• Journal of Preventive Medicine and Public Health
• /
• v.51 no.1
• /
• pp.1-5
• /
• 2018

Smokers keep smoking despite knowing that tobacco claims many lives, including their own and others'. What makes it hard for them to quit smoking nonetheless? Tobacco companies insist that smokers choose to smoke, according to their right to self-determination. Moreover, they insist that with motivation and willpower to quit smoking, smokers can easily stop smoking. Against this backdrop, this paper aims to discuss the addictive disease called tobacco use disorder, with an assessment of the addictiveness of tobacco and the reasons why smoking cessation is challenging, based on neuroscientific research. Nicotine that enters the body via smoking is rapidly transmitted to the central nervous system and causes various effects, including an arousal response. The changes in the nicotine receptors in the brain due to continuous smoking lead to addiction symptoms such as tolerance, craving, and withdrawal. Compared with other addictive substances, including alcohol and opioids, tobacco is more likely to cause dependence in smokers, and smokers are less likely to recover from their dependence. Moreover, the thinning of the cerebral cortex and the decrease in cognitive functions that occur with aging accelerate with smoking. Such changes occur in the structure and functions of the brain in proportion to the amount and period of smoking. In particular, abnormalities in the neural circuits that control cognition and decision-making cause loss of the ability to exert self-control and autonomy. This initiates nicotine dependence and the continuation of addictive behaviors. Therefore, smoking is considered to be a behavior that is repeated due to dependence on an addictive substance, nicotine, instead of one's choice by free will.

• Nuclear Engineering and Technology
• /
• v.41 no.3
• /
• pp.307-318
• /
• 2009

KAERI (Korea Atomic Energy Research Institute) has developed the GAMMA+ code for a thermo-fluid and safety analysis of a VHTR (Very High Temperature Gas-Cooled Reactor). A key safety issue of the VHTR design is to demonstrate its inherent safety features for an automatic reactor power trip and power stabilization during an anticipated transient without scram (ATWS) accident such as a loss of forced cooling by a trip of the helium circulator (LOFC) or a reactivity insertion by a control rod withdrawal (CRW). This paper intends to show the ATWS assessment capability of the GAMMA+ code which can simulate the reactor power response by solving the point-kinetic equations with six-group delayed neutrons, by considering the reactivity changes due to the effects of a core temperature variation, xenon transients, and reactivity insertions. The present benchmark calculations are performed by using the safety demonstration experiments of the 10 MW high temperature gas cooled-test module (HTR-10) in China. The calculation results of the power response transients and the solid core temperature behavior are compared with the experimental data of a LOFC ATWS test and two CRW ATWS tests by using a 1mk-control rod and a 5mk-control rod, respectively. The GAMMA+ code predicts the power response transients very well for the LOFC and CRW ATWS tests in HTR-10.

• Journal of Families and Better Life
• /
• v.9 no.2
• /
• pp.267-284
• /
• 1991

The Purpose of this study is to explain marital power processes perceived by Korean urban husbands. To do the task, this study examined the possibility of classifying the power processes and the effect of resources by using resource theory and normative resource theory . The main results were as follows. 1) Power precesses are classified into five factors, such as, 'induction'. 'isolation' quarreling' 'carelessness' and 'withdrawal of love'. Induction, which makes control attempts by using verbal, indirect communication strategies, is proved to be the most factor. 2) Power resource variables are proved to be significant in their effects on the power processes. That is, objective are proved to be significant in their effects on the power processes. That is , objective resources are influencing on 'induction' and 'isolation' behavior and subjective variables are influencing on the other control attempts, Thus, it is found that including subjective variables as well as objective ones is very important. Above all, that the concept of the centrality of patriarchy is supported to be an appropriate concept for the study on the marital power processes i8s a fruitful result in research. But the variances explained by resource variables are relatively small. It is suggested. therefore, further study should include more significant subjective resource variables.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2006.05a
• /
• pp.123-124
• /
• 2006

Usually, hydraulic cylinder is widely used as the actuator in the equipment of construction machines, airplane and military machines. In case of these devices, due to use under severe environment such as water, $SiO^2$ and dust, etc. seal which has high packing ability and long service life has been required. These characteristics are largely influenced by material and geometries of seal such as approach angle, withdrawal angle and interference. Recently, many a study about seal material has been performed so that many materials have been developed. But the concrete studies including the relationships between geometry of seal and sealing performance have hardly been performed yet. Therefore, in this study, we predicted the deformation behavior and contact normal distribution of dust seal with the variation of geometries of seal lip using finite element analysis. And based on the results of analyses, we discussed the effects of the design variables fur sealing performance of the dust seal.

