• Biomolecules & Therapeutics
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• v.14 no.1
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• pp.45-49
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• 2006

The purpose of this study was to clarify the efflux transport system of choline from brain to blood across the blood-brain barrier (BBB) in rats using the brain efflux index (BEI) method. $[^3H]$Choline was micro-injected into parietal cortex area 2 (Par2) of the rat brain, and was eliminated from the brain with elimination halflife of 45 min. The BBB efflux clearance of $[^3H]$choline was about 124 mL/min/g brain, which was determined from combination of an elimination rate constant $(1.54X10^{-2}min^{-1})$ and the distribution volume in the brain (8.05 mL/g brain). The efflux of $[^3H]$choline was inhibited by unlabeled choline in a dose-dependent manner and was significantly inhibited by cationic substrates, such as hemicholinium-3 and tetraethylammonium (TEA). These results suggest that the BBB may act as an efflux pump for choline to reduce the excessive choline concentration in the brain interstitial fluid.

• Korean Journal of Chemical Engineering
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• v.35 no.11
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• pp.2164-2171
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• 2018

Heavy duty diesel vehicles deteriorate urban air quality by discharging a large volume of air pollutants such as soot and nitrogen oxides. In this study, a newly introduced auxiliary device a fuel activation device (FAD) to improve the combustion efficiency of internal engines by utilizing the cavitation effect was closely investigated by the fluid flow mechanism via a numerical analysis method. As a result, the FAD contributed to fuel atomization from the injection nozzle at lower inlet pressure by reducing the pressure energy. The improved cavitation effect facilitated fuel atomization, and ultimately reduced pollutant emission due to the decrease in fuel consumption. The axial velocity along the flow channel was increased 8.7 times with the aid of FAD, which improved the primary break-up of bubbles. The FAD cavitation effect produced 1.09-times larger turbulent bubbles under the same pressure and fuel injection amount than without FAD.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.3
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• pp.279-285
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• 2011

We perform a numerical study to determine the time of onset of natural convection in a transient hot wire (THW) device for measuring the thermal conductivity of nanofluids. The samples used in this simulation are water-based $Al_2O_3$ nanofluids with volume fractions of 1%, 4%, and 10%, and the properties are calculated by theoretical models and experimental correlations. The THW apparatus using coated wire is modeled by the control-volume-based finite difference method, and the start of natural convection is determined by observing the temperature rise of the wire under a gravity field. The onset time is 11.5 s for water and 41.6 s for water-based $Al_2O_3$ nanofluids predicted by Maxwell thermal conductivity model with a 10% volume fraction. We confirm that the onset time of natural convection of nanofluids in the cylinder increases with the nanoparticle volume fraction. We suggest a correlation for predicting the onset time on the basis of the numerical results. Finally, it is shown that the measurement error due to natural convection is negligible if the measurement using the transient hot wire method is completed before the onset of natural convection in the base fluid.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1307-1311
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• 2007

Three-dimensional transient keyhole profile is numerically analyzed for the case of stationary laser keyhole welding. Volume of fluid (VOF) method is adopted to track the free surface of molten metal based on the three governing equations which are continuity, momentum and energy equations. Multiple reflections of laser beam at the keyhole walls are also included in analysis through a real-time ray tracing technique. In this simulation, especially, polarization of laser is considered as an energy absorption mechanism following the Fresnel reflection theory. Both cases of linearly and circularly polarized beam are simulated and compared. The results show that the theoretically generated keyhole is asymmetrically stretched along the direction of polarization which is already observed experimentally before.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.9 no.4
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• pp.484-496
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• 1997

The fluid flow and heat transfer characteristics of conjugate forced and natural convection in the triple-glazed airflow window, where the outer air passes through a space contrived between the interior and exterior window panes, were studied numerically by a finite volume method for the elliptic form of the Navier-Stokes equations. The investigation focused on the influence of window geometry, ventilastion rate and solar energy on the temperature, velocity distribution and thermal performance of the airflow window. The comparison between the triple-glazed airflow window and the enclosed triple-glazed window was also made to evaluate the effect of buoyancy upon which the thermal performance of the window depended.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.532-537
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• 2007

Nano imprint lithography(NIL) is a cost-efficient, high-throughput processing technique to transfer nano-scale patterns onto thin polymer films. Polymers used as the resist include UV cured resins as well as thermoplastics such as polymethyl-methacrylate(PMMA). In this study, an analytic investigation was performed for the NIL process of transferring nano scale patterns onto polymeric films. Process optimization calls for a thorough understanding of resist flow during the process. We carried out 2D and 3D numerical analyses of resist flow during NIL process. The simulation incorporated continuum-hypothesis and the effects of surface tension were taken into account. For a more effective prediction of free surface, fixed grid scheme with the volume of fluid (VOF) method were used. The simulation results were verified with experimental results qualitatively. And the parametric study was performed for various process conditions.

• International Journal of Air-Conditioning and Refrigeration
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• v.9 no.2
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• pp.51-61
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• 2001

A numerical study has been conducted to characterize the transient pressure in a simple water supply pipe system with an air chamber by utilizing a commercial code that employs the method of characteristics. Some results produced for validation in the study agree quite well with the previously reported. Several parameters are than varied. Among them are the valve closure time, the wave speed, the static pressure, the polytropic exponent, the air chamber volume, the diameter and the shape of orifice in the air chamber, etc, while the water temperature and velocity are kept constant at $20^\circ{C}$ and 0.8m/s, respectively. Results reported in this parametric study may be useful to understand the unsteady behavior of the system.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.1195-1200
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• 2004

A fully coupled fluid flow, heat, and solute transport model was developed to investigate turbulent flow, solidification, and macrosegregation in a continuous casting process of steel slab with EMBR. Transport equations of mass, momentum, energy, and species for a binary iron-carbon alloy system were solved using a continuum model. The electromagnetic field was described by the Maxwell equations. A finite-volume method was employed to solve the conservation equations associated with appropriate boundary conditions. The effects of intensity of magnetic field and carbon segregation were investigated. The electromagnetic field reduces the velocity of molten flow in the mold and an increase in the percentage of C in steel results in a decrease of carbon segregation ratio.

• Proceedings of the KIEE Conference
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• 2006.10c
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• pp.591-593
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• 2006

The differential pressure method has been used in the level measurement of steam generator in nuclear power plant. Two sensing lines from a steam generator to a pressure transmitter are needed to measure the high pressure and low pressure. The fluid conditions in the sensing line require the uniform phase with no bubbles and the slope of sensing line should be installed with forward slope. The expansion of the bubble volume according to the upper pressure and the reverse slope of sensing lines explain how the level errors took place.

• Wind and Structures
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• v.18 no.3
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• pp.215-233
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• 2014

This paper presents a method to extract flutter derivatives of bridge decks based on a combination of the computational fluid dynamics (CFD), system simulations and system identifications. The incompressible solver adopts an Arbitrary Lagrangian-Eulerian (ALE) formulation with the finite volume discretization in space. The imposed sectional motion in heaving or pitching relies on exponential time series as input, with aerodynamic forces time histories acting on the section evaluated as output. System identifications are carried out to fit coefficients of the inputs and outputs of ARMA models, as to establish discrete-time aerodynamic models. System simulations of the established models are then performed as to obtain the lift and moment exerting on the sections to a sinusoidal displacement. It follows that flutter derivatives are identified. The present approaches are applied to a hexagon thin plate and a real bridge deck. The results are compared to the Theodorsen closed-form solution and those from wind tunnel tests. Satisfactory agreements are observed.