• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2000년도 The 7th International Symposium
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• pp.34-51
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• 2000

Narcotic drugs generally refer to serious and habitual hidden rash such as opium, heroin, methyphetamin, nabinol, cocaine, and so forth. At present, narcotic drugs are spread unchecked and are causing a big social problem. So many countries and narcotists are making every effort to set up a barricade against narcotic drugs. And there is a limit suitable treatment for them. Thus Tuo Yin Tang hang is developed. As indicated by Chinese letters, Tuo yin Tang Jiang(TYTJ) is a crude drug. It is a traditional chinese medicine developed by the study done from lune in 1998 to lune in 1999 that Hubeisheng was entrusted with by People's Republic of China. This study is a treatise on etiology and syntomatology or narcotism. TYTJ is a medicine which is in accord with Pharmacopeia of the People's Republic of China in order to remove from the body the toxic materials resulting from narcotic drugs such as opium and heroin. According to the standard diagnosis on narcotism, 105 cases are studied and treated at the Rehabilitation Center attached to Enshi Autonomous Region Hospital in Hubeisheng. 105 cases are divided into 2 groups by double-blind method. One is the experimental group which has 56 cases. The other is the control group which has 49 ones. 13 cases among 105 cases are addicted by intravenously injections. 9 cases are by oral takings. It took 10 days for this experiment to be performed. Two groups didn't show a striking individual variation based on the age, gender, period of taking drugs, withdrawal symptoms, complication, and state of health. The experimental group had a higher effect of treatment than the control group had. TYTJ treats diseases effectively and has no side effect, irrespective of the serious or slight addiction to opium and morphine.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제23권2호
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• pp.76-81
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• 2012

Objectives : Childhood is a critical period involving various developmental tasks that need to be accomplished. Childhood depression has overall negative implications for certain areas of development, including cognition, emotion, social skills, academic achievement, and ability to cope with stress. Yet, because depression can be "masked" by accompanying behavioral problems, early detection and diagnosis of childhood depression is somewhat challenging. In this study, using the Korean version of the Child Behavior Checklist (K-CBCL), we evaluated the association between children's self reports on depression and parents' assessment of children's behaviors. Methods : Subjects were recruited from the S city, a cohort comprising a non-random convenience sample of 226, 10-year-old ethnic Koreans in their fourth year of elementary school and their parents. All participants underwent several tests, including Children's Depression Inventory (CDI) and K-CBCL. Results : A total of 226 children, including 166 boys (73.5%) and 60 girls (26.5%), participated in the study. The average CDI for the participants was 14.57 (SD=7.54). Two items on the K-CBCL, total scale of adjustment scale and social withdrawal problems, showed a close association with the CDI. Conclusion : Although much remains to be elucidated, after controlling for covariates, the results of this study suggested that behavioral problems observed in children may be closely associated with depression.

• 한국농공학회논문집
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• 제53권1호
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• pp.17-28
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• 2011

This study was performed to ascertain the possibility of securing inflows to reservoir with low ratio of watershed to paddy field areas by outside diversion weir. The case of Maengdong reservoir and Samryong diversion weir was selected. Most of inflows to Maengdong reservoir with watershed area of $7.06\;km^2$ and total storage capacity of $1,269{\times}10^4\;m^3$ are filled with intake water from outside Samryong diversion weir. Only using water storage data in Maengdong reservoir from 1991 to 2009, the range of water intake in Samryong diversion weir to Maengdong reservoir was optimized to 0.135~30 mm/d, from which water intake to Maengdong reservoir was $1,672.9{\times}10^4\;m^3$ (70.1 %) and downstream outflow to Weonnam reservoir was $714.4{\times}10^4\;m^3$ (29.9 %). The parameters of DAWAST model for reservoir inflow were determined to UMAX of 313.8 mm, LMAX 20.3 mm, FC 136.8 mm, CP 0.018, and CE 0.007. Inflows to Maengdong reservoir were $427.1{\times}10^4\;m^3$ (20.3 %) from inside watershed, and $1,672.9{\times}10^4\;m^3$ (79.7 %) from outside. Paddy irrigation water requirements were estimated to $1,549{\times}10^4\;m^3$ on annual average. Operation rule curve was drawn by using daily inflow and irrigation requirement data. By securing the amount of inflow to Maengdong reservoir to about 80 % from outside Samryong diversion weir, water supply capacity for irrigation of $1,549{\times}10^4\;m^3/yr$ was analyzed to be enough. Additional water supplies for instream flow were analyzed to $1,412\;m^3/d$ in normal reservoir operation, $36,000\;m^3/d$ in withdrawal limit operation by operation rule curve from October to March of non irrigation period.

• Journal of Ginseng Research
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• 제46권1호
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• pp.147-155
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• 2022

Background: Methamphetamine (METH) is the most widely used psychostimulant and has been known to exhibit reinforcing effects even after long abstinence. We showed the inhibitory effect of Korean Red Ginseng extract (RGE) on METH-induced addictive behaviors in animal models mimicking the human drug-use pattern. Methods: We first investigated the effect of RGE on the acquisition of METH-induced dependence using self-administration and conditioned place preference (CPP) tests. Additionally, further experiments such as METH-induced motivational behavior and seeking behavior were conducted. To study the underlying mechanism, dopamine receptor, dopamine transporter, and N-methyl-D-aspartate receptor were assessed through Western blot analysis. Results: Treatment with RGE significantly reduced METH-induced self-administration on a fixed-ratio 1 schedule of reinforcement. It could be also decreased a progressive ratio schedule, and inhibited METH-primed reinstatement. In CPP, RGE significantly prevented the development of METH-induced CPP. Moreover, RGE not only shortened the withdrawal period clearly, but also prevented the reinstatement of CPP. RGE treatment also reversed METH-induced overexpression of dopamine transporter, dopamine receptor D1, and NMDA receptor in the nucleus accumbens. Conclusion: Our findings reflect that RGE has therapeutic potential to suppress METH-induced addictive behaviors by regulating dopaminergic and NMDAergic system.

• Journal of Yeungnam Medical Science
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• 제40권1호
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• pp.78-85
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• 2023

Background: Poor sleep quality is associated with psychoactive substance abuse/addiction/withdrawal. Auricular acupuncture (AA) is a nonpharmacological method used for the treatment of sleep disturbances. This study aimed to examine the quality of sleep before and after AA in participants with mental and behavioral disorders due to prior multiple drug use in the therapeutic community. Methods: This was a consecutive case series of 27 participants (25 male [92.6%]). The median age was 35.0 years (interquartile range [IQR], 29.0-37.2 years), methadone/buprenorphine were not used, and the participants were treated with AA (median number of treatments, 15.0 [IQR, 12.0-18.0]) during a median period of 51.0 days (IQR, 49.0-51.0 days) according to the National Acupuncture Detoxification Association (NADA)-Acudetox protocol. Sleep quality was determined using the Pittsburgh Sleep Quality Index (PSQI), a self-rated questionnaire that assesses sleep quality and disturbances over a 1-month interval. Results: The global PSQI score dropped (indicating better sleep quality) by a median of 3.0 points (IQR, 0.0-8.0 points) after treatment. In the multivariate logistic regression analysis, with an increase in global PSQI score during AA by 1 point, there was a 0.73-fold reduction in the risk of poor sleep quality post-AA (adjusted odds ratio, 0.73; 95% confidence interval, 0.52-1.01; p<0.055; Nagelkerke's R² =0.66). Conclusion: The results revealed a positive effect of AA (by the NADA-Acudetox protocol) on sleep quality (as measured by PSQI) among participants in a treatment center with mental and behavioral disorders due to multiple drug use.

• Journal of Hospice and Palliative Care
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• 제26권4호
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• pp.185-189
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• 2023

Purpose: Limited research has been conducted on the prevalence of non-medical opioid use (NMOU) in Korean cancer patients who have received prescription opioids (PO). This study aimed to identify the potential proportion of NMOU in cancer patients who had been prescribed opioids in Korea. Methods: A retrospective cohort analysis was conducted on 14,728 patients who underwent cancer-related treatment between January 2009 and December 2019, using electronically collected data from a tertiary hospital in Korea. Information regarding the type and duration of opioid use was gathered. A detailed review of medical charts was carried out, focusing on patients who had been prescribed opioids for over 60 days beyond a 12-month period following the completion of their cancer treatment (long-term PO users). Results: Out of the 5,587 patients who were prescribed PO and followed up for at least 12 months, 13 cases of NMOU were identified, representing 0.23% of the patient population. Among the 204 long-term PO users, the rate was 6.37% (13/204). The most commonly misused opioids were oxycodone and fentanyl. For the group confirmed to have NMOU, the median duration of prescription was 1,327 days in total. Of the 13 patients diagnosed with NMOU, 9 reported withdrawal symptoms, 3 exhibited craving behavior for opioids, and 1 experienced both symptoms. Conclusion: This study found that 0.23% of cancer patients who had been prescribed opioids in Korea demonstrated NMOU. Despite this relatively low rate, careful monitoring is necessary to minimize the risk of NMOU in this population, especially among long-term PO users.

• 한국동물위생학회지
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• 제36권4호
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• pp.311-320
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• 2013

The purpose of this study was to evaluate detecting methods and the relationship between tissues and blood for enrofloxacin and metabolic ciprofloxacin residues in broiler chickens. Two groups of broiler chickens were administrated via the drinking water with $50{\mu}g/mL$ and $100{\mu}g/mL$ of enrofloxacin for 5 days, respectively. The concentration of enrofloxacin and metabolic ciprofloxacin in tissues (muscle and kidney) and blood were measured during administration period (for 5 days) and withdrawal period (for 12 days) by high performance liquid chromatography (HPLC) method. Also, all samples were conducted for screening of residues by microbial method using E. coli for quinolone detection and immuno-chromatography method using Smart kit. The relationship between tissues (muscle and kidney) and blood for enrofloxacin and metabolic ciprofloxacin residues in broiler chickens was followed : The levels of enrofloxacin and metabolic ciprofloxacin residues in muscle and kidney were higher 2.9~3.2 folds, 3.6~3.8 folds more than the residues levels in blood, respectively. These results support we can predict the residues in muscle and kidney from the residues in blood. In comparison of detecting methods for antibiotic residues, microbial method using E. coli for quinolone detection and immuno-chromatography method using Smart kit could detect positive reaction at similar or lower concentration than violative concentration of enrofloxacin and metabolic ciprofloxacin in chicken tissues. These results support what two screening methods are useful for screening of quinolone detection in chickens.

• 한국수산과학회지
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• 제44권6호
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• pp.577-583
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• 2011

In 2007, pet food contaminated with melamine caused hundreds of dogs and cats to develop renal failure all over the world. In 2008, over 294,000 infants consumed infant formula and developed kidney stones in China. Further investigation revealed that fish feed also contained melamine; this raised concerns about melamine residues in edible fish tissues, which could have caused the urinary tract stone epidemic. In Korea, catfish fed with assorted feed that included cuttlefish organs that contained melamine developed whitening syndrome and fell dead in some populations in 2008. This event raised suspicions about the toxicity of melamine and all feeds containing melamine were immediately recalled. In this study, we investigated the rates of melamine accumulation and depletion in muscle and viscera of catfish to propose proper withdrawal periods. One group of catfish was fed a commercially available diet that contained 30, 100 and 300 mg melamine per kg diet for 14 days. To investigate residual melamine contents in muscle and viscera, other experimental groups were fed a melamine free diet after being fed melamine for 7 days. The residual amount of melamine was analyzed by LC-MS/MS. The melamine concentration in muscle was estimated to be 3.7 mg/kg after 6 days of feeding with a diet containing 300 mg melamine/kg. After 2 days of culture with a melamine free diet, the residual melamine was depleted and the concentration had decreased from 1.15 mg/kg to 0.19 mg/kg in the muscle of catfish fed a diet containing 300 mg melamine/kg for 7 days. The residual amount of melamine was reduced to 0.03 mg/kg in muscle after 7 days of culture with a melamine free diet and was undetectable after a prolonged culture period of 14 days. Catfish tend to excrete melamine rapidly after oral administration and changes in body color were not observed during the short dosing period.

• 농촌의학ㆍ지역보건
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• 제29권2호
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• pp.287-301
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• 2004

