• Genomics & Informatics
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• 제20권2호
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• pp.22.1-22.9
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• 2022

The rise of newer coronavirus disease 2019 (COVID-19) variants has brought a challenge to ending the spread of COVID-19. The variants have a different fatality, morbidity, and transmission rates and affect vaccine efficacy differently. Therefore, the impact of each new variant on the spread of COVID-19 is of interest to governments and scientists. Here, we proposed mathematical SEIQRDVP and SEIQRDV3P models to predict the impact of the Omicron variant on the spread of the COVID-19 situation in South Korea. SEIQEDVP considers one vaccine level at a time while SEIQRDV3P considers three vaccination levels (only one dose received, full doses received, and full doses + booster shots received) simultaneously. The omicron variant's effect was contemplated as a weighted sum of the delta and omicron variants' transmission rate and tuned using a hyperparameter k. Our models' performances were compared with common models like SEIR, SEIQR, and SEIQRDVUP using the root mean square error (RMSE). SEIQRDV3P performed better than the SEIQRDVP model. Without consideration of the variant effect, we don't see a rapid rise in COVID-19 cases and high RMSE values. But, with consideration of the omicron variant, we predicted a continuous rapid rise in COVID-19 cases until maybe herd immunity is developed in the population. Also, the RMSE value for the SEIQRDV3P model decreased by 27.4%. Therefore, modeling the impact of any new risen variant is crucial in determining the trajectory of the spread of COVID-19 and determining policies to be implemented.

• Journal of Ginseng Research
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• 제7권2호
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• pp.133-147
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• 1983

This study was carried out to obtain the basic information for the development of new ginseng varieties. The two variants (violet-stem variant and yellow-berry variant) of Korean ginseng (Panax ginseng C.A. Meyer) and American ginseng (Panax quinquefolium L.) of one to four-year were used for this study. All of the characteristics, such as leaf length, leaf width, petiol length, number of leaves per plant, number of leaflets per plants, stem diameter, stem length, number of stems per plant, root length, primary root length, root diameter, root weight were determined and correlations among them were estimated. The results obtained were summarized as follows. 1. Leaf length, petiol length, number of leaves per plant, and number of leaflets per plant of Panax ginseng, violet-stem variant and yellow-berry variant, were larger than those of Panax quinquefolium at all of the plant ages, while leaf width was wider in Panax quinquefolium. 2. The length of stem of Panax quinquefolium was shorter than that of Panax ginseng, and the frequency of multi-stem plants at 4-year-old ginseng was larger in violet-stem variant than in Panax quinquefolium and yellow-berry variant. 3. In the characteristics of ginseng root, the primary root length of Panax ginseng, violet-stem variant and yellow-berry variant, were less than that of Panax quinquefolium, while root weight, root diameter, and umber of secondary root related to yield were larger in Panax ginseng. 4. The root weight per plant related to the yield had positive and highly significant correlations with stem diameter, leaf length, leaf length, leaf width, number of compound leaves and leaflets in Panax ginseng and Panax quinguefolium. 5. The root weight related to the wield of ginseng had been influenced to stem diameter, leaf length, and leaf width directly, and number of compound leaves and leaflets indirectly. 6. The number, total area and activity of stomate per mm2 of Panax quinquefolium were more, larger and stronger than those of Panax ginseng.

• 대한두경부종양학회지
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• 제20권2호
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• pp.123-127
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• 2004

Objectives: The tall cell variant is an uncommon variant and has been known as more aggressive form of papillary thyroid carcinoma (PTC). Owing to the rarity of these thyroid cancers, their clinical behavior remains incompletely understood. To elucidate the clinicopathologic characteristics of tall cell variant, we retrospectively reviewed our surgical experience of patients with tall cell variant. Methods: Between August 1993 and July 2004, a total of 11 consecutive patients who were pathologically diagnosed with tall cell variant of papillary thyroid carcinoma were enrolled in this study. All patients underwent total (8 cases) or subtotal thyroidectomy (3 cases) with central compartment node dissections. The lateral neck dissection was added in 6 patients. After the operation, neck ultrasound and serum thyroglobulin were checked regularly during the follow-up period. Results: The mean age of the patients was 56.6years (range, 30-74years) at the time of diagnosis. 3 patients were men, and 8 were women. The mean diameter of tumor was 3.7cm(range, 1.5-6.0cm), and 6 patients had lateral neck node metastasis. Extrathyroidal extension was seen in 5 patients (45%). Loco-regional recurrence was found in 2 patients (18%), and distant metastasis in 1 patient (9%). The 5-year disease free survival rate was 68%. Conclusion: The tall cell variant of papillary thyroid carcinoma is an uncommon disease. Clinicopathologic feature and prognosis of this disease show more aggressive behaviors than ordinary papillary thyroid carcinoma. More aggressive treatment and close follow-up should be undertaken in the tall cell variant of papillary thyroid carcinoma.

• Journal of Ginseng Research
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• 제3권1호
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• pp.35-39
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• 1979

Present studies were carried out to clarify the variation of flowering date in the variants of Korean ginseng Plants. In general, the variation of flowering date of violet-stem variant was found to be mere variable as compared with that of yellow-berry variant. And flowers began to bloom earlier in yellow-berry variant than in violet-stem variant. In violet-stem variant as well as in yellow-berry variant, the flowering date of 5-year old plants was earlier than that of 3- and 4-year old plants. As for the flowering date according to the different lines, the third line was earlier than the first or the fifth line.

• 중국학논총
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• 제63호
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• pp.1-28
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• 2019

This study set out to examine the variant forms in the Korean block-printed edition of YouYangZaZu(酉陽雜俎)n terms of modifications of writing forms, increase and decrease of strokes, shortening and lengthening of strokes, connection and interruption of strokes, replacement of Pyeonbang(偏旁), and changing structures and positions. The study also aims to investigate the frequent uses and characteristics of variant forms. The findings show that the variant forms of YouYangZaZu(酉陽雜俎) include characters in some parts. There are 1,500 variant forms in the Korean block-printed edition of YouYangZaZu(酉陽雜俎)ith numerous characters of both various modifications and increasing or decreasing strokes based on the same characters. There are mixed uses of block letters and variant forms throughout the book from a single form to ten different forms of a character.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1999-2002
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• 2012

Background: DNA polymerase is a single-copy gene that is considered to be part of the DNA repair machinery in mammalian cells. The encoded enzyme is a key to the base excision repair (BER) pathway. It is evident that pol beta has mutations in various cancer samples, but little is known about ovarian cancer. Aim: Identification of any variant form of $pol{\beta}$ cDNA in ovarian carcinoma and determination of association between the polymorphism and ovarian cancer risk in Indian patients. We used 152 samples to isