• Journal of the Society of Naval Architects of Korea
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• v.56 no.4
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• pp.298-307
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• 2019

The evolution of the cavity and the variation of the drag for an underwater body with control fins are investigated through a numerical analysis of the steady cavitating turbulent flow. The continuity and the steady-state RANS equations are numerically solved using a mixture fluid model for calculating the multiphase turbulent flow of air, water and vapor together with the SST $k-{\omega}$ turbulence model. The method of volume of fluid is applied by the use of the Sauer's cavitation model. Numerical solutions have been obtained for the cavity flow about an underwater body shaped like the Russian high-speed torpedo, Shkval. Results are presented for the cavity shape and the drag of the body under the influence of the gravity and the free surface. The evolution of the cavity with the body speed is discussed and the calculated cavity shapes are compared with the photographs of the cavity taken from an underwater launch experiment. Also the variation of the drag for a wide range of the body speed is investigated and analyzed in details.

• Journal of Ocean Engineering and Technology
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• v.35 no.1
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• pp.38-49
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• 2021

Slug flow is the most common multi-phase flow encountered in oil and gas industry. In this study, the hydrodynamic features of flow in pipes investigated numerically using computational fluid dynamic (CFD) simulations for the effect of slug flow on the vertical and bent pipeline. The compressible Reynold averaged Navier-Stokes (RANS) equation was used as the governing equation, with the volume of fluid (VOF) method to capture the outline of the bubble in a pipeline. The simulations were tested for the grid and time step convergence, and validated with the experimental and theoretical results for the main hydrodynamic characteristics of the Taylor bubble, i.e., bubble shape, terminal velocity of bubble, and the liquid film velocity. The slug flow was simulated with various air and water injection velocities in the pipeline. The simulations revealed the effect of slug flow as the pressure occurring in the wall of the pipeline. The peak pressure and pressure oscillations were observed, and those magnitudes and trends were compared with the change in air and water injection velocities. The mechanism of the peak pressures was studied in relation with the change in bubble length, and the maximum peak pressures were investigated for the different positions and velocities of the air and water in the pipeline. The pressure oscillations were investigated in comparison with the bubble length in the pipe and the oscillation was provided with the application of damping. The pressures were compared with the case of a bent pipe, and a 1.5 times higher pressures was observed due to the compression of the bubbles at the corner of the bent. These findings can be used as a basic data for further studies and designs on pipeline systems with multi-phase flow.

• Journal of the Society of Naval Architects of Korea
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• v.54 no.3
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• pp.215-226
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• 2017

This paper presents numerical results of the performance of a marin propeller in cavitating and non-cavitating flow conditions. The geometry and experimental validation data of the propeller are provided in Potsdam Propeller Test Case(PPTC) in the framework of the second International Symposium on Marine Propulsors 2011(SMP'11) workshop. The PPTC includes open water tests, velocity field measurements and cavitation tests. The present numerical analysis was carried out by using the Reynolds averaged Navier-Stokes(RANS) method on a wall-resolved grid ensuring a y+=1, where the SST k-${\omega}$ model was mainly used for turbulence closure. The influence of the turbulence model was investigated in the prediction of the wake field under a non-cavitating flow condition. The propeller tip vortex flows in both cavitating and non-cavitating conditions were captured through adaptation of additional grids. For the cavitation flows at three operation points, Schnerr-Sauer's cavitation model was used with a Volume-Of Fluid(VOF) approach to capture the two-phase flows. The present numerical results for the propeller wake and cavitation predictions including the open water performance showed a qualitatively reasonable agreement with the model test results.

• Journal of Periodontal and Implant Science
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• v.45 no.5
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• pp.169-177
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• 2015

Purpose: Despite the high success rates of endosseous dental implants, their placement is restricted according to the height and volume of bone available. The use of short or mini dental implants could be one way to overcome this limitation. Thus, this study aimed to compare standard, short, and mini dental implants with regard to associated clinical parameters and peri-implant crevicular fluid (PICF) levels of cathepsin-K (CTSK), RANK ligand (RANKL), and osteoprotegerin (OPG), after prosthodontic loading. Methods: A total of 78 non-submerged implants (Euroteknika, $Aesthetica^{+2}$, Sallanches, France) were installed in 30 subjects (13 male, 17 female; range, 26-62 years) who visited the clinic of the Periodontology Department, Faculty of Dentistry, Selcuk University. Sampling and measurements were performed on the loading date (baseline) and 2, 14, and 90 days after loading. Assessment of the peri-implant status for the implant sites was performed using the pocket probing depth (PPD), modified plaque index, modified gingival index, modified sulcular bleeding index, and radiographic signs of bone loss. PICF samples collected from each implant were evaluated for CTSK, RANKL, and OPG levels using the ELISA method. Keratinized tissue and marginal bone loss (MBL) were also noted. Results: Clinical parameters statistically significantly increased in each group but did not show statistical differences between groups without PPD. Although implant groups showed a higher MBL in the upper jaw, only the standard dental group demonstrated a statistically significant difference. At 90 days, the OPG:sRANKL ratio and total amounts of CTSK for each group did not differ from baseline. Conclusions: Within the limitations of this study, both short and mini dental implants were achieving the same outcomes as the standard dental implants in the early period after loading.

