• BMB Reports
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• 제37권4호
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• pp.402-407
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• 2004

A human gene T-complex protein 10 like (TCP10L) was cloned in our lab. A previous study showed that it expressed specifically in the liver and testis. A transcription experiment revealed that TCP10L was a transcription factor with transcription inhibition activity. In this study, the human MAD4 was identified to interact with TCP10L by a yeast two-hybrid screen. This finding was confirmed by immunoprecipitation and subcellular localization experiments. As MAD4 is a member of the MAD family, which antagonizes the functions of MYC and promotes cell differentiation, the biological function of the interaction between TCP10L and MAD4 may be to maintain the differentiation state in liver cells. Also, we propose that the up-regulation of Myc is caused by the down-regulation of TCP10L in human hepatocarcinomas.

• Journal of Acupuncture Research
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• 제17권2호
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• pp.53-68
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• 2000

As compared with acupuncture, The moxibustion occurred differently in the background of formation and also disagreed in the process of development. From the Jin(晉) dynasty to the Song(宋) dynasty, The school that attached importance to moxibustion had occupied superority by far and had schemed the development of moxibustion. But after the Song(宋) dynasty, The school that attached importance to acupuncture rose. Therefore, The school that attached importance to moxibustion, even if the power decreased, still had kept in existence and had achieved the development of moxibustion. Especially, Among the chinese physicians that recognized "Moxibustion can cure all disease, so don't discuss the weakness the firmness the chills the fever and cauterize the skin" till the Song(宋) dynasty, Ge Hong(葛洪) put in order the basic theory for moxibustion in (A handbook of prescriptions for emergencies). Wang Tao(王燾) only respected the moxibustion and said "Moxibustion has a strange effect, then all acupuncture herb-med(medical decoction) herb-ex are unattainable to it" in volume 14 (Medical secrets of an official). Dou Cai(實材) insisted that moxibustion is prime for supporting the Yang(陽) and always must be cauterized with moxa on Guan Yuan(關元) Qi Hai(氣海) Ming Guan(命關), Zhons Wan(中脘) etc. for supporting the Yang of Pi Shen(脾腎) in

• 한국해양환경ㆍ에너지학회지
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• 제13권1호
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• pp.12-17
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• 2010

OWC 파력발전장치는 에너지 변환장치로 널리 사용되고 있고 공기실의 작동성능을 향상시키기 위하여 파랑집중장치를 고안 하였다. 본 논문에서 사용된 수치조파수조는 two-phase VOF모델을 기반으로 하여 구현되었고 재생된 규칙 입사파는 공기실까지 전달되어 내부의 왕복 유동장을 형성하게 하였다. 수치조파수조는 연속방정식, Reynolds-averaged Navier-Stokes방정식, two-phase VOF 법으로 구성 되였고 standard k- 난류모델, 유한체적법, NITA-PISO 알고리즘 그리고 dynamic mesh기능을 채택하였다. OWC 공기실 파랑집중장치의 성능에 대하여 수치적으로 고찰하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권1호
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• pp.131-146
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• 2012

As one of the four basic technologies of IOT (Internet of Things), M2M technology whose advance could influence on the technology of Internet of Things has a rapid development. Mobile Payment is one of the most widespread applications in M2M. Due to applying wireless network in Mobile Payment, the security issues based on wireless network have to be solved. The technologies applied in solutions generally include two sorts, encryption mechanism and authentication mechanism, the focus in this paper is the authentication mechanism of Mobile Payment. In this paper, we consider that there are four vital things in the authentication mechanism of Mobile Payment: two-way authentication, re-authentication, roaming authentication and inside authentication. Two-way authentication is to make the mobile device and the center system trust each other, and two-way authentication is the foundation of the other three. Re-authentication is to re-establish the active communication after the mobile subscriber changes his point of attachment to the network. Inside authentication is to prevent the attacker from obtaining the privacy via attacking the mobile device if the attacker captures the mobile device. Roaming authentication is to prove the mobile subscriber's legitimate identity to the foreign agency when he roams into a foreign place, and roaming authentication can be regarded as the integration of the above three. After making a simulation of our proposed authentication mechanism and analyzing the existed schemes, we summarize that the authentication mechanism based on the mentioned above in this paper and the encryption mechanism establish the integrate security framework of Mobile Payment together. This makes the parties of Mobile Payment apply the services which Mobile Payment provides credibly.

