• Title/Summary/Keyword: Weinberg

Search Result 163, Processing Time 0.021 seconds

Genetic Relationships among Australian and Mongolian Fleece-bearing Goats

  • Bolormaa, S.;Ruvinsky, A.;Walkden-Brown, S.;van der Werf, J.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.21 no.11
    • /
    • pp.1535-1543
    • /
    • 2008
  • Microsatellites (MS) are useful for quantifying genetic variation within and between populations and for describing the evolutionary relationships of closely related populations. The main objectives of this work were to estimate genetic parameters, measure genetic distances and reconstruct phylogenetic relationships between Australian Angora/Angora_Aus/ and Cashmere/Cashmere_Aus/ populations and three Mongolian Cashmere goat (Bayandelger/BD/, Zavkhan Buural/ZB/, and Gobi Gurvan Saikhan/GGS/) populations based on variation at fourteen MS loci. The level and pattern of observed and expected heterozygosity and polymorphic information content of the fourteen loci studied across the populations were quite similar and high. Except for SRCRSP07, all studied microsatellites were in Hardy-Weinberg Equilibrium (p<0.001). Moderate genetic variation (7.5%) was found between the five goat populations with 92.5% of total genetic variation attributable to diversity existing between the individuals within each population. The greatest Nei's genetic distances were found between the Angora and four Cashmere populations (0.201-0.276) and the lowest distances were between the Mongolian Cashmere goat populations (0.026-0.031). Compared with other Cashmere goat populations, the GGS (crossbred with Russian Don Goats) population had the smallest pairwise genetic distance from the Australian Angora population (0.192). According to a three-factorial correspondence analysis (CA), the three different Mongolian Cashmere populations could hardly be distinguished from each other.

Quantification and Graphical Method for DNA Fingerprinting (유전자검사자료의 통계분석을 위한 수량화 및 그래프 방법)

  • 박미라
    • The Korean Journal of Applied Statistics
    • /
    • v.15 no.1
    • /
    • pp.85-105
    • /
    • 2002
  • To explore the relationships among frequencies for sets of alleles, within or between loci, is one of the first analyses in population genetic study. The general question is whether the frequency of a set of alleles is the same as the product of each of the separate allele frequencies. For two alleles of a single locus, Hardy-Weinberg equilibrium is tested and for an allele from each of two loci, linkage disequilibrium is tested. However, it is more useful if we can quantify and graphically represent this information. In this study, we suggest graphical methods to find associations between alleles. We also analyze the STR data of Korean population as an illustration.

Reliability of the Tremaine-Weinberg Method for Measuring Multiple Pattern Speeds in Barred-Spiral Galaxies

  • Kim, Yonghwi;Kim, Woong-Tae
    • The Bulletin of The Korean Astronomical Society
    • /
    • v.38 no.1
    • /
    • pp.31.1-31.1
    • /
    • 2013
  • Barred-spiral galaxies possess double patterns: a bar and spiral arms. While their angular speeds play an important role in governing gas dynamical evolution of barred spiral galaxies, there is no direct way to observe them. The Tremaine-Weinberg (TW) method has been one of the most reliable indirect methods to estimate pattern speeds, although it requires a few strict assumptions, notably one that the gas tracer is in a quasi-steady state. In barred-spiral galaxies, however, non-steady gas flows are significant especially when the double patterns have different angular speeds. Using numerical models, we explore the effect of non-steady gas motions on the determination of double pattern speeds based on the TW method. We find that the TW method is accurate within 15% when there is only a single pattern or when double patterns have the same angular speed. When double patterns have different speeds, on the other hand, neglecting the non-steady flows leads to quite large errors (> 30%) in the derived pattern speeds, and severely underestimate the real values for the viewing angle parallel to the bar minor axis. This suggests that one should be cautious when applying the TW method to galaxies with double patterns with different speeds.

  • PDF

Modeling and Analysis of an Avionic Battery Discharge Regulator

  • Chen, Qian;Yu, Haihong;Huang, Xiaoming;Lu, Yi;Qiu, Peng;Tong, Kai;Xuan, Jiazhuo;Xu, Feng;Xuan, Xiaohua;Huang, Weibo;Zhang, Yajing
    • Journal of Power Electronics
    • /
    • v.16 no.3
    • /
    • pp.1218-1225
    • /
    • 2016
  • The avionic battery discharge regulator (BDR) plays an important role in a power-conditioning unit. With its merits of high efficiency, stable transfer function, and continuous input and output currents, the non-isolated Weinberg converter (NIWC) is suitable for avionic BDR. An improved peak current control strategy is proposed to achieve high current-sharing accuracy. Current and voltage regulators are designed based on a small signal model of a three-module NIWC system. The system with the designed regulators operates stably under any condition and achieves excellent transient response and current-sharing accuracy.