• Journal of the Society of Naval Architects of Korea
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• v.53 no.6
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• pp.494-502
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• 2016

The accurate assessment of hull-appendage interaction in the early design stage is important to control the inflow to the propeller plane, which can cause undesirable hydrodynamic effects in terms of cavitation phenomenon. This paper describes a numerical analysis for the flow around a fully appended surface ship model for which KRISO has carried out a model test in the Large Cavitation Tunnel(LCT). This numerical study was performed with the LCT model test in a complementary manner for a good reproduction of the wake distribution of surface ships. A second order accurate finite volume method provided by a commercial computational fluid dynamics(CFD) program was used to solve the governing Reynolds Averaged Navier-Stokes(RANS) equations, where the SST $k-{\omega}$ model was used for turbulence closure. The numerical results were compared to available LCT experimental data for validation. The calculations gave good predictions for the boundary layer profiles on the walls of the empty cavitation tunnel and the wake at the propeller plane of the fully appended hull model in the LCT.

• JSTS:Journal of Semiconductor Technology and Science
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• v.1 no.4
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• pp.239-247
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• 2001

The Fluorescence-Activated Cell Sorter (FACS) is a well-established instrument used for identifying, enumerating, classifying and sorting cells by their physical and optical characteristics. For a miniaturized FACS device, a disposable plastic microchip has been developed which has a hydrodynamic focusing chamber using soft lithography. As the characteristics of the spatially confined sample stream have an effect on sample throughput, detection efficiency, and the accuracy of cell sorting, systematic fluid dynamic studies are required. Flow visualization is conducted with a laser scanning confocal microscopy (LSCM), and three-dimensional flow structure of the focused sample stream is reconstructed from 2D slices acquired at $1\mutextrm{m}$ intervals in depth. It was observed that the flow structure in the focusing chamber is skewed by unsymmetrical velocity profile arising from trapezoidal cross section of the microchannel. For a quantitative analysis of a microscopic flow structure, Confocal Micro-PIV system has been developed to evaluate the accelerated flow field in the focusing chamber. This study proposes a method which defines the depth of the measurement volume using a detection pinhole. The trajectories of red blood cells (RBCs) and their interactions with surrounding flow field in the squeezed sample stream are evaluated to find optimal shape of the focusing chamber and fluid manipulation scheme for stable cell transporting, efficient detection, and sorting

• Journal of dental hygiene science
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• v.21 no.1
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• pp.45-51
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• 2021

Background: Periodontal disease, also known as gum disease, is a major dental inflammatory disease with a very high prevalence; it is the main cause of tooth loss. Therefore, diagnostic biomarkers that can monitor gum inflammation are important for oral healthcare. Since the gingival crevicular fluid (GCF) adequately reflects changes in the periodontal environment, they have become a target for the development of effective diagnostic biomarkers for periodontitis. In the present study, the level of the target molecules suggested as diagnostic biomarkers for periodontitis were analyzed in GCF samples collected from healthy individuals and periodontitis patients. In addition, useful targets for the diagnosis of periodontitis were evaluated. Methods: GCF samples were collected from healthy individuals and periodontitis patients using absorbent paper points. SDS-PAGE and Coomassie staining were performed for protein analysis. The protein concentrations of GCF specimens were determined using the Bradford method. The levels of the target molecules appropriate for diagnosing periodontal disease were measured by ELISA, according to the manufacturer's protocol. Results: The protein concentration of GCF collected from periodontitis patients was 3.72 fold higher than that in an equal volume of GCF collected from healthy individuals. ELISA analysis showed that the level of interukin-6 (IL-6), IL-8, metalloproteinases 2 (MMP-2), MMP-9, tumor necrosis factor-alpha (TNF-α), azurocidin, and odontogenic ameloblast-associated protein (ODAM) were higher in the GCF samples from the periodontitis patients than in those from the healthy individuals. However, the level of IL-6 and TNF-α were relatively low (> 5 pg/ml). The prostaglandin E2 (PGE2) levels were not significantly different between the two GCF samples. Conclusion: These results indicate that IL-8, MMP-2, MMP-9, azurocidin, and ODAM are potentially useful diagnostic biomarkers for periodontitis; combining multiple biomarkers will improve the diagnostic accuracy of periodontitis.

