• Transactions of the Korean Society of Automotive Engineers
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• v.5 no.3
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• pp.159-171
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• 1997

Sound intensity distributions and energy flow in the near field of dipole source system and flat plate were investigated. First, the effectiveness of complex acoustic intensity was proved by using mathmatical and experimental methods in order to inden- tify noise sources and transmission paths of dipole field which is effected by the presence of neighbouring coherent sources. Next, analytical complex acoustic intensity method was discussed and the characteristics and energy flow of sound induced from the plate are clarified. The velocity of plate obtained from Finite Element Method was used for calculation of complex acoustic intensity in the near field. Finally experimental complex acoustic intensity method using both of active and reactive intensity is vital in devising a strategy for the identification and the reduction of vibration and noise.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.25 no.8
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• pp.546-552
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• 2015

In the previous study, the air flow noise around 1.6 k~1.8 kHz was analyzed, and could be reduced by machining a groove in the bore of compressor inlet in front of the main blades of a compressor wheel. It was proven that this groove was very effective for removing the noise without critical sacrifice of compressor performance, and in addition, it did not noticeably deteriorate vehicle performance, drivability and acceleration. It is interesting that the type of groove tried for 1.6~1.8 kHz noise reduction could be effective for another air flow noise, 4 k~6 kHz which is the 3rd order frequency range of turbocharger speed. This study tried various shapes of grooves for minimizing engine performance difference as well as reducing the 3rd order noise. Finally, it was shown that the groove should be round for the engine performance, and an optimal size exist for the noise and the engine performance.

• Journal of the Korean Society of Propulsion Engineers
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• v.18 no.6
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• pp.75-81
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• 2014

The flame deflector should be constructed to minimize the induced environmental effects on the launch vehicle and to minimize the exhaust impingement effects on the launch complex structures during the lift-off operation. Therefore, it should be designed to avoid recirculation and reverse flow of rocket exhaust plumes. The circumstance around launch complex and characteristics of launch vehicle should be taken into consideration for the flame deflector design. In this paper, we designed the flame deflector reflecting KSLV-II 1st engine characteristics and analyzed the effect of exhaust plumes related to change geometry by means of computational flow analysis.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.4
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• pp.355-363
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• 2021

Dynamic changes in adipose tissue blood flow (ATBF) with nutritional status play a role in the regulation of metabolic and endocrine functions. Activation of the sympathetic nervous system via β-adrenergic receptors (β-AR) contributes to the control of postprandial enhancement of ATBF. Herein, we sought to identify the role of each β-AR subtype in the regulation of ATBF in mice. We monitored the changes in visceral epididymal ATBF (VAT BF), induced by local infusion of dobutamine, salbutamol, and CL316,243 (a selective β1-, β2-, and β3-AR agonist, respectively) into VAT of lean CD-1 mice and global adipose triglyceride lipase (ATGL) knockout (KO) mice, using laser Doppler flowmetry. Administration of CL316,243, known to promote lipolysis in adipocytes, significantly increased VAT BF of CD-1 mice to a greater extent compared to that of the vehicle, whereas administration of dobutamine or salbutamol did not produce significant differences in VAT BF. The increase in VAT BF induced by β3-AR stimulation disappeared in ATGL KO mice as opposed to their wild-type (WT) littermates, implying a role of ATGL-mediated lipolysis in the regulation of VAT BF. Different vascular reactivities occurred despite no significant differences in vessel density and adiposity between the groups. Additionally, the expression levels of the angiogenesis-related genes were significantly higher in VAT of ATGL KO mice than in that of WT, implicating an association of ATBF responsiveness with angiogenic activity in VAT. Our findings suggest a potential role of β3-AR signaling in the regulation of VAT BF via ATGL-mediated lipolysis in mice.

• Journal of Aerospace System Engineering
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• v.13 no.3
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• pp.56-63
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• 2019

Performance analyses were performed on a propeller developed for use in a PAV (Personal Air Vehicle) under 600 kg Maximum Take-Off Weight (MTOW). The actuator disc theory and CFD analyses were used to estimate the hovering time with regards to MTOW variation for a given battery weight. The interference induced power factor kint was introduced to account for the effect of flow interference between the propellers and to estimate the performance of counter-rotating propellers. The Maximum Figure of Merit (FM) value of the propeller pitch was determined and the design RPM range for the required power inversely obtained from the CFD results. Previous research indicate that the flight time of large multi-copter is limited by the available battery energy density. Similarly, the propeller pitch settings and spacing are important factors in reducing the kint value.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.199-199
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• 1998

In this study, the effects of ursodeoxycholic acid (UDCA) on ischemia/reperfusion injury were investigated on retrograded aortic perfusion model. Hearts from Sprague-Dawley rats were perfused with oxygenated Krebs-Henseleit solution (pH 7.4, 37) on a Langendorff apparatus. After equilibration, hearts were treated with ursodeoxycholic acid 10, 20, 40 and 800 M or vehicle (0.04% DMSO) for 10 min before the onset of ischemia. Following 25 min of global ischemia, ischemic hearts were reperfused and allowed to recover for 30 min. The physiological (i.e. heart rate, left ventricular diastolic pressure, coronary flow and time to contracture formation) and biochemical (lactate dehydrogenase, LDH) endpoints were evaluated. In vehicle group, time to contracture formation (TTC) value was 19.5 min during ischemia, LVDP was 20.8 mmHg at the endpoint of reperfusion and LDH activity in reperfusate was 59.7 U/L. Cardioprotective effects of UDCA following ischemia/reperfusion consisted of a reduced TTC (EC$\_$25/ = 16.10 M), reduced LDH release and enhanced recovery of contractile function during reperfusion. Especially, the treatments of UDCA 80 M remarkably increased LVDP (68.1 mmHg) and reduced LDH release (33.2 U/L). Our findings suggest that UDCA ameliorates ischemia/reperfusion-induced myocardial damage, in agreement with physiological and biochemical parameters.

• Archives of Pharmacal Research
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• v.22 no.5
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• pp.479-484
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• 1999

In this study, the effects of ursodeoxycholic acid (UDCA) on ischemia/reperfusion injury were investigated on isolated heart perfusion model. Hearts were perfused with oxygenated Krebs-Henseleit solution (pH 7.4, $37^{\circ}C$) on a Langendroff apparatus. After equilibration, isolated hearts were treated with UDCA 20 to 160 $\mu$M or vehicle (0.04% DMSO) for 10 min before the onset of ischemia. After global ischemia (30 min), ischemic hearts were reperfused and allowed to recover for 30 min. The physiological (i.e. heart rate, left ventricular developed pressure, coronary flow, double product and time to contracture formation) and biochemical (lactate dehydrogenase; LDH) parameters were evaluated. In vehicle-treated group, time to contracture formation was 21.4 min during ischemia, LVDP was 18.5 mmHg at the endpoint or reperfusion and LDH activity in total reperfusion effluent was 54.0 U/L. Cardioprotective effects of UDCA against ischemia/reperfusion consisted of a reduced TTC $(EC_{25}=97.3{\mu}M)$, reduced LDH release and enhanced recovery of cardiac contractile function during reperfusion. Especially, the treatments of UDCA 80 and $160 {\mu}M $ significantly increased LVDP and reduced LDH release. Our findings suggest that UDCA ameliorates ischemia/reperfusion-induced myocardial damage.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.115-121
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• 2017

The efficiency of railway track cleaning vehicle for eliminating fine particulate matter (PM10 and PM2.5) in a subway tunnel depends strongly on the structure of the air blowing and suction system installed under the train. To increase the efficiency of underbody suction system, this paper proposes a novel method to use the Coanda effect for the air blower and dust suction module. In particular, through Computational Fluid Dynamics (CFD) analysis, the flow control device induced by the Coanda effect enables an increase in the overall flow velocity and to stabilize the flow distribution of the suction module at a control angle of $90^{\circ}$. In addition, the flow velocity drop at the edge of the air knife-type blower can be improved by placing small inserts at the edge of the blower. Those 4 modular designs of the dust suction system can help remove the dust accumulated on the track and tunnel by optimizing the blowing and suction flows.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.04a
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• pp.98-98
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• 1997

This study was done to investigate the effect of vitamin E on hypoxia/reoxygenation-induced hepatic injury in isolated perfused rat liver. Rats were pretreated with vitamin E or vehicle(soybean oil). Isolated livers from fasted 18 hours were subjected to 45min of low flow hypoxia or N$_2$ hypoxia followed by reoxygenation for 30min. The perfusion medium used was KHBB(pH 7.4) and 50${\mu}$㏖/$\ell$ of ethoxycoumarin was added to the perfusate to determine the ability of hepatic drug-metabolizing systems, In low flow hypoxia model, total glutathione and oxidised glutathione levels were significantly increased by hepoxia/reoxygenation with slight increase in LDH levels. These increases were prevented by vitamin E pretreatment. In N$_2$ hypoxia model, LDH, total glutathione and oxidized glutathione levels were increased significantly by hypoxia but restored to normal level by reoxygenation. Vitamin E had little effect on this hypoxic damage. There were no significant changes in the rate of hepatic oxidation of 7-EC to 7-HC in both hepoxic models. But, the subsequent conjugation of 7-HC by sulfate or glucuronic acid were significantly decreased by hypoxia, but restored by reoxygenation in both hypoxia models. As opposed to our expectation, treatment with vitamin E aggrevated the decrease of the rate of conjugation and even inhibited the restoration by reoxygenation. Our findings suggest that hypoxia/reoxygenation diminishes phase II drug metabolizing function and this is, in part, related to decreased energy level.

• Journal of the Korean Society of Propulsion Engineers
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• v.21 no.5
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• pp.29-36
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• 2017

In this study, a numerical analysis is made of the fluid flow and heat transfer characteristics in the solar arrays of HALE (High Altitude Lond Endurance) UAV. In the stratosphere where UAV operates, high level solar radiation is induced, heat transfer decreases due to natural convection and forced convection is dominated by ambient flow. In order to predict the solar array temperature range in this environment condition, the conjugate heat transfer analysis was carried out for the solar arrays on the main wing. The investigation focused on the temperature distribution of solar array and heat transfer characteristics according to influence of solar energy, flight condition as vehicle speed, air density, temperature.