• Toxicological Research
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• v.19 no.2
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• pp.133-139
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• 2003

Allergic contact dermatitis may be caused by a wide variety of chemicals. A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for assessing the contact sensitization potential of chemical. However, there is a need to develop a nonradioisotopic endpoint for the LLNA, because of the radioisotopic method's requiring the use of special facilities. In this study, we investigated the development of a nonradioisotopic endpoint for LLNA using ELISA (enzyme-linked immunosorbent assay). Female Balb/c mice were treated by the topical application on the dorsum of both ears with four different strong sensitizers, 2,4-dinitrochlorobenzene (DNCB), oxazolone (OXZ), toluene diisocyanate (TDI), and trimellitic anhydride (TMA), and a strong irritant, sodium lauryl sulfate (SLS), once daily for three consecutive days. The proliferation of cells in the auricular Iymph node was analyzed by means of the labelling index (Ll) of bromodeoxyuridine (BrdU) incorporation into cells. The weights of the Iymph nodes in the mice treated with allergens, DNCB, OXZ, TDl and TMA were increased compared to the vehicle control. The stimulation index (Sl) of mice treated with DNCB, OXZ, TDl, and TMA was over three-fold increase compared to the vehicle control. However, the S1 of mice exposed to SLS was not significantly increased compared to the vehicle control, while the lymph node weight of SLS was significantly increased. These results suggest that the LLNA modified endpoint using ELISA based on BrdU incorporation could provide a useful method of screening for irritants and allergens.

• Current Optics and Photonics
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• v.1 no.6
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• pp.613-617
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• 2017

Due to optimal advances such as chromatic performance, durability, low power consumption, high efficiency, long-lifetime, and excellent environmental friendliness, white LEDs (WLEDs) are widely used in vehicle front lighting, backlighting, decorative lighting, street lighting, and even general lighting. In this paper, the remote packaging WLEDs (RP-WLEDs) with bi-layer red-emitting $Sr_2Si_5N_8:Eu^{2+}$ and yellow-emitting YAG:Ce phosphor was proposed and investigated. The simulation results based on the MATLAB software and the commercial software Light Tools indicated that the color rendering index (CRI) of bi-layer phosphor RP-WLEDs had a significant increase. The CRI had a considerable increase from 72 to 94. In conclusion, the results showed that bi-layer red-emitting $Sr_2Si_5N_8:Eu^{2+}$ and yellow-emitting YAG:Ce phosphor could be a prospective approach for manufacturing RP-WLEDs with enhanced optical properties.

• Journal of Korean Society of Transportation
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• v.29 no.2
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• pp.25-35
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• 2011

In order to reduce Green House Gas(GHG) reduction in the road freight sector and thus establish green logistics, running efficiency of goods vehicles is of paramount importance. Providing effective transportation infrastructure can contribute to achieve the green logistics by reducing empty running of heavy goods vehicles and van, increasing the average payload on the vehicle, and shifting the transportation mode. In order to reduce the environmental impact from the road freight sector, it is essential to quantify the amount of environmental loading from the sector. However, any systematic survey on the environmental loading from the logistics companies has not been carried out in Korea. In this study, the environmental index for the road freight sector is defined as the amount of $CO_2$ emission per ton km generated from goods vehicles. The computational analysis shows that the average $CO_2$ emission per ton km generated by the logistics companies in Korea is $363g-CO_2/ton{\cdot}km$. Compared to UK (=$130g-CO_2/ton{\cdot}km$) and France (=$97g-CO_2/ton{\cdot}km$), the efficiency of logistics in Korea is 2.8 and 3.7 times as low as in the advanced countries. It also indicates that the main reasons for the low efficiency are mainly due to the high rate of empty operation of goods vehicles and the low payload.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.5
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• pp.224-239
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• 2023

C-ITS (Cooperative-Intelligent Transportation System) refers to user safety-oriented technology and systems that provide forward traffic situation information based on a two-way wireless communication technology between vehicles or between vehicles and infrastructure. Since the Daejeon-Sejong pilot project in 2016, the C-ITS infrastructure has been installed at various locations to provide C-ITS safety services through highway and local government demonstration projects. In this study, a methodology was developed to verify the effectiveness of the warning information using individual vehicle data collected through the Gwangju Metropolitan City C-ITS demonstration project. The analysis of the effectiveness was largely divided into driving behavior impact analysis and environmental analysis. Compliance analysis and driving safety evaluation were performed for the driving impact analysis. In addition, to supplement the inadequate collection of Probe Vehicle Data (PVD) collected during the C-ITS demonstration project, Digital Tacho Graph ( DTG ) data was additionally collected and used for effect analysis. The results of the compliance analysis showed that drivers displayed reduced driving behavior in response to warning information based on a sufficient number of valid samples. Also, the results of calculating and analyzing driving safety indicators, such as jerk and acceleration noise, revealed that driving safety was improved due to the provision of warning information.

