• 제목/요약/키워드: a SPR

검색결과 238건 처리시간 0.021초

정신건강문제 해결자원의 유용성에 관한 신념: 우울증과 정신분열병의 비교 (Koreans' Beliefs on Helpfulness of Mental Health Resources: A Comparison between Depression and Schizophrenia)

  • 서진환;이선혜
    • 보건교육건강증진학회지
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    • 제26권3호
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    • pp.97-110
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    • 2009
  • Objectives: This study investigated Korean public's beliefs on helpfulness of various resources and preferred ways of addressing symptoms of mental health problems. Methods: A household survey was conducted on a stratified sample of adults aged between 18 and 74 (N=1,584). The participants were asked to provide their opinion on helpfulness of 39 resources for problems presented in the vignette, either depression(DEP) or schizophrenia(SPR). Descriptive statistics and factor analysis were conducted to summarize their opinion and to identify the underlying structure of beliefs about helpfulness of various resources. Results: Counselors/psychologists/social workers, family, psychiatrists, other therapists, and religious leaders were believed to be the most helpful. Methods that require one's initiatives marked percentages much higher than those of 'waiting to get better' or 'dealing with it alone'. The percentages for medications were lower than other methods in general, but higher than those of a western sample especially on antidepressants and anti-psychotics. Psycho/social approach was favored more for SPR than for DEP, and popular/cultural approach was favored much more for DEP than for SPR; physical/medical approach was strongly unfavored against DEP. Conclusion: Strategies need to be developed for utilizing various helpful resources to diversify modality of mental health services and facilitate referrals and gatekeeping. The differences in beliefs on helpfulness of various methods between DEP and SPR point to the need for problem-specific strategies.

Minor Coat Protein pIII Domain (N1N2) of Bacteriophage CTXф Confers a Novel Surface Plasmon Resonance Biosensor for Rapid Detection of Vibrio cholerae

  • Shin, Hae Ja;Hyeon, Seok Hywan;Cho, Jae Ho;Lim, Woon Ki
    • 한국미생물·생명공학회지
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    • 제49권4호
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    • pp.510-518
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    • 2021
  • Bacteriophages are considered excellent sensing elements for platforms detecting bacteria. However, their lytic cycle has restricted their efficacy. Here, we used the minor coat protein pIII domain (N1N2) of phage CTXφ to construct a novel surface plasmon resonance (SPR) biosensor that could detect Vibrio cholerae. N1N2 harboring the domains required for phage adsorption and entry was obtained from Escherichia coli using recombinant protein expression and purification. SDS-PAGE revealed an approximate size of 30 kDa for N1N2. Dot blot and transmission electron microscopy analyses revealed that the protein bound to the host V. cholerae but not to non-host E. coli K-12 cells. Next, we used amine-coupling to develop a novel recombinant N1N2 (rN1N2)-functionalized SPR biosensor by immobilizing rN1N2 proteins on gold substrates and using SPR to monitor the binding kinetics of the proteins with target bacteria. We observed rapid detection of V. cholerae in the range of approximately 103 to 109 CFU/ml but not of E. coli at any tested concentration, thereby confirming that the biosensor exhibited differential recognition and binding. The results indicate that the novel biosensor can rapidly monitor a target pathogenic microorganism in the environment and is very useful for monitoring food safety and facilitating early disease prevention.

적응적 p-Version 유한요소법에서 정규 크리깅에 의한 응력복구기법 (Stress Recovery Technique by Ordinary Kriging Interpolation in p-Adaptive Finite Element Method)

  • 우광성;조준형;이동진
    • 대한토목학회논문집
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    • 제26권4A호
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    • pp.677-687
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    • 2006
  • 크리깅 보간법은 지구통계학 분야에 주로 사용되는 보간법의 하나이다. 이 방법은 실험적 베리오그램과 이론적 베리오그램의 작성과 크리깅 보간법의 정식화에 관한 연구를 포함하고 있다. 종래의 응력복구를 위한 최소제곱법과 대조적으로, 가우스적분점에서의 응력데이타로부터 준정해를 얻기 위해 가중 최소제곱법에 기초를 둔다. 즉, 동일한 가중치를 사용하는 종래의 방식들과는 달리 가우스적분점에서의 응력값의 보간을 위하여 베리오그램 모델링을 통한 가중치가 결정된다. 한편, 분할된 요소망에 Zienkiewicz와 Zhu에 의해 제안된 SPR기법에 기초를 둔 사후오차평가를 통해 p-차수를 균등 또는 선택적으로 증가시키는 자동체눈 방식이 도입되었다. 이 방법의 정당성을 보기위해 인장력을 받는 개구부를 갖는 평판문제를 해석하였다. 또한, 기존의 최소제곱법과의 비교를 통한 크리깅보간법의 정당성을 보여 주었다.

