• Journal of Periodontal and Implant Science
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• v.47 no.2
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• pp.77-85
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• 2017

Purpose: Guided bone regeneration (GBR) is the most widely used technique to regenerate and augment bones. Even though augmented bones (ABs) have been examined histologically in many studies, few studies have been conducted to examine the biological potential of these bones and the healing dynamics following their use. Moreover, whether the bone obtained from the GBR procedure possesses the same functions as the existing autogenous bone is uncertain. In particular, little attention has been paid to the regenerative ability of GBR bone. Therefore, the present study histologically evaluated the regenerative capacity of AB in the occlusive space of a rat guided bone augmentation (GBA) model. Methods: The calvaria of 30 rats were exposed, and plastic caps were placed on the right of the calvaria in 10 of the 30 rats. After a 12-week healing phase, critical-sized calvarial bone defects (diameter: 5.0 mm) were trephined into the dorsal parietal bone on the left of the calvaria. Bone particles were harvested from the AB or the cortical bone (CB) using a bone scraper and transplanted into the critical defects. Results: The newly generated bone at the defects' edge was evaluated using micro-computed tomography (micro-CT) and histological sections. In the micro-CT analysis, the radiopacity in both the augmented and the CB groups remained high throughout the observational period. In the histological analysis, the closure rate of the CB was significantly higher than in the AB group. The numbers of cells positive for runt-related transcription factor 2 (Runx2) and tartrate-resistant acid phosphatase (TRAP) in the AB group were larger than in the CB group. Conclusions: The regenerative capacity of AB in the occlusive space of the rat GBA model was confirmed. Within the limitations of this study, the regenerative ability of the AB particulate transplant was inferior to that of the CB particulate transplant.

• 한국공간정보시스템학회:학술대회논문집
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• 2007.06a
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• pp.3-8
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• 2007

최근 도로 네트워크 환경에서 이동 객체 위치 정보를 관리하고 이동 객체의 미래 위치를 예측하는 이동 객체 위치 예측 시스템의 필요성이 나날이 증가되고 있다. 이동 객체위치 예측 시스템은 교통 관제 및 다양한 응급 상황 시 이동 객체의 미래 위치를 신속히 예측하기 위해 사용되며, 보다 편리한 위치 기반 서비스의 제공을 가능하게 해준다. 이러한 시스템을 위한 대부분의 미래 인덱싱 기법은 일반적으로 이동 객체의 미래 위치 예측을 위해 과거 이동 궤적을 이용하고 있다. 그러나, 수많은 이동 객체의 과거 이동 궤적 관리가 어렵고, 실시간으로 변화하는 이동 객체의 미래 궤적을 반영하기 위한 방대한 미래 인덱스의 갱신 요청으로 인해 인덱스 유지 비용이 증가하여 미래 위치 질의 요청에 대한 신속한 처리 성능이 떨어지게 된다. 따라서 본 논문에서는 이동 객체 위치 예측 시스템에서 방대한 이동 객체의 과거 이동 궤적으로부터 효율적으로 미래 위치를 예측하기 위해 셀 기반의 미래 인덱싱 방법인 PFCT-Tree(Probability Future Cell Trajectory-Tree)를 제시한다. PFCT-Tree는 방대한 과거 이동 궤적을 셀 단위로 재구성하여 인덱스 크기를 줄이고, 셀 내부 경험치를 기반으로 장기간 질의 시 빠른 미래 위치를 예측할 수 있다. 또한 신속한 미래 이동 궤적의 갱신 속도를 향상시키기 위해 미래 시간을 미래 궤적과 분리하여 인덱싱함으로써 위치 예측 오류로 인한 미래 인덱스 갱신 비용을 최소화 할 수 있다. 마지막으로 실험을 통해 도로 네트워크 환경에서 PFCT-Tree가 기존 인덱싱 기법들보다 갱신 및 검색 성능이 우수함도 입증하였다.ential oil (Bergamot, Grapefruit, Lemon, Petigrain)은 농도 의존적으로 ROS 생성을 증가시켰다. 이상의 결과를 종합하여 볼 때 citrus essential oil은 MSH에 의한 melanin 생성을 억제하는 것으로 보아 미백제로서의 개발 가능성이 있는 것으로 사료된다.가 사용될 수 있음을 제시한다.찍 발견되어 크기는 작았으며, 육안적으로 폴립의 Yamada 형태의 분류는 II, III의 형태를 띠고 있었다.EX>로 한반도 후기 백악기의 고지자기극$(Lat./Long.=70.9^{\circ}N/215.4^{\circ}E,\;A_{95}=5.3^{\circ})$의 위치와 유사하므로 암석의 생성 시기는 후기 백악기로 판단하였다. 한편 함평분지에 분포하는 백악기 화산암류에서는 한 개의 정자화 방향과 두 개의 역자화 방향이 확인되었다. 이들 특성잔류자화 방향은 백악기 화산암 형성 당시 암석에 기록된 성분으로써 당시 지구자기장의 상태를 기록한 것으로 해석하였으며, 이중 정자화 방향을 함평분지 화산암의 대표 방향으로 채택하였다 함평분지 화산암의 고지자기 극의 위치는 정자극의 경우는 $Lat./Long.=70.2^{\circ}N/199.5^{\circ}E,\;(K=18.1,\;A_{95}=9.6^{\circ})$ 이며 역자극의 경우는 $Lat./Long.=65.5^{\circ}S/251.3^{\circ}E,\;(K=7.1,\;A_{95}=20.7^{\circ})$이다. 이중 정자극의 위치는 한반도의 후기 백악기극의 위치와 통계적으로 동일한 것으로 나타나 함평분지 화산암

• Journal of the Korean Society of Food Culture
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• v.8 no.1
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• pp.73-77
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• 1993

We obtained the following results from determination of the sodium and potassium content contained in Denjang made in Korea and Japan. The mean sodium content of commercial denjang and home made denjang made in Korea and those of Japan are 4181.3 mg/100g, 6015.6 mg/100g and 5082.5 mg/100g, 5890.6 mg/100g, respectively. The mean potassium content of commercial denjang and home made denjang made in Korea and those of Japan are 595.8 mg/100g, 331.3 mg/100g and 365.4 mg/100g, 381.3 mg/100g, respectively. The mean NaCl concentration of commercial denjang and home made denjang made in Korea and those of Japan are 10.62%, 15.28% and 12.91%, 14.96% respectively. The mean Na/K ratios of commercial denjang and home made denjang made in Korea and those of Japan are 7.25, 21.54 and 14.42, 16.14 respectively.

• Journal of the Korean Society of Marine Environment & Safety
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• v.16 no.4
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• pp.345-352
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• 2010

The objective of this paper is to explore the short-term variability of water temperature and chlorophyll a (Chl-a) derived from in-situ and satellite data (NOAA, Sea WiFS and QuikScat) in the upwelling region of the southeastern part of Korean Peninsula in June and August, 2007. Particularly we focused on the spatial variability of sea surface temperature(SST) and Chl-a in the East Korean Warm Current region. In the results of the in-situ data, the peaks of Chl-a in june was shown at a depth of 50m The peaks of Chl-a in August was shown at a depth of 10m at the stations 4 and 5 near the land, and a depth of 30m at the other stations. The Chl-a concentrations in August were also lower than those in june except for station 5. As a result, the peaks of Chl-a in August occurred at a depth of 20~40 m shallower than those of Chl-a in june. This indicates that the nutrient-rich water within the mixed layer depth may be immediately supplied by the coastal upwelling, which is due to the southerly component of wind. The relationship between SST and Chl-a showed a negative correlation, and the high concentration of Chl-a occurred in the cold water area. The southerly wind and the East Korean Warm Current influenced a remarkable offshore movement of the cold water and Chl-a near the coastal area.

• Toxicological Research
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• v.17
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• pp.47-57
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• 2001

Alzheimer's disease (AD) is the most common cause of dementia in the elderly, and its pathology is characterized by the presence of numerous numbers of senile plaques and neurofibrillary tangles. Several genetic and transgenic studies have indicated that excess amount of $\beta$-amyloid protein (A$\beta$) is produced by mutations of $\beta$TEX>$\beta$-amyloid precursor protein and causes learning impairment. Moreover, $A\beta$ has a toxic effect on cultured nerve cells. To prepare AD model animals, we have examined continuous (2 weeks) infusion of $A\beta$ into the cerebral ventricle of rats. Continuous infusion of $A\beta$ induces learning impairment in water maze and passive avoidance tasks, and decreases choline acetyltransferase activity in the frontal cortex and hippocampus. Immunohistochemical analysis revealed diffuse depositions of $A\beta$ in the cerebral cortex and hippocampus around the ventricle. Furthermore, the nicotine-evoked release of acetylcholine and dopamine in the frontal cortex/hippocampus and striatum, respectively, is decreased in the $A\beta$-infused group. Perfusion of nicotine (50 $\mu\textrm{M}$) reduced the amplitude of electrically evoked population spikes in the CA1 pyramidal cells of the control group, but not in those of the $A\beta$-infused group, suggesting the impairment of nicotinic signaling in the $A\beta$-infused group. In fact, Kd, but not Bmax, values for ［$^3H$］ cytisine binding in the hippocampus significantly increased in the $A\beta$-infused rats. suggesting the decrease in affinity of nicotinic acetylcholine receptors. Long-term potentiation (LTP) induced by tetanic stimulations in CA1 pyramidal cells, which is thought to be an essential mechanism underlying learning and memory, was readily observed in the control group, whereas it was impaired in the $A\beta$-infused group. Taken together, these results suggest that $A\beta$ infusion impairs the signal transduction mechanisms via nicotinic acetylcholine receptors. This dysfunction may be responsible, at least in part, for the impairment of LTP induction and may lead to learning and memory impairment. We also found the reduction of glutathione- and Mn-superoxide dismutase-like immunoreactivity in the brains of $A\beta$-infused rats. Administration of antioxidants or nootropics alleviated learning and memory impairment induced by $A\beta$ infusion. We believe that investigation of currently available transgenic and non-transgenic animal models for AD will help to clarify the pathogenic mechanisms and allow assessment of new therapeutic strategies.

• Korean Journal of Food Science and Technology
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• v.14 no.2
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• pp.179-183
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• 1982

This experiment was carried out to clarify the optimal concentrations of growth regulators for callus induction and the condition of callus culture of leaf tissue taken from Stevia rebaudiana Bertoni. The content of stevioside, sweetening component, in leaf-derived callus of stevia was also investigated. It was shown that the optimal concentrations of benzyladenine (BA) and ${\alpha}-naphthalene$acetic acid (NAA) for callus induction were $10^{-6}M$ and $10^{-5}M$, respectively. Reculture of these calli in media (Linsmaier and Skoog) supplemented with BA $10^{-6}M$ and NAA $10^{-5}M$ resulted in profuse calli 15 to 20 days after incubation. When sweetening components produced by callus were extracted and identified by TLC, stevioside appeared to have Rf value 0.50 in TLC which was exactly same as standard stevioside. Stevioside content obtained by TLC-FID analyzer was 260mg per 100g on the basis of dry weight.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.539-543
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• 2016

Background: It is well known that peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is associated with a poor prognosis. However, data on the prognostic significance of modern chemotherapy containing bevacizumab, cetuximab or panitumumab are not available. Materials and Methods: This retrospective review concerned 526 patients with metastatic CRC who were classified into two groups according to the presence or absence of PC, and were treated with systemic chemotherapy, with or without bevacizumab or anti-EGFR antibodies. The genetic background, in particular KRAS, BRAF, and PIK3CA gene mutations, and overall survival (OS) were compared between the two groups. Results: The median OS values were 23.3 and 29.1 months for PC and non-PC patients, respectively (hazard ratio [HR]=1.20; p=0.17). Among all patients, tumor location, number of metastatic sites and BRAF mutation status were significant prognostic factors, whereas the presence of PC was not. In the PC group, chemotherapy with bevacizumab resulted in a significantly longer OS than forchemotherapy without bevacizumab (HR=0.38, p<0.01), but this was not the case in the non-PC group (HR=0.80, p=0.10). Furthermore, the incidence of the BRAF V600E mutation was significantly higher in PC than in non-PC patients (27.7% versus 7.3%, p<0.01). BRAF mutations displayed a strong correlation with shorter OS in non-PC (HR=2.26), but not PC patients (HR=1.04). Conclusions: Systemic chemotherapy, especially when combined with bevacizumab, improved survival in patients with PC from CRC as well as non-PC patients. While BRAF mutation demonstrated a high frequency in PC patients, but it was not associated with prognosis.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.683-687
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• 2015

Aloe vera gel exhibits protective effects against insulin resistance as well as lipid-lowering and anti-diabetic effects. The anti-diabetic compounds in this gel were identified as Aloe-sterols. Aloe vera gel extract (AVGE) containing Aloe-sterols has recently been produced using a new procedure. We previously reported that AVGE reduced large-sized intestinal polyps in Apc-deficient Min mice fed a high fat diet (HFD), suggesting that Aloe vera gel may protect against colorectal cancer. In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt foci (ACF) in mice fed a HFD. Male C57BL/6J mice were given a normal diet (ND), HFD, HFD containing 0.5% carboxymethyl cellulose solution, which was used as a solvent for AVGE (HFDC), HFD containing 3% or 1% AVGP, and HFDC containing 0.0125% (H-) or 0.00375% (L-) AVGE. The number of ACF was significantly lower in mice given 3% AVGP and H-AVGE than in those given HFD or HFDC alone. Moreover, 3% AVGP, H-AVGE and L-AVGE significantly decreased the mean Ki-67 labeling index, assessed as a measure of cell proliferation in the colonic mucosa. In addition, hepatic phase II enzyme glutathione S-transferase mRNA levels were higher in the H-AVGE group than in the HFDC group. These results suggest that both AVGP and AVGE may have chemopreventive effects on colorectal carcinogenesis under the HFD condition. Furthermore, the concentration of Aloe-sterols was similar between 3% AVGP and H-AVGE, suggesting that Aloe-sterols were the main active ingredients in this experiment.

• Journal of the Korean earth science society
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• v.36 no.6
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• pp.553-566
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• 2015

The effects of vertical resolutions and planetary boundary layer (PBL) physics schemes in a numerical simulation with a very high resolution over the metropolitan area were investigated. The numerical experiments using the Weather Research and Forecast model were conducted from 0000 UTC 25 October to 0000 UTC 26 October 2013. We verified the numerical results against with six hourly observation data from the radiosonde at Seolleung, which was located in southern part of Seoul, and forty three auto weather systems in Seoul. In the experiments of vertical resolutions in low level atmosphere with 44, 50, and 60 layers, which are set to be subdivided particularly under 2 km height. The experiment in 60 layers, which has the highest vertical resolution in this study, showed relatively a clear diurnal variation of PBL heights. Especially, the difference of PBL heights and 10-meter wind fields were mainly seen in the area of high altitude lands for the experiments of vertical resolution. In the sensitivity experiment of PBL schemes such as asymmetric convective model-version 2 (ACM2), Yonsei University (YSU), and Mellow-Yamada-Janjic (MYJ) to the temperature, all three PBL schemes revealed lower temperature than observed profile from the radiosonde in the entire period. The experiments with YSU PBL and ACM2 PBL schemes show relatively less biased in comparison with the experiment of the MYJ PBL scheme.

• Parasites, Hosts and Diseases
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• v.40 no.1
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• pp.45-54
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• 2002

Field trials evaluating selected commercially available mosquito traps variously baited with light, carbon dioxide, and/or octenol were conducted from 18-27 September 2000 in a malarious area near Paekyeon-ri (Tongil-Chon) and Camp Greaves in Paju County, Kyonggi Province, Republic of Korea. The host-seeking activity for common mosquito species, including the primary vector of Japanese encephalitis, Culex tritaeniorhynchus Giles. was determined using hourly aspirator collections from a human and propane lantern-baited Shannon trap doting hours when temperatures exceeded $15^{\circ}C$. The total number of mosquitoes and number of each species captured during the test was compared using a block design. Significant differences were observed for the total number of mosquitoes collected, such that, the Mosquito MagnetTM with octenol > Shannon trap > ABC light trap with light and dry ice > Miniature Black Light trap (manufactured by John W. Hock) $\geq$ New Jersey Trap > ABC light trap with light only. Significant differences in numbers collected among trapes were noted for several species including: Aedes vexans (Meigen), Anopheles lesteri Baisas and Hu. An. sinensis Weidemann, An. sineroides Yamada, An. yatsushiroensis Miyazaki. Culex pipiens pallets Coquillett L., Cx. orientalis Edwards and Cx. tritaeniorhynchus. Host-seeking activity for most common species showed a similar bimodal pattern. Results from these field trap evaluations can significantly enhance current vector and disease surveillance efforts especially for the primary vector of Japanese encephalitis, Cx. tritaeniorhunchus.