• Journal of Life Science
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• v.22 no.3
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• pp.312-317
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• 2012

The time-dependent effects of highly intensive exercise on the hematological properties of leukocytes, as well as $CD4^+$ and $CD8^+$ level changes as T-lymphocyte activation subsets and the cell death of lymphocytes in rats were studied in this research. Twenty, 60, and 120 min of highly intensive exercise was performed daily for 8 weeks. Total leukocyte counts in the blood of rats exercising for 20 min were elevated; they then decreased to less than the level of the control group up to 120 min. The patterns of lymphocyte level changes were directly influenced by exercise duration and the extents of alteration were similar to the total leukocytes counts. The levels of $CD4^+$ and $CD8^+$ in the blood of the exercising rats were not statistically different even when the exercise was continued for 120 min; thus, the exercise did not affect T-lymphocyte activation. Early- and late-stage lymphocyte apoptosis was not affected by the length of exercise, except that late-phase apoptosis was slightly increased at 120 min, suggesting that aging processes for lymphocyte apoptosis might be stimulated at that time. As the exercise time became longer, stimulated necrosis of lymphocytes was observed, so damage in lymphocytes and a potential loss of immunity might be presumed. The current observation suggests that long-term, highly intensive exercise might result in a loss of immunity that could be due to the damage of lymphocytes in terms of both their numbers and inflammation-related functions. The results suggest that under highly intensive exercise conditions, more than 20 min of exercise should not be suggested for health care purposes.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.8
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• pp.3544-3551
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• 2012

As Korean society is quickly aging and experiencing longer life-spans, there has been increasing interest in the quality of life of the elderly. Depression has been indicated as an significant factor in the later years of one's life. The purpose of this study is to seek ways to improve the quality of life of the elderly in senior welfare center as it examines the quality of life and the extent of depression in them. One-on-one interviews were conducted with 127 subjects from the senior welfare center from November, 2011 to January, 2012, using Korean versions of WHOQOL-BREF and the Beck Depression Inventory. Among the interviewees were 62 males and 65 females. The study showed that the quality of life measured 85.82(${\pm}16.35$) points out of 130 and the extent of depression measured 9.45(${\pm}8.02$) points. The quality of life showed significant differencies according to education, degree of health, type of health insurance, occupation, and financial independence; while the depression varied according to gender, education, degree of health, type of health insurance, occupation, means of daily living, financial independence and leisure activities. Significant correlation was shown statistically between quality of life and depression. It is recommended that local communities develop programs for the promotion of the aged health and active social participation as well as job creation for the elderly, in order to improve the quality of life.

• Journal of Nutrition and Health
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• v.46 no.5
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• pp.410-417
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• 2013

Caloric restriction is recognized as one of the best treatment options for obesity, and is associated with changes in body composition. The purpose of this study was to determine the influence of age in caloric restriction in overweight and obese women. In this caloric restriction study, nutrient intake of 61 women was evaluated using food records written by subjects for three days. Body composition and metabolic risk factors were assessed before and after caloric restriction. Blood levels of lipids, glucose, leptin, and adiponectin were measured. Visceral fat and subcutaneous fat were evaluated using bioimpedance analysis. General linear models (GLM) identified the independent effects of age after co-varying baseline weight and difference of energy intake. Weight, fat mass, visceral fat, subcutaneous fat, and blood pressure showed a significant decrease by caloric restriction of 452 kcal/day. The percent changes in weight, visceral fat, and subcutaneous fat were -4.5%, -12.0%, and -8.2%, respectively, after caloric restriction. The percent changes of weight, visceral fat, and subcutaneous fat showed an independent association with age co-varying baseline weight and difference of energy intake. Decreased change in percent of leptin by caloric restriction also showed an association with age. Changes in body composition and leptin by caloric restriction showed an independent association with age. This may indicate greater difficulty in achievement of change of body composition as well as greater obesity-related metabolic risk with aging. Therefore, caloric restriction considering age should be recommended for effective dietary treatment in overweight or obese women.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.2
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• pp.83-92
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• 2021