Association of Dopamine D4 Receptor(DRD4) Gene Polymorphism with Korean Schizophrenic Patients (정신분열병에서 도파민 D4 수용체(DRD4) 유전자의 다형성)

  • Lee, Hong Seock;Lee, Min Soo;Han, Deock-Jeong;Lee, Heon-Jeong
    • Korean Journal of Biological Psychiatry
    • /
    • v.7 no.2
    • /
    • pp.152-158
    • /
    • 2000
  • Background : No association between schizophrenia and dopamine D4 receptor polymorphisms have been reported. Despite these results, it is premature to exclude the association. It has been suggested that the susceptibility to develop schizophrenia could result from variation at a number loci which may interact or coact with each other. Therefore, we investigated a possible association of combinations of exon III 48bp polymorphism[D4E3] and exon I 12bp polymorphism of the DRD4 gene [D4E1] with schizophrenia. Methods : 207 unrelated Korean schizophrenic patients and 191 healthy controls were recruited. DRD4 genotype was established using the polymerase chain reaction. Statistical analysis consisted of ${\chi}^2$ tests for Hardy-Weinberg proportions and genotypic and allelic frequencies in the patients and control groups. Results : There were no statistically significant differences in the each polymorphisms between schizophrenics and controls. And all genotype frequencies were within Hardy-Weinberg expectations. When the combinations of the polymorphism in schizophrenia and controls were compared, however, there were significant differences at $A1A2^*2/4$ in the distributions of the combinations of D4E1 and D4E3(p<0.01). Conclusions : These findings suggest that the certain combination of D4E1 and D4E3($A1A2^*2/4$) has the protective role to a susceptibility for schizophrenia.

  • PDF

Bootstrap Confidence Intervals for a One Parameter Model using Multinomial Sampling

  • Jeong, Hyeong-Chul;Kim, Dae-Hak
    • Journal of the Korean Data and Information Science Society
    • /
    • v.10 no.2
    • /
    • pp.465-472
    • /
    • 1999
  • We considered a bootstrap method for constructing confidenc intervals for a one parameter model using multinomial sampling. The convergence rates or the proposed bootstrap method are calculated for model-based maximum likelihood estimators(MLE) using multinomial sampling. Monte Carlo simulation was used to compare the performance of bootstrap methods with normal approximations in terms of the average coverage probability criterion.

  • PDF

Hanwoo individual identification with DNA marker information

  • Lee, Jea-Young;Choi, Yu-Mi
    • Journal of the Korean Data and Information Science Society
    • /
    • v.18 no.3
    • /
    • pp.599-608
    • /
    • 2007
  • This study was conducted to establish an individual identification system in Hanwoo cattle. Samples of 33 Hanwoo individuals from Korean elite sire families were used. Thirteen major microsatellite markers were selected from alleles amplified, their frequencies, H(Heterozygosity) and PIC(Polymorphism Information Content) with Hardy-Weinberg equilibrium. Next, in order to evaluate the power of the markers selected on the individual animal identification, MP(Match probability) and R(Relatedness coefficient) with the percentage of animal incorrectly identified were computed. Finally nine microsatellite markers were selected and discussed.

  • PDF

Genetic Diversity and Population Structure of Pseudobagrus fulvidraco in the Nakdong River (낙동강에 분포하는 동자개 집단의 유전적 다양성과 집단구조)

  • Huh, Man-Kyu;Choi, Joo-Soo;Heo, Youn-Seong;Lee, Bok-Kyu
    • Journal of Life Science
    • /
    • v.17 no.7 s.87
    • /
    • pp.882-888
    • /
    • 2007
  • Enzyme electrophoresis was used to estimate genetic diversity and population genetic structure of Pseudobagrus fulvidraco in Korea. Nine of the 14 loci (64.3%) showed detectable polymorphism. Genetic diversity at the population and species levels were 0.286 and 0.277, respectively. Analysis of fixation indices, calculated for all polymorphic loci in each population, showed a substantial deficit of hetero-zygotes relative to Hardy-Weinberg expectations. This deficit is expected that it is due to a limited effective number of individuals per population. The average $G_{ST}$ for polymorphic loci was 0.064, indicating that most (93.6%) of the genetic diversity occurred within populations. The indirect estimate of gene flow based on mean $G_{ST}$ was 3.67. Given limited gene flow is expected to diverge genetically due to drift and reduced populations. Most populations in our study experience annual, severe demo-graphic bottlenecks due to drought and floods.

DNA Marker Traceability Techniques for Hanwoo Industry

  • Lee, Jea-Young;Bae, Jung-Hwan;Lee, Yoon-Seok;Yeo, Jung-Sou
    • Journal of the Korean Data and Information Science Society
    • /
    • v.17 no.4
    • /
    • pp.1041-1051
    • /
    • 2006
  • The effectiveness of genetic markers on Hanwoo traceability systems was applied and evaluated from Korean 33 Hanwoo elite sire families. Five microsatellite markers were selected finally, which were located on chromosomes different chromosomes with the end sequencing of 100 HW-YUBAC that were recorded in the NCBI by Yeungnam University. Eleven major microsatellite markers were selected from allele amplified, their frequencies, H(Heterozygosity) and PIC(Polymorphism information content) with Hardy-Weinberg equilibrium. Next, in order to evaluate the power of the markers selected on the individual animal identification with experimental condition, the match probability(MP) and the relatedness coefficient(R) were computed.

  • PDF

Hanwoo(Korean Cattle) Traceability Using DNA Markers

  • Yeo, Jung-Sou;Rhee, Sung-Won;Choi, Yu-Mi;Kwon, Jae-Chul;Lee, Jea-Young
    • Communications for Statistical Applications and Methods
    • /
    • v.13 no.3
    • /
    • pp.733-743
    • /
    • 2006
  • To apply and evaluate the effectiveness of genetic markers on Hanwoo traceability systems, samples of 33 Hanwoo individuals from Korean elite sire families were used, and five microsatellite markers were selected finally, which were located on chromosomes different chromosomes with the end sequencing of 100 HW-YUBAC that were recorded in the NCBI by Yeungnam University. Ten major microsatellite markers were selected from alleles amplified, their frequencies, H(Heterozygosity) and PIC(Polymorphism information content) with Hardy-Weinberg equilibrium. Next, in order to evaluate the power of the markers selected on the individual animal identification, the match probability(MP) and the relatedness coefficient(R) were computed.