• Journal of Pharmaceutical Investigation
• /
• v.32 no.3
• /
• pp.185-190
• /
• 2002

To improve the solubility of poorly water-soluble drug and to develop a sustained release tablets, the need for the technique, the formation of solid dispersion with polymeric materials that can potentially enhance the dissolution rate and extent of drug absorption was considered in this study. The 1:1, 1:4, and 1:5 solid dispersions were prepared by spray drying method using PVP K30, ethanol and methylene chloride. The dissolution test was carried out at in phosphate buffer solution at $37^{\circ}C$ in 100 rpm. Solid dispersed drugs were examined using differential scanning calorimetry and scanning electron microscopy, wherein it was found that felodipine is amorphous in the PVP K30 solid dispersion. Felodifine SR tablets were prepared by direct compressing the powder mixture composed of solid dispersed felodipine, lactose, Eudragit and magnesium stearate using a single punch press. In order to develop a sustained-release preparation containing solid dispersed felodipine, a comparative dissolution study was done using commercially existing product as control. The dissolution rate of intact felodipine, solid dispersed felodipine and its physical mixture, respectively, were compared by the dissolution rates for 30 minutes. The dissolution rates of felodipine for 30 minutes from 1:1, 1:4, 1:5 PVP K30 solid dispersion were 70%, 78% and 90%. However, dissolution rate offelodipine from the physical mixture was 5% of drug for 30 minutes. Our developed product Felodipine SR Tablet showed dissolution of 17%, 50% and 89% for 1, 4, and 7 hours. This designed oral delivery system is easy to manufacture, and drug releases behavior is highly reproducible and offers advantages over the existing commercial product. The dissolution rate of felodipine was significantly enhanced, following the formation of solid dispersion. The solid dispersion technique with water-soluble polymer could be used to develop a solid dispersed felodipine SR tablet.

• Food Science and Preservation
• /
• v.23 no.2
• /
• pp.194-203
• /
• 2016

The purpose of this study was to investigate the properties of tteok prepared from white (Samkwang) and brown rice (Heugseol, Heugjinju). The moisture and crude protein contents of rice were 14.89~17.15% and 4.79~6.81%, respectively. The crude lipid and crude ash contents of rice were 0.48~2.66% and 0.39~1.60%, respectively. The water binding capacity of Heugjinju (141.97%) was higher than those of other rice flours. As the soaking time increased, water absorption ability was in the order of Samkwang > Heugseol > Heugjinju. Using a rapid visco analyser (RVA), the initial pasting temperature of Heugseol was the highest, and the peak viscosities of Heugseol were higher than those of other rice flours. The quality characteristics of Tteokbokki tteok were assessed after its preparation by adding different amounts of Heugseol and Heugjinju (0, 5, 10, and 20%, w/w) content. The textural properties (hardness), of Heugseol and Heugseol measured using a texture analyzer, were greater than those of the control. Sensory preference tests revealed that 10% Heugseol and, 10% Heugjinju had the highest scores in appearance, color, and overall acceptability. The sensory test results revealed that Tteokbokki tteok prepared by addition of 10% added brown rice was the best.

• Journal of the Korea Concrete Institute
• /
• v.28 no.2
• /
• pp.205-212
• /
• 2016

This research investigates the influence of ground granulated blast furnace slag (GGBFS) composition on the alkali-activated slag cement (AASC). Aluminum oxide ($Al_2O_3$) was added to GGBFS binder between 2% and 16% by weight. The alkaline activators KOH (potassium hydroxide) was used and the water to binder ratio of 0.50. The strength development results indicate that increasing the amount of $Al_2O_3$ enhanced hydration. The 2M KOH + 16% $Al_2O_3$ and 4M KOH + 16% $Al_2O_3$ specimens had the highest strength, with an average of 30.8 MPa and 45.2 MPa, after curing for 28days. The strength at 28days of 2M KOH + 16% $Al_2O_3$ was 46% higher than that of 2M KOH (without $Al_2O_3$). Also, the strength at 28days of 4M KOH + 16% $Al_2O_3$ was 44% higher than that of 4M KOH (without $Al_2O_3$). Increase the $Al_2O_3$ contents of the binder results in the strength development at all curing ages. The incorporation of AASC tended to increases the ultrasonic pulse velocity (UPV) due to the similar effects of strength, but increasing the amount of $Al_2O_3$ adversely decreases the water absorption and porosity. Higher addition of $Al_2O_3$ in the specimens increases the Al/Ca and Al/Si in the hydrated products. SEM and EDX analyses show that the formation of much denser microstructures with $Al_2O_3$ addition.