Purpose : Keratinocytes are the main cellular components involved in wound healing during re-epithelization and inflammation. Dysfunction of tight junction (TJ) adhesions is a major feature in the pathogenesis of various diseases. The purpose of this study was to identify the various effects of a Sparassis crispa water extract (SC) on HaCaT cells and to investigate whether these effects might be applicable to human skin. Methods : We investigated the effectiveness of SC on cell HaCaT viability using MTS. The antioxidant effect of SC was analyzed by comparing the effectiveness of ABTS to that of the well-known antioxidant resveratrol. Reverse-transcription quantitative polymerase chain reaction (qRT-PCR) is the most widely applied method Quantitative RT-PCR analysis has shown that SC in HaCaT cells affects mRNA expression of tight-junction genes associated with skin moisturization. In addition, Wound healing is one of the most complex processes in the human body. It involves the spatial and temporal synchronization of a variety of cell types with distinct roles in the phases of hemostasis, inflammation, growth, re-epithelialization, and remodeling. wound healing analysis demonstrated altered cell migration in SC-treated HaCaT cells. Results : MTS analysis in HaCaT cells was found to be more cytotoxic in SC at a concentration of 0.5 mg/㎖. Compared to 100 µM resveratrol, 4 mg/㎖ SC exhibited similar or superior antioxidant effects. SC treatment in HaCaT cells reduced levels of claudin 1, claudin 3, claudin 4, claudin 6, claudin 7, claudin 8, ZO-1, ZO-2, JAM-A, occludin, and Tricellulin mRNA expression by about 1.13 times. Wound healing analysis demonstrated altered cell migration in SC-treated HaCaT cells and HaCaT cell migration was also reduced to 73.2 % by SC treatment. Conclusion : SC, which acts as an antioxidant, reduces oxidative stress and prevents aging of the skin. Further research is needed to address the effects of SC on human skin given the observed alteration of mRNA expression of tight-junction genes and the decreased the cell migration of HaCaT cells.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.20 no.2
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• pp.95-111
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• 2021

As the population decreases in an aging society, the average age of drivers increases. Accordingly, the elderly at high risk of being in an accident need autonomous-driving vehicles. In order to secure driving safety on the road, several technologies to respond to various obstacles are required in those vehicles. Among them, technology is required to recognize static obstacles, such as poor road conditions, as well as dynamic obstacles, such as vehicles, bicycles, and people, that may be encountered while driving. In this study, we propose a deep neural network algorithm capable of simultaneously detecting these two types of obstacle. For this algorithm, we used 1,418 road images and produced annotation data that marks seven categories of dynamic obstacles and labels images to indicate road damage. As a result of training, dynamic obstacles were detected with an average accuracy of 46.22%, and road surface damage was detected with a mean intersection over union of 74.71%. In addition, the average elapsed time required to process a single image is 89ms, and this algorithm is suitable for personal mobility vehicles that are slower than ordinary vehicles. In the future, it is expected that driving safety with personal mobility vehicles will be improved by utilizing technology that detects road obstacles.

• Journal of Convergence for Information Technology
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• v.8 no.6
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• pp.367-374
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• 2018

The purpose of this research is to promote traditional markets, which are part of urban regeneration project, and to promote cultural and tourism market by applying characteristics and differentiated elements through story development through market-related resources in order to secure identity of the JeCheon Central market that lost function of the traditional market and regional aging of the traditional market. To this end, the basic survey and analysis of the Jecheon area and the current situation of the Jecheon Central Market were conducted to diagnose problems and to analyze keywords through surveys by local merchants and visitors. By drawing up measures to vitalize the Jecheon Central Market by floor and space, the Jecheon Central Market's design story is developed and applied so that it can restore the image of the local traditional market through regional and cultural elements and become a center of space and culture that can become a landmark for the region in the future. The storytelling designed for this purpose shall be linked to the spatial planning of each floor as well as the C.I. and exterior of the C.I. and the building of the Jecheon Central Market, and the identity of the Jecheon Central Market can be reestablishe.

• The Journal of the Korea Contents Association
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• v.19 no.8
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• pp.653-666
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• 2019

This study is designed to find out the protection system of intangible cultural property as the current national policy and analyze the foundational problems in order to suggest the future vision in a way of transmitting the traditional cultural heritage to the descendants, based on the policy support for the intangible cultural property under the control of Commission for Ibuk 5-do (5 Northern Provinces of Korean peninsula). The research issue is first, the aging of the holders of the important cultural properties in Ibuk 5-do and the overcoming of the incomplete transmission system. The second issue is the protective policy of the transmission from the national perspective and the justification of the government's financial support. The third issue is the development of cultural contents by using the intangible cultural properties in Ibuk 5-do and the suggestion of the creative development for the resourcing of culture. As for the research methods, reference research and analysis on interview data and data from the related entities was done were analyzed and the results were actively adopted. The research results showed the followings to be required; first, the aged holders of the cultural properties shall be treated well and at the same time, the holders recognized to hold the transmission ability shall be dually designated. Second, the training system for the younger generation to keep the traditional cultural heritage shall be established; Third, the educational program and school education shall be extended so that the importance of the transmission of the intangible traditional cultural properties in Ibuk 5-do (northern 5 provinces of Korea) shall be recognized; Fourth, the recording system shall be constructed and its application system shall be required. In the end, in order for such development methods to be implemented effectively, active government support is desperately required.

