• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4699-4701
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• 2012

Objective: To explore the effect of portal vein chemotherapy on liver metastasis after surgical resection of colorectal cancer. Methods: Patients fulfilling the eligibility criteria were assigned to receive either surgery plus 1-week continuous infusion of 5-FU (study group) or surgery alone (observational group). Patients in the study group received portal vein chemotherapy, whereby 5-FU (1000 mg/d) and heparin (5000 IU/d) infusion was initiated from the day of surgery and lasted for 7 consecutive days. Liver metastasis was monitored during five years follow-up postoperatively. Results: Sixty four patients were recruited and assigned to the study group (12 with colon and 20 with rectal cancer) or the control group (10 with colon and 22 with rectal cancer). Liver metastasis rate was 12.5% in study and 25.0% in observational group, the difference being significant (P<0.01). Conclusion: Portal vein chemotherapy could be an effective treatment in preventing liver metastasis after surgical resection of colorectal cancer.

• Journal of Distribution Science
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• v.15 no.12
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• pp.53-60
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• 2017

Purpose - This paper analyzes the effect of the handset subsidy and the Mobile Number Portability subscriber subsidy regulation, which are the main regulation adopted in "Law on the Improvement of the Mobile Terminal Distribution System" (Mobile Terminal Distribution Act), on the social surplus, the consumer surplus and profits of telecommunications carriers. We focus our analysis on whether the service charge competition is stimulated enough so that it can compensate for the loss of subsidies. Research design, data, and methodology - We use simple economic model to assess the impact of the handset subsidy and the Mobile Number Portability subscriber subsidy regulation. Unlike the former researches on this topic, we depart from using Hotelling model, and instead use the switching cost model, which uses switching cost as a parameter of market powers of telecommunications carriers. We also study the effect of the two different regulations when they are adopted both independently and concurrently. Results - If the market powers of telecommunications carriers are over certain threshold, contrary to the regulatory agency's assertion, the service charge competition would not be stimulated enough to compensate for the deduction in the subsidies, and thus the consumer surplus is compromised. Number Portability subsidy, especially, undermines the rival's market power and thus reduces the service charge. On the other hand, the regulations will also increase the profits of telecommunications carriers. However, social surplus is maximized when both of the regulations are present because the regulations reduces the frequency of switching handsets inefficiently. Conclusions - In enacting the Mobile Terminal Distribution Act, the telecommunications regulatory agency asserted that the regulation on subsidies will stimulate service charge competition, and in the long run, enhance the consumer surplus. However, contrary to the regulatory agency's assertion, subsidy regulation, especially the regulation on Number Portability subsidy, reduces consumer surplus. On the other hand, the Mobile Terminal Distribution Act can also increase the profits of telecommunications carriers because it decreases competition among the telecommunications carriers. However, the Mobile Terminal Distribution Act can increase the social surplus because it reduces inefficient switching of handsets.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8775-8778
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• 2014

Background: To explore the relationship between polymorphisms of interleukin17 (IL-17) gene(A-832G 7488A/G) and the susceptibility to silicosis, a risk factor for lung cancer. Materials and Methods: A total of 113 silicosis patients and 116 workers without silicosis were enrolled in the case-control study. IL-17A A-832G and IL-17F 7488A/G polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The frequencies of AA,GG and AG of IL-17A A-832G locus in the case and control groups were 46.9%, 8.0%, 45.1%, and 49.2%, 7.6%, 43.2%, respectively, with no significant differences (p>0.05).The GG genotype in the IL-17F (7488A/G) locus was not found. The frequencies of AA and GA of IL-17F 7488A/G locus in the case and control groups were 84.1%, 15.9% and 66.4%, 33.6%, respectively (p<0.05). Analysis of combined effects showed that the individuals with GG+AG genotype of IL-17A and GG+GA genotype of IL-17F are protected against silicosis (OR=0.469). Conclusions: IL-17F 7488A/G is associated with susceptibility to silicosis, and G allele may have a protective effect. No relationship was found between IL-17A gene polymorphisms at A-832G and silicosis.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.3
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• pp.1043-1048
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• 2012

