• Biomolecules & Therapeutics
• /
• v.20 no.4
• /
• pp.413-417
• /
• 2012

Chrysanthemum indicum Linne is an ancient herbal medicine used to treat bone and muscle deterioration, ocular inflammation, headache, and anxiety in Korea, China, and Japan. Furthermore, tea derived from Chrysanthemum indicum Linne has been used to treat anxiety by facilitating relaxation and curing insomnia. However, no reports exist on the anxiolytic-like effects of Chrysanthemum indicum Linne water extract (CWE) in mice. In the present study, we investigated the anxiolytic-like effects of CWE using the elevated plus-maze (EPM) test in mice. CWE, at a dose of 500 mg/kg (p.o.), significantly increased the time spent in the open arms of the EPM compared to a vehicle-injected control group. Moreover, the effect of CWE (500 mg/kg) was blocked by bicuculline (a selective $GABA_A$ receptor antagonist) and WAY 100635 (a selective 5-$HT_{1A}$ receptor antagonist). Taken together, these findings suggest that the anxiolytic-like effects of CWE might be mediated by the $GABA_A$ receptor and the 5-$HT_{1A}$ receptor.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 2007.11a
• /
• pp.153-158
• /
• 2007

Background: Naturally occurring antioxidants were used to regulate the skin damage caused by ultraviolet (UV) radiation because several antioxidants have demonstrated that they can inhibit wrinkle formation through prevention of matrix metalloproteinases (MMPs) and/or increase of collagen synthesis. We examined the effect of oral administration of the antioxidant mixture ("L-Skin Care") on UVB-induced wrinkle formation. In addition, we investigated the possible molecular mechanisms of photoprotection against UVB through inhibition of collagen-degrading MMP activity or through enhancing of pro collagen synthesis in mouse dorsal skin. Methods: Female SKH-l hairless mice were orally administrated "L-Skin Care" (test group) or vehicle (control group) for 10 weeks with UVB irradiation by three times a week. The intensity of irradiation was gradually increased from 30 to $180mJ/cm^2$. Microtopographic and histological assessments of the dorsal skins were carried out at the end of 10 weeks to evaluate wrinkle formation. Western blot analysis and EMSA were also carried out to investigate the changes in the balance of collagen synthesis and collagen degradation. Results: Our "L-Skin Care" significantly reduced UVB-induced wrinkle formation, accompanied by significant reduction of epidermal thickness, and UVB-induced hyperplasia, acanthosis and hyperkeratosis. Oral administration of "L-Skin Care" significantly prevented UVB-induced expressions of MMPs, mitogen-activated protein (MAP) kinases and activation of activator protein (AP)-1 transcriptional factor in addition to enhanced type I procollagen and transforming growth factor-$\beta$ (TGF-$\beta$) expression. Conclusion: Oral administration of "L-Skin Care" significantly inhibited wrinkle formation caused by chronic UVB irradiation through significant inhibition of UVB-induced MMP activity accompanied with enhancement of collagen synthesis.

• Biomolecules & Therapeutics
• /
• v.25 no.3
• /
• pp.259-265
• /
• 2017

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey's test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4-L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.

• Journal of Korea Society of Industrial Information Systems
• /
• v.25 no.5
• /
• pp.31-39
• /
• 2020

According to lessons learned from an accident of Fukushima Daiichi nuclear power plant, it is advisable to make a comprehensive radiation survey by the accident phase for efficient response and risk management using diverse survey platforms. This study focuses on the technical status of environmental radiation monitoring using a UAV (Unmanned aerial vehicle) and the performance test of developed aerial survey system based on two detectors with an high energy resolution through the field application to contaminated areas. Finally, the performance of aerial survey at diverse flight heights was successfully achieved by introducing the correction factor to represent the results into ambient dose rate at 1m above the ground.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.10 no.9
• /
• pp.2210-2220
• /
• 2009

Independent-suspension type axles for heavy duty special vehicles are usually produced by only a few specialized companies. The special techniques, such as designing, producing, testing techniques has been unveiled. The test of durability with the vehicle in which is installed a prototype taking several years is required for setting the designing parameters. In this research, through-drive the core-component of the independent-suspension type axle has been tested with the reverse engineering and the testing methods for the confirmation of the accomplishment in the development goal has been suggested. Also the prototype is developed from designing and testing the design with the CAD and CAE tools. As a result, the process and testing methods studied in this research are useful in the development of power train.

