• Journal of Preventive Medicine and Public Health
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• 제39권4호
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• pp.317-324
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• 2006

Objectives: This study was conducted to estimate the unbiased smoking prevalence and its standard errors among adolescents in a large city in Korea, by design-based analysis. Methods: All the students in Daegu city were stratified by grade, gender and region, and then schools as primary sampling units (PSU) were selected by probability proportional to size (PPS) sampling. One or two classes were sampled randomly from each grade, from 5th grade in elementary schools to the 3rd grade in high schools. The students anonymously completed a standardized self-administered questionnaire from October to December 2004. The total number of respondents was 8,480 in the final analysis, excluding the third graders in the general high schools because of incomplete sampling. The sampling weight was calculated for each student after post-stratification adjustment, with adjustment being made for the missing cases. The data were analyzed with Stata 8.0 with consideration of PSU, weighting and the strata variables. Results: The smoking prevalence (%) and standard errors for male students from the fifth grade in elementary schools to the second grade in high schools were $0.93{\pm}0.47,\;1.83{\pm}0.74,\;3.16{\pm}1.00,\;5.12{\pm}1.02,\;10.86{\pm}1.13,\;15.63{\pm}2.44\;and\;17.96{\pm}2.67$, and those for the female students were $0.28{\pm}0.28,\;1.17{\pm}0.73,\;3.13{\pm}0.60,\;1.45{\pm}0.58,\;3.94{\pm}0.92,\;8.75{\pm}1.86\;and\;10.04{\pm}1.70$, sequentially. Conclusions: The smoking prevalence from this study was much higher than those from the other conventional studies conducted in Korea. The point estimates and standard errors from the design-based analysis were different from those of the model-based analysis. These findings suggest the importance of design-based analysis to estimate unbiased prevalence and standard errors in complex survey data and this method is recommended to apply to future surveys for determining the smoking prevalence for specific population.

• 한국음향학회:학술대회논문집
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• 한국음향학회 2004년도 춘계학술발표대회 논문집 제23권 1호
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• pp.337-340
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• 2004

한국어 문-음성 합성 시스템(TTS: Text-To-Speech)은 합성음의 자연스러움을 증가시키기 위해 운율 발생 알고리듬을 만들어 시스템에 적용하고 있다. 운율 법칙은 각국의 언어에 대한 언어학적 정보나 자연음에서 구한 운율에 대한 지식을 기반으로 음성 합성 시스템에 적용하고 있다. 그러나 이렇게 구한 운율 법칙이 자연음에 존재하는 모든 운율 법칙을 포함할 수도 없고, 또 추출한 운율 법칙이 틀린 법칙이라면, 합성음의 자연감이나 이해도는 떨어질 것이므로, TTS의 실용화에 장애가 될 수 있다. 이러한 점을 감안하여 본 논문에서는 자연음에 내재하는 운율을 학습할 수 있는 인공 신경망을 이용한 운율발생 신경망을 제안하였다. 훈련단계에서 인공 신경망의 입력 단에 한국어 문장의 음소 열을 차례로 이동시켜 인가하면 입력 단의 중앙에 해당하는 음소의 운율 정보가 출력되도록 훈련시킬 때, 목표 패턴을 이용한 감독학습을 통해, 자연음에 내재하는 운율을 학습하도록 하였다. 평가 단계에서 문장의 음소 열을 입력하고, 추정율을 측정하여 인공 신경망이 한국어 문장에 내재하는 운율을 학습하여 발생시킬 수 있음을 살펴보았다.

• 한국항공우주학회지
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• 제36권10호
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• pp.969-978
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• 2008

선형 캐스케이드 실험장치에서 블레이드간에 주기조건을 만족하면서 적은 개수의 블레이드를 적용하는 것은 실험의 정확도 향상뿐만 아니라 실험수행에 여러 장점을 제공한다. 따라서 본 연구에서는 유로를 캐스케이드 피치의 두 배 넓이로 설정하고 두 개의 블레이드만을 설치하였을 때 주기조건이 얻어지도록 하는 벽면의 형상설계에 관한 연구를 수행하였다. 이를 위하여 주기조건에서 얻어진 블레이드 표면에서의 마하수와 동일한 결과가 얻어지도록 목적함수를 설정하였으며, 설계변수로는 벽면의 형상과 관련이 있는 12개의 변수를 선정하였다. 벽면의 설계를 위하여 기울기 기반의 최적화법을 사용하였으며, 목적함수에 민감한 변화를 나타내는 영역의 조정과 가중치를 사용하였다. 이러한 방식으로 얻어진 결과에서 주기조건과 동일한 유동특성이 얻어질 수 있음을 확인하였다.

