• 한국산학기술학회논문지
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• 제22권3호
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• pp.408-414
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• 2021

본 연구의 목적은 수세미오이 추출물을 유산균을 이용한 발효를 통해 항산화 활성과 함께 생체 활성 물질의 생산을 중대하고 자외선 흡수 및 피부 흑색종 세포 성장 억제를 강화하여 피부암 예방 효과를 향상시키는 데 있다. 수세미오이 발효추출물의 총 폴리페놀(TPC)과 항산화 활성도가 30.23 mg GA/g DM와 45.12%로 열수추출물보다 약 1.4배 높은 수준으로 확인되었다. 자외선 흡수율에 있어 발효추출물은 열수추출물보다 1.5배 높은 53.9%의 흡수율을 보였는데 발효를 통해 증가된 TPC에 의해 UV 흡수가 증가했다는 결론을 도출하였다. 항암효과에 있어 발효추출물과 열수추출물에서 각각 1.0 와 2.0 mg/mL에서 피부 흑색종세포에 대한 성장저해 효과가 나타나 추출물 발효에 따른 항암효과가 증가했음을 알 수 있었다. 발효추출물의 자외선 흡수율에 있어 열수출물보다 2.4배 높아 피부암 예방효과가 예상되며, 수세미오이 발효를 통해 항산화, 자외선차단과 피부암 저해 효과를 가지는 화장품, 식품 및 의약품 소재 개발 가능할 것으로 사료된다.

• Journal of Pharmaceutical Investigation
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• 제36권3호
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• pp.169-174
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• 2006

The aim of this work was to prepare tenoxicam-ethanolamine salt with improved physicochemical properties for transdermal application. Tenoxicam-ethanolamine salt was prepared in methylene chloride and its physicochemical properties were investigated by DSC and FT-lR. The broad peak of tenoxicam around 3600-3200 $cm^-1$ was shifted to lower wavenumber and more broadened. The characteristic endothermic melting peak of tenoxicam appeared at $223^{\circ}C$. The melting peak of tenoxicam-ethanolamine salt was shifted to $159^{\circ}C$. In contrast to relatively small difference in the partition coefficients of tenoxicam and the tenoxicam-ethanolamine salt, large difference in aqueous solubility was observed. $Crovol^{\circledR}$ PK4O (PEG-12 palm kernel glycerides) provided the highest skin flux for both compounds. The order of the enhancing effect of the various vehicles tested was similar for tenoxicam and tenoxicam-ethanolamine salt, which indicated that their enhancing mechanism for tenoxicam and tenoxicam-ethanolamine salt is similar. Tenoxicam-ethanolamine salt had a higher skin flux than tenoxicam by 1.2- to 31.7-fold, depending on the vehicles used. It is suggested that the vehicles with medium HLB value, 1 double bond, and lower ethylene oxide chain length have a better ability to modify the permeability of the stratum corneum and to promote the effective penetration of tenoxicam and tenoxicam-ethanolamine salt.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.130.1-130.1
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• 2013

We made attempts to improve photocatalytic activity of $TiO_2$ nanoparticles under visible light exposure by combining two additional treatments. N-doping of $TiO_2$ by ammonia gas treatment at $600^{\circ}C$ increased absorbance of visible light. By coating thin film of polydimethylsiloxane (PDMS), and subsequent vacuum-annealing at $800^{\circ}C$, $TiO_2$, became more hydrophilic, thereby enhancing photocatalytic activity of $TiO_2$. Four types of $TiO_2$ samples were prepared, bare-$TiO_2$, hydrophilic-modified $TiO_2$ ($h-PDMS/TiO_2$), N-doped $TiO_2$ ($N/TiO_2$) and hydrophilic-modified and N-doped $TiO_2$ ($h-PDMS/N/TiO_2$). Adsorption capability was evaluated under dark condition and photocatalytic activity of $TiO_2$ was evaluated by photodegradation of MB under blue LED (400 nm< ${\lambda}$) irradiation. N-doping on $TiO_2$ was characterized using XPS and hydrophilic modification of $TiO_2$ surface was analyzed by FT-IR spectrometer. It was found that N-doping and hydrophilic modification both had positive effect on enhancing adsorption capability and photocatalytic activity of $TiO_2$ at the same time. Particularly, N-doping enhanced visible light absorption of $TiO_2$, whereas hydrophilic surface modification increased MB adsorption capacity. By combining these two strategies, photocatalytic acitivity under visible light irradiation became the sum of individual effects of N-doping and hydrophilic modification.