• The Korean Journal of Emergency Medical Services
• /
• v.1 no.1
• /
• pp.42-53
• /
• 1997

To offer basic data about the influential factors on patient's Satisfaction level for emergency medical services the authors were performed this study in 60 patients visited to emergency room of third stage general hospital in Taejeon city. Data were collected through interview with patients by using a 15 items' questionaire according to care subscale, teaching subscale of Likert's five stage quantitative scale and the tools developed by Barbara Davis. The data were analyzed by using the SPSS/PC computerized program for mean, standard deviation, percentage, ANOVA, t-test, and pearson correlation. The results are as followings ; 1. Satisfaction of emergency medical service were showed in care area, but not showed in teaching and total area 2. Satisfaction of sociodemographic characteristics were a statistically significant difference only marriage, that were the higher in marriaged than single(P<.0.05). 3. In the emergency situation characteristics the satisfaction accordings to the visit cause were lower in accident than disease group, the reason of hospital selection were in order trust, introduction group, distance, traffic, kinds, and score of satisfaction were showed each of 43.47, 51.27(P<.001), the transportation vehicle was the 119, hospital ambulance group. but were not a satistically significant difference. 4. The negative correlation was observed between satisfaction and the length of stay at ER and the longer length of stay at ER was showed the lower satisfaction. But the positive correlation was observed between satisfacton and the arrival time, patients who arrived ER from 6:00P.M. to midnight were more satisfied than patients who arrived other time. 5. The length of stay at ER was significantly different according to the reason of hospital selection, the reason of ER selection, the visitant cause and hopital decisioner. Especially the length of stay was much longer in accident group and unconscious group.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.37 no.5
• /
• pp.367-377
• /
• 2019

As an alternative navigation system for the non-GNSS (Global Navigation Satellite System) environment, a new type of DBRN (DataBase Referenced Navigation) which applies both gravity gradient and terrain, and combines filter-based algorithm with profile matching was suggested. To improve the stability of the performance compared to the previous study, both centralized and decentralized EKF (Extended Kalman Filter) were constructed based on gravity gradient and terrain data, and one of filters was selected in a timely manner. Then, the final position of a moving vehicle was determined by combining a position from the filter with the one from a profile matching. In the simulation test, it was found that the overall performance was improved to the 19.957m by combining centralized and decentralized EKF compared to the centralized EKF that of 20.779m. Especially, the divergence of centralized EKF in two trajectories located in the plain area disappeared. In addition, the average horizontal error decreased to the 16.704m by re-determining the final position using both filter-based and profile matching solutions. Of course, not all trajectories generated improved performance but there is not a large difference in terms of their horizontal errors. Among nine trajectories, eights show smaller than 20m and only one has 21.654m error. Thus, it would be concluded that the endemic problem of performance inconsistency in the single geophysical DB or algorithm-based DBRN was resolved because the combination of geophysical data and algorithms determined the position with a consistent level of error.

• Journal of International Academy of Physical Therapy Research
• /
• v.9 no.4
• /
• pp.1683-1686
• /
• 2018

Low back pain (LBP) is the most common reason for seeking physical therapy (PT) care. Recent studies suggest that axial loading can have a positive impact on the intervertebral disc by improving its tensile strength. Further, whole body vibration (WBV) appears to improve spinal muscle relaxation. Therefore, this case study describes the use of axial loading using a mini-trampoline in a female with chronic LBP. This case report is a single subject design. This patient is a 29-year-old female with a six-month history of low back pain following a motor vehicle accident. MRI found herniated discs at L4 and L5, clinical tests were positive for pain in the L4 and L5 dermatome and myotome the slump test was positive for neural tension, and LBP was constant at 4-6/10 over the past four months. She received axial loading exercises using a mini-trampoline and performed six sessions that were, scheduled twice a week for three weeks. Her Oswestry Disability Index (ODI) score improved from 40% at the time of her first visit to 22% at her final visit. Pain measure on the Numeric Pain Rating Scale (NPRS) after the first treatment was 7/10, and her pain after the final treatment was 0/10. These changes in the pain scores are clinically significant and exceed the minimal clinically important difference (MCID). This patient had a significant improvement in her pain using the NPRS and the ODI. This case study suggests that axial loading may be an effective treatment for some individuals with discogenic chronic low back pain.

• Journal of the Korean Society for Railway
• /
• v.16 no.3
• /
• pp.175-182
• /
• 2013

Rolling noise is an important source of noise from railways; it is caused by wheel and rail vibrations induced by acoustic roughness at the wheel/rail contact. To reduce rolling noise, it is necessary to have a reliable prediction model that can be used to investigate the effects of various parameters related to the rolling noise. This paper deals with modeling rolling noise from wheel and rail vibrations. In this study, the track is modeled as a discretely supported beam by regarding concrete slab tracks, and the wheel vibration is simulated by using the finite element method. The vertical and lateral wheel/rail contact forces are modeled using the linearized Hertzian contact theory, and then the vibration responses of the wheel and rail are calculated to predict the radiated noise. To validate the proposed model, a field measurement was carried out for a test vehicle. It was found that the predicted result agrees well with the measured one, showing similar behavior in the frequency range between 200 and 4000 Hz where the rolling noise is prominent.

• Journal of Aerospace System Engineering
• /
• v.14 no.3
• /
• pp.10-16
• /
• 2020

We propose a capture mechanism based on the principles of fishing nets that can be mounted on the drone using cable. The gripper mechanism, mainly proposed for the drone is heavy, and is limited to catch standardized objects. In contrast, the proposed capture device in this paper is light, flexible, and can capture various types of objects from a long distance. The theoretical relationships between cables and mechanisms were analyzed. Finally, the capture device was designed and manufactured to be installed in the drone (DJI S900) to conduct capturing experiments for various objects and verify the validity.