• 제목/요약/키워드: Volume of distribution

검색결과 2,605건 처리시간 0.027초

중년비만 여성용 재킷패턴의 여유량 분포에 따른 착시효과 (The Visual Illusion Using the Adequate Ease Distribution of Jacket Pattern for the Middle Aged Women of Obese Figure)

  • 손부현
    • 한국생활과학회지
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    • 제17권3호
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    • pp.469-483
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    • 2008
  • Body image is important as it is related to self-esteem and can be enhanced by clothing and the degree of enhancement is related to clothing fit. The purpose of the paper is to find the adequate ease distribution of jacket pattern for the obese women who want to slenderize their shape by optical illusion. Subjective evaluation of the visual appearance we collected and, at the same time, 3D clothing air volume was observed for the nine types of experimental jackets with different ease distribution. As results it was found that jacket pattern for the obese women is that the front width of pattern is wider than what of back width in waist and abdomen. It was also noted that there was distance between clothing and skin in the girth around hip of jacket. 3D scanner clearly demonstrated the distribution of ease is useful to find the pattern variables responsible for the slender appearance of the obese women. The ready-to-made clothes for the obese women's clothing should be manufactured systematically in due consideration of the diversity and scarcity of the obese women's body shape.

육계에서 경구투여시 enrofloxacin 제제에 따른 생체이용율 및 약물동태 (Bioavailability and Comparative Pharmacokinetics of Two Enrofloxacin Formulations in Broiler Chickens)

  • 윤효인;박승춘
    • 한국임상수의학회지
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    • 제14권2호
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    • pp.195-200
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    • 1997
  • In order to compare the pharmacokinetic profiles of enrofloxacin-HCL)ENFLX-HCL) and enrofloxacin-KOH (ENFLX-KOH) after oral administration in broiler chickens, the study was performed. The chickens used in this study weighed $1.82 {\pm}0.2 kg$ and clinically healthy. The dose of intravenous and lral administration was 5 mg per kg of body weight as enrofloxacin. After intravenous injection of enrofloxacin, it showed two-compartment model with the rapid distribution phase and the slow elimination phase. The mean apparent volume of distribution (Vd) was 2.70 l/kg. The mean half-life of elimination and distribution showed 8.26 h and 0.44 h, respectively. The mean area under curve (AUC) was calculated as $19.7 {\mu} g{\cdot} h/ml$. After oral administration of ENFLX-HCL and ENFLX-KOH with a rate of dose 5 mg of enrofloxacin/kg of body weight, Both of the products were showed one-compartment model unlike that of i.v. enrofloxacin standard solution showed the mean bioavailability of 79.64% for the ENFLX-KOG and 86.24% for the ENFLX-HCL. The mean total body clearance of the former was 0.24 l/kg/h and the latter 0.42 l/kg/h. Both enorfloxacin formulations seemed to have good tissue distribution and penetration as indicated by large volume of distribution : 2.72 l/kg for the -KOH and 4.44 l/kg for the -HCL. With the results obtained in this study, ENFLX-HCL could be used in place of its salt form in chickens.

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자유체적이론을 고려한 플라스틱의 급냉시 잔류응력의 분포 (The Distribution of Residual Stresses in Quenched Plastic Parts including Fee Volume Theory)

  • 김종선
    • 한국소성가공학회:학술대회논문집
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    • 한국소성가공학회 2000년도 춘계학술대회논문집
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    • pp.106-111
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    • 2000
  • The residual stresses in molded plastic parts can be divided into the flow induced residual stresses produced in flowing stages and the thermally induced residual stresses produced in cooling state. Reducing residual stresses in the final parts is one of the goals in recent study. The present study focused on comparing the predicted values for thermal residual stresses in freely and constrained quenched plastic plates with and without free volume theory. As a result the final residual stresses showed the opposite pattern in thickness direction. furthermore by applying free volume theory the predicted residual stress at the center showed about 50% of the values without free volume theory for constrained quenched case.

