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A Follow-up Association Study of Genetic Variants for Bone Mineral Density in a Korean Population

  • Ham, Seokjin;Roh, Tae-Young
    • Genomics & Informatics
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    • v.12 no.3
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    • pp.114-120
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    • 2014
  • Bone mineral density (BMD) is one of the quantitative traits that are genetically inherited and affected by various factors. Over the past years, genome-wide association studies (GWASs) have searched for many genetic loci that influence BMD. A recent meta-analysis of 17 GWASs for BMD of the femoral neck and lumbar spine is the largest GWAS for BMD to date and offers 64 single-nucleotide polymorphisms (SNPs) in 56 associated loci. We investigated these BMD loci in a Korean population called Korea Association REsource (KARE) to identify their validity in an independent study. The KARE population contains genotypes from 8,842 individuals, and their BMD levels were measured at the distal radius (BMD-RT) and midshaft tibia (BMD-TT). Thirteen genomic loci among 56 loci were significantly associated with BMD variations, and 3 loci were involved in known biological pathways related to BMD. In order to find putative functional variants, nearby SNPs in relation to linkage equilibrium were annotated, and their possible functional effects were predicted. These findings reveal that tens of variants, not a single factor, may contribute to the genetic architecture of BMD; have an important role regardless of ethnic group; and may highlight the importance of a replication study in GWASs to validate genuine loci for BMD variation.

Characteristics of Space Usage Patterns by Types of Single or Couple Elderly Households - Focused on an Analysis of Time Use Survey - (노인단독가구 유형별 주거 공간 사용 특성 - 생활시간조사 분석을 중심으로 -)

  • Kwon, Oh-Jung;Lee, Yong-Min;Ha, Hae-Hwa;Shin, Hye-In;Kim, Hyoung-Woo
    • Journal of the Korean housing association
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    • v.22 no.4
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    • pp.33-41
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    • 2011
  • The purpose of this study was to identify characteristics of space usage patterns by types of elderly households(single or couple). For the study, 74 elders who were older than 65 were selected and their living behaviors at their home during a day (24 hours) were analyzed. Respondents were classified into 6 types based on a combination of their household type, income level and health status. The results showed that the elderly residents tended to live a well-regulated life, however, each type had unique time and space use pattern. For example, the more the elder residents were healthy, the more they used many rooms. Frail elderly residents spent most of the day in their bedroom. Also, if they had a spouse, each one tended to use a separate private room for his or her daily life whether they shared a bedroom or not.

Characteristics of TiAlCrSiN coating to improve mold life for high temperature liquid molding (고온 액상 성형용 금형 수명 향상을 위한 TiAlCrSiN 코팅의 특성)

  • Yeo, Ki-Ho;Park, Eun-Soo;Lee, Han-Chan
    • Journal of the Korean institute of surface engineering
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    • v.54 no.5
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    • pp.285-293
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    • 2021
  • High-entropy TiAlCrSiN nano-composite coating was designed to improve mold life for high temperature liquid molding. Alloy design, powder fabrication and single alloying target fabrication for the high-entropy nano-composite coating were carried out. Using the single alloying target, an arc ion plating method was applied to prepare a TiAlCrSiN nano-composite coating had a 30 nm TiAlCrSiN layers are deposited layer by layer, and form about 4 ㎛-thickness of multi-layered coating. TiAlCrSiN nano-composite coating had a high hardness of about 39.9 GPa and a low coefficient of friction of less than about 0.47 in a dry environment. In addition, there was no change in the structure of the coating after the dissolution loss test in the molten metal at a temperature of about 1100 degrees.

