acquired and evaluated before and after injection of the combined contrast imaging agent (¹⁸F-FDG labeled MNP) from a glioma stem cell mouse model. After setting the region of interest (ROI) on each acquired image, the area of the lesion was calculated by segmentation. As a result, the PET image was larger than the MRI. In particular, the simultaneous PET-MRI images showed accurate lesions along with the surrounding soft tissue. The mean and standard deviation values were higher in the MRI images alone than in the PET images or the simultaneous PET-MRI images, regardless of whether the contrast agent was injected. In addition, the simultaneous PET-MRI image values were higher than for the PET images. For PSNR experiments, the original image was PET Image using 18F-FDG, MRI using MNPs, and MRI without contrast medium, and the target image was simultaneous PET-MRI image using 18F-FDG labeled MNPs contrast medium. As a result, all of them appeared significantly, suggesting that the 18F-FDG labeled MNPs contrast medium is useful. Future research is needed to develop an agent that can simultaneously diagnose and treat through SPECT-MRI imaging research that can use various nuclides.

• Investigative Magnetic Resonance Imaging
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• v.7 no.1
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• pp.39-46
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• 2003

Purpose : To develop a theoretical model for magnetic relaxation behavior of the superparamagnetic nano-particle agent, which demonstrates multi-functionality such as liver- and lymp node-specificity. Based on the developed model, the computer simulation was performed to clarify the relationship between relaxation time and the applied magnetic field strength. Materials and Methods : The ultrasmall superparamagnetic iron oxide (USPIO) was encapsulated with biocompatiable polymer, to develop a relaxation model based on outsphere mechanism, which was resulting from diffusion and/or electron spin fluctuation. In addition, Brillouin function was introduced to describe the full magnetization by considering the fact that the low-field approximation, which was adapted in paramagnetic case, is no longer valid. The developed model describes therefore the T1 and T2 relaxation behavior of superparamagnetic iron oxide both in low-field and in high-field. Based on our model, the computer simulation was performed to test the relaxation behavior of superparamagnetic contrast agent over various magnetic fields using MathCad (MathCad, U.S.A.), a symbolic computation software. Results : For T1 and T2 magnetic relaxation characteristics of ultrasmall superparamagnetic iron oxide, the theoretical model showed that at low field (<1.0 Mhz), $\tau_{S1}(\tau_{S2}$, in case of T2), which is a correlation time in spectral density function, plays a major role. This suggests that realignment of nano-magnetic particles is most important at low magnetic field. On the other hand, at high field, $\tau$, which is another correlation time in spectral density function, plays a major role. Since $\tau$ is closely related to particle size, this suggests that the difference in R1 and R2 over particle sizes, at high field, is resulting not from the realignment of particles but from the particle size itself. Within normal body temperature region, the temperature dependence of T1 and T2 relaxation time showed that there is no change in T1 and T2 relaxation times at high field. Especially, T1 showed less temperature dependence compared to T2. Conclusion : We developed a theoretical model of r magnetic relaxation behavior of ultrasmall superparamagnetic iron oxide (USPIO), which was reported to show clinical multi-functionality by utilizing physical properties of nano-magnetic particle. In addition, based on the developed model, the computer simulation was performed to investigate the relationship between relaxation time of USPIO and the applied magnetic field strength.