• 재활복지
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• v.22 no.3
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• pp.69-91
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• 2018

This study aims to identify factors of life satisfaction of the adults with developmental disabilities, focusing on the comparison between young and old. Data are collected through in-depth interview of the adults with developmental disabilities as well as via workers proxy responses at the group home. Regression model analysis is conducted based on 387 cases. The result shows that the young adults with developmental disabilities are more likely to satisfied with life when they evaluate job performance of workers at the group home and when they are more actively involved in community activities. For the old adults with developmental disabilities, life satisfaction is positively associated with their evaluation of job performance of workers at the group home as in the young adults. In addition, life satisfaction of the old adults is higher when they feel less fatigue. It is also higher for those with more choices on residence and higher level of social activities. The findings reveals that enhancement of life satisfaction for the old adults with developmental disabilities dwelling at group home require supports and services for health and social activities different from other ages. It shares the general ideas that service efforts should be made for needs and desires of the recipients. The present study suggests to expand our research interests to include the disabled in danger of early aging, such as the persons with Down Syndrome and the persons with intellectual disability and cerebral palsy, and look into their particular needs.

• 한국노년학
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• v.28 no.4
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• pp.953-968
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• 2008

This research was performed to recognize anxiety level of older people, to find out anxiety level after or before regular exercises, and to find out how much anxiety level could be lowered by the sports activities. This research selected a population among the students who enrolled at sport activity classes (e, g., physical exercises, gate ball, volume dance) at L, S, J, Y (a), Y (b), D older people college located in Seoul and Gyoenggi area. 200 of the population were chosen as candidates by convenience sampling, nonprobability sampling. Considering the age of the candidates, total 200 cases were collected by using two methods (survey and interview) simultaneously. The data assessment was made by SPSS 12.0 Version. Error tolerance in statistics is .05. The data was analyzed by using frequency analysis, paired t-test and independent t-test. After analyzing anxiety awareness level after and before regular exercises, anxiety of older people are classified by four factors. First, anxiety for loss is 3.756 (M=3.756) before exercises, while 1.942 (M=1.942) after exercises. Second, fear for aging is 3.443 before exercises and 2.243 after exercises. Third, anxiety for physical appearance is 3.253 before exercises and 2.310 after exercises. Finally, anxiety caused by psychological insecurity is 3.060 before exercises, while 1.666 after exercises. Error of tolerance for all factors falls within .001. Anxiety score after exercises is lower than that of before exercises for every factor as well. As a result, regular physical exercises appeared to reduce anxiety level of older people.

• Journal of Life Science
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• v.28 no.12
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• pp.1455-1460
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• 2018

Due to a rapidly expanding aging population, the incidence of degenerative bone disease has increased, and efforts to handle the issue using regenerative medicine have become more important. In order to control various bone diseases such as osteoarthritis and osteoporosis, regenerative medicine utilizing adult stem cells has been extensively studied. And it is now clear that the mitochondrial energy metabolism, oxidative phosphorylation, is important for the process of stem cell differentiation. Interestingly, a recent study reported that salicylate promotes mitochondrial biogenesis by regulating the expression of $PGC-1{\alpha}$ in murine cells. However, the possible effects of salicylate on osteogenic differentiation through increased mitochondrial biogenesis in stem cells remain unknown. Thus, here we investigated whether salicylate could influence osteogenic differentiation and mitochondrial biogenesis of periosteum-derived mesenchymal stem cells (POMSCs). We found that salicylate treatments of POMSCs undergoing osteogenic differentiation increased the activity of alkaline phosphatase, a well-known early marker of bone cell differentiation. In addition, we observed that mitochondrial mass was increased by salicylate treatments in POMSCs. Together, these results indicate that salicylate can enhance osteogenic differentiation and mitochondrial biogenesis in POMSCs. Therefore, the findings in this study suggest that small molecules augmenting mitochondrial function such as salicylate can be a novel modulator for osteogenic differentiation and regenerative medicine.