Effect of Polyethylenimine Type in Polylactic acid Nanoparticles/DNA Complex on the Transfection Efficiency

  • Published : 2002.10.01

Abstract

Nanoparticles of polylactic acid (PLA) and polyethylenimine (PEI) as an effective gene delivery agent were prepared and characterized. As a model plamid DNA. PME185/$\beta$-gal. a mammalian expression vector. and fluorescence enhancing protein (pEGHP) were used. The effects of PEI type on the physical properties of nanoparticles and transfection efficiency were examined. (omitted)

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