• Health Policy and Management
• /
• v.6 no.2
• /
• pp.149-189
• /
• 1996

The aims of this study were to find out present situation of self-medication, and to explicate the factors affecting self-medication propensity. To explicate empirically the factors affecting self-medication propensity, a model containing five groups of determining factors such as attitudinal, behavioral, knowled해, and need of health care factors, and demographic factors were developed. Data were collected from 647 residents in Pusan and Kyungnam using the self-administered questionnaire. The major reslts obtained were as follows: First, self-medication was 32% of all utilization of pharmacy. The drugs used for self-medication most commonly were analgesics(16.2%), followed by antacids and stomachics(14.2%), dermatologic preparations(13.1%), tonics and drinks (12.6%). Second, the sources from which people obtained drug information at self-medication were label of the container(50.8%), pharmacist(32.4%), self-decision or lay person(16.8%). The experience of side effect was 10.6% of all self-medication and how people cope with was withdrawal(59.0%), consultation by pharmacist or doctor(35.9%). Third, the results of ANOVA showed a statistically significant relationship between self-medication propensity and 3 demograpic factors, such as sex(p<0.10), age(p<0.10) and job(p<0.05). Forth, the results of multiple regression analysis showed a statistically significant positive relationship betwee self-medication propensity and satisfaction of previous self-medication, knowledge of drug, drug dependency, the frequency of doctor visiting, confidence in drug advertisement, tendency toward self-treatment of the family, and job. And it showed negative relationship between self-medication propensity and confidence in the medical profession, and health behavior. The model explained 29.5% of the variance in self-medication(p<0.001).

• Proceedings of the Korean Society for Emotion and Sensibility Conference
• /
• 1999.03a
• /
• pp.127-132
• /
• 1999

Cardiovascular, respiratory and electrodermal responses to acute stress episodes modeled by combined presentation of intense white noise and performance of word recognition task with noise background were studied in 15 college students. Experimental procedure consisted in sessions with white noise, word recognition task presentation with noise background and test with noise background. Recorded physiological variables were analyzed in terms of their sensitivity to detect activation of sympathetic and parasympathetic branches of autonomic nervous system and thus reflect autonomic arousal level during shout-term stress-inducing experimental manipulations. It was shown that performance of effortful mental task with noise background elicited significant physiological responses typical for active coping behavior, namely electrodermal arousal and increased cardiovascular activity. this response profile was more profound as compared to white noise only or attending task in noise background. However, all physiological responses were mostly phasic, without long-term tonic changes, since almost all variables recovered to their initial baseline levels, suggesting that dominant autonomic mechanisms in transient acute stress episodes were of parasympathetic nature (withdrawal in stress with subsequent activation in restoration period), while sympathetic contribution was not long-lasting. Nevertheless, increased number of stressors and their longer exposure may result in higher profile of tonic sympathetic arousal and reduced functional role of vagal mechanisms in autonomic balance regulation.

• Journal of Ginseng Research
• /
• v.40 no.4
• /
• pp.445-452
• /
• 2016

Background: Red ginseng and ginsenosides have shown plethoric effects against various ailments. However, little is known regarding the effect of red ginseng on morphine-induced dependence and tolerance. We therefore investigated the effect of red ginseng extract (RGE) and biotransformed ginsenosides Rh2, Rg3, and compound K on morphine-induced dependence in mice and rats. Methods: While mice were pretreated with RGE and then morphine was injected intraperitoneally, rats were infused with ginsenosides and morphine intracranially for 7 days. Naloxone-induced morphine withdrawal syndrome was estimated and conditioned place preference test was performed for physical and psychological dependence, respectively. Western blotting was used to measure protein expressions. Results: Whereas RGE inhibited the number of naloxone-precipitated jumps and reduced conditioned place preference score, it restored the level of glutathione in mice. Likewise, ginsenosides Rh2, Rg3, and compound K attenuated morphine-dependent behavioral patterns such as teeth chattering, grooming, wet-dog shake, and escape behavior in rats. Moreover, activated N-methyl-D-aspartate acid receptor subunit 1 and extracellular signal-regulated kinase in the frontal cortex of rats, and cultured cortical neurons from mice were downregulated by ginsenosides Rh2, Rg3, and compound K despite their differential effects. Conclusion: RGE and biotransformed ginsenosides could be considered as potential therapeutic agents against morphine-induced dependence.

