• Proceedings of the Korea Information Processing Society Conference
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• 한국정보처리학회 2021년도 춘계학술발표대회
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• pp.273-276
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• 2021

최근의 기계 학습 (딥러닝)은 기존의 전통적인 통계 분석 방법들에 비해 효율성과 정확도가 높은 장점이 있지만, 처리과정이 블랙박스와 같아 결과 값의 중요한 원인 또는 근거 요인을 찾기 어렵다는 단점을 가지고 있다. 이를 해결하기 위한 최근의 XAI (eXplainable AI) 연구를 기반으로 하여, 본 논문에서는 의료기관에서 전정기관의 이상을 판별하기 위해 수작업으로 이루어지고 있는 HIT (head impulse test) 테스트 결과를 자동화하고, 설득력 있는 신뢰도 검정을 위해, XAI 기반 DoWhy 프레임 워크를 사용하였다. 전정기관 이상으로 의심되는 환자의 동공 움직임을 optical flow 로 추적하고, 정상인과의 Wasserstein metric 의 DoWhy 검증을 통해 전정기관 이상 여부의 신뢰도 구간을 검정한다.

• Korean Journal of Veterinary Research
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• 제63권3호
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• pp.26.1-26.5
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• 2023

Syringobulbia is a rare neurological disorder characterized by a fluid-filled cavity in the brainstem. In this study, clinical signs, features on magnetic resonance imaging (MRI), and the diseases present concurrently with syringobulbia were investigated in 33 small breed dogs. Most dogs (97%) had concurrent syringomyelia, and some dogs (24%) presented with vestibular or cranial nerve symptoms associated with the medulla oblongata. MRIs revealed slit-like, bulbous, and vertical linear shapes of the cavities on T2-weighted hyperintense and T1-weighted hypointense signals similar to the cerebrospinal fluid. Chiari-like malformations were identified in all dogs. This study highlights the association of syringobulbia with syringomyelia and Chiari-like malformations in small breed dogs with or without brainstem-associated clinical signs.

• Journal of the korean academy of Pediatric Dentistry
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• 제26권2호
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• pp.323-330
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• 1999

It is well recognized that a cross-bite tends to occur more frequently among Japanese, Chinese and Koreans more than among Europeans. A variety of functional appliances have already invented for the treatment of cross-bites. One of them is the FR III(by Rolf $Fr\ddot{a}nkel$) which applies a quite different philosophy based on the using vestibular region compared with other methods which utilize muscular forces applied directly on the teeth. The FR III also increases both the lack of muscular tension against the dental arch and the dentition and muscular forces which can then influence the teeth indirectly. This mechanism can achieve favorable developments with the basal bone, teeth, and alveolar bone. After using FR III to the anterior cross-bite patient with the eruption of a maxillary incisor the results were as follows: 1. Forward growth of maxilla and proclination of the upper incisor 2. Downward and backward rotation of the mandible 3. Increase the facial height 4. The case which was normal mandible, underdevelopmental maxilla, deeper overbite and more nagative overjet exhibited good prognosis

• Journal of the Korea Academia-Industrial cooperation Society
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• 제12권12호
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• pp.5518-5524
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• 2011

The purpose of this study is to investigate the change of balance ability on aging by measuring balance ability of elderly females whose age is over 65. The subjects are ten elderly women (the mean age: 71.9) able to walk without assistants, the assistant equipments and drug dependence and ten young healthy women (the mean age: 23.2). We measured stability index (ST), Fourier index (F), weight distribution (WD), weight distribution index (WDI), synchronization index (SI) and fall index (FI) by using Tetrax (Tetra-ataxiometric Posturography). In result, STs and Fs at the low frequency region (F1) represented the significant difference between two groups at all postures with PO (pillow with eye open) exception (p<.01). Fs at the other frequency regions (F2~F8) represented the significant difference between two groups (p<.05). WDI of the elderly women represented the higher values than the young women at all postures but there are the significant difference at PO and PC (pillow with eye closed) only. These results may be due to age-related ability decline of somatesthesia, vestibular organ, central nervous system.

• Journal of Biomedical Engineering Research
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• 제28권5호
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• pp.590-600
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• 2007

We performed experimental studies on the muscle activities in the lower limbs for the different movement patterns on an unstable platform. A training system for postural control using an unstable platform that we previously developed was applied for the experiments. This unstable platform provides 360 degrees of movement allowing for training of posture in various directions and provides simultaneous excitations to visual sensory, somatic sensation and vestibular organs. Compare with the stable platform, keeping body balance on the unstable platform requests more effective sensation from vision, vestibular sense and somatic sense. Especially, the somatosensory inputs from the muscle proprioceptors and muscle force are crucial. To study the muscle activities for the different movement patterns and find the best training method for improving the ability of postural control through training and improving the lower extremity muscular strength, fifteen young healthy participants went through trainings and experiments. The participants were instructed to move the center of pressure following the appointed movement pattern while standing on the unstable platform. The electromyographies of the muscles in the lower limbs were recorded and analyzed in the time and the frequency domain. Our experimental results showed the significant differences in muscle activities for the different movement patterns. Especially, the spectral energy of electromyography signals in muscle for the movement pattern in anterior-posterior direction was significantly higher than those occurred in the other patterns. The muscles in the lower leg, especially tibialis anterior and gastrocnemius were more activated compared to the others for controlling the balance of body on the unstable platform. The experimental results suggest that, through the choice of different movement pattern, the training for lower extremity strength could be performed on specific muscles in different intensity. And, the ability of postural control could be improved by the training for lower extremity strength.

