• Fisheries and Aquatic Sciences
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• 제22권5호
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• pp.10.1-10.14
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• 2019

Fish skin waste accounts for part of the solid waste generated from seafood processing. Utilization of fish skin by bioconversion into high-grade products would potentially reduce pollution and economic cost associated with treating fish processing waste. Fish skin is an abundant supply of gelatin and collagen which can be hydrolyzed to produce bioactive peptides of 2-20 amino acid sequences. Bioactivity of peptides purified from fish skin includes a range of activities such as antihypertensive, anti-oxidative, antimicrobial, neuroprotection, antihyperglycemic, and anti-aging. Fish skin acts as a physical barrier and chemical barrier through antimicrobial peptide innate immune action and other functional peptides. Small peptides have been demonstrated to possess biological activities which are based on their amino acid composition and sequence. Fish skin-derived peptides contain a high content of hydrophobic amino acids which contribute to the antioxidant and angiotensin-converting enzyme inhibitory activity. The peptide-specific composition and sequence discussed in this review can be potentially utilized in the development of pharmaceutical and nutraceutical products.

• 대한약침학회지
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• 제21권4호
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• pp.226-240
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• 2018

Neuroprotection or prevention of neuronal loss is a complicated molecular process that is mediated by various cellular pathways. Use of different pharmacological agents as neuroprotectants has been reported especially in the last decades. These neuroprotective agents act through inhibition of inflammatory processes and apoptosis, attenuation of oxidative stress and reduction of free radicals. Control of this injurious molecular process is essential to the reduction of neuronal injuries and is associated with improved functional outcomes and recovery of the patients admitted to the intensive care unit. This study reviews neuroprotective agents and their mechanisms of action against central nervous system damages.

• 식품과학과 산업
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• 제51권4호
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• pp.334-342
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• 2018

People in Korea, a peninsular, have acquired a variety of marine food resources including seaweeds. Ecklonia stolonifera, a brown algae, is commonly dwelling in Korean coasts and their cultivation methods were developed for a mass-production. Recently, studies have revealed that Ecklonia stolonifera is a promising material for the development of health functional foods. In an effort to carefully review the current understating in the effects and mechanisms of Ecklonia stolonifera on liver functions by deduction from relevant literatures, the effective components were identified as phlorotannins, including dieckol, eckstolonol, eckol, phlorofucofuroeckol A, and phlorosterol. Their aiding action on the hepatic functions is categorized as follows. A) Regulation of oxidative stress by anti-oxidant capacity, B) Protection of hepatocytes from toxins, C) Prevention of alcoholic fatty liver and fibrogenesis, D) Regulation of chronic disease by improvement of inflammatory responses and lipid metabolisms, and E) indirect benefit conferred by a personal total wellness.

• Molecules and Cells
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• 제44권8호
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• pp.549-556
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• 2021

Decoding the molecular mechanisms underlying axon guidance is key to precise understanding of how complex neural circuits form during neural development. Although substantial progress has been made over the last three decades in identifying numerous axon guidance molecules and their functional roles, little is known about how these guidance molecules collaborate to steer growth cones to their correct targets. Recent studies in Drosophila point to the importance of the combinatorial action of guidance molecules, and further show that selective fasciculation and defasciculation at specific choice points serve as a fundamental strategy for motor axon guidance. Here, I discuss how attractive and repulsive guidance cues cooperate to ensure the recognition of specific choice points that are inextricably linked to selective fasciculation and defasciculation, and correct pathfinding decision-making.

• 시스템엔지니어링학술지
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• 제17권2호
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• pp.82-90
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• 2021

The spent fuel pool (SFP) of a nuclear power plant functions to store the spent fuel. The spent fuel pool is designed to properly remove the decay heat generated from the spent fuel. If the cooling function is lost and proper operator action is not taken, the spent fuel in the storage pool can be damaged. Probabilistic safety assessment (PSA) is a safety evaluation method that can evaluate the risk of a large and complex system. So far, the probabilistic safety assessment of nuclear power plants has been mainly performed on the reactor. This study defined the requirements and the functional architecture for the probabilistic safety assessment of the spent fuel pool (SFP-PSA) by applying the systems engineering process. And, a systematic and efficient methodology was defined according to the architecture.

• 한국과학예술포럼
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• 제30권
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• pp.217-230
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• 2017

The purpose of this study is to develop a theoretical model identifying how consumers accept a fashionable technology product. A systematic review of 39 influential TAM studies focusing on theory development in the context of information technology results in three tendencies, which become backbone of the model of fashionable technology acceptance. A subsequent review of the nature of fashion fleshes out the backbone with detailed propositions in the more specific context of fashionable technology. The model of fashionable technology acceptance includes key propositions of Theory of Reasoned Action, in which internal beliefs consist of functional, aesthetic and symbolic values, and other factors, such as technology features (i.e., hardware specification, software specification, brand, and price factors), environmental conditions (i.e., technical infrastructure and user occasion), individual differences (i.e., age, gender, experience, personality, aesthetic sense, fashion innovativeness, and income), and social influence (i.e., subjective norms, social reputation, and cultural difference). Implications, limitations, and suggestions for future research are also discussed.