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아음속 횡단류에 수직 분사되는 분무의 액적크기 및 속도 분포 특성 (Droplet Sizes and Velocities from Single-Hole Nozzle in Transversing Subsonic Air-stream)

  • 이인철;조우진;이봉수;김종현;구자예
    • 한국추진공학회:학술대회논문집
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    • 한국추진공학회 2007년도 제28회 춘계학술대회논문집
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    • pp.106-109
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    • 2007
  • The spray plume characteristics of liquid water jet injected into subsonic cross-flow at 42 m/s were experimentally investigated. Nozzle has a 1.0 m diameter and L/D=5. Droplet sizes, velocities, volume flux were measured at each downstream area of the injector exit using phase Doppler particle anemometry. Measuring probe position is moved with 3-way transversing machine. Experimental results indicate that SMD is varied from 75 to $120{\mu}m$ distribution and it is uncertain layer structure. SMD peaks at the top of the spray plume. This phenomenon is related to the momentum exchange between column waves and cross-flow stream. Droplet vector velocities were varied from 11.5 to 33 m/s. A higher-velocity region can be identified in down edge region at Z/D : 40, 70 and 100. Lower-velocity region were observed on bottom position of the spray plume. Volume flux is a criterion to the droplet concentration. All volume flux distribution has a same structure that continuously decreases from the center region to the edge of the plume. Z/D : 20 is spatially less concentrated than in Z/D : 100.

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2차원 배열형 이온함의 부피효과가 세기조절방사선치료의 선량분포 측정에 미치는 영향 (The Influence of Volume Effect in 2D-array Ion Chamber on the Measurement of IMRT Dose Distribution)

  • 김성준;이승준;박인규;이정은;박신형;설기호;김재철
    • 한국의학물리학회지:의학물리
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    • 제24권1호
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    • pp.41-47
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    • 2013
  • 부피효과를 가지는 2차원 배열형 이온함으로부터 측정된 세기조절방사선치료의 선량분포와 부피효과를 가지지 않는 장치로부터 측정된 선량분포를 비교함으로써 이 효과가 측정결과에 미치는 영향에 대해 평가하였다. 조사면 크기에 따라 총 5개의 세기조절방사선치료계획을 5문 조사방식으로 가상의 팬톰에 시행하였다. 선량분포 측정은 매트릭스 팬톰, 빔 영상시스템, 필름 등 총 3가지 측정장치를 이용하였다. 측정된 값은 분석프로그램을 이용하여 전산화치료계획 시스템을 통해 획득된 선량분포와 비교하였다. 비교된 선량분포는 분석프로그램 상에서 상관계수와 감마값을 통해 측정장치의 부피효과 유무에 따른 차이를 분석한 결과 매트릭스 팬톰에서 최대 1.3% 이상으로 나타났다. 매트릭스 팬톰은 조사면의 크기가 작아질수록 내부의 이온함에 의해 부피효과가 커지게 되므로 다른 측정장치에 비해 더 큰 측정오차를 가지는 것으로 판단되었다.

한국재래(韓國在來) 염소의 체액량(體液量) (Body Fluid Volumes of Korean Native Goats)

  • 양일석;이영소;정순동
    • 대한수의학회지
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    • 제16권2호
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    • pp.187-190
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    • 1976
  • In order to approximate plasma volume, extracellular fluid volume and total body water volume of Korean native goats, measurements were made of the volumes of distribution of Evans blue, potasium thiocyanate and antipyrine. The results obtained in this work were summarized as follows: 1. Plasma volume showed a range of 50 to 72ml/kg with a mean of $62{\pm}6.2ml/kg$ (SD). 2. Blood volume showed a range of 69 to 98ml/kg with a mean of $85{\pm}7.9ml/kg$. 3. Extracellular fluid volume showed a range of 265 to 310ml/kg with a mean of $297{\pm}18.3ml/kg$. 4. Interstitial fluid volume showed a range of 204 to 261ml/kg with a mean of $236{\pm}16.8ml/kg$. 5. Intracellular fluid volume showed a range of 380 to 436ml/kg with a mean of $420{\pm}12.6ml/kg$. 6. The volume of total body water showed a range of 680 to 735ml/kg with a mean of $714{\pm}17.7ml/kg$.

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Assessment of The Accuracy of The MR Abdominal Adipose Tissue Volumetry using 3D Gradient Dual Echo 2-Point DIXON Technique using CT as Reference

  • Kang, Sung-Jin
    • Journal of Magnetics
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    • 제21권4호
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    • pp.603-615
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    • 2016
  • In this study, in order to determine the validity and accuracy of MR imaging of 3D gradient dual echo 2-point DIXON technique for measuring abdominal adipose tissue volume and distribution, the measurements obtained by CT were set as a reference for comparison and their correlations were evaluated. CT and MRI scans were performed on each subject (17 healthy male volunteers who were fully informed about this study) to measure abdominal adipose tissue volume. Two skilled investigators individually observed the images acquired by CT and MRI in an independent environment, and directly separated the total volume using region-based thresholding segmentation method, and based on this, the total adipose tissue volume, subcutaneous adipose tissue volume and visceral adipose tissue volume were respectively measured. The correlation of the adipose tissue volume measurements with respect to the observer was examined using the Spearman test and the inter-observer agreement was evaluated using the intra-class correlation test. The correlation of the adipose tissue volume measurements by CT and MRI imaging methods was examined by simple regression analysis. In addition, using the Bland-Altman plot, the degree of agreement between the two imaging methods was evaluated. All of the statistical analysis results showed highly statistically significant correlation (p<0.05) respectively from the results of each adipose tissue volume measurements. In conclusion, MR abdominal adipose volumetry using the technique of 3D gradient dual echo 2-point DIXON showed a very high level of concordance even when compared with the adipose tissue measuring method using CT as reference.

Optimization and Mathematical Modeling of the Transtubular Bioreactor for the Production of Monoclonal Antibodies from a Hybridoma Cell Line

  • Halberstadt, Craig R.;Palsson, Bernhanrd O.;Midgley, A.Rees;Curl, Rane L.
    • Biotechnology and Bioprocess Engineering:BBE
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    • 제7권3호
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    • pp.163-170
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    • 2002
  • This report describes the use of a transtubular bioreactor to study the relative effects of diffusion versus perfusion of medium on antibody production by a hybridoma cell line. The study was performed with a high-density cell culture maintained in a serum-free, low-protein medium for 77 days. It was determined that the reactor possessed a macro-mixing pattern residence time distribution similar to a continuous stirred tank reactor (CSTR), However, due to the arrangement of the medium lines in the reactor, the flow patterns for nutrient distribution consist of largely independent medium path lengths ranging from short to long. When operated with cyclic, reversing, transtubular medium flow, some regions of the reactor (with short residence times) are more accessible to medium than others (with long residence times). From this standpoint, the reactor can be divided into three regions: a captive volume, which consists of medium primarily delivered via diffusion; a lapped volume, which provides nutrients through unilateral convection; and a swept volume, which operates through bilateral convection. The relative sizes of these three volumes were modified experimentally by changing the period over which the direction of medium flow was reversed from 15 min (larger captive volume) to 9 h (larger swept volume). The results suggest that antibody concentration increases as the size of the diffusion-limited (captive) volume is increased to a maximum at around 30 min with a sharp decrease thereafter. As reflected by changes in measured consumption of glucose and production of lactate, no significant difference in cellular metabolism occurred as the reactor was moved between these different states. These results indicate that the mode of operation of the transtubular bioreactor may influence antibody productivity under serum-free, low-protein conditions with minimal effects on cellular metabolism.