• Applied Microscopy
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• 제41권2호
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• pp.123-128
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• 2011

The micropyles on the prefertilized and artificial fertilized eggs of Epinephelus fasciatus were investigated using scanning electron microscope (SEM). The micropyles ($6.6{\pm}0.41\;{\mu}m$) of E. fasciatus eggs were found in the animal pole and theirs shape were observed as a flat crateriform of cylindrical shape. The micropylar vestibule arranged by 6~7 thickened spiral annuli on the ridge and contributed to differentiate and form fertilization cone for blocking to polyspermy by presenting swollen vestibule structure. As E. fasciatus eggs was pelagic, so chorionic surface was an uneven structures such as circular and fillar form nodules. Especially, various pores (0.15~0.55 ${\mu}m$, 230~270 pores) distributed at the only around micropyles, those pores radiately exhibited regular projection structures showing gill filament-shape. These ultrastructural characters of E. fasciatus eggs can be utilized in a taxonomical cue of grouper species.

• Journal of Life Science
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• 제30권11호
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• pp.939-946
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• 2020

Stroke is one of the leading causes of neurological disability worldwide and stroke patients exhibit a range of motor, cognitive, and psychiatric impairments. GPR88 is an orphan G protein-coupled receptor (GPCR) that is highly expressed in striatal medium spiny neurons; its deletion results in poor motor coordination and motor learning. There are currently no studies on the involvement of GPR88 in stroke or in post-stroke brain function recovery. In this study, we found a decrease in GPR88 protein and mRNA expression levels in an ischemic mouse model using Western blot and real-time PCR, respectively. In addition, we observed that, among the three types of cells derived from the brain (brain microvascular endothelial cells, BV2 microglial cells, and HT22 hippocampal neuronal cells), the expression of GPR88 was highest in HT22 neuronal cells, and that GPR88 expression was downregulated in HT22 cells under oxygen-glucose deprivation (OGD) conditions. Moreover, pretreatment with RTI- 13951-33 (10 mg/kg), a brain-penetrant GPR88 agonist, ameliorated brain injury following ischemia, as evidenced by improvements in infarct volume, vestibular-motor function, and neurological score. Collectively, our results suggest that GPR88 could be a potential drug target for the treatment of central nervous system (CNS) diseases, including ischemic stroke.

• The Korean Journal of Physiology and Pharmacology
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• 제19권5호
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• pp.427-434
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• 2015

Significant evidence supports the role of the vestibular system in the regulation of blood pressure during postural movements. In the present study, the role of the vestibulo-spino-adrenal (VSA) axis in the modulation of blood pressure via the vestibulosympathetic reflex was clarified by immunohistochemical and enzyme immunoassay methods in conscious rats with sinoaortic denervation. Expression of c-Fos protein in the intermediolateral cell column of the middle thoracic spinal regions and blood epinephrine levels were investigated, following microinjection of glutamate receptor agonists or antagonists into the medial vestibular nucleus (MVN) and/or sodium nitroprusside (SNP)-induced hypotension. Both microinjection of glutamate receptor agonists (NMDA and AMPA) into the MVN or rostral ventrolateral medullary nucleus (RVLM) and SNP-induced hypotension led to increased number of c-Fos positive neurons in the intermediolateral cell column of the middle thoracic spinal regions and increased blood epinephrine levels. Pretreatment with microinjection of glutamate receptor antagonists (MK-801 and CNQX) into the MVN or RVLM prevented the increased number of c-Fos positive neurons resulting from SNP-induced hypotension, and reversed the increased blood epinephrine levels. These results indicate that the VSA axis may be a key component of the pathway used by the vestibulosympathetic reflex to maintain blood pressure during postural movements.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권2호
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• pp.133-139
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• 2012

This is a review regarding Mulliken's Modification using the Millard rotation-advancement principle for the repair of unilateral complete cleft lip and nasal deformity. All patients underwent prior labionasal adhesion and dentofacial orthopedics with a pin-retained (Latham) appliance used for infants with a cleft of the lip and palate. Technical variations concerning the operation are described. A high rotation and releasing incision in the columella lengthens the medial labial element and produces a symmetric prolabium with minimal transgression of the upper philtral column through the advancement flap. The orbicularis oris muscle is everted, from caudad to cephalad, to form the philtral ridge. A minor variation of unilimb Z-plasty is used to level the cleft side of Cupid's bow handle, and cutaneous closure proceeds superiorly from this junction. The dislocated alar cartilage is visualized though a nostril rim incision and suspended to the ipsilateral upper lateral cartilage. Symmetry of the alar base is addressed in three dimensions, including maneuvers to position the deviated anterior-caudal septum, configure the sill, and efface the lateral vestibular web. The authors believe the technical refinements described herein contribute favorably to the outcome of repair regarding unilateral cleft lip and nasal distortion.

• The Journal of Korean Academy of Sensory Integration
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• 제15권1호
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• pp.10-20
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• 2017

Objective : The purpose of this study was to investigate the effect of proprioceptive-vestibular based sensory integrative intervention on handwriting and fine motor function in elementary school students in grades 1 to 3. Methods : In this study, eight students in an elementary school in Busan were enrolled. The intervention was conducted twice a week from May to October, 2016, and a total of 14 intervention sessions were conducted. In order to evaluate the writing ability and the fine-motor exercise ability before and after the intervention, the fine-motor movement items of the Korean alphabet writing test and the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) evaluation were used. Results : There was a statistically significant difference between the total scores of consonant writing and the Korean alphabet writing assessment after the intervention. In BOTMP-Fine motor, the response speed items showed statistically significant difference. Visual-motor control scores increased during intervention, but the statistical significance was not found. Conclusion : Sensory integration interventions might have positive effects on elementary school students' writing skills and fine motor functions.