• BMB Reports
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• 제52권4호
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• pp.250-258
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• 2019

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by selective and progressive loss of dopaminergic neurons. Genetic and environmental risk factors are associated with this disease. The genetic factors are composed of approximately 20 genes, such as SNCA, parkin, PTEN-induced kinase1 (pink1), leucine-rich repeat kinase 2 (LRRK2), ATP13A2, MAPT, VPS35, and DJ-1, whereas the environmental factors consist of oxidative stress-induced toxins such as 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), rotenone, and paraquat. The analyses of their functions and mechanisms have provided important insights into the disease process, which has demonstrated that these factors cause oxidative damage and mitochondrial dysfunction. The most invaluable studies have been performed using disease model organisms, such as mice, fruit flies, and worms. Among them, Drosophila melanogaster has emerged as an excellent model organism to study both environmental and genetic factors and provide insights to the pathways relevant for PD pathogenesis, facilitating development of therapeutic strategies. In this review, we have focused on the fly model organism to summarize recent progress, including pathogenesis, neuroprotective compounds, and newer approaches.

• 생약학회지
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• 제49권4호
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• pp.322-327
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• 2018

Methanol extract of Salvia miltiorrhiza Bunge (Labiatae) root was investigated to research the anti-oxidative activity, by using a Caenorhabditis elegans model system. The methanol extract of this plant showed significant DPPH radical scavenging and superoxide quenching activities. Ethyl acetate soluble fraction of the methanol extract that showed the most potent DPPH radical scavenging and superoxide quenching activities. The ethyl acetate fraction was tested on its activities of superoxide dismutase (SOD), catalase, and oxidative stress tolerance in C. elegans. Furthermore, in order to see if regulation of stress-response genes is responsible for the increased stress tolerance of the ethyl acetate fraction treated C. elegans, we checked SOD-3 expression using a transgenic strain. Consequently, the ethyl acetate fraction of S. miltiorrhiza root increased the catalase and SOD activities in a dose-dependent manner in C. elegans. Besides, the ethyl acetate fraction-treated CF1553 worms showed higher SOD-3::GFP intensity than the non-treated ones.

• 한국임상수의학회지
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• 제36권4호
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• pp.207-211
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• 2019

This study was performed to compare the radiographic and echocardiographic features of cardiovascular changes between small and large dogs with heartworm diseases. Total of 49 dogs from two institutions were included in this study. The dogs were diagnosed with heartworm infestation and underwent thoracic and echocardiography. On thoracic radiographs, vertebral heart scale, reverse D shape, main pulmonary artery dilation, peripheral pulmonary artery dilation, and evidence of right heart failure were evaluated. On echocardiographs, visibility of worms, main pulmonary artery to aortic root (MPA/Ao) ratio, right to left ventricular basal diameter (RVD/LVD) ratio, and pulmonary hypertension were evaluated and analyzed between small and large dogs. The proportion of reverse D shape of the heart and accuracy for right ventricular hypertrophy in small dogs were lower than those of the large dogs. For echocardiographic parameter, the MPA/Ao and RVD/LVD ratio in the small dogs were significantly lower than those of the large dogs. As the results, thoracic radiography have a tendency to underestimate the severity of HWD in small dogs and should be used with echocardiography.

• Asian-Australasian Journal of Animal Sciences
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• 제32권11호
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• pp.1641-1656
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• 2019

The present paper reviews the findings of different research studies on the effect of natural ingredients in the Japanese quail (Coturnix coturnix japonica) diet on carcass characteristics and meat quality. The results show a relationship between the type and concentration of ingredients used in diets and carcass characteristics and meat quality. The inclusion of medicinal herbs (thyme, black seed, and mint), plants (canola), seeds (chickpea), spices (cinnamon and coriander), worms (earthworms), bee products (propolis), phytochemicals (lycopene), and edible fungi (common mushrooms) in the diet improved carcass quality characteristics compared to the control diets (basal diets). The inclusion of medicinal herbs (spearmint and green tea), spices (cinnamon), vegetables (tomato), plants (verbena and canola), seeds (marijuana), and edible fungi (oyster mushrooms) improved meat quality. In conclusion, the use of ingredients of natural origin in the diet of Japanese quail improves carcass quality characteristics and meat quality.

• 한국정보통신학회논문지
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• 제24권4호
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• pp.522-528
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• 2020

엄청난 속도로 확산하는 랜섬웨어, 트로이목마, 인터넷 웜과 같은 악성코드는 인터넷의 주요한 위협이 되고 있다. 이러한 악성코드의 행위에 대응하기 위해서는 악성코드의 확산 방식과 영향을 끼치는 영향 요인을 이해하는 것이 필수적이다. 본 논문에서는 악성코드 확산 모델링에 기반을 둔 확산 예측 도구를 개발하였다. 이를 위하여 관련 연구를 살펴보고, 시스템 구성과 구현 방법을 살펴본 후 확산 예측 도구를 이용하여 워머블 악성코드 확산 실험을 수행하였다. 제안 확산 예측 도구를 잘 활용한다면, 최근 악명을 떨치는 워머블 악성코드에 대한 기본 지식만으로도 거시적 관점의 여러 조건에서 확산 형태를 예측하고 다양한 대응 방안을 모색할 수 있게 해준다.

• Molecules and Cells
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• 제44권3호
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• pp.160-167
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• 2021

The determinant factors of an organism's size during animal development have been explored from various angles but remain partially understood. In Caenorhabditis elegans, many genes affecting cuticle structure, cell growth, and proliferation have been identified to regulate the worm's overall morphology, including body size. While various mutations in those genes directly result in changes in the morphological phenotypes, there is still a need for established, clear, and distinct standards to determine the apparent abnormality in a worm's size and shape. In this study, we measured the body length, body width, terminal bulb length, and head size of mutant worms with reported Dumpy (Dpy), Small (Sma) or Long (Lon) phenotypes by plotting and comparing their respective ratios of various parameters. These results show that the Sma phenotypes are proportionally smaller overall with mild stoutness, and Dpy phenotypes are significantly stouter and have disproportionally small head size. This study provides a standard platform for determining morphological phenotypes designating and annotating mutants that exhibit body shape variations, defining the morphological phenotype of previously unexamined mutants.

• Molecules and Cells
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• 제44권12호
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• pp.861-878
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• 2021

The human genome contains many retroviral elements called human endogenous retroviruses (HERVs), resulting from the integration of retroviruses throughout evolution. HERVs once were considered inactive junk because they are not replication-competent, primarily localized in the heterochromatin, and silenced by methylation. But HERVs are now clearly shown to actively regulate gene expression in various physiological and pathological conditions such as developmental processes, immune regulation, cancers, autoimmune diseases, and neurological disorders. Recent studies report that HERVs are activated in patients suffering from coronavirus disease 2019 (COVID-19), the current pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection. In this review, we describe internal and external factors that influence HERV activities. We also present evidence showing the gene regulatory activity of HERV LTRs (long terminal repeats) in model organisms such as mice, rats, zebrafish, and invertebrate models of worms and flies. Finally, we discuss several molecular and cellular pathways involving various transcription factors and receptors, through which HERVs affect downstream cellular and physiological events such as epigenetic modifications, calcium influx, protein phosphorylation, and cytokine release. Understanding how HERVs participate in various physiological and pathological processes will help develop a strategy to generate effective therapeutic approaches targeting HERVs.

• 한국수산과학회지
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• 제55권5호
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• pp.590-597
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• 2022

We analyzed the diet composition of smallmouth argentine Argentina kagoshimae, which were collected via bottom trawl in the South Sea during February, April, August, and October 2021. Their size range was 8.1-21.4 cm total length. A. kagoshimae are mesopelagic carnivores, mainly consuming benthopelagic Euphausiacea and Caridea crustaceans. Polychaetes were the second largest prey component in their diet, which also included small quantities of copepods, amphipods, and arrow worms. Stomach content compositions substantially differed among body size levels in A. kagoshimae. The results of non-metric multidimensional scaling ordination and permutational multivariate analysis of variance of dietary data revealed no significant dietary differences. The results of a graphical analysis of the diet composition showed that A. kagoshimae are specialized feeders characterized by strong individual feeding specialization.

• Parasites, Hosts and Diseases
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• 제59권6호
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• pp.635-638
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• 2021

In this study, we intended to describe a human case of lumbosacral canal sparganosis in People's Republic of China (China). A 56-year-old man was admitted to Xiangya Hospital Central South University in Changsha, Hunan province, China after having an experience of perianal pain for a week. An enhancing mass, a tumor clinically suggested, was showed at the S1-S2 level of the lumbosacral spine by the examination of magnetic resonance imaging (MRI) with gadolinium contrast. The patient was received the laminectomy from S1 to S2, and an ivory-white living worm was detected in inferior margin of L5. In ELISA-test with cerebrospinal fluid (CSF) and serum samples, anti-sparganum antibodies were detected. He had a ingesting history of undercooked frog meat in his youth. By the present study, a human case of spinal sparganosis invaded in lumbosacral canal at the S1-S2 level was diagnosed in China. Although the surgical removal of larvae is known to be the best way of treatment for sparganosis, we administered the high-dosage of praziquantel, albendazole and dexamethasone to prevent the occurrence of another remain worms in this study.

• 한국콘텐츠학회논문지
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• 제6권12호
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• pp.155-162
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• 2006

Code Red와 같은 인터넷 웜이 얼마나 심각하게 우리들 일상생활에 영향을 미쳤는지 잘 알려져 있다. 오늘날 인터넷의 고속화와 함께 이러한 웜의 피해는 단기간 내에 발생할 것이 자명하다. 따라서 이러한 웜에 대항하기 위해서 웜의 전파 특성을 분석하는 것이 무엇보다 중요하다. 본 논문에서는 컴퓨터 시뮬레이션을 통해 Code Red 웜의 전파 특성을 분석한다. 특히 Code Red웜 감염 호스트 수에 관한 기존 시뮬레이션 연구 결과가 관측된 자료와 매칭되지 않음을 보이고 이를 해결하기 위해 개선된 시뮬레이션 환경을 제시하였다. 또한 웜에 대한 초기 대응과 감염에 따른 대응이 웜의 전파 속도 변화에 어떠한 영향을 미치는지 그 결과를 보였다.