• Physical Therapy Rehabilitation Science
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• 제4권1호
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• pp.17-21
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• 2015

Objective: In this study, we aimed to test the hypothesis that aerobic exercise might exert its cardio-protective effect by preventing oxidative stress and improving cardiac function in rat models with doxorubicin-induced cardiomyopathy. Design: Randomized controlled trial. Methods: We randomly divided experimental rats into four groups: the normal group was used as a non-cardiomyopathy normal control (n=10); the control group included non-aerobic exercise after doxorubicin-induced cardiomyopathy (n=10); the experimental group I included aerobic exercise (3 m/min) after doxorubicin-induced cardiomyopathy (n=10); and experimental group II included aerobic exercise (8 m/min) after doxorubicin-induced cardiomyopathy. Rats in the treadmill training groups underwent treadmill training, which began at 2 weeks after the first intraperitoneal injection. At the end of the exercise period, we determined the heart weight change for each rat. Changes in the levels of oxidative stress enzymes (superoxide dismutase [SOD], thiobarbituric acid-reactive substances [TBARS], and catalase) in the cardiac tissue of rats from all four groups were examined at the end of the experiment. Results: Significant cardiac myocyte injury and increase in myocardial TBARS concomitant with a reduction in myocardial SOD and catalase were observed following cardiomyopathy (p<0.05). Significant cardiac tissue and increase in myocardial TBARS along with reduction in myocardial SOD and catalase were observed following cardiomyopathy (p<0.05). Oxidative parameters were significantly improved in the aerobic exercise groups compared with the control group. Conclusions: These findings indicate that aerobic exercise effectively prevents oxidative stress in rat models with cardiomyopathy.

• 운동영양학회지
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• 제23권3호
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• pp.22-28
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• 2019

[Purpose] The purpose of this study was to investigate the effect of diet plus exercise training and detraining for 12 weeks on body composition, aerobic performance, and stress-related variables in obese women. [Methods] Twenty-five women in their 20s-40s with 30% body fat and body mass indices above 25 kg/m² were divided into HR_LT (heart rate at lactate threshold) and HR_LT + 5% groups. Dietary intervention of 70% recommended dietary allowance (RDA) and exercise treatment composed of aerobic exercises on a bicycle (30 min) and treadmill (30 min) were then performed. These interventions were performed three times a week for 12 weeks. [Results] Dietary intake was significantly decreased, while daily activity significantly increased within the 12-week intervention period, and this effect was sustained after 12 weeks of detraining. Exercise training based on dietary intake and daily activity presented a significantly decreased weight and % body fat, improvement of aerobic performance, and a significant increase in heart rate variability (HRV) (e.g., average of all RR intervals and the square root mean squared differences of successive RR intervals) as stress-related variables. It was also confirmed that the improvement of body composition and stress-related variables were maintained even after detraining. [Conclusion] Our results suggest that 70% RDA of dietary intervention and exercise training corresponding to HR_LT and HR_LT + 5% for 12 weeks were effective in improving body composition and aerobic performance, and relieving stress. In particular, enhanced HRV persisted for up to 12 weeks after the end of exercise training in obese women.

• 지역사회간호학회지
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• 제23권1호
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• pp.22-30
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• 2012

Purpose: This study was conducted in order to investigate the effects of an aerobic exercise program on mobility, fall efficacy, balance, and stress in the elderly at senior centers. Methods: This research was conducted as a quasi-experimental pretest and posttest control and experimental comparison study. The subjects were 41 senior residents (Exp.=18, Cont.=23) who aged above 65 at senior centers in S City. The period of time for data collection and intervention was from August 25 to December 5, 2008. Results: Mobility (t=-3.10, p<.01) in the experimental group were significantly higher than those in the control group without an aerobic exercise program. However, fall efficacy (t=1.28, p=.207), balance (t=-.53, p=.602; t=.36, p=.723), stress (t=-1.32, p=.199) in the experimental group was not significantly higher than that in the control group. Conclusion: These findings confirmed that aerobic exercise programs make a contribution to improving mobility in the elderly at senior centers.

• 생명과학회지
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• 제28권10호
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• pp.1186-1192
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• 2018