• 한국환경농학회지
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• 제39권3호
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• pp.171-177
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• 2020

BACKGROUND: Recently, biomass conversion from agricultural wastes to carbon-rich materials such as biochar has been recognized as a promising option to maintain or increase soil productivity, reduce nutrient losses, and mitigate greenhouse gas emissions from the agro-ecosystem. This experiment was conducted to select an optimum conditions for enhancing the NH₄-N adsorption capacity of rice hull activated biochar. METHODS AND RESULTS: For deciding the proper molarity of KOH for enhancing its porosity, biochars treated with different molarity of KOH (0, 1, 2, 4, 6, 8) were carbonized at 600℃ in the reactor. The maximum adsorption capacity was 1.464 mg g^-1, and an optimum molarity was selected to be 6 M KOH. For the effect of adsorption capacity to different carbonized temperatures, 6 M KOH-treated biochar was carbonized at 600℃ and 800℃ under the pyrolysis system. The result has shown that the maximum adsorption capacity was 1.76 mg g^-1 in the rice hull activated biochar treated with 6 M KOH at 600℃ of pyrolysis temperature, while its non-treated biochar was 1.17 mg g^-1. The adsorption rate in the rice hull activated biochar treated with 6 M KOH at 600℃ was increased at 62.18% compared to that of the control. Adsorption of NH₄-N in the rice hull activated biochar was well suited for the Langmuir model because it was observed that dimensionless constant (R_L) was 0.97 and 0.66 at 600℃ and 800℃ of pyrolysis temperatures, respectively. The maximum adsorption amount (q_m) and the bond strength constants (b) were 0.092 mg g^-1 and 0.001 mg L^-1, respectively, for the rice hull activated biochar treated with 6 M KOH at 600℃ of pyrolysis. CONCLUSION: Optimum condition of rice hull activated biochar was 6M KOH at 600℃ of pyrolysis temperature.

• Preventive Nutrition and Food Science
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• 제20권1호
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• pp.43-51
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• 2015

${\varepsilon}$-Polylysine (EPL) is used as a natural preservative in food. However, few studies have been conducted to assess the beneficial functions of dietary EPL. The purpose of this study was to elucidate the mechanism underlying the inhibition of neutral and acidic sterol absorption and hepatic enzyme activity-related fatty acid biosynthesis following EPL intake. EPL digest prepared using an in vitro digestion model had lower lipase activity and micellar lipid solubility and higher bile acid binding capacity than casein digest. Male Wistar rats were fed an AIN-93G diet containing 1% (wt/wt) EPL or L-lysine. After 4 weeks of feeding these diets, the marked decrease in serum and liver triacylglycerol contents by the EPL diet was partly attributed to increased fecal fatty acid excretion. The activities of hepatic acetyl-coenzyme A carboxylase and glucose-6-phosphate dehydrogenase, which are key enzymes of fatty acid biosynthesis, were enhanced in rats fed EPL diet. The increased fatty acid biosynthesis activity due to dietary EPL may be prevented by the enhancement of fecal fatty acid excretion. The hypocholesterolemic effect of EPL was mediated by increased fecal neutral and acidic sterol excretions due to the EPL digest suppressing micellar lipid solubility and high bile acid binding capacity. These results show that dietary EPL has beneficial effects that could help prevent lifestyle-related diseases such as hyperlipidemia and atherosclerosis.

• Biomolecules & Therapeutics
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• 제16권3호
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• pp.210-214
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• 2008

The pharmacokinetic parameters and bioavailability of pranoprofen from the gel were measured to determine the enhancing effect of octanoic acid on the transdermal absorption of pranoprofen in rats. 8 mg/kg of pranoprofen was administered from gel with octanoic acid (the enhancer group) or that without octanoic acid (the control group) via the transdermal route, and the results were compared with those obtained from the intravenously (0.5 mg/kg, IV group) or orally administered group (4 mg/kg, oral group). The AUC of the control, the enhancer, the IV, and the oral groups were $20.2{\pm}5.1$, $50.7{\pm}12.7$, $19.9{\pm}2.5$, and $70.5{\pm}17.6\;ug/ml{\cdot}h$ respectively. The average $C_{max}$ of the control and the enhancer group were $0.93{\pm}0.23$ and $2.82{\pm}0.71\;ug/ml$, respectively, and the mean $T_{max}$ of the control and the enhancer group was 7.00 h. The relative bioavailability of the transdermally administered pranoprofen gel containing octanoic acid was approximately 2.50 times higher than the control group, showing a relatively constant, sustained blood concentration with minimal fluctuation. This suggests that it might be feasible to develop a pranoprofen gel preparation containing an enhancer for the transdermal administration, which is more convenient dosage form than the oral dosage forms.