• 대한지역사회영양학회지
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• 제4권4호
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• pp.529-538
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• 1999

It is very important to collect information on the nutritional status of the Korean population for the development of health promotion programs including nutrition. The purpose of this study was to assess the nutritional status of various population living in selected areas for model nutritional work. Seven hundred eighty households(30 households per each area)from 26 areas participated in this study from November 1 to November 20, 1996. Dietary intake data for two consecutive days were collected at household level by a weighting method. The mean energy intake of the subjects(1,934kcal) was higher than that resulted from the ‘95 Korean National Nutrition Survey(1,839kcal). The proportion of energy derived from cereals was 60.1%. The proportion of total protein intake from animal sources was 49.4%. These results were similar to those found in the ‘95 Korean National Nutrition Survey. Most nutrients(except iron, thiamin, riboflavin, vitamin C, and crude fiber) were higher than the result of the ‘95 Korean National Nutrition Survey. However, the average iron intake was about 68% of the result of ‘95 Korean National Nutrition Survey. This may be due to the adjustment of iron content in rice(3.7mg/100glongrightarrow0.5mg/100g) included in nutrient database for calculating nutrient intakes. The mean energy contribution from carbohydrate, protein, and fat were 64.2%, 16.4% and 19.4%, respectively. Significant differences of nutrient intakes were noted among some areas, which may be due to different food intake patterns according to the needs of the particular area. Therefore, the result of this study indicates that there are significant differences in food and nutrient intakes among the areas, suggesting that nutritional improvement programs may need to be developed differently by areas.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2012년도 학술발표회
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• pp.155-155
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• 2012

최근 집중호우에 따른 자연재해가 크게 증가하여 수문 및 기상분야에서 강우를 관측 및 예측하기 위한 레이더 활용성이 증대되고 있으며, 이에 따라 정부 각 관련부처에서는 레이더의 도입 및 확충을 위한 방안을 계획 제시하고 있다. 특히, 레이더강우 자료는 수문해석분야에서의 GIS 등 디지털정보를 이용하여 유역매개변수를 추정함에 따라 더 정확하고 상세한 수문자료 확보가 가능하게 되어, 격자기반의 분포형 강우-유출모형 등을 이용하여 수문해석을 하는데 있어 그 활용성이 크게 증가하고 있다. 그러나 레이더강우 자료의 정확성은 아직까지 만족할 만한 수준에 이르지 못하고 있기 때문에, 그 불확실성으로 인하여 레이더강우 자료의 활용 및 적용에 한계를 가지고 있는 실정이다. 본 연구에서는 지상강우를 이용한 레이더강우 보정을 위하여 SOA(Statistical Objective Analysis)보정방법을 이용하였으며, 기존 SOA방법에서의 거리에 따른 가중치($_{kd}$)와 함께 지형(고도)에 따른 가중치($W_{ike}$), 바람의 영향에 따른 가중치($W_{ikw}$)를 추가로 산정하여 적용하였으며, 이를 통하여 보정된 강우장을 생성하였다. SOA방법을 통해 생성된 강우장이 어느 정도의 강우정확도를 가지고 강우분포를 재현하는지 검증하기 위하여 2011년 7~9월의 수문학적 분석에 활용 가능한 강우사상과 낙동강유역을 대상으로, 분포형모형인 $Vflo^{TM}$ 모형을 이용하여 산정된 유출량과 관측 유출량과의 비교를 실시하였다. 또한, 유출량에 대한 오차 및 ME(Model Efficiency)를 통해 레이더강우 자료의 유출모형에서의 효율성을 검토하고자 하였다. 본 연구에서 수행된 보정 강우장에 따른 유출량 비교를 통해 레이더 강우의 정확도에 대한 정량적 평가 방법 도출이 가능할 것으로 판단된다.

• Korean Circulation Journal
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• 제52권2호
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• pp.136-146
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• 2022

Background and Objectives: There still are controversies on which type between bovine pericardial and porcine valves is superior in the setting of aortic valve replacement (AVR). This study aims to compare clinical outcomes of AVR using between pericardial or porcine valves. Methods: The study involved consecutive 636 patients underwent isolated AVR using stented bioprosthetic valves between January 2000 and May 2016. Of these, pericardial and porcine valves were implanted in 410 (pericardial group) and 226 patients (porcine group), respectively. Clinical outcomes including survival, structural valve deterioration (SVD) and trans-valvular pressure gradient were compared between the groups. To adjust for potential selection bias, inverse probability treatment weighting (IPTW) was conducted. Results: The mean follow-up duration was 60.1±50.2 months. There were no significant differences in the rates of early mortality (3.1% vs. 3.1%; p=0.81) and SVD (0.3%/patient-year [PY] vs. 0.5%/PY; p=0.33) between groups. After adjustment using IPTW, however, landmark mortality analyses showed a significantly lower late (>8 years) mortality risk in pericardial group over porcine group (hazard ratio [HR], 0.61; 95% confidence interval, [CI] 0.41-0.90; p=0.01) while the risks of SVD were not significantly difference between groups (HR, 0.45; 95% CI, 0.12-1.70; p=0.24). Mean pressure gradient across prosthetic AV was lower in the Pericardial group than the Porcine group at both immediate postoperative point and latest follow-up (p values <0.001). Conclusions: In patients undergoing bioprosthetic surgical AVR, bovine pericardial valves showed superior results in terms of postoperative hemodynamic profiles and late survival rates over porcine valves.

• 정신신체의학
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• 제31권2호
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• pp.108-117
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• 2023

연구목적 신체 증상 장애(Somatic Symptom Disorder, SSD)는 다양한 신체 증상의 발현을 특징으로 하며, 현재까지 환자군 내에서 증상 심각도에 따른 자율신경계 활성의 차이에 대해서는 연구된 바가 거의 없다. 이에 본 연구에서는 신체 증상 장애 환자군에서 심박변이도(Heart Rate Variability, HRV) 차이를 검정하여 증상 심각도에 따른 자율신경계 변화를 반영하는 대표적 지표를 분석하였다. 방 법 2020년 9월 18일부터 2021년 10월 29일까지 강남세브란스병원 정신건강의학과에 내원했던 환자 중, DSM-5 진단 기준에 따라 SSD로 진단받은 환자 총 51명의 의무기록을 후향적으로 수집하였다. 이후, 집단 간 인구사회학 및 임상적 선택편의 보정을 위해 역확률 가중치(Inverse Probability Treatment Weighting, IPTW)를 적용하여 HRV 지표 차이 검정을 실시하였다. 결 과 신체 증상 심각도와 LF (nu), HF (nu), LF/HF, 그리고 SD1/SD2, Alpha1/Alpha2는 통계적으로 유의한 상관관계를 보였으며, IPTW 적용 후 비중증군은 27명(53.0%), 중증군은 24명(47.0%)로 보정되었고, 인구사회학적 요인 및 임상적 특성 차이가 유의미하지 않아 동질성이 확보되었다. 본 모형 분석 결과 고위험군일수록 시간 영역의 RMSSD (β=-0.70, p=0.003), pNN20 (β=-1.04, p=0.019), 주파수 영역은 LF (nu) (β=0.29, p<0.001), HF (nu) (β=-0.29, p<0.001), LF/HF (β=1.41, p=0.001), 그리고 비선형 영역에서는 SampEn15 (β=-0.35, p=0.014), SD1/SD2 (β=-0.68, p<0.001), Alpha1/Alpha2 (β=0.43, p=0.001)에서 유의미한 차이가 검정되었다. 결 론 신체 증상 심각도에 따른 HRV 지표의 차이는 시간과 주파수 영역, 그리고 비선형 영역 전반에서 검정되었으며, 신체 증상이 심할수록 교감신경의 과활성화 및 부교감신경의 저하를 시사하는 HRV 지표들이 유의미하게 높은 경향성을 보였다.

• International Journal of Quality Innovation
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• 제8권3호
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• pp.156-172
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• 2007

The high-tech industry is the economic lifeline for Taiwan. Its characteristics are short product life cycle, rapid changes in the market, and a high obsolescence rate for new products. Under globalization, the high-tech industry has adopted Information Technology (IT) to shorten the manufacturing process, reduce costs and conduct product research and development (R&D) to increase the core competence of enterprises and achieve the goal of sustainable operations. Enterprises should actively strengthen their integration with internal and external resources and lead in R&D management to increase industrial operating performance. Effectively managing operations and R&D management evaluation in Taiwan's High-tech Industry has become a critical subject. This study adopted 4 major Balanced Scorecard (BSC) perspectives to establish the Total Performance Evaluation Indicators for the R&D management department in Taiwan's High-tech Industry. The Analytic Network Process (ANP) was applied to evaluate the overall performance of the R&D management department. The research framework is divided into 2 phases. The first phase is combined with the 4 major perspectives, Financial, Customer, Internal Business Process and Learning and Growth, as the related indicators for each measurement perspective. The Key Performance Indicators (KPI) were selected using Factor Analysis to identify the key factor from the complicated indicators. The relationship between the characteristics of each BSC's evaluation perspective is dependence and feedback. This study applied ANP to conduct the calculation and adjustment of correlation between each KPI, and determine on their relative weights for the objective KPI. The "Financial Perspective" for R&D management department in Taiwan's High-tech Industry focused on the budget achievement rate of R&D management. The weight indicator value is (0.05863). The "Customer Perspective" focused on problem-solving satisfaction. The weight value of this indicator is (0.17549). The "Internal Business Process Perspective" focused on the quantity and quality of R&D. The weight value of this indicator is (0.13506). The "Learning and Growth Perspective" focused on improving competence in the research personnel's professional techniques. The weight value of this indicator is (0.02789). From the total weighting indicators, the order of the Performance Indicators for the R&D management department in Taiwan's High-tech Industry is: (1) Customer Perspective; (2) Internal Business Process Perspective; (3) Financial Perspective; and (4) Learning and Growth Perspective.

• Korean Journal of Radiology
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• 제24권12호
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• pp.1284-1292
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• 2023

Objective: We investigated the impacts of computed tomography (CT) added to ultrasound (US) for preoperative evaluation of patients with papillary thyroid carcinoma (PTC) on staging, surgical extent, and postsurgical survival. Materials and Methods: Consecutive patients who underwent surgery for PTC between January 2015 and December 2015 were retrospectively identified. Of them, 584 had undergone preoperative additional thyroid CT imaging (CT + US group), and 859 had not (US group). Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were used to adjust for 14 variables and balance the two groups. Changes in nodal staging and surgical extent caused by CT were recorded. The recurrence-free survival and distant metastasis-free survival after surgery were compared between the two groups. Results: In the CT + US group, discordant nodal staging results between CT and US were observed in 94 of 584 patients (16.1%). Of them, CT accurately diagnosed nodal staging in 54 patients (57.4%), while the US provided incorrect nodal staging. Ten patients (1.7%) had a change in the extent of surgery based on CT findings. Postsurgical recurrence developed in 3.6% (31 of 859) of the CT + US group and 2.9% (17 of 584) of the US group during the median follow-up of 59 months. After adjustment using IPTW (580 vs. 861 patients), the CT + US group showed significantly higher recurrence-free survival rates than the US group (hazard ratio [HR], 0.52 [95% confidence interval {CI}, 0.29-0.96]; P = 0.037). PSM analysis (535 patients in each group) showed similar HR without statistical significance (HR, 0.60 [95% CI, 0.31-1.17]; P = 0.134). For distant metastasis-free survival, HRs after IPTW and PSM were 0.75 (95% CI, 0.17-3.36; P = 0.71) and 0.87 (95% CI, 0.20-3.80; P = 0.851), respectively. Conclusion: The addition of CT imaging for preoperative evaluation changed nodal staging and surgical extent and might improve recurrence-free survival in patients with PTC.

• Journal of Chest Surgery
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• 제57권3호
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• pp.242-251
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• 2024

Background: This study compared the outcomes of surgical aortic valve replacement (AVR) in patients aged 50 to 70 years based on the type of prosthetic valve used. Methods: We compared patients who underwent mechanical AVR to those who underwent bioprosthetic AVR at our institution between January 2000 and March 2019. Competing risk analysis and the inverse probability of treatment weighting (IPTW) method based on propensity score were employed for comparisons. Results: A total of 1,580 patients (984 patients with mechanical AVR; 596 patients with bioprosthetic AVR) were enrolled. There was no significant difference in early mortality between the mechanical AVR and bioprosthetic AVR groups (0.9% vs. 1.7%, p=0.177). After IPTW adjustment, the risk of all-cause mortality was significantly higher in the bioprosthetic AVR group than in the mechanical AVR group (hazard ratio [HR], 1.39; 95% confidence interval [CI], 1.07-1.80; p=0.014). Competing risk analysis revealed lower risks of stroke (sub-distributional hazard ratio [sHR], 0.44; 95% CI, 0.28-0.67; p<0.001) and anticoagulation-related bleeding (sHR, 0.35; 95% CI, 0.23-0.53; p<0.001) in the bioprosthetic AVR group. Conversely, the risk of aortic valve (AV) reintervention was higher in the bioprosthetic AVR group (sHR, 6.14; 95% CI, 3.17-11.93; p<0.001). Conclusion: Among patients aged 50 to 70 years who underwent surgical AVR, those receiving mechanical valves showed better survival than those with bioprosthetic valves. The mechanical AVR group exhibited a higher risk of stroke and anticoagulation-related bleeding, while the bioprosthetic AVR group showed a higher risk of AV reintervention.