비만에 의한 근형질세망 스트레스(Endoplasmic stress, ER stress) 발생은 비접힙 단백질의 축적으로 근육내 대사와 근기능 저하를 초래한다. 유산소 운동과 폴리페놀은 비만에 유도된 염증성 사이토카인과 ER stress를 감소시키는 것으로 잘 알려졌다. 그러나 신체활동과 약물에 의한 염증성 사이토카인과 ER stress 변인들의 변화에 선택적인 반응이 있는지에 대한 연구는 이루어지지 않았다. 따라서, 이 연구의 목적은 유산소 운동과 폴리페놀섭취에 따른 골격근내 ER stress 관련 변인에 우선적인 효과가 있는지 비교분석하고자 하였다. 이 연구의 목적을 위해 (1) 정상식이 그룹, (2) 60% 고지방식이 그룹, (3) 고지방식와 레스베라트롤 25 mg/kg 그룹, (4) 고지방식이와 크리신 50 mg/kg 투여 그룹, (5) 고지방식이와 운동 그룹으로 나누어 실시하였다. 레스베라트롤과 크리신 그룹은 16주간 경구 투여 하였고, 운동 그룹은 1일 40-60분간 10-14 m/min의 속도로 주 4일, 총 16주간 트레드밀 운동을 수행하였다. 운동그룹에서 $IRE1{\alpha}$, BIP/GRP78는 고지방 식이 그룹과 비교하여 유의하게 낮아졌다(p<0.05). 고지방식이와 레스베라트롤 투여 그룹에서 ATF6, $IRE1{\alpha}$, BIP/GRP78는 고지방식이 그룹과 비교하여 유의하게 낮아졌다(p<0.05). 고지방식이와 크리신 투여 그룹은 고지방식이 그룹과 비교하여 ATF6가 유의하게 낮아졌다(p<0.05). 이러한 결과는 유산소 운동과 레스베라트롤, 크리신 섭취에 의해 ER stress 관련 변인을 조절할 수 있다. 그러나 유산소 운동은 고지방 식이에 의해 유도되는 ER stress 개선이 더욱 효과적인 것으로 나타났다.

• 지역사회간호학회지
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• 제6권1호
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• pp.98-113
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• 1995

The purpose of this study were two fold : first, to determine the effect of aerobic exercise on BP, pulse rate, body fat, body weight, symptoms of sterss response: and secondly, to apply the aerobic exercise on nursing practice in the healthy or ill subjects. In an attempt to investigate the physiological and psychological effect of exercise, a quasi -experiment, non-equivalent control group pre-test & post-test design was planned. Experiments were carried out from July 4, through August 30, 1994 with 37 subjects conveniently sampled from K & Y sports center located in Taejon. The 37 research subjects were assigned to experimental(16 subjects) and control(21 subjects) groups. Aerobic exercise was carried out for experimental group from three times to five times a week for 6 weeks in aerobic center. Data were analyzed with t-test, mean, per centage of change using SAS program. Results were obtained as follows: 1) Systolic blood pressure (M=123.75mmHg, % of change=1.12%) and diastolic blood pressure (M=74.38mmHg, % of change=5.79%) was increased on that of experimental group after 6 weeks experiment. But there was no significant difference between experimental group and control group. 2) Body weight was decreased on that of experimental group(M=56.54Kg, % of change=-1.60%) and that of control group(M=52.05, % of change=-0.99%) after 6 weeks. But there was no significant difference between experimental group and control group. 3) Body fat was decreased on that of experimental group(M=30.53%, % of change=-3.60%) and that of control group (M=28.75%, % of change=-3.52%) after 6 weeks. There was no significant difference between experimental group and control group. 4) Pulse rate was decreased on that of experimental group(M=69.19회/min, % of change -8.43%) and that of control group(M=76.0회/min, % change -0.07%) after 6weeks. There was significant difference(t=-2.621, P<0.05) between experimental group and control group. 5) Symptoms of stress response were decreased on that of experimental group(M=0.97) and that of control group(M=1.15) after 6 weeks. There was no significant difference between experimental group and control group. Therefore, adherence to aerobic exercise for 6 week seem to be affected mainly pulse rate of subjects. A futher study is necessary to determine the difference in the effect of variety exercise, programs, to study over 6 weeks, to produce professional educational program for exercise speciality nurses.

• Physical Therapy Rehabilitation Science
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• 제10권4호
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• pp.421-429
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• 2021

Objective: The purpose of this study was to examine the effect of personalized complex aerobic training programs using wearable device on cardiovascular and respiratory functions in community based female elderly. Design: One group pre-post intervention study. Methods: Twenty-one older female participants lived in 'D' city were included. The personalized complex aerobic training program using wearable devices was applied to all participants for 4 weeks, 3 times a week, 30 minutes for per session. The participants' blood pressure, heart rate, oxygen saturation, respiration rate, submaximal exercise stress test, pulmonary function test and respiratory muscle strength test were evaluated before and after the complex training program. Results: After intervention, resting diastolic blood pressure, resting systolic blood pressure and the systolic blood pressure after submaximal exercise stress test were significantly decreased over time (p<0.05), and the submaximal exercise stress test duration were significantly increased over time (p<0.05). The maximal inspiratory pressure (MIP) was significantly increased compare to before the intervention (p<0.05). Conclusions: This study showed that personalized complex training program using wearable device can provide personalized exercise intensity according to cardiopulmonary function that give feedback, and these interventions have a significant effect on improving the cardiovascular and respiratory system functions of the female elderly in the community dwelling.