The COPS3 gene has stimulating effect on cell proliferation and progression of osteosarcomas and related cells. However, the features of COPS3 and its potential application as a therapeutic target in other cancers has not yet been studied. In this study, therefore, the effect of COPS3 silencing via COPS3 siRNA on lung cancer cell proliferation was examined. Expression levels of COPS3 gene in COPS3 siRNA infected cells and control siRNA infected cells were compared with real time PCR and Western blot analysis. Cell proliferation levels were comprehensively analyzed by MTT, BrdU incorporationy, and colony formation assays. For mechanistic assessment the effects of COPS3 silencing on cell cycle and apoptosis were analyzed using flow cytometry. Results showed that successful silencing of the COPS3 gene at both translational and transcriptional levels significantly reduced the proliferation and colony formation by lung cancer cells (p<0.01). Flow cytometry showed cell cycle arrest in the G0/G1 phase after COPS3 silencing, and more importantly, apoptosis was induced as a result of COPS3 knockdown, which negatively affected cell survival. Therefore, these results provide another piece of important evidence that the COPS3 gene expressed in lung cancer cells may play a critical role in stimulating proliferation. Down-regulation of COPS3 could significantly inhibit lung cancer cell growth, which was most likely mediated via induction of cell cycle arrest in G0/G1 phase and apoptosis.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.8
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• pp.1142-1147
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• 2011

Lysine intake during gestation has a major impact on subsequent reproductive performance. The objective of this experiment was to determine the effect of lysine intake from mid-gestation until farrowing on the reproductive performance of multiparous sows. On day 30 of gestation, 200 Landrace${\times}$Large White sows were randomly assigned to one of four groups based on body weight and parity (n = 50). The gestation diets contained 0.46, 0.56, 0.65 or 0.74% lysine. Increasing dietary lysine concentration improved sow body condition at farrowing and increased litter weights (p<0.05). Dietary lysine level also had a significant effect on the dry matter (p<0.05) and protein content (p<0.05) of colostrum. Increased lysine intake increased serum insulin concentration (p<0.05) and there was a trend towards increased serum prolactin content (linear, p = 0.07). However, increased lysine tended to decrease blood urea N (quadratic, p = 0.05). These results suggest that higher lysine levels (0.65-0.75%) than those recommended by the National Research Council improved reproductive performance for multiparous gestating sows and this increase may be partially mediated through blood metabolites or metabolic hormone levels.

• Steel and Composite Structures
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• v.37 no.2
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• pp.117-136
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• 2020

Curved steel-concrete composite box girder has been widely adopted in urban overpasses and ramp bridges. In order to investigate its mechanical behavior under complicated and combined bending, shear and torsion load, two large-curvature composite box girders with interior angles of 25° and 45° were tested under static hogging moment. Based on the strain and deflection measurement on critical cross-sections during the static loading test, the failure mode, cracking behavior, load-displacement relationship, and strain distribution in the steel plate and rebar were investigated in detail. The test result showed the large-curvature composite box girders exhibited notable shear lag in the concrete slab and steel girder. Also, the constraint torsion and distortion effect caused the stress measured at the inner side of the composite beam to be notably higher than that of the outer side. The strain distribution in the steel web was approximately linear; therefore, the assumption that the plane section remains plane was approximately validated based on strain measurement at steel web. Furthermore, the full-process non-linear elaborate finite element (FE) models of the two specimens were developed based on commercial FE software MSC.MARC. The modeling scheme and constitutive model were illustrated in detail. Based on the comparison between the FE model and test results, the FE model effectively simulated the failure mode, the load-displacement curve, and the strain development of longitudinal rebar and steel girder with sufficient accuracy. The comparison between the FE model and the test result validated the accuracy of the developed FE model.

• Journal of the Korean Wood Science and Technology
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• v.35 no.1
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• pp.11-16
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• 2007

This study was carried out to investigate the effect of Vapor-dam treatment on drying drying rates, prevention of checks and V-shaped split during air circulating oven drying bamboo (Phyllostachys pubescens Mazel et Z) tube. It was shown that the drying time from green to around 7~8 % of moisture content was required less as drying schedule was more severe, and distinctly dominated by the drying rate during the initial drying stage. Area shrinkages in cross section and thickness shrinkages measured during air circulating oven drying test were very large. Surface checks and V-shaped splits were occurred in untreated samples just after the beginning of drying, while sixty seven percentages of all the Vapor-dam treated samples could be produced without drying defects. The V-shaped splits occurred in the Vapor-dam treated samples were influenced more by the sealing of the vapor evaporation through the cross section than drying schedule.