능동음향진동제어를 위한 센서와 액추에이터의 동위치화 연구 (Collocation of Sensor and Actuator for Active Control of Sound and Vibration)

  • 이영섭
    • 한국소음진동공학회논문집
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    • 제14권3호
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    • pp.253-263
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    • 2004
  • The problem considered in this paper is about the collocation of sensor and actuator for the active control of sound and vibration. It is well-known that a point collocated sensor-actuator pair offers an unconditional stability with very high performance when it is used with a direct velocity feedback (DVFB) control, because the pair has strictly positive real (SPR) property. In order to utilize this SPR characteristics, a matched piezoelectric sensor and actuator pair is considered. but this pair suffers from the in-plane motion coupling problem with the out-of-plane motion due to the piezo sensor and actuator interaction. This coupling phnomenon limits the stability and performance of the matched pair with DVFBcontrol. As a new alternative, a point sensor and distributed piezoelectric actuator pair is also considered, which provides SPR property in all frequency range when the pair is implemented on a clamped-clapmed beam. The use of this sensor-actuator pair is highly expected for the applications to more practical active control of sound and vibration systems with the DVFB control strategy.

지능판에 동위치화된 압전 센서-액추에이터의 응답특성 연구 (Response between Collocated Sensor and Actuator Bonded on a Smart Panel)

  • 이영섭
    • 한국소음진동공학회논문집
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    • 제17권3호
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    • pp.264-273
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    • 2007
  • A smart panel with structural sensors and actuators for minimizing noise radiation or transmission is described in the paper with the concept of active structural acoustical control. The sensors and actuators are both quadratically shaped piezoelectric polyvinylidene fluoride(PVDF) Polymer films to implement a volume velocity sensor and uniform force actuator respectively. They are collocated on either side of the panel to take advantage of direct velocity feedback(DVFB) strategy, which can guarantee a robust stability and high performance as long as the sensor-actuator response is strictly positive real(SPR). However, the measured sensor-actuator response of the panel showed unexpected result with non-SPR property. In the paper, the reason of the non-SPR property is investigated by theoretical analysis, computer simulation and experimental verification. The investigation reveals that the arrangement of collocated piezoelectric PVDF sensor and actuator pair on a panel is not relevant to get a high feedback gain and good performance with DVFB strategy.

Nano-scale Probe Fabrication Using Self-assembly Technique and Application to Detection of Escherichia coli O157:H7

  • Oh, Byung-Keun;Lee, Woochang;Lee, Won-Hong;Park, Jeong-Woo
    • Biotechnology and Bioprocess Engineering:BBE
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    • 제8권4호
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    • pp.227-232
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    • 2003
  • A self-assembled monolayer of protein G was fabricated to develop an immunosensor based on surface plasmon resonance (SPR), thereby improving the performance of the antibodybased biosensor through immobilizing the antibody molecules (lgG). As such, 11-mercaptoundecanoic acid (11-MUA) was adsorbed on a gold (Au) support, while the non-reactive hydrophilic surface was changed through substituting the carboxylic acid group (-COOH) in the 11-MUA molecule using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrocholide (EDAC). The formation of the self-assembled protein G layer on the Au substrate and binding of the antibody and antigen were investigated using SPR spectroscopy, while the surface topographies of the fabricated thin films were analyzed using atomic force microscopy (AFM). A fabricated monoclonal antibody (Mab) layer was applied for detecting E. coli O157:H7. As a result, a linear relationship was achieved between the pathogen concentration and the SPR angle shift, plus the detection limit was enhanced up to 10$^2$ CFU/mL.