• 한국정밀공학회지
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• 제10권3호
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• pp.175-181
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• 1993

In this paper, a practical method to generate task strategies applicable to chamferless and high-precision assembly, is proposed. The difficulties in devising reliable assembly strategies result from various forms of uncertainty such as imperfect knowledge on the parts being assembled and functional limitations of the assembly devices. In approach to cope with these problems, the robot is provided with the capability of learning the corrective motion in response to the force signal trrough iterative task execution. The strategy is realized by adopting a learning algorithm and represented in a binary tree type database. To verify the effectiveness of the proposed algorithm, a series of simulations and experiments are carried out under assimilated real production environments. The results show that the sensory signal-to-robot action mapping can be acquired effectively and, consequently, the chamferless assembly can be performed successfully.

• The Korean Journal of Physiology and Pharmacology
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• 제27권4호
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• pp.289-298
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• 2023

Complex diseases including cardiovascular disease are caused by a combination of the alternation of many genes and the influence of environments. Recently, non-coding RNAs (ncRNAs) have been shown to be involved in diverse diseases, and the functions of various ncRNAs have been reported. Many researchers have elucidated the mechanisms of action of these ncRNAs at the cellular level prior to in vivo and clinical studies of the diseases. Due to the characteristics of complex diseases involving intercellular crosstalk, it is important to study communication between multiple cells. However, there is a lack of literature summarizing and discussing studies of ncRNAs involved in intercellular crosstalk in cardiovascular diseases. Therefore, this review summarizes recent discoveries in the functional mechanisms of intercellular crosstalk involving ncRNAs, including microRNAs, long non-coding RNAs, and circular RNAs. In addition, the pathophysiological role of ncRNAs in this communication is extensively discussed in various cardiovascular diseases.

• 생명과학회지
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• 제29권2호
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• pp.181-190
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• 2019

시스템 약리학적 분석을 통해 대회향(Anisi Stellati Fructus)의 활성성분 스크리닝, 표적유전자 확보 및 관련 질병과의 네트워크를 구축한 후 대회향의 항균작용을 중점적으로 분석하였다. Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database 와 Analysis Platform을 통해 대회향의 잠재적 활성성분 49개를 확보하였으며, 그 중 설정한 조건에 부합하는 9개 활성성분을 스크리닝 하였다. TCMSP Database는 활성성분의 약물 동태학적 특성 및 약물-표적-질병 간의 관련성을 네트워크 수준에서 파악할 수 있는 획기적인 in silico적 접근을 가능하게 해준다. 활성성분과 반응하는 201개의 유전자 정보를 UniProt database를 통해 확인하고, 취합한 유전자들이 관여하는 348개의 생물학적 과정을 David 6.8 Gene Functional Classification Tool에서 확보하였다. Chemokine ligand 2, Interleukin-10, Interleukin-6, Tumor Necrosis Factor를 포함한 총 47개의 유전자가 항균작용에 관여하였고 이들을 표적으로 하는 luteolin, kaempferol, quercetin 등이 대표적 항균 관련 활성성분이었다. 이와 같이 확보된 데이터는 연구 재료 선정에 정확성과 시간, 노력, 비용 절감의 효과를 제공함과 더불어 추후 실험적 증명으로 이어져 감염병의 예방과 치료 전략에 과학적인 근거를 제시할 수 있을 것이다.

• 대한수학교육학회지:수학교육학연구
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• 제25권2호
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• pp.241-261
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• 2015

디지털교과서는 정부에서 제시하는 새로운 교육 시스템을 지칭하는 스마트교육을 실현시키기 위한 주요 전략 중 하나이다. 우리나라는 과학, 수학, 사회, 영어 교과의 디지털교과서를 2013년까지 개발하여 2014년에 적용하려고 하였다. 하지만 수학 과목의 경우, 디지털교과서의 초안이 기능적인 측면에서 서책형 교과서와 크게 다르지 않아 무기한 연기되었다. 이러한 상황은 수학 교과에 부적합한 저작도구의 사용으로 인해 수학교육에서 가장 중요한 측면 중의 하나인 학생의 탐구 활동이 매우 제한적으로 구현될 수밖에 없었기 때문이다. 본 논문은 디지털교과서가 보다 잘 사용되어지기 위한 개발 방향과 저작도구로서 Cabri LM을 사용하여 고등학교 3학년의 수학과 디지털교과서를 개발하고 적용하면서 나타난 결과를 소개한다.