• Advances in pediatric surgery
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• v.14 no.1
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• pp.83-87
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• 2008

Accessory cervical thymic tissue has been rarely reported. However, it should be included in the differential diagnosis of neck masses in children, along with branchial anomalies, lymph nodes and other tumors. This lesion occurs along the descending line of the thymus between the angle of mandible and superior mediastinum. A 2-month-old infant presented with an asymptomatic left sided neck mass. MRI revealed a well defined homogeneous mass in the deep lobe of left parotid gland. At operation, an easily identified soft tissue mass was found in the left submandibular area, measuring $3{\times}1.5cm$. It was completely excised. Microscopic examination revealed normal thymic tissue.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.747-750
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• 2004

Lightweight concrete is known for its advantage of reducing the self-weight of the structures, reducing the areas of sectional members as well as making the construction convenient. Thus the construction cost can be saved when applied. to . structures such as long-span bridge and high rise buildings. However, the lightweight concrete requires specific design mix method that is quite different from the typical concrete, since using the typical mix method would give rise the material segregation as well as lower the strength by the reduced weight of the aggregate. In order to avoid such problems, it is recommended to apply the design mix method of high performance self-compacting concrete for the lightweight concrete. Therefore, this study introduces a production of self-compacting concrete, PF-modified and improved version of Nan-Su's design mix method of self-compacting concrete. Through a series of test mixes conducted during the study, the quality of the concrete at its fresh condition has been evaluated per the 2nd class rating standards of self-compacting concrete published by JSCE, especially focused in its fluidity, segregation resistance ability, and filling ability.

• Journal of muscle and joint health
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• v.16 no.1
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• pp.26-35
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• 2009

Purpose: The purpose of this study was to investigate the effects of Tai Chi exercise program on physical fitness, pain, and self-efficacy in patients with osteoarthritis. Method: A preexperimental research design was applied to 22 subjects who dwelled at a welfare institution in C-city and agreed to participate in this study. The Tai Chi exercise was conducted with a duration of 60 minutes per session twice a week for 9 weeks. Outcome measures were physical fitness($VO_{2}max$, strength, flexibility, foot power, agility, balance), pain, and self-efficacy. Data were analyzed by descriptive statistics and paired t-test. Result: After participating in the Tai Chi exercise program, the subjects showed significant improvements in strength, agility, balance, pain and self-efficacy. But there were no significant differences in $VO_{2}max$, flexibility and foot power. Conclusion: The results showed that Tai Chi exercise would partially improve physical fitness and be effective for pain reduction and self efficacy as well. Further studies are needed to confirm the effects of Tai Chi exercise on physical fitness.

• Archives of Pharmacal Research
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• v.29 no.12
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• pp.1080-1085
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• 2006

A series of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-one derivatives were synthesized using 7-hydroxy-3,4-dihydro-2(1H)-quinolone as the starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES) and the subcutaneous pentylenetetrazole test (sc-PTZ), and their neurotoxicities were measured by the rotarod neurotoxicity test (Tox). The tests demonstrated that 8-hexyloxy-4,5-dihydro-[1.2.4]triazole[4.3-a]quinoline-1-one (4e) and 8-heptyloxy-4,5-dihydro-[1,2,4]triazole[4, 3-a]quinoline-1-one (4f) were the most potent anticonvulsants, with 4e having $ED_{50}$ values of 17.17 mg/kg and 24.55 mg/kg and protective index ($PI=TD_{50}/ED_{50}$) values of 41.9 and 29.3 in the MES and sc-PTZ tests, respectively, and 4f having $ED_{50}$ values of 19.7 mg/kg and 21.2 mg/kg and PI values of 36.5 and 33.9 in the MES and sc-PTZ tests, respectively. The PI values of 4e and 4f were many fold better than that of the marketed drugs phenytoin, carbamazepine, phenobarbital and valproate, which have PI values in the range of 1.6-8.1 in the MES test and <0.22-5.2 in the sc-PTZ test. Structure-activity relationships were also discussed.

• Journal of Korean Clinical Nursing Research
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• v.20 no.1
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• pp.90-101
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• 2014

Purpose: The purpose of this study was to develop a nursing intervention program for rehabilitation inpatients and to evaluate the effects of the program on depression, motivation and self-efficacy. Methods: The study was conducted using a nonequivalent control group non-synchronized design. Participants were rehabilitation inpatients, 27 patients in the control group and 20 in the experimental group. Data were collected from May to November, 2012. Questionnaires were completed three times (pretest, 5 days, 10 days) Final data for 40 patients were analyzed, 23 patients in the control group and 17 in the experimental group. Data were analyzed using $x^2-test$, t-test, and repeated measure ANOVA. Results: Depression in the experimental group decreased compared to the control group, but it was not significant. Motivation for the experimental group changed significantly (F=3.90, p=.029) and self-efficacy increased, but not significantly (F=0.59, p=.559) Conclusion: Results of this study indicate that nursing intervention programs for rehabilitation inpatients could be useful to decrease depression and to improve motivation and self-efficacy.