• Steel and Composite Structures
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• v.29 no.4
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• pp.451-464
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• 2018

This paper presents some quasi-static tests for 4 mixed columns composed of CFST column and RC column. The seismic performance and failure mode were studied under low-cyclic revised loading. The failure mode was observed under different axial compression ratios. The hysteretic curve and skeleton curve were obtained. The effects of axial compression ratio on yield mechanism, displacement ductility, energy dissipation, stiffness and strength attenuation were analyzed. The results indicate that the failure behavior of CFST-RC mixed column with archaized style is mainly caused by bending failure and accompanied by some shear failure. The axial compression ratio performs a control function on the yielding order of the upper and lower columns. The yielding mechanism has a great influence on the ductility and energy dissipation capacity of specimens. Based on the experiment, finite element analysis was made to further research the seismic performance by ABAQUS software. The variable parameters were stiffness ratio of upper and lower columns, axial compression ratio, yielding strength of steel tube, concrete strength and rebar ratio. The simulation results show that with the increase of stiffness ratio of the upper and lower columns, the bearing capacity and ductility of specimens can correspondingly increase. As the axial compression ratio increases, the ductility of the specimen decreases gradually. The other three parameters both have positive effect on the bearing capacity but have negative effect on the ductility. The results can provide reference for the design and engineering application of mixed column consisted of CFST-RC in Chinese archaized buildings.

• Advances in concrete construction
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• v.8 no.3
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• pp.173-185
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• 2019

This article presents a comparative study of the effect of steel layouts on the seismic behavior of transition steel-concrete composite connections, both experimental and analytical investigations of concrete filled steel tube-reinforced concrete (CFST-RC) and steel reinforecd concrete-reinforced concrete (SRC-RC) structures were conducted. The steel-concrete composite connections were subjected to combined constant axial load and lateral cyclic displacements. Tests were carried out on four full-scale connections extracted from a real project engineering with different levels of axial force. The effect of steel layouts on the mechanical behavior of the transition connections was evaluated by failure modes, hysteretic behavior, backbone curves, displacement ductility, energy dissipation capacity and stiffness degradation. Test results showed that different steel layouts led to significantly different failure modes. For CFST-RC transition specimens, the circular cracks of the concrete at the RC column base was followed by steel yielding at the bottom of the CFST column. While uncoordinated deformation could be observed between SRC and RC columns in SRC-RC transition specimens, the crushing and peeling damage of unconfined concrete at the SRC column base was more serious. The existences of I-shape steel and steel tube avoided the pinching phenomenon on the hysteresis curve, which was different from the hysteresis curve of the general reinforced concrete column. The hysteresis loops were spindle-shaped, indicating excellent seismic performance for these transition composite connections. The average values of equivalent viscous damping coefficients of the four specimens are 0.123, 0.186 and 0.304 corresponding to the yielding point, peak point and ultimate point, respectively. Those values demonstrate that the transition steel-concrete composite connections have great energy dissipating capacity. Based on the experimental research, a high-fidelity ABAQUS model was established to further study the influence of concrete strength, steel grade and longitudinal reinforcement ratio on the mechanical behavior of transition composite connections.

• The Journal of Advanced Prosthodontics
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• v.13 no.5
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• pp.333-342
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• 2021

PURPOSE. To evaluate the impact of five different tooth preparation designs on the marginal and internal fit discrepancies of cobalt-chromium (CoCr) crowns produced by computer-aided designing (CAD) and selective laser melting (SLM) processes. MATERIALS AND METHODS. Five preparation data were constructed, after which design crowns were obtained. Actual crowns were fabricated using an SLM process. After the data of actual crowns were obtained with structural light scanning, intaglio surfaces of the design crown and actual crown were virtually superimposed on the preparation. The fit-discrepancies were displayed with colors, while the root means square was calculated and analyzed with one-way analysis of variance (ANOVA), Tukey's test or Kruskal-Wallis test (α = .05). RESULTS. The marginal or internal color-coded images in the five design groups were not identical. The shoulder-lip and sharp line angle groups in the CAD or SLM process had larger marginal or internal fit discrepancies compared to other groups (P < .05). In the CAD process, the mean marginal and internal fit discrepancies were 10.0 to 24.2 ㎛ and 29.6 to 31.4 ㎛, respectively. After the CAD and SLM processes, the mean marginal and internal fit discrepancies were 18.4 to 40.9 ㎛ and 39.1 to 47.1 ㎛, respectively. The SLM process itself resulted in a positive increase of the marginal (6.0 - 16.7 ㎛) and internal (9.0 - 15.7 ㎛) fit discrepancies. CONCLUSION. The CAD and SLM processes affected the fit of CoCr crowns and varied based on the preparation designs. Typically, the shoulder-lip and sharp line angle designs had a more significant effect on crown fit. However, the differences between the design groups were relatively small, especially when compared to fit discrepancies observed clinically.