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Magnetic resonance imaging features of syringobulbia in small breed dogs

  • Young-Mok Song (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University) ;
  • In Lee (Ian Animal Diagnostic Center) ;
  • Yu-Mi Song (Ian Animal Diagnostic Center) ;
  • Ho-Jung Choi (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University) ;
  • Young-Won Lee (College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University)
  • Received : 2023.07.27
  • Accepted : 2023.08.28
  • Published : 2023.09.30

Abstract

Syringobulbia is a rare neurological disorder characterized by a fluid-filled cavity in the brainstem. In this study, clinical signs, features on magnetic resonance imaging (MRI), and the diseases present concurrently with syringobulbia were investigated in 33 small breed dogs. Most dogs (97%) had concurrent syringomyelia, and some dogs (24%) presented with vestibular or cranial nerve symptoms associated with the medulla oblongata. MRIs revealed slit-like, bulbous, and vertical linear shapes of the cavities on T2-weighted hyperintense and T1-weighted hypointense signals similar to the cerebrospinal fluid. Chiari-like malformations were identified in all dogs. This study highlights the association of syringobulbia with syringomyelia and Chiari-like malformations in small breed dogs with or without brainstem-associated clinical signs.

Keywords

References

  1. Williamson B, Davies E, Epperly E, Roynard P, Scrivani PV. Signs consistent with syringobulbia may be detected in dogs undergoing MRI. Vet Radiol Ultrasound 2019;60:390-399. https://doi.org/10.1111/vru.12733
  2. Sherman JL, Citrin CM, Barkovich AJ. MR imaging of syringobulbia. J Comput Assist Tomogr 1987;11:407-411. https://doi.org/10.1097/00004728-198705000-00007
  3. Jha S, Das A, Gupta S, Banerji D. Syringomyelia with syringobulbia presenting only with paralysis of 9th and 10th cranial nerves. Acta Neurol Scand 2002;105:341-343. https://doi.org/10.1034/j.1600-0404.2002.1c232.x
  4. Menezes AH, Greenlee JD, Dlouhy BJ. Syringobulbia in pediatric patients with Chiari malformation type I. J Neurosurg Pediatr 2018;22:52-60. https://doi.org/10.3171/2018.1.PEDS17472
  5. Taghipour M, Derakhshan N, Ghaffarpasand F. Isolated post-traumatic syringobulbia; case report and review of the literature. Bull Emerg Trauma 2014;2:166-169.
  6. Mousele C, Georgiopoulos M, Constantoyannis C. Syringobulbia: a delayed complication following spinal cord injury: case report. J Spinal Cord Med 2019;42:260-264. https://doi.org/10.1080/10790268.2018.1439437
  7. Shen J, Shen J, Huang K, Wu Y, Pan J, Zhan R. Syringobulbia in patients with Chiari malformation type I: a systematic review. Biomed Res Int 2019;2019:4829102.
  8. Shuster A, Landry D. Case 191: giant hemorrhagic syringomyelia and syringobulbia mimicking intramedullary neoplasm. Radiology 2013;266:991-993. https://doi.org/10.1148/radiol.12110071
  9. Greenlee JD, Menezes AH, Bertoglio BA, Donovan KA. Syringobulbia in a pediatric population. Neurosurgery 2005;57:1147-1153. https://doi.org/10.1227/01.NEU.0000188282.72429.79
  10. Menezes AH, Greenlee JD, Longmuir RA, Hansen DR, Abode-Iyamah K. Syringohydromyelia in association with syringobulbia and syringocephaly: case report. J Neurosurg Pediatr 2015;15:657-661. https://doi.org/10.3171/2014.11.PEDS14189
  11. Milhorat TH. Classification of syringomyelia. Neurosurg Focus 2000;8:E1.
  12. Nogues M, Lopez L, Meli F. Neuro-ophthalmologic complications of syringobulbia. Curr Neurol Neurosci Rep 2010;10:459-466. https://doi.org/10.1007/s11910-010-0139-x
  13. Gennaro P, Miller M. Syringobulbia without syringomyelia. Arch Neurol 1983;40:394.
  14. Nogues M, Gene R, Benarroch E, Leiguarda R, Calderon C, Encabo H. Respiratory disturbances during sleep in syringomyelia and syringobulbia. Neurology 1999;52:1777-1783. https://doi.org/10.1212/WNL.52.9.1777
  15. Cerda-Gonzalez S, Olby NJ, Griffith EH. Medullary position at the craniocervical junction in mature cavalier King Charles spaniels: relationship with neurologic signs and syringomyelia. J Vet Intern Med 2015;29:882-886. https://doi.org/10.1111/jvim.12605
  16. Driver CJ, Volk HA, Rusbridge C, Van Ham LM. An update on the pathogenesis of syringomyelia secondary to Chiari-like malformations in dogs. Vet J 2013;198:551-559. https://doi.org/10.1016/j.tvjl.2013.07.014
  17. Knowler SP, Galea GL, Rusbridge C. Morphogenesis of canine Chiari malformation and secondary syringomyelia: disorders of cerebrospinal fluid circulation. Front Vet Sci 2018;5:171.
  18. Marino DJ, Loughin CA, Dewey CW, Marino LJ, Sackman JJ, Lesser ML, Akerman MB. Morphometric features of the craniocervical junction region in dogs with suspected Chiarilike malformation determined by combined use of magnetic resonance imaging and computed tomography. Am J Vet Res 2012;73:105-111. https://doi.org/10.2460/ajvr.73.1.105
  19. Rusbridge C. Chiari-like malformation and syringomyelia. Eur J Companion Anim Pract 2013;23:70-89.
  20. Kiviranta AM, Rusbridge C, Laitinen-Vapaavuori O, Hielm-Bjorkman A, Lappalainen AK, Knowler SP, Jokinen TS. Syringomyelia and craniocervical junction abnormalities in Chihuahuas. J Vet Intern Med 2017;31:1771-1781. https://doi.org/10.1111/jvim.14826
  21. Cerda-Gonzalez S, Olby NJ, Griffith EH. Dorsal compressive atlantoaxial bands and the craniocervical junction syndrome: association with clinical signs and syringomyelia in mature cavalier King Charles spaniels. J Vet Intern Med 2015;29:887-892. https://doi.org/10.1111/jvim.12604
  22. Takahashi F, Kouno S, Yamaguchi S, Hara Y. Evaluation of atlantooccipital overlapping and cerebral ventricle size in dogs with atlantoaxial instability. J Vet Med Sci 2019;81:229-236. https://doi.org/10.1292/jvms.17-0553
  23. Matiasek LA, Platt SR, Shaw S, Dennis R. Clinical and magnetic resonance imaging characteristics of quadrigeminal cysts in dogs. J Vet Intern Med 2007;21:1021-1026. https://doi.org/10.1111/j.1939-1676.2007.tb03059.x
  24. Morgan D, Williams B. Syringobulbia: a surgical appraisal. J Neurol Neurosurg Psychiatry 1992;55:1132-1141. https://doi.org/10.1136/jnnp.55.12.1132
  25. Rusbridge C, Stringer F, Knowler SP. Clinical application of diagnostic imaging of Chiari-like malformation and syringomyelia. Front Vet Sci 2018;5:280.
  26. Alisauskaite N, Spitzbarth I, Baumgartner W, Dziallas P, Kramer S, Dening R, Stein VM, Tipold A. Chronic post-traumatic intramedullary lesions in dogs, a translational model. PLoS One 2017;12:e0187746.