• Journal of the Korea Concrete Institute
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• v.17 no.6 s.90
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• pp.923-930
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• 2005

This paper was to evaluate the high strength lightweight self-compacting concrete(HLSCC) manufactured by Nan-Su, which main factor, Packing Factor(PF) for mixing design, has been modified and improved. We have examined HLSCC performance at its fresh condition as well as its mechanical properties at the hardened condition. The evaluation of HLSCC fluidity has been conducted per the standard of second class rating of JSCE, by three categories of flowability(slump-flow), segregation resistance ability(time required to reach 500mm of slump-flow and time required to flow through V-funnel) and filling ability(U-box test) of fresh concrete. The compressive strength of HLSSC at 28 days has come out to more than 30MPa in all mixes. The relationship between the compressive strength-splitting tensile strength and compressive strength-modulus of elasticity of HLSSC were similar those of typical lightweight concrete. Compressive strength and dry density of HLSCC at 28 days from the multiple regression analysis resulted as $f_c=-0.16LC-0.008LS+50.05(R=0.83)\;and\;f_d=-3.598LC-2.244LS+2,310(R=0.99)$, respectively.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.621-623
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• 2012

To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma ($P_{trend}$ <0.05) in six genes ($IL1RN$, $IL2$, $IL12RB1$, $JAK3$, $TNFRSF13B$, and $XRCC3$). The most significant association was seen for $IL2$ variant rs2069762 ($OR_{TG+GG}$ vs. TT=3.43 (1.29-9.11), $P_{trend}$=0.002, min$P$=0.005). These findings suggest that common genetic variants in $IL2$ might play a role in the pathogenesis of childhood lymphoma.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5659-5663
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• 2012

To investigate the expression of hPOT1 in the HeLa cell line and screen point mutations of hpot1 in different tumor tissues a two step osmotic method was used to extract nuclear proteins. EMSA was performed to determine the expression of hPOT1 in the HeLa cell line. PCR was also employed to amplify the exon14 sequence of the hpot1 gene in various of cancer tissues. A SV gel and PCR clean-up system was performed to enrich PCR products. DNAStar was used to analyse the exon14 sequence of the hpot1 gene. hPOT1 was expressed in the HeLa cell line and the signal was gradually enhanced as the amount of extracted nuclear proteins increased. The DNA fragment of exon14 of hpot1 was successfully amplified in the HeLa cell line and all cancer tissues, point mutations being observed in 2 out of 3 cases of endometrial cancer (66.7%) despite the hpot1 sequence being highly conserved. However, the sequence of hpot1 exon14 do not demonstrate point mutations in most cancer tissues. Since hPOT1 was expressed in HeLa cell and the probability of gene point variants was obviously higher in endometrial cancer than other cancers, it may be involved in the pathogenesis of gynecological cancers, especially in cervix and endometrium.

• YAKHAK HOEJI
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• v.50 no.3
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• pp.172-176
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• 2006

The purpose of this study is to develop a mass preparation method of (+)-decursinol from Angelica gigas roots. Recently; it has been shown that (+)-decursin, (+)-decursinol angelate and its analogues, isolated from Angelica gigas roots, exhibit various biological activities such as antitumor, antibacterial and neuroprotective activities. The contents of these compounds, ester form of (+)-decursinol, is very high in the Angelica gigas roots, whereas the content of (+)-decursinol itself is very low Therefore, (+)-decursinol which can be used as starting material to synthesize various its analogues was easily prepared from decursin analogues in the Angelica gigas roots. In order to achieve such aim, the Ether-Fr. of the ethanol exact of Angelica gigas roots was hydrolysed with various alkalis and solvents. As a result, the order of (+)-decursinol preparation was 1) NaOH, KOH, 2) $K_2CO_3$, and 3) $NaHCO_3$ as alkali. Also, the yield of (+)-decursinol was higher in diethyl ether than any other solvent conditions. From 1 kg of dried Angelica gigas roots, we could obtain 27.4 g of (+)-decursinol as a pure white solid.

• YAKHAK HOEJI
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• v.50 no.5
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• pp.338-344
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• 2006

A novel series of 4-senecioyloxymethyl-6,7-dimethoxycoumarin, isolated from Crinum latifolium, was prepared by reacting 4-bromomethyl or 4-bromomethyl-6,7- dimethoxycoumarin with various carboxylic acids and examined for their anti-angiogenic activities in human umbilical vein endothelial cells (HUVECs). Among them, 4e, 4f, 4g and 4i with noncyclic moiety exhibited potent anti-angiogenic activity. However, compounds with cyclic moiety such as phenyl, pyridinyl, thiophenyl and furanyl group did not exhibit any anti-angiogenic activity. Also, compounds 4f and 4g which exhibited strong anti-angiogenic activity in a dose-dependent manner showed antitumor activity.