수정 SPR 기법에 의한 휨을 받는 평판문제의 적응적 p-체눈 세분화 (p-Adaptive Mesh Refinement of Plate Bending Problem by Modified SPR Technique)

  • 조준형;이희정;우광성
    • 한국전산구조공학회:학술대회논문집
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    • 한국전산구조공학회 2007년도 정기 학술대회 논문집
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    • pp.481-486
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    • 2007
  • The Zienkiewicz-Zhu(Z/Z) error estimate is slightly modified for the hierarchical p-refinement, and is then applied to L-shaped plates subjected to bending to demonstrate its effectiveness. An adaptive procedure in finite element analysis is presented by p-refinement of meshes in conjunction with a posteriori error estimator that is based on the superconvergent patch recovery(SPR) technique. The modified Z/Z error estimate p-refinement is different from the conventional approach because the high order shape functions based on integrals of Legendre polynomials are used to interpolate displacements within an element, on the other hand, the same order of basis function based on Pascal's triangle tree is also used to interpolate recovered stresses. The least-square method is used to fit a polynomial to the stresses computed at the sampling points. The strategy of finding a nearly optimal distribution of polynomial degrees on a fixed finite element mesh is discussed such that a particular element has to be refined automatically to obtain an acceptable level of accuracy by increasing p-levels non-uniformly or selectively. It is noted that the error decreases rapidly with an increase in the number of degrees of freedom and the sequences of p-distributions obtained by the proposed error indicator closely follow the optimal trajectory.

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보의 진동제어를 위한 압전 액추에이터의 길이변화 효과 연구 (Effect of Piezoactuator Length Variation for Vibration Control of Beams)

  • 이영섭
    • 한국소음진동공학회논문집
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    • 제18권11호
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    • pp.1185-1191
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    • 2008
  • This paper presents an approach to define an optimal piezoactuator length to actively control structural vibration. The optimal ratio of the piezoactuator length against the beam length when a pair of piezoceramic actuator and accelerometer is used to suppress unwanted vibration with direct velocity feedback(DVFB) control strategy is not clearly defined so far. It is well known that DVFB control can be very useful when a pair of sensor and actuator is collocated on structures with a high gain and excellent stability. It is considered that three different collocated Pairs of piezoelectric actuators (20, 50 and 100 mm long) and accelerometers installed on three identical clamped-clamped beams($30{\times}20{\times}1mm$). The response of each sensor-actuator pair requires strictly positive real(SPR) property to apply a high feedback gain. However the length of the piezoactuator affects the SPR property of the sensor-actuator response. Intensive simulation and experiment show the effect of the actuator length variation is strongly related with the frequency range of the SPR property. Thus an optimal length ratio was suggested to obtain relevant performance with a good stability under the DVFB strategy.

Self-Piercing Rivet 접합공정의 수치예측에 미치는 리벳 유동응력의 영향 (Influence of the Flow Stress of the Rivet on the Numerical Prediction of the Self-Piercing Rivet (SPR) Joining)

  • 김성호;배기현;송정한;박근영;박남수
    • 소성∙가공
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    • 제29권5호
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    • pp.257-264
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    • 2020
  • This paper is concerned with the influence of the plastic property of the rivet on the numerical prediction of the Self-Piercing Rivet (SPR) Joining. In order to predict the plastic property of the rivet, a ring compression specimen was directly fabricated from the rivet used for the mechanical joining of dissimilar materials, and the FE analysis together with the ring compression test was iteratively carried out by changing the plastic property of the rivet. For reliable FE analysis, a friction coefficient was estimated based on a friction calibration curve, measuring the reductions in inner diameter and height of the ring specimen after the compression test. From each simulation result, the force-displacement curves were then compared from each other so as to obtain the rivet plastic property that shows good agreement with the experimental result. The SPR joining between GA590 1.0t and Al5052 2.0t was conducted, and the numerical prediction was performed with the use of the plastic property evaluated based on the inverse analysis and the one referred from Mori et al. [11]. Comparison of the experiment and the numerical predictions in terms of the interlock and bottom thickness revealed that the reliable evaluation of the plastic property of the rivet is necessary for the trustworthy numerical prediction of the SPR joining.

DYNAFLECT에 의한 아스팔트 콘크리트 포장도로의 분산도 특성에 관한 연구 (A Study on the Spreadability Characteristics of Asphalt Concrete Pavement using Dynaflect)

  • 김수일;최정훈;유지형
    • 한국지반공학회지:지반
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    • 제3권1호
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    • pp.53-64
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    • 1987
  • 도로포장의 구조평가 및 유지관리를 위하여 매우 효율적인 장비로 알려진 Dynaflect의 이용이 날 로 증가하고 있어, 이에 대한 연구가 절실하다. 따라서 본 연구에서는 도로포장에 사용되는 재료의 탄성계수에 따른 해석모질을 설정하고, 이를 다층토 이론에 근거한 콤퓨터 프로그램을 통하여 Dyn select의 처짐곡선을 산출함으로써 표층 두께와 탄성계수에 따른 분산도의 특성을 연구하였다.

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