• Toxicological Research
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• v.18 no.2
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• pp.175-181
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• 2002

Allergic contact dermatitis (skin sensitization) may be caused by a wide variety of chemicals. A murine local lymph node assay (LLNA) has been developed as an alternative to guinea pig models for assessing the contact sensitization potential of chemical. This study was carried out to evaluate the skin sensitization potential for chemicals in Balb/c mice by LLNA. Contact allergen, dinitrochlorobenzene (DNCB), respiratory allergen, toluene diisocyanate (TDI) and a weak allergen, $\alpha$-hexlycinnamaldehyde (HCA) were wed as positive chemicals and irritant, sodium lauryl sulfate(SLS) also wed as a reference chemical in this study. The weights of lymph node in the mice treated with DNCB, TDI, and HCA were increased compared to vehicle control. There was a significant increase in lymph node weight of mice treated with high concentration of SLS compared to vehicle control. The stimulation index (SI) of Lymph node cell in the mice treated with DNCB, TDI, and HCA revealed over three-fold increase compared to vehicle control by $3^H$-thymidine uptake. All allergens correctly identified in this LLNA study wing Balb/c mice. These results suggest that LLNA wing Balb/c mice could be a useful method for screening the allergenic potential of chemicals. The expression of IL-2 mRNA was slightly increased in draining auricular lymph node cell of the mice treated with TDI and HCA by RT-PCR. However the IL-2 levels in DNCB and SLS of treated animals were not significantly changed.

• Journal of Korean Society of Transportation
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• v.26 no.4
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• pp.17-28
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• 2008

Favorable policies for freight vehicles (i.e., trucks), such as exclusive "Truck-ways," have been proposed, and at the same time restricted policies for freight vehicles have been suggested because transportation of goods by truck aggravates traffic congestion and environmental conditions in urban areas. This study discusses the limitations of assessment processes for freight vehicle route management systems which have been carried out from limited perspectives such as physical distribution efficiency and traffic circulation. The objective of this study is to propose an assessment method of truck route management systems in urban areas which includes more varied criteria. This research modified the two existing assessment indices of physical distribution efficiency and traffic circulation. In addition two new assessment indexes are proposed: (i) exposure indices for population directly influenced by nitrous oxide, a representative pollutant, and (ii) a friction index between trips for attending elementary school and freight vehicle trips. It was found that from the perspective of physical distribution efficiency and traffic circulation, the "before" alternative is better than "after". However, from the aspect of traffic safety and environmental impacts the "after" alternative is better than "before". It is expected that the proposed evaluation method in this study would be useful when identifying reasonable policies for truck route management in urban areas.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.22 no.1
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• pp.61-72
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• 2019

With the diversification of research using UAV(Unmanned Aerial Vehicle)s, the possibility of remote sensing research for urban green spaces is increasing. UAVs can be used as an investigation method to monitor the successful construction of the park and the planting of vegetation since its creation. This study was carried out to investigate UAVs utilization of urban green space monitoring in Dosol Square. It was photographed three times on May 21, July 13, and September 16, 2018 using DJI Phantom3 pro, Inspire2, and Parrot Sequoia multispectral camera. Orthographic images were overlaid on the planting plan of the site and the construction results were checked, the change of vitality of the plantation area was analyzed by NDVI(Normalized Difference Vegetation Index) and SAVI(Soil Adjusted Vegetation Index). As a result, it was confirmed that the UAVs are very effective for surveying the view of the urban green space after the construction and recording the results, which can be grasped quantitatively by overlaying the planting plan map. UAVs are more likely to be used in terms of monitoring vegetation vitality. It is interpreted that SAVI is better than NDVI in the green space just after composition. Chionanthus retusus and Pinus strobus were analyzed for their low level of vitality, and partially damaged and their vitality was lowered. In addition, there was difficulty in grass planting area and flower garden due to drainage and summer drought problems. In the future, it is expected that orthoimage and multispectral data using UAVs will be useful in the early vegetation monitoring and management field of urban green spaces.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.15 no.4
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• pp.1-11
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• 2012