• 한국콘텐츠학회논문지
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• 제15권10호
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• pp.346-353
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• 2015

본 연구는 유산소 운동과 복합운동 후 신체조성과 스트레스의 변화를 확인하고 비만관리 운동프로그램 개발 시 근거자료로 활용하고자 시행하였다. 비만 여대생 40명을 유산소운동군(20명), 복합운동군(20명)으로 분류하였다. 매회 60분, 1주에 3회, 총 8주간 각각 운동프로그램을 시행한 후 신체조성 및 스트레스를 비교하였다. 연구결과, 유산소 운동군과 복합운동군 모두 체지방율이 유의하게 감소되었고, 비만스트레스는 복합운동군에서 유의한 감소가 있음을 알 수 있었다. 따라서 비만관리 운동프로그램을 개발 시 비만스트레스를 고려한 복합운동군이 더 적합할 것으로 생각된다.

• 한국엔터테인먼트산업학회논문지
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• 제14권5호
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• pp.267-276
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• 2020

본 연구는 제7기 국민건강영양조사의 원시자료를 이용하여, 65세 이상의 골관절염 노인 104명을 대상으로 3가지 신체활동 즉 걷기, 근력운동, 유산소 활동에 대한 각각의 실천율과, 일반적 특성에 따른 신체활동 실천율의 차이와 신체활동이 스트레스 및 삶의 질에 미치는 영향을 알아보고자 하였다. 연구 결과 여성이 남성에 비해 근력운동 실천율 낮았으며, 주관적 건강상태가 좋을수록 걷기와 유산소 활동 실천율이 높게 나타났다. 스트레스에서는 스트레스를 느끼는 군이 스트레스가 전혀 없다는 군에 비해 걷기와 유산소 활동 실천율이 높은 것으로 나타났으며, 스트레스를 조금 느낀다고 한 군이 3일 이상 걷기를 가장 많이 실천하였다. 건강관련 삶의 질(EQ-5D)에서 운동능력은 신체활동을 실천하지 않는 군에 비해 걷기, 근력운동, 유산소 활동을 실천하는 군이 운동능력이 좋았으며, 자기 관리에서는 걷기, 유산소 활동을 실천하는 군이 자기 관리에 문제가 없었고, 일상활동은 걷기, 근력운동을 실천하는 군이 일상활동 수준도 높게 나타났다. 통증/불편 영역에서는 걷기를 실천하는 군이 통증/불편감이 적게 나타났으며, 불안/우울 영역에서는 걷기 실천하는 군이 불안/우울이 적게 나타났다. 결론적으로 골관절염 노인의 삶의 질을 높이고, 스트레스를 관리하기 위해서는 신체활동 수준을 높이려는 적극적인 노력이 필요하며, 특히 여성 골관절염 노인의 신체활동의 중요성에 대한 인식개선이 우선적으로 강조되어야 한다고 본다.

• Journal of Microbiology and Biotechnology
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• 제23권4호
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• pp.451-458
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• 2013

The human gastric pathogen Helicobacter pylori (Hp) has been considered a microaerophile. However, we recently reported that, when supplied with 10% $CO_2$, Hp growth is stimulated by an atmospheric level of $O_2$, suggesting that Hp is a capnophilic aerobe. In this study, we investigated the effects of aerobic $O_2$ tension on Hp cells by comparing gene expression profiles of cultures grown under microaerobic and aerobic conditions in the presence of 10% $CO_2$. The results showed that overall differences in gene expression in Hp cells grown under the two $O_2$ conditions were predominantly growth-phase-dependent. At 6 h, numerous genes were down-regulated under the aerobic condition, accounting for our previous observation that Hp growth was retarded under this condition. At 36 h, however, diverse groups of genes involved in energy metabolism, cellular processes, transport, and cell envelope synthesis were highly up- or down-regulated under the aerobic condition, indicating a progression of the cultures from the log phase to the stationary phase. The expression of several oxidative stress-associated genes including tagD, katA, and rocF was induced in response to aerobic $O_2$ level, whereas trxA, trxB, and ahpC remained unchanged. Altogether, these data demonstrate that aerobic $O_2$ tension is not detrimental to Hp cells but stimulates Hp growth, supporting our previous finding that Hp may be an aerobic bacterium that requires a high $CO_2$ level for its growth.

• Journal of Applied Biological Chemistry
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• 제43권4호
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• pp.211-217
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• 2000

Oxidative stress is implicated in a number of diseases, in ageing of organisms, and in damage to plants that have been exposed to freezing and thawing or water stress. From the perspective of yeast as a model eukaryotic system, this article reviews the systems that are involved in the cellular responses to exposure to reactive oxygen species (ROS) generated during aerobic growth of the organism. The discussion includes the defense systems involved, the ability of cells to adapt to ROS treatment, cell-division cycle delay and the systems regulating gene expression that are activated by oxidative stress.