• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.4085-4089
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• 2014

Background: Atelectasis is an important prognostic factor that can cause pleuritic chest pain, coughing or dyspnea, and even may be a cause of death. In this study, we aimed to investigate the potential impact of atelectasis and PET parameters on survival and the relation between atelectasis and PET parameters. Materials and Methods: The study consisted of patients with lung cancer with or without atelectasis who underwent $^{18}F$-FDG PET/CT examination before receiving any treatment. $^{18}F$-FDG PET/CT derived parameters including tumor size, SUVmax, SUVmean, MTV, total lesion glycosis (TLG), SUV mean of atelectasis area, atelectasis volume, and histological and TNM stage were considered as potential prognostic factors for overall survival. Results: Fifty consecutive lung cancer patients (22 patients with atelectasis and 28 patients without atelectasis, median age of 65 years) were evaluated in the present study. There was no relationship between tumor size and presence or absence of atelectasis, nor between presence/absence of atelectasis and TLG of primary tumors. The overall one-year survival rate was 83% and median survival was 20 months (n=22) in the presence of atelectasis; the overall one-year survival rate was 65.7% (n=28) and median survival was 16 months (p=0.138) in the absence of atelectasis. With respect to PFS; the one-year survival rate of AT+ patients was 81.8% and median survival was 19 months; the one-year survival rate of AT-patients was 64.3% and median survival was 16 months (p=0.159). According to univariate analysis, MTV, TLG and tumor size were significant risk factors for PFS and OS (p<0.05). However, SUVmax was not a significant factor for PFS and OS (p>0.05). Conclusions: The present study suggested that total lesion glycolysis and metabolic tumor volume were important predictors of survival in lung cancer patients, in contrast to SUVmax. In addition, having a segmental lung atelectasis seems not to be a significant factor on survival.

• Journal of dental hygiene science
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• v.16 no.6
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• pp.415-423
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• 2016

This study examined the relationship between oral health behaviors and in senior citizens to determine how to improve their happiness index. The subjects in this study were 260 senior citizens aged 65 years or older, who resided in North Jeolla Province. A survey was conducted from June 17 to 30, 2016. The happiness index of elderly people who brushed their teeth more often and had dental checkups on a regular basis was significantly higher (p<0.05). Evaluation of subfactors associated with quality of life related to oral health showed significant differences in functional disturbances according to gender, age, the presence or absence of a spouse, and the use or nonuse of dentifrice (p<0.05). Physical pain significantly varied with the presence or absence of a spouse, educational level, monthly mean allowance, and regular dental checkups (p<0.05); significant differences were found in psychological discomfort according to gender, tooth brushing frequency, and regular dental checkups (p<0.05). There were significant differences in declining physical capacity according to gender, age, educational level, and monthly mean allowance (p<0.05); waning mental capacity significantly differed with age, living alone or with another person, the presence or absence of a spouse, and regular dental checkups (p<0.05). The factors that influenced the happiness index in senior citizens were age, living alone or with another person, educational level, monthly mean allowance and the Oral Health Impact Profile score (p<0.05). The study showed that measures are needed to improve the quality of life and happiness index in elderly people, including the development of oral health programs for this population.

• Environmental Analysis Health and Toxicology
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• v.18 no.2
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• pp.121-129
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• 2003

The genotoxicity of pendimethalin [N-(l-ethylpropyl)-2, 6-dinitro-3, 4-xylidine, C$\_$13/H$\_$19/N$_3$O$_4$, M.W.=281.3, CAS No. 40487-42-1], one of selective herbicide, was evaluated in bacterial gene mutation system, chromosome aberration in mammalian cell system and in vivo micronucleus assay with rodent. In bacterial gene mutation assay, pendimethalin revealed dose-dependent mutagenic potential in 313 ∼ 5,000 ${\mu}$g/plate of Salmonella typhimurium TA 98 and TA 1537 both in the absence and presence of S-9 metabolic activation system, and TA 100 only in the absence of S-9 mixture. In the TA 1535, slight increase of revertant was also observed in the presence of S-9 metabolic activation system. No mutagenic potential was observed in the TA 1535 without metabolic activation system and TA l00 in the presence of S-9 mixture. In mammalian cell system using Chinese hamster lung (CHL) fibroblast, no clastogenicity of pendimethalin was observed both in the absence and presence of S-9 metabolic activation system in the concentration range of 2.32∼9.28 ${\mu}$g/ml. And also, in vivo bone marrow micronucleus assay, pendimethalin revealed no clastogenic potential in the dose range of 203∼810 mg/kg body weight after oral administration in mice. Consequently, in vitro chromosome aberration with mammalian cells and in vivo bone marrow micronucleus assay revealed no clastogenic potential of pendimethalin. However, pendimethalin revealed mutagenic potential in bacterial gene mutation assay.