• Journal of Power Electronics
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• 제19권6호
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• pp.1366-1379
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• 2019

High-gain DC/DC converters have become one of the key technologies for the grid-connected operation of new energy power generation, and its research provides a significant impetus for the rapid development of new energy power generation. Inspired by the transformer effect and the ripple-suppressed ability of a coupled inductor, a double-coupled inductor high gain DC/DC converter with a ripple absorption circuit is proposed in this paper. By integrating the diode-capacitor voltage multiplying unit into the quadratic Boost converter and assembling the independent inductor into the magnetic core of structure coupled inductors, the adjustable range of the voltage gain can be effectively extended and the limit on duty ratio can be avoided. In addition, the volume of the magnetic element can be reduced. Very small ripples of input current can be obtained by the ripple absorption circuit, which is composed of an auxiliary inductor and a capacitor. The leakage inductance loss can be recovered to the load in a switching period, and the switching-off voltage spikes caused by leakage inductance can be suppressed by absorption in the diode-capacitor voltage multiplying unit. On the basis of the theoretical analysis, the feasibility of the proposed converter is verified by test results obtained by simulations and an experimental prototype.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.775-780
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• 2008

This paper reports on the internal flow of a centrifugal mini pump working at the low flow rate operating conditions. The RNG $\kappa-\varepsilon$ turbulence model was employed to simulate the three-dimensional turbulent flow in the pump. To examine and certify the simulation results, a transparent acrylic centrifugal mini pump model which is suitable for PIV measurement has been developed. The tongue region and the passages region between blades were investigated using PIV. In order to eliminate the effect of refraction on the area closed to the wall and increase the measurement accuracy, the fluorescent particles were scatted into the working fluid with the tracing particles. It is found from the calculation and PIV measurement results that there is a large area of recirculation flow near the tongue at low flow rate operating conditions. The computationally predicted water head using the $\kappa-\varepsilon$ turbulence model at low flow rate operating conditions are in very good agreement with the experimentally measured water head and the mean velocity distributions at investigation area obtained by PIV and calculation showed a satisfactory agreement as well. Meanwhile, the results of PIV measurements show that the flow status in one passage is different to another. And for capturing the internal flow detail information, the $\kappa-\varepsilon$ turbulence model is not very suitable.

• Journal of Microbiology and Biotechnology
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• 제31권9호
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• pp.1191-1199
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• 2021

Enteropathogenic Escherichia coli (EPEC), which belongs to the attaching and effacing diarrheagenic E. coli strains, is a major causative agent of life-threatening diarrhea in infants in developing countries. Most EPEC isolates correspond to certain O serotypes; however, many strains are non-typeable. Two EPEC strains, EPEC001 and EPEC080, which could not be serotyped during routine detection, were isolated. In this study, we conducted an in-depth characterization of their putative O-antigen gene clusters (O-AGCs) and also performed constructed mutagenesis of the O-AGCs for functional analysis of O-antigen (OAg) synthesis. Sequence analysis revealed that the occurrence of O-AGCs in EPEC001 and E. coli O132 may be mediated by recombination between them, and EPEC080 and E. coli O2/O50 might acquire each O-AGC from uncommon ancestors. We also indicated that OAg-knockout bacteria were highly adhesive in vitro, except for the EPEC001 wzy derivative, whose adherent capability was less than that of its wild-type strain, providing direct evidence that OAg plays a key role in EPEC pathogenesis. Together, we identified two EPEC O serotypes in silico and experimentally, and we also studied the adherent capabilities of their OAgs, which highlighted the fundamental and pathogenic role of OAg in EPEC.