• Korean Journal of Food Science and Technology
• /
• v.16 no.4
• /
• pp.429-436
• /
• 1984

To expand the utility of barley the experiments on the extrusion characteristics of barley flour for snack processing were carried out and the effects of the extrusion conditions on the quality of the extrudates were investigated. The optimum moisture content of barley flour for snack processing was 20%. The moisture content and the density of the extrudates decreased with increasing extrusion temperature and decreasing die size. The die swell ranged from 0.98 to 2.18 according to various extrusion conditions and decreased with increasing temperature above $150^{\circ}C$. The lightness, redness and yellowness increased at higher temperature. The water absorption index and the water solubility index showed their maximum values at $180^{\circ}C$.The gelatinization degree of the extrudates increased with increasing temperature. The fracture fore, Young's modulus and maximum fiber stress decreased, but the deformation to fracture increased, with increasing temperature and decreasing die size. The yield force in puncture test showed lower values at higher temperature. The size and the fraction of the air cells increased with increasing temperature and decreasing die size. The optimum extrusion conditions of barley for snack processing were at the temperature of $180^{\circ}C$, with the die size of 4.5mm when processed at 160 rpm.

• Journal of the Korean Recycled Construction Resources Institute
• /
• v.3 no.4
• /
• pp.355-365
• /
• 2015

This study examined the fluidity and strength properties, water resistance, durability, and freeze-thaw of cementless loess mortar using an eco-friendly hardening agent. The experimental result indicates that 28 days compressive and flexural strength of the loess mortar was increased regardless of the weathered granite soil and loess mixture ratio as the replacement ratio of the hardening agent increases. The strengths were significantly increased until 14 days regardless of the hardening agent, while the effect on the strengths increasement was relatively low after 14 days. Thus, the strength development of loess mortar concrete was found to be faster than that of the normal concrete. In addition, when the hardening agent of 10% was used, the average flexural strength was 1.7MPa which is insufficient compared to the 28-day flexural strength of 4.5MPa for the paving concrete. However, the flexural strengths of the loess mortar concrete using the hardening agents of 20% and 30% were 4.0MPa and 5.3MPa, respectively. Thus, the hardening agent need to be at least 20% so that the loess mortar can be used for paving concrete. The experiment for water resistance shows that the repeated absorption and dry reduced mass regardless of the mixing ratio of the loess. The maximum length change also decreased with increasing the substitution rate loess mixture ratio and the hardening agent. The result of the freeze-thaw resistance test indicates that the relative dynamic modulus of elasticity at 300 cycle freeze-thaw with the hardening agents of 20% and 30% were 75% and 79%, relatively. Thus, the hardening agent of at least 20% is required to obtain the relative dynamic modulus of elasticity of 60% for the loess mortar.

• Journal of the Korean Recycled Construction Resources Institute
• /
• v.4 no.4
• /
• pp.418-424
• /
• 2016

This study is an experimental study on the recycling of bottom ash in coal ash discharged from a thermal power plant. Bottom ash has limited research on recycling because it has more porous and higher water absorption ratio than fly ash. In this paper, the bottom ash was pulverized to a specific surface area of $4,000cm^2/g$ in order to use as a binder, and the flow, compressive strength test and microstructure analysis of the bottom ash based geopolymer mortar were performed. The flow measurement results of the geopolymer mortar showed that the flow rate was improved by increasing mixing water as the molar concentration of activator was increased. Compressive strength increased with increasing curing temperature and molar concentration. Through the microstructure analysis, we could confirm the geopolymer gel produced by the reaction of the condensation polymerization. It is considered that it is possible to make the bottom ash based geopolymer concrete through proper molar concentration of activator and high temperature curing.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2008.04a
• /
• pp.817-820
• /
• 2008

The river environments of many streams in korea have been deteriorate through the rapid industrialization and urbanization since the 1960s. In korea, on the other hand, much efforts on the research and project have been made for the restoration of the deteriorated streams to close-to-nature. in order to restore the deteriorated streams, therefore, it is necessary to investigate such advanced technologies and materials. In view of this requirement, various research paths are being taken focusing on coarse aggregates to make multi-functional porous concrete having continuous voids so as to improve water and air permeability, acoustic absorption, water purification and applicability to vegetation. The Purpose of this study is to investigate the method for recovery of the environment in the streams area using porous concrete retaining wall block. the multi-P.O.C block applies for test in the Jangduri-cheon have been monitored planting, stability etc. after 6 months, plant grows flourishing and reconstructed in state such as nature rivers.