• Ocean Systems Engineering
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• 제13권4호
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• pp.385-399
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• 2023

A collision between a ship and an offshore platform may result in structural damage and closure; therefore, damage analysis is required to ensure the platform's integrity. This paper presents a damage assessment of a three-legged jacket platform subjected to ship collisions using the industrial finite element program Bentley SACS. This study considers two ships with displacements of 2,000 and 5,000 tons and forward speeds of 2 and 6.17 meters per second. Ship collision loads are applied as a simplified point load on the center of the platform's legs at inclinations of 1/7 and 1/8; diagonal bracing is also included. The jacket platform is modelled as beam elements, with the exception of the impacted jacket members, which are modelled as nonlinear shell elements with elasto-plastic material and constant isotropic hardening to provide realistic dented behavior due to ship collision load. The structural response is investigated, including kinetic energy transfer, stress distribution, and denting damage. The simulation results revealed that the difference in leg inclination has no effect on the level of localized denting damage. However, it was discovered that a leg with a greater inclination (1/8) resists structural displacement more effectively and absorbs less kinetic energy. In this instance, the three-legged platform collapses due to the absorption of 27.30 MJ of energy. These results provide crucial insights for enhancing offshore platform resilience and safety in high-traffic maritime regions, with implications for design and collision mitigation strategies.

• Toxicological Research
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• 제33권1호
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• pp.49-54
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• 2017

Vitamin D3 is a fat-soluble secosteroid responsible for enhancing intestinal absorption of calcium, iron, and other materials. Vitamin D3 deficiency, therefore, can cause health problems such as metabolic diseases, and bone disorder. Female sex hormones including estrogen and progesterone are biosynthesized mainly in the granulosa cells of ovary. In this study, we isolated granulosa cells from porcine ovary and cultured for the experiments. In order to examine the effect of vitamin D3 on the ovarian granulosa cells, the mRNA and protein levels of genes were analyzed by real-time PCR and Western blot assay. The production of estrogen from the granulosa cells was also measured by the ELISA assay. Genes associated with follicle growth were not significantly altered by vitamin D3. However, it increases expression of genes involved in the estrogen-biosynthesis. Further, estrogen concentrations in porcine granulosa cell-cultured media increased in response to vitamin D3. These results showed that vitamin D3 is a powerful regulator of sex steroid hormone production in porcine granulosa cells, suggesting that vitamin D deficiency may result in inappropriate sexual development of industrial animals and eventually economic loss.

• 한국멀티미디어학회논문지
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• 제15권5호
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• pp.664-671
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• 2012

가상 의료 시뮬레이션을 통한 실습 교육은 학습 효과를 높이는 장점이 있기 때문에 최근 실제 의료 환경에 도입이 확대되고 있다. 특히 최소 침습적 수술 분야에서 가상 수술 의료 시뮬레이션의 필요성이 증가하고 있다. 하지만, 가상 수술 의료 시뮬레이션 환경에서 자주 발생하는 출혈 특수 효과를 현실감이 있게 표현하기 위한 출혈 애니메이션 기술은 아직까지 제안되지 않고 있다. 본 논문에서는 사실적인 실시간 출혈 애니메이션 기법을 제안한다. 제안 기법은 출혈 시뮬레이션을 위해서 주 출혈 방향 벡터 방향을 기준으로 주 출혈 영역과 유효 출혈 영역을 계산하여 자연스러운 출혈 효과의 표현이 가능하다. 또한, 출혈 렌더링을 위해서 정점들의 불투명도 값을 시그모이드 함수를 이용한 가중치 부여로 부드러운 불투명도 변화를 통하여 사실적이고, 자연스러운 출혈 애니메이션이 가능하다. 본 논문에서 제안한 기법은 가상 수술 의료 시뮬레이션의 현실감, 몰입감을 증진시켜 이러한 시뮬레이션을 사용하는 의사 혹은 의대생들에 대한 교육의 효과를 증진시킬 수 있다.

• 대한토목학회논문집
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• 제12권4호
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• pp.95-106
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• 1992

강섬유의 형태가 콘크리트의 휨거동에 미치는 영향을 알아 보기 위하여 5종의 강섬유를 사용한 실험을 실시하였다. 강섬유 혼입율은 1~2%로 변화를 주었고 전단 스팬비와 철근비는 고정하였다. 형태가 다른 강섬유의 보강 효과를 비교 분석하기 위한 방법으로 섬유 보강 효과 지수를 채택하였고, 인성 효과를 분석하기 위하여 유효 인성 지수를 제안하였으며, 이들 지수들은 강섬유 보강 효과를 비교 분석하는데 유용한 방법으로 평가되었다. 실험 결과에 의하면 강섬유 혼입율은 양단이 hook 형태인 강섬유의 경우에는 1% 이내가 효과적이며, dog bone 형태인 강섬유는 1~2%, 기타 강섬유는 2% 정도가 적절하였다. 강섬유의 혼입으로 인한 휨강도 및 파괴인성의 증진 효과는 무근 콘크리트보의 경우가 철근 콘크리트보의 경우보다 크게 나타났다. 또한 강섬유의 형태에 의한 휨강도와 인성의 증진 효과는 양단이 hook나 dog bone(paddled)형태의 강섬유가 섬유 혼입율이 상대적으로 낮음에도 straight나 crimped 및 wavy 형태보다 우수한 것으로 판명되었다.