• Journal of Biomedical Engineering Research
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• v.43 no.4
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• pp.193-198
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• 2022

Contrast enhanced magnetic resonance imaging using gadolinium-based contrast agent (GBCA) is a very useful in vivo technique to visualize the inner ear pathology including endolymphatic hydrops. Although systemic intravenous (IV) administration can visualize the perilymph space, the visualization was possible by indirect passage of contrast agent through blood-perilymph barrier. All animal experimental procedures were performed under anesthesia with 5% isoflurane. Lipopolysaccharide (LPS) was instilled into the left tympanic cavity through the tympanic membrane using a sterile 27gauge needle to induce hydrops model. Tucker-Davis Technologies system was used to measure Auditory Brainstem Responses (ABRs). For intracerebroven-tricular (ICV) administration, 25 µmol of GADOVIST (Bayer, Berlin, Germany) was used and diluted GADOVIST injection was 10 µl. MR imaging was acquired with a 9.4 Tesla MRI scanner. Transmit-receive volume coil with 40 mm inner diameter and 75 mm out diameter was used. ICV administration well demonstrated the strong enhancement along the cerebrospinal fluid (CSF) microcirculation pathway including CSF fluid in the subarachnoid space and CSF space of the inner ear structures. On the other hand, IV administration showed no contrast enhancement along the CSF microcirculation pathway and showed weak enhancement in the inner ear structures. In case of rat hydrops model, ICV administration showed that the reduced contrast enhancement in the perilymph space of the hydrops induced inner ear compared to the contrast enhancement in the perilymph space of the normal inner ear. New systemic ICV administration method provide contrast enhancement of GBCA in the inner ear through CSF microcirculation pathway.

• Applied Biological Chemistry
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• v.44 no.3
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• pp.197-201
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• 2001

Extraction efficiency of ${\beta}-ecdysone$ in Achyranthis radix was investigated using the methods of solvent extraction and supercritical fluid extraction (SFE). The optimum SFE conditions for the analysis of ${\beta}-ecdysone$ in A. radix were 300 atm, $80^{\circ}C$, 100 ml of extraction volume, and 20% ratio of modifier(methanol). As revealed through SFE, detection limit of ${\beta}-ecdysone$ in A. radix was 5 ng and recoveries of ${\beta}-ecdysone$ in A. radix shoots and root were $90.7{\sim}93.5%$ and $77.8{\sim}81.9%$, respectively. Recoveries of ${\beta}-ecdysone$ in A. radix shoots and root through solvent extraction were $76.4{\sim}93.0%$ and $80.6{\sim}93.1%$, respectively. ${\beta}-Ecdysone$ content was determined to be highest at 654.9 ppm in the first year A. radix roots harvested in August.

• The KSFM Journal of Fluid Machinery
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• v.11 no.1
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• pp.9-17
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• 2008

A numerical study for three-dimensional laminar flow in the entrance region of helical tubes connected with straight ones is carried out to investigate the effects of Reynolds number, pitch and curvature ratio on the oscillation periods of the flow. The fully elliptic governing equations were solved by means of a finite volume method. The fully developed laminar flow boundary condition was applied at the straight tube inlet. This results cover a curvature ratio range of 1/10${\sim}$1/320, a pitch range of 0.0${\sim}$3.2, and a Reynolds number range of 62.5${\sim}$2000. A comparison is made with previous experimental correlations and numerical data. The developments of velocity, local and average friction factors are discussed. The average friction factors are oscillatory in the entrance region of helical pipes. It has been found that the angle required for the flow to be similarly developed is most affected by the curvature ratio. The pitch and Reynolds number do not have any significant effect on the angle. The characteristic angle ${\phi}_c(={\phi}/sqrt{\delta})$, or the characteristic length to diameter ratio $s_c(=l\sqrt{\delta} cos(atan{\lambda})/d)$, can be useful to represent the development of flow in helical tubes. As the pitch increases and as the curvature ratio and Reynolds number decrease, the amplitude and the number of flow oscillations along the main streamwise direction decrease.