• Journal of the Korea Institute of Building Construction
• /
• v.14 no.4
• /
• pp.308-313
• /
• 2014

Recently, for longevity of resident building, the main trend is that the change of the inside space organization of resident building from wall construction to rhamen construction, which resulted in increase in use of lightweight composite panel. Thus, in this study, authors analyzed the engineering property of oxide of magnesium depending on the magnesium chloride addition ratio. The results of this research is expected to contribute on providing a fundamental material for the surface materials of lightweight composite panel. As the result of the experiment, as fluidity increased, air content decreased and initial set and final set as the magnesium chloride addition ratio increase. In the aspect of flexural strength and compressive strength, the test specimen showed the highest strength at 40% of the magnesium chloride addition ratio. At 20% of the magnesium chloride addition ratio, the test specimen showed the lowest water absorption rate. As the magnesium chloride addition ratio increases, the expansibility tends to increase as well in the aspect of shrinkage strain. After observing microstructure, we can see hydration products in the form of needle. It appeared high flexural strength because the hydration products have mineral fibrous tissue shape, which also contribute to the cause of the expansibility.

• Journal of Korean Society of Forest Science
• /
• v.46 no.1
• /
• pp.1-9
• /
• 1980

This study was carried out to examine the substitution possibility into fiber pot instead of Jiffy pot for the good transplanting. Fiber pot was made of fiber, wood waste particle, and bark powder (10% of the particle weight) and also latex was added into the furnish as a binder. The pots were sprayed with just enough urea solution to prevent nitrogen deficiency of pot media coming from the breakdown of wood fiber in the pot wan during the plant growing. The utility of fiber pot was compared with that of Jiffy pot in the service test of two tree species under a green-house condition. The results obtained can be summarized as follows ; 1. Fiber pot made of 30% wood fiber+70% particle including 10% of bark powder, and 3%-latex has shown a good results like that of Jiffy pot in the sp. gr., tear factor and burst factor. For water absorption, fiber pot made of 50% fiber+50% particle, and 3%-latex got the best result. In the consideration of the above physical and mechanical properties of the fiber pot for good root penetration through the pot wall and facile handling, fiber pot made of 30% fiber+70% particle, and 3%-latex may be seemed to be good. 2. There were no harms in sapling growth in fiber pot as well as in Jiffy pot. The root penetration ability through the fiber pot was slightly inferior to that of Jiffy pot, and yet the pot damage through transportation seemed to be slighter in fiber pot than in Jiffy pot.

• Korean Journal of Food Science and Technology
• /
• v.40 no.1
• /
• pp.21-30
• /
• 2008

In this study, the antioxidant activities of 27 medicinal herbs and plants were measured. The dried medicinal herbs and plants were pulverized and extracted by water, 15% ethanol, and 45% ethanol, respectively at above $80^{circ}C$ for 90 minutes. The original and diluted extracts were tested for their antioxidant activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging activity assay. Cornus officinalis (C) and Scutellaria baicalensis (S) were selected to develop rice wines with higher antioxidant activities, based on the result of the 45% ethanol extraction. The rice wine developed using sample showed the highest antioxidant activity as comparing to those of other commercial rice wines. The rice wine samples were analyzed for titratable acidity, pH, $^{\circ}Brix$, reducing sugar content, color (L, a, b), amino-acidity, and ultraviolet absorption. The preferences for color, aroma, and overall acceptability were determined using a 9-point hedonic scale by 150 consumers. The sweetness, sourness, fruitiness, color, and medicinal herb-taste levels of the developed rice wines were also evaluated, using a 9-point just-about-right scale. The mean overall acceptability score of c (5.54) was higher than that of sample S. Based on the results, the sourness and medicinal herb-taste levels of sample s should be modified to higher levels, and the fruitiness of sample S also needs to be adjusted. For a future study, the final compositions of the developed rice wines will be adjusted for product launching based on the preference test data acquired in this study.