This study prepared the list of planning components required for constructing environment-friendly industrial complex and grasped major environment-friendly planning components by measuring the importance per each planning component via the survey for specialists. As a result of measuring the importance of planning component according to each field for constructing environment-friendly industrial complex, it is indicated that important planning components in natural environment field are establishing complex location plan considering its configuration and slope, excluding projects for steep slope-land, establishing countermeasures for reducing contaminants per its source, and separated location of contamination industry around living space. In living environment field, proposed planning components having relatively high importance are separated location of pollution causing industry, establishing energy saving land use plan, linking with green way, circulation network plan, lowering noise level at roadside, plan for separating between pedestrian and vehicle, securing parking space, extending green park and proper location, installing green buffer zone, conserving and forming landscapes, land use for raising energy efficiency, and expansion of energy source. In case of ecological environment, core planning components such as conserving upper class of ecological naturality degree, conserving main habitat, and biotope forming plan are suggested. This study is limited to find out planning components for constructing environment-friendly physical environment of industrial complex which is a part of non-production process. The approach to solve environmental problem by linking spatially production process and non-production process. There is a need to conduct follow-up study to constructing technique for environment-friendly industrial complex considering production & nonproduction process afterward.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.38 no.3
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• pp.467-475
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• 2018

The purpose of this study is to propose the evaluation criteria of asphalt pavement condition in narrow regional road considering the traffic environment in order to reduce road budget of local governments. In general, narrow regional roads are considered relatively less important because they have low travel speed and low traffic volume of heavy-vehicle. Generally, automatic surveying equipment is used for investigations of pavement condition, but the operating costs are not efficient for the narrow regional roads because the cost is too high. This study presents the pavement condition evaluation index suitable for narrow regional roads. In this study, the pavement condition evaluation index is presented considering the traffic environment of narrow regional roads. The pavement condition were classified into three classes based on the crack measured by visual inspection, and the validity of the pavement condition evaluation index presented through the expert's questionnaire survey was examined. Pavement condition for the narrow regional roads was classified into three grades based on the index values calculated by visual inspection. Expert's surveys were conducted to evaluate the validity of the proposed pavement condition evaluation. The proposed evaluation index shows a high correlation with questionnaire survey result ($R^2=0.88$). The proposed evaluation index which is obtained through visual crack inspection under limited conditions can be applied to narrow regional roads. In addition, it is expected that it will be effective not only for road management but also for road management budget by more economical evaluation method of pavement condition.

• Smart Structures and Systems
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• v.21 no.5
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• pp.705-713
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• 2018

High-speed rail (HSR) has been in operation and development in many countries worldwide. The explosive growth of HSR has posed great challenges for operation safety and ride comfort. Among various technological demands on high-speed trains, vibration is an inevitable problem caused by rail/wheel imperfections, vehicle dynamics, and aerodynamic instability. Ride comfort is a key factor in evaluating the operational performance of high-speed trains. In this study, online monitoring data have been acquired from an in-service high-speed train for condition assessment. The measured dynamic response signals at the floor level of a train cabin are processed by the Sperling operator, in which the ride comfort index sequence is used to identify the train's operation condition. In addition, a novel technique that incorporates salient features of Bayesian inference and time series analysis is proposed for outlier detection and change detection. The Bayesian forecasting approach enables the prediction of conditional probabilities. By integrating the Bayesian forecasting approach with time series analysis, one-step forecasting probability density functions (PDFs) can be obtained before proceeding to the next observation. The change detection is conducted by comparing the current model and the alternative model (whose mean value is shifted by a prescribed offset) to determine which one can well fit the actual observation. When the comparison results indicate that the alternative model performs better, then a potential change is detected. If the current observation is a potential outlier or change, Bayes factor and cumulative Bayes factor are derived for further identification. A significant change, if identified, implies that there is a great alteration in the train operation performance due to defects. In this study, two illustrative cases are provided to demonstrate the performance of the proposed method for condition assessment of high-speed trains.