The Retardation Behaviors due to a Single Overload and High-Low Block Loads, and Retardation Model in 7075-T73 Aluminum Alloy (7075-T73 알루미늄 합금의 단일과대 및 고-저블럭하중에 의한 지연거동과 수명예측 모델)

  • 김정규;송달호;박병훈
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.16 no.9
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    • pp.1605-1614
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    • 1992
  • The effects of % overload (% O.L), baseline stress intensity factor range (.DELTA. $K_{b}$) and dimension-less crack depth (a/W) are examined for the retardation behaviors after a single overload and high-low block loads in 7075-T73 aluminum alloy. And wheeler model, which is one of the fatigue life prediction models, is modified to predict retardation life using these test results. The retardation cycles( $N_{d}$) increased with a decrease in a/W and an increase in % O.L. and (.DELTA. $K_{b}$) These effects are more severe after high-low block loads than single overload. In the case of single overload, the main mechanisms of the retardation are the crack closure and the relaxation of K due to crack branching. But in the case of high-low block loads, that of the main mechanism is the crack closure caused by the accumulated compressive residual stree at the crack tip, which is related with the contact of fracture surfaces. Test results were multiple regression analyzed and got regressed shaping correction factors, (n)$_{REG}$, as function of %O.L., a/W and (.DELTA. $K_{b}$) Wheeler model is modified by using these (n)$_{REG}$. The number of delay cycles calculated by modified Wheeler model were in good agreement with the test results of this study.y.udy.y.y.y.

Experimental Study on Low-income Single-Parent Family Case Management (저소득 여성 한부모가족 사례관리 실천 경험 연구)

  • Kang, Ki Jung;Park, Su Sun
    • Journal of Family Resource Management and Policy Review
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    • v.17 no.1
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    • pp.39-61
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    • 2013
  • This paper analyzed the experience of case management experts and single mothers in managing the cases, as the useful approach for family enrichment of a low-income single parent family. The analysis included five case managements and interview with three case management experts for single-parent families. Four of the five cases have been in progress at present. According to the analysis, the main appeals for single-parent families were economy and basic life, physical and mental health, family and social relationships, and child care and education. Furthermore, the interview with the case management experts identified the difficulty in managing single-parent family cases, especially those cases with complicated demands and problems, barriers to expert management, and required support for family enrichment. Finally, this paper analyzed the implementation process of case management for single-parent families in a specific area, meaning that the results of this paper do not represent all single-parent families. Moreover, the analyzed reports were specific to the case management implementation process. Thus, the contents, which were not recorded in the reports, were not fully reflected, and the in-depth analysis of multilateral aspects was restricted.

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Study of a Durability Test for Single-input Multi-output Power Take-off Gearboxes (단일입력 다출력 PTO 기어박스의 내구성시험에 관한 연구)

  • Lee, Yong Bum;Yoo, Han Ju
    • Journal of Drive and Control
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    • v.14 no.1
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    • pp.29-34
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    • 2017
  • This study analyzed a life test method for a power take-off (PTO) gearbox. An engine transfers mechanical power (rotation and torque) to a hydraulic pump through a PTO Gearbox with one input shaft and three output shafts. PTO gear box durability under high loads over long time periods was tested using dynamometers. In order to reflect the rated operating conditions, power must be distributed to each output shaft, and experiments were conducted under various conditions to verify the characteristics of the distributed power. An accelerated life test was designed using speed and torque as acceleration factors. Also, efficiency tests were conducted under various load conditions. Also, a lubrication oil composition analysis was performed to analyze gearbox wear status.

Wife-Husband Role Division on Household Financial Management : Comparing Between Dual Income Household and Single Income Household (가계재무관리의 부부간 역할분담에 관한 연구 : 맞벌이여부별 비교를 중심으로)

  • Lee, Eun-Hwa;Yang, Se-Jeong
    • Journal of Families and Better Life
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    • v.26 no.6
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    • pp.143-158
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    • 2008
  • The purpose of the study was to investigate the wife and husband role division in household financial management between dual-income household and single-income household. Household financial management included the following five categories: financial planning, consumption/expenditure management, savings/investment management, risk management and credit management. Data for this research was collected through 610 married women living in Seoul, Korea. Using SAS-PC program, Chi-square and t-test Analyses were executed. The results showed that dual- and single-income households tend to have different perspectives on marital role division in household management. Wives of dual-income households had more significant roles in financial management rather than wives of single income households. Especially, wives of dual-income managed more active credit management and saving/investment management. On the other hand, wives of single-income households played a major role in making decision over cheap items than that of wives of dual-income household.