• Korean Parent-Child Health Journal
• /
• v.6 no.2
• /
• pp.103-114
• /
• 2003

This descriptive study was conducted to explore the mothers' perceived temperament of their preschoolers, and its related factors. Survey from 212 mothers of preschoolers residing in Seoul, Daejeon, and Suwon was performed, and Schaefer's MBRI(Maternal Behavior Research Instrument), and PTQ(Parent Temperament Questionnaire) by Thomas and Chess, Child-rearing burden instrument by Han were used to collect data from September 15 to October 31, 2002. Data was analyzed with SPSS 10.0 Win program. Summaries of results were as follows: 1. There was no significant difference in temperament type-easy or difficult child-depending upon the demographic characteristics. 2. In temperament subscale, boys showed higher activity level than girls, and in working mothers group, adaptability was significantly lower although mood was higher. Preschoolers with expanded families were higher in activity level and intensity of reaction than with nuclear families. 3. Approach-withdrawal, adaptability, and mood showed significant negative relationship with maternal childrearing burden. 4. Temperament showed significant positive or negative relationship with maternal childrearing attitudes. In conclusion, it determined preschoolers' temperament was affected by primary environment such as maternal attitude, childrearing burden, and family type as well as children's gender. It was suggested that parent education and counselling program in nursing would be needed to promote children's desirable temperament.

• Research in Community and Public Health Nursing
• /
• v.12 no.1
• /
• pp.261-268
• /
• 2001

Recently, social concerns about addiction problems not only to substances like alcohol and drug but also to gambling or internet have been increasing. Addiction is caused by a combined influence of biological, psychological. and social factors. However, addiction may also occur due to weak will-power or poor education on addiction. Even though addicted behavior provides temporal mood change such as euphoria, satisfaction. or relaxation. it leads to serious physical and mental disorder of the addicted person and its family members, which possibly results in fatal consequences. Nurses are in an environment to meet and take care of those who are addicted or vulnerable to addiction in order to help the clients to recover or to prevent people from addiction. Despite the importance of nurses role in addiction problems, there is a lack of consistency of addiction is often interchangeably used with other similar concepts in the society. In this study, a concept analysis of addiction was performed to more clearly and comprehensively understand addiction and to develop effective nursing intervention methods for addicted clients. The analysis is conducted according to a series of processes described by Walker and Avant. The defining attributes of addiction identified in this study are as follows: 1) existence of object 2) control loss 3) withdrawal symptoms 4) continued use despite adverse consequences.

• The Korean Journal of Pain
• /
• v.34 no.2
• /
• pp.165-175
• /
• 2021

Background: Management of pain from open wounds is a growing unmet healthcare need. However, the models available to study pain from wounds or to develop analgesics for the patients suffering from them have primarily relied on incisional models. Here, we present the first characterized and validated model of open wound pain. Methods: Unilateral full-skin excisional punch biopsy wounds on rat hind paws were evaluated for evoked pain using withdrawal responses to mechanical and thermal stimulation, and spontaneous pain was measured using hind paw weight distribution and guarding behavior. Evaluations were done before wounding (baseline) and 2-96 hours post-wounding. The model was validated by testing the effects of buprenorphine and carprofen. Results: Pain responses to all tests increased within 2 hours post-wounding and were sustained for at least 4 days. Buprenorphine caused a reversal of all four pain responses at 1 and 4 hours post-treatment compared to 0.9% saline (P < 0.001). Carprofen decreased the pain response to thermal stimulation at 1 (P ≤ 0.049) and 4 hours (P < 0.011) post-treatment compared to 0.9% saline, but not to mechanical stimulation. Conclusions: This is the first well-characterized and validated model of pain from open wounds and will allow study of the pathophysiology of pain in open wounds and the development of wound-specific analgesics.