• The Journal of the Korea Contents Association
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• v.18 no.8
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• pp.36-50
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• 2018

The subjects of this study are three visually-impaired undergraduates currently considering if they should take a leave of absence after finishing the first year in S University located in Busan City. From March to July, 2018, this researcher explored the meaning of their university entrance and the essential meaning and structure of their school life experiences by using Giorgi's phenomenological methodology. According to the results, this author drew 32 meaningful statements and also 10 main themes, "the excitement of campus life and the name of being an undergraduate", "parents' suggestion", "something other than being a massager", "Is it a place that anyone can enter? Or, is it a special place?", "loneliness within the public", "Everything is an obstacle.", "It's not giving up, but still I am in a vague moment.", "the beginning of another conflict", and "studying in a university is not for the present but for the future". They were categorized into being a university student and the meaning of it (category1), adaptation to university life and reality (category 2), and one year after the entrance: the meaning of being a university student (category 3). Based on the above results, this author intends to provide foundational material about what universities can do for visually-impaired students to adapt to university life in the initial steps properly.

• Journal of the Korean Chemical Society
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• v.38 no.10
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• pp.769-773
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• 1994

Higher order structure of 5S rRNA isolated from Xanthomonas celebensis was examined using angiogenic extracted from milk. Angiogenin cleaved exclusively 3' P-O bonds on the far sides of pyrimidines in the single-stranded sequences of 5S rRNA. Whereas angiogenin acted only on the loop d of 5S rRNA at pH 7.0 in the presence of 10 mM $Mg^{2+}$, it acted on all the loops (a, b, c and d) except loop e in the absence of $Mg^{2+}$. In the absence of $Mg^{2+}$, bonds $U_{74}$-$G_{75}$, $U_{77}$-$A_{78}$ and $U_{103}$-$A_{104}$ were highly susceptible to the action of angiogenin both at pH 7.0 and at pH 3.5. On the other hand, at pH 3.5 in the absence of $Mg^{2+}$ angiogenin strongly cleaved the bond $C_{17}$-$G_{18}$ of loop a and the bond $U_{55}$-$G_{56}$ of loop b. The results lead us to the following conclusion. First, angiogenin can be used as one of the probes for the tertiary structure analysis of 5S rRNA. Second, the structure of loop d of 5S rRNA is variable depending on the concentrations of $Mg^{2+}$ and $H^{1+}$.

• Journal of Digital Convergence
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• v.12 no.7
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• pp.327-336
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• 2014

This study aims to identify factors to affect regular utilization status of medical care in cardio-cerebrovascular patients. The research selected 770 cardio-cerebrovascular patients among surveyees from the Korea Health Panel 2010. We analyzed states of medical care utilization using descriptive statistics. Logistic regression analysis was used to examine the main factors associated with regular utilization status of medical care in cardio-cerebrovascular patients. In result, the significant factors associated with regular utilization status of medical care in cardio-cerebrovascular patients were age, education level, household income level. CCI, presence or absence of high risk drinking, and presence or absence of obesity. There's a high probability that patients aged between 60 and 69, equal to and higher than those of high school graduate in education level, upper middle class in household income, the higher CCI, absence of high risk drinking, presence of obesity utilize medical care services more regularly. Therefore, it is necessary to develop effective program and individualized approach for patients using lesser periodical medical care and patients with high risk drinking problem. In the future, these findings can be used an important data for healthcare policy and assessment.

• Journal of the Korea society of information convergence
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• v.1 no.1
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• pp.47-54
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• 2008

This study analyzed the status and causes for the dropouts of college based on the survey conducted among 14,210 freshmen attending D College, other than the supernumerary special selection, from 2001 through 2005. A significant difference was shown in all items of general characteristics. The dropout rate of women, generally selected and general highschool graduated were higher than for men, specially selected and special high school graduated, respectively. The most dropouts were due to Not Return(40.16%), followed by Unenrolled(32.98%), Voluntary Leave(26.05%) and Expelled(0.81%) in order. In the distribution of the central tendency values measured from the entire subjects, the high school records and the days of absence showed a positive skewness, while the college records showed a negative skewness with the data mostly around a higher grade. The standard deviation indicating that the dropouts got the scores higher than those of the continuing students demonstrated that there was relatively insignificant difference in scores between two groups. It was demonstrated that both the high school records and the days of absence affected the dropout. The lower the high school records were, and the more the days of absence were, the more influence both items had on the dropout. The influence degree of each item was similar. Lower the scores were in terms other than the first term in the freshmen year, the more influence it had on the dropout. The most dropouts were influenced by the scores of the freshmen year, followed by the credits of the second term, the scores of the first term, the scores of the second term, and the credits of the first term in the freshmen year. Among the general characteristic items, the most dropouts were influenced by the course of study, followed by the gender. The effect of other items was insignificant.