Selection of Tropane Alkaloids High-Producing Lines by Single Cell Cloning of Hyoscyamus niger L. Root Cultures

  • Min, Ji-Yun;Park, Dong-Jin;Jeong, Mi-Jin;Song, Hyun-Jin;Kang, Seung-Mi;Kang, Young-Min;Choi, Myung-Suk
    • Journal of Korean Society of Forest Science
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    • v.98 no.2
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    • pp.142-147
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    • 2009
  • Hyoscyamus species is sources of the hypnotic and sedative drugs hyoscyamine and scopolamine. Single cells of Hyoscyamus niger were dissociated from suspension cultures and adventitious roots obtained from single-cell clones which were cultured on B5 medium containing 3% (w/v) sucrose, 0.1 mg/L IBA and 0.4% (w/v) gelrite. H. niger adventitious root lines showed wide variation in tropane alkaloids production and growth. An effective selection of 200 root lines was made possible by the application of the 'Dragendorff's reagent' for qualitative detection of the alkaloids from root. A high correlation coefficient (r=0.9390) was observed between the values obtained with the two methods based on HPLC and Dragendorff's reagent analysis. Among the selected roots, the highest scopolamine content was 16.64 mg/g DW (Hn-59), which was 8.82-fold more productive than the lowest alkaloid producing line (Hn-25). Here, we established an efficient selection method on tropane alkaloids production and suggest that the Dragendorff's reagent is of great practical value in selection of invisible compounds.

Life Planning Program for the Elderly -Analysis of Life Planning of Middle-aged and Aged- (노년기 생활설계 프로그램 개발을 위한 기초연구-중노년층의 노후생활계획을 중심으로-)

  • 홍성희
    • Journal of the Korean Home Economics Association
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    • v.36 no.10
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    • pp.1-22
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    • 1998
  • The purpose of this study was to analyze the state of the living arrangement plan, the housing plan, and economic plan for elderly's life and contributing factors to their life plan. The sample in this study consisted of 713 middle-aged and aged couple living in Korea. Statistics employed for the analysis were frequencies, means, x2 test, logit analysis and multiple regression. The results could be summarized as follows. The middle-aged and aged couple were planning to live independently in their elderly life. The husband's age, religion, living area, total income, total asset, home owenership had significant effects on the living arrangement of the middle-aged and aged. They had a plan to live in single detached house in their elderly life. And husband's age, educational attaintment, job, and living region were affecting the housing type in their elder life. The middle-aged and aged people had a economic plan that they estimated 970,000 won as living cost in their elderly life. And the factors affecting living costs were husband's educational attaintment, job, and total asset.

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College Students′ Internalizing and Externalizing Problems : Parent-Child Communication and Adjustment to College Life (대학생의 내면화 및 외현화된 행동문제 부모와의 의사소통과 대학생활적응을 중심으로)

  • 민하영;이윤주;이영미
    • Journal of Families and Better Life
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    • v.22 no.5
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    • pp.17-27
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    • 2004
  • This study investigated the relationships among college students' internalizing/externalizing problems, parent-child communication, and college adjustment. The participants were 281 freshmen and sophomores (103 males and 178 females) from a university in Gyeongbuk Province. A self-report survey questionnaire was used to measure parent-child communication, adjustment to college life, and the student's internalizing/externalizing problems. Data were analyzed by t-test, and single and multiple regressions. The results were as follows: (1) The college students' communication with parents was negatively associated with their internalizing/externalizing problems. (2) The college students' communication with parents was positively associated with adjustment to college life. (3) The students' adjustment to college life was negatively associated with their internalizing/externalizing problems. (4) The college students' communication with parents partly or fully exerted indirect effects on the students' internalizing/externalizing problems, mediated by their adjustment to college life.