본 연구는 전남 곡성군 주민을 대상으로 지역사회 주민의 흡연율을 감소시키고, 금연 희망자의 금연 의지를 강화시키기 위해 2002년도에 개발된 곡성군 금연 클리닉의 '금연 개인관리 프로그램'을 중심으로 흡연 욕구 및 금연 장애요인에 대처하고, 금연 실천을 독려할 수 있는 금연 강화 프로그램을 개발하였으며, 프로그램의 지속적인 관리를 위해 지역 보건소가 수행의 주체가 되는 금연정보 지원시스템을 구축하는데 그 목적을 두었다. 본 연구의 중심이 된 '금연 개인관리 프로그램'은 지역 주민들에게 금연관련 정보 및 금연 기술을 제공하고, 금연에 관한 자기 통제력을 강화시키기 위해 개발된 인터넷 금연 프로그램이다. 그러나 '금연 개인관리 프로그램'은 참여자의 자발적인 행위를 원칙으로 하기 때문에 금연행위 유도 및 지속적인 금연 유지에 취약성을 지니고 있다. 따라서 이러한 단점을 보완하기 위해 성공적인 금연이 이루어질 수 있도록 개인별 금연실천을 돕기 위한 금연 강화 프로그램인 인터넷 금연 푸쉬 서비스를 개발하였고, 이에 관한 효과평가를 수행함으로써 프로그램의 문제점을 보완하기 위한 단계별 개선방안을 제시하고자 하였다. 연구결과를 요약하면 다음과 같다. 첫째, 금연 푸쉬 서비스를 활용한 금연 강화시스템은 개인별 금연실천을 돕기 위해 회원 가입이 이루어진 당일부터 금연 푸쉬 서비스가 제공되도록 설계하였으며, 모든 금연 푸쉬 서비스는 금연도전 프로그램의 단계에 맞추어 전자메일을 활용하여 제공되도록 고안하였다. 또한 각 단계별로 일정 형식에 따라 하루 1회씩 프로그램 참여 일정에 맞추어 제공하도록 설계하였다. 둘째, 금연 의지를 강화시키기 위해 금연 압력 메시지 및 경고 메시지, 성공 메시지를 개발하였으며, 금연 압력 메시지는 '금연 개인관리 프로그램' 에서 작성된 각 단계별 개인 정보를 활용하였고, 이전 단계에서 수립된 금연전략의 재확인 및 활용수준을 점검할 수 있도록 구성하였다. 셋째, 금연 푸쉬 서비스를 활용한 금연 강화 프로그램 및 운영 시스템을 평가하기 위해 군청 공무원 및 보건의료원의 보건직 공무원 중 흡연자로서 금연 강화 프로그램에 참여를 희망하는 10명으로 평가단을 구성하였으며, 1개월 간 시범 운영을 수행하였다. 넷째, 금연 강화 프로그램에 관한 내용 및 접근형식을 평가한 결과, 참여자의 기록 분량, 내용의 난이도. 시각적 효과의 불충분이 문제점으로 지적되었으며, 이를 개선하기 위해 참여자 중심의 기록방식을 클릭중심의 기록방식으로 전환, 참여자의 이해수준의 고려한 내용수정, 그래픽 요인의 추가 및 시각적 효과의 보완, 추구관리를 모듈 개발 등을 대안으로 제시하였다. 다섯째, 금연 강화 프로그램의 운영 시스템에 관하여 평가한 결과, 금연 압력 메시지를 제공하는 금연 푸쉬 서비스와 홈페이지와의 연계성 및 금연 개인관리 프로그램과의 연계성이 문제점으로 지적되었으며, 이를 보완하기 위해 홈페이지와의 링크 작업 개선 및 금연 개인관리 프로그램과의 링크 작업 새선, 휴대폰의 문자서비스(SMS) 기능 활용 등을 대안으로 제시하였다. 여섯째, 금연 강화 프로그램의 향후 단계별 개선방안을 프로그램의 일부 코드의 수정으로 가능한 즉시 개선방안과 프로그램 흐름의 일부 수정, 가감해야 하는 단기 개선방안, 프로그램 흐름의 대폭 수정 및 추가 모듈 개발이 필요한 중장기 개선방안으로 구분하여 제시하였다. 따라서 향후 금연 강화 프로그램을 지원하기 위한 금연자 추후관리 시스템이 구축되어야 하고, 지역 주민의 금연 실천을 독려하기 위한 다양한 컨텐츠가 개발이 선행되어야 하겠다. 또한 이를 지원하기 위해 지역 보건소 실무 담당자의 지속적인 교육 훈련 및 금연 사업을 위한 예산확보, 표준화된 금연사업 관리 지침서가 개발되어야 하겠다.

• 대한감각통합치료학회지
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• 제18권1호
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• pp.34-43
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• 2020

목적 : 스마트폰 중독 위험군 유아의 스마트폰 사용시간에 따른 스마트폰 중독 정도와 감각처리능력의 차이를 알아보고자 하였다. 연구방법 : 연구 대상자는 스마트폰 중독 위험군 유아 124명이었고, 연구 기간은 2019년 9월부터 동년 12월까지이었다. 연구 방법은 설문조사로 일반적 특성, 유·아동 스마트폰 중독 관찰자 척도, 단축감각프로파일을 사용하였다. 분석방법은 스마트폰 사용시간에 따른 스마트폰 중독의 차이와 중독군에 따른 감각처리능력의 차이를 비교하기 위해 독립표본 t-test를 사용 하였다. 결과 : 스마트폰 사용시간에 따른 집단 간 스마트폰 중독의 차이는 스마트폰 중독합계(p=.000)와 현저성(p=.027), 충동·강박적 사용(p=.019), 금단(p=.046), 내성(p=.003), 대인 간 갈등(p=.046)에서 유의한 차이를 보였다. 집단 간 감각처리능력의 차이는 SSP 총점(p=.000) 및 하위영역 모두에서 유의한 차이를 보였다(p=.000~.042). 결론 : 본 연구는 유아의 스마트폰 사용시간에 따른 스마트폰 중독과 감각처리능력의 차이가 있는 것을 확인하였다. 이를 통해 유아의 스마트폰 사용에 대한 교육의 필요성을 제기하였다는 점에서 의의를 갖는다.