대기 중 다환방향족 탄화수소의 측정을 위한 시료포집방법의 비교평가 (Evaluation of Sampling Methodology for the Measurement of Polycyclic Aromatic Hydrocarbons in the Atmosphere)

  • 백성옥;최진수
    • 한국대기환경학회지
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    • 제14권1호
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    • pp.43-62
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    • 1998
  • This study was carried out to investigate the influence of different sampling methods on the measured concentrations of polycyclic aromatic hydrocarbons (PAH) both in the vapor and particulate phases, and to evaluate the effects of ambient temperature and sampling duration on the losses of PAH associated with particle samples due to volatilization. The experimental protocol of this study is consisted of two parts. The first part is related to the comparison of PAH concentrations measured by 4 different sampling systems, each of which involves different sampling principles for comparison purposes, including a medium-volume sampler with XAD-2 adsorbent, a high-volume sampler with polyurethane foam (PUF), two identical low-volume samplers: one with XAD-2 and the other with PUF, respectively. The second part of this study is to quantitatively estimate the losses of particulate PAH samples by volatilization during sampling, using two identical low-volume samplers: one was used for changing the filters every 3 hrs, 6 hrs, 12 hrs, and 24 hrs sampling, while the other was maintained for continuous 48 hours sampling without changing the filter. The concentrations of volatile PAH including 2-3 rings appeared to be significantly affected by the type of adsorbent. Measured levels of these lower-molecular weight PAH by XAD-2 adsorbent were much higher than those by PUF for both high-volume and low-volume sampling. PUF was found to give rise to unknown components that interfered with the PAH analysis, even after extensive clean-up. In addition, the retention efficiency of PUF for lower molecular weight PAH was subject to a large variation, being significantly influenced by sampling conditions such as ambient temperature. However, the effect of sampling methods with different adsorbents on the measured levels of semi-volatile compounds including 4 rings PAH such as fluoranthene, pyrene, BaA and chrysene, was not so much significant as more volatile PAH compounds. It was also clear from this study that volatilization losses of the semi-volatile PAH collected on the filters were inevitably occurred during prolonged sampling, and hence the results obtained from conventional sampling methods may not be expected to yield an accurate distribution of PAH between the vapor and particulate phases.

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The Proper Volume and Distribution of Cement Augmentation on Percutaneous Vertebroplasty

  • Kim, Dong-Joon;Kim, Tae-Wan;Park, Kwan-Ho;Chi, Moon-Pyo;Kim, Jae-O
    • Journal of Korean Neurosurgical Society
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    • 제48권2호
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    • pp.125-128
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    • 2010
  • Objective : The purpose of this study was to determine the optimal volume of injected cement and its distribution when used to treat vertebral compression fractures, and to identify factors related to subsequent vertebral fractures. Methods : A retrospective analysis of newly developing vertebral fractures after percutaneous vertebroplasty was done. The inclusion criteria were that the fracture was a single first onset fracture with exclusion of pathologic fractures. Forty-three patients were included in the study with a minimum follow up period of six months. Patients were dichotomized for the analysis by volume of cement, initial vertebral height loss, bone marrow density, and endplate-to-endplate cement augmentation. Results : None of the four study variables was found to be significantly associated with the occurrence of a subsequent vertebral compression fracture. In particular, and injected cement volume of more or less that 3.5 cc was not associated with occurrence (p = 0.2523). No relation was observed between initial vertebral height loss and bone marrow density (p = 0.1652, 0.2064). Furthermore, endplate-to-endplate cement augmentation was also not found to be significantly associated with a subsequent fracture (p = 0.2860) by Fisher's exact test. Conclusion : Neither volume of cement, initial vertebral height loss, bone marrow density, or endplate-to-endplate cement augmentation was found to be significantly related to the occurrence of a subsequent vertebral compression fracture. Our findings suggest that as much cement as possible without causing leakage should be used.