• Psychiatry investigation
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• 제15권11호
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• pp.1064-1070
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• 2018

Objective Several cell line studies have demonstrated thioridazine's anticancer, multidrug resistance-reversing and apoptosis-inducing properties in various tumors. We conducted this nationwide population-based study to investigate the association between thioridazine use and cancer risk among adult patients with schizophrenia. Methods Based on the Psychiatric Inpatient Medical Claim of the National Health Insurance Research Database of Taiwan, a total of 185,689 insured psychiatric patients during 2000 to 2005 were identified. After excluding patients with prior history of schizophrenia, only 42,273 newly diagnosed patients were included. Among them, 1,631 patients ever receiving thioridazine for more than 30 days within 6 months were selected and paired with 6,256 randomly selected non-thioridazine controls. These patients were traced till 2012/12/31 to see if they have any malignancy. Results The incidence rates of hypertension and cerebrovascular disease were higher among cases than among matched controls. The incidence of hyperlipidemia, coronary artery disease and chronic pulmonary disease did not differ between the two groups. By using Cox proportional hazard model for cancer incidence, the crude hazard ratio was significantly higher in age, hypertension, hyperlipidemia, cerebrovascular disease, coronary artery disease and chronic pulmornary disease. However, after adjusting for other covariates, only age and hypertension remained significant. Thioridazine use in adult patients with schizophrenia had no significant association with cancer. Conclusion Despite our finding that thioridazine use had no prevention in cancer in adult patients with schizophrenia. Based on the biological activity, thioridazine is a potential anticancer drug and further investigation in human with cancer is warranted.

• Journal of Ginseng Research
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• 제43권3호
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• pp.442-451
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• 2019

Background: Ginseng has a wide range of beneficial effects on health, such as the mitigation of minor and major inflammatory diseases, cancer, and cardiovascular diseases. There are abundant data regarding the health-enhancing properties of whole ginseng extracts and single ginsenosides; however, no study to date has determined the receptors that mediate the effects of ginseng extracts. In this study, for the first time, we explored whether the antiinflammatory effects of Rg3-enriched red ginseng extract (Rg3-RGE) are mediated by retinoid X receptor ${\alpha}$-peroxisome-proliferating receptor ${\gamma}$ ($RXR{\alpha}-PPAR{\gamma}$) heterodimer nuclear receptors. Methods: Nitric oxide assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay, quantitative reverse transcription polymerase chain reaction, nuclear hormone receptor-binding assay, and molecular docking analyses were used for this study. Results: Rg3-RGE exerted antiinflammatory effects via nuclear receptor heterodimers between $RXR{\alpha}$ and $PPAR{\gamma}$ agonists and antagonists. Conclusion: These findings indicate that Rg3-RGE can be considered a potent antiinflammatory agent, and these effects are likely mediated by the nuclear receptor $RXR{\alpha}-PPAR{\gamma}$ heterodimer.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제13권2호
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• pp.1020-1042
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• 2019

Reversible data hiding in encrypted images (RDHEI) provides some real-time cloud applications; i.e. the cloud, acting as a data-hider, automatically embeds timestamp in the encrypted image uploaded by a content owner. Many existing methods of RDHEI only satisfy user privacy in which the data-hider does not know the original image, but leaks owner privacy in which the receiver can obtains the original image by decryption and extraction. In the literature, the method of Zhang et al. is the one providing weak content-owner privacy in which the content-owner and data-hider have to share a data-hiding key. In this paper, we take care of the stronger notion, called strong content-owner privacy, and achieve it by presenting a new reversible data hiding in encrypted images. In the proposed method, image decryption and message extraction are separately controlled by different types of keys, and thus such functionalities are decoupled to solve the privacy problem. At the technique level, the original image is segmented along a Hilbert filling curve. To keep image privacy, segments are transformed into an encrypted image by using random permutation. The encrypted image does not reveal significant information about the original one. Data embedment can be realized by using pixel histogram-style hiding, since this property, can be preserved before or after encryption. The proposed method is a modular method to compile some specific reversible data hiding to those in encrypted image with content owner privacy. Finally, our experimental results show that the image quality is 50.85dB when the averaged payload is 0.12bpp.