• Investigative Magnetic Resonance Imaging
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• v.17 no.1
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• pp.33-40
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• 2013

Purpose : To evaluate late gadolinium enhancement (LGE) pattern of left ventricular (LV) myocardium and presence or absence of LGE in other regions of the heart on cardiac magnetic resonance (CMR) imaging in patients diagnosed with cardiac amyloidosis. Materials and Methods: From 2009 to 2011, 9 patients who were suspected cardiac amyloidosis underwent CMR. We retrospectively analyzed the presence or absence of LGE and enhancement pattern in LV myocardium, and the presence or absence of LGE in other chambers as well. Also we measured interatrial septal thickness (IST), relative signal intensities of atrial septum and epicardial fat over the left atrial (LA) cavity on delayed enhanced images. MRI parameters in these patients were compared to those of control group of patients with ischemic heart disease by Wilcoxon rank sum test. Results: Of nine patients, LGE were found in 8; subendocardial circumferential pattern in 4 and diffuse pattern in 4. LGE in right ventricle was observed in 7. IST was significantly increased in patients with cardiac amyloidosis (P = 0.02). Ratio of atrial septum to LA cavity and ratio of epicardial fat to LA cavity showed a significant difference (P = 0.0002 and P = 0.0006, respectively). Conclusion: In LGE CMR, subendocardial or diffuse enhancement pattern is a typical finding for patients with cardiac amyloidosis. Atrial septum and epicardial fat show relatively increased signal intensities over LA blood cavity.

• Korean Journal of Microbiology
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• v.46 no.4
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• pp.313-318
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• 2010

Deinococcus radiodurans RecA protein, when bound to DNA, exhibits a DNA-dependent ATPase. In the absence of DNA, the rate of RecA protein-promoted ATP hydrolysis drops 1,000-fold under the physiological concentrations of salt. This DNA-independent activity can be stimulated to levels approximating those observed with DNA by adding high concentrations (approximately 1.6 M) of a wide variety of salts. This effect was characterized by varying salt concentration and comparing the effects of different ion types. The higher concentrations of salt stimulated the ATP hydrolysis by RecA protein in the absence of DNA. At 1.6 M chloride, the observed stimulation showed the following cation trend $K^+{\geq}Na^+$ > $NH_4^+$ and the following anion sequence was observed: $glutamate^- \; > \; C1^- \;> \; acetate^-\; > \;PO_4^-$ at 1.6 M $K^+$. The catalytic properties of the salt-stimulated ATP hydrolysis reaction was optimal between pH 7.0 and 8.0, which was similar to the double stran nded DNA-dependent ATPase activities of Deinococcus radiodurans RecA protein. In the absence of DNA the active species for ATP hydrolysis by RecA protein was shown to be an aggregate of three RecA protein molecules.

• Molecular & Cellular Toxicology
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• v.2 no.3
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• pp.176-184
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• 2006

The controversy on genotoxicity of molinate, an herbicide, has been reported in bacterial system, and in vitro and in vivo mammalian systems. To clarify the genotoxicity of molinate, we performed bacterial gene mutation test, in vitro chromosome aberration and mouse lymphoma $tk^{+/-}$ gene assay, and in vivo micronucleus assay using bone marrow cells and peripheral reticulocytes of mice. In bacterial gene mutation assay, no mutagenicity of molinate ($12-185{\mu}g/plate$) was observed in Salmonella typhimurium TA 98, 100, 1535 and 1537 both in the absence and in the presence of S-9 metabolic activation system. The clastogenicity of molinate was observed in the presence ($102.1-408.2\;{\mu}g/mL$) of metabolic activation system in mammalian cell system using Chinese hamster lung fibroblast. However, no clastogenicity was observed in the absence ($13.6-54.3\;{\mu}g/mL$) of metabolic activation system. It is suggested that the genotoxicity of molinate was derived some metabolites by metabolic activation. Molinate was also subjected to mouse lymphoma L5178Y $tk^{+/-}$ cells using microtiter cloning technique. In the absence of S-9 mixture, mutation frequencies (MFs) were revealed $1.4-1.9{\times}10^{-4}$ with no statistical significance. However, MFs in the presence of metabolic activation system revealed $3.2-3.4{\times}10^{-4}$ with statistical significance (p<0.05). In vivo micronucleus (MN) assay using mouse bone marrow cells, molinate revealed genotoxic potential in the dose ranges of 100-398 mg/kg of molinate when administered orally. Molinate also subjected to acridine orange MN assay with mouse peripheral reticulocytes. The frequency of micronucleated reticulocytes (MNRETs) induced 48 hr after i.p. injection at a single dose of 91, 182 and 363 mg/kg of molinate was dose-dependently increased as $10.2{\pm}4.7,\;14.6{\pm}3.9\;and\;28.6{\pm}6.3\;(mean{\pm}SD\;of\;MNRETs/2,000\;reticulocytes)$ with statistical significance (p<0.05), respectively. Consequently, genotoxic potential of molinate was observed in in vitro mammalian mutagenicity systems only in the presence of metabolic activation system and in vivo MN assay using both bone marrow cells and peripheral reticulocytes in the dose ranges used in this experiment. These results suggest that metabolic activation plays a critical role to express the genotoxicity of molinate in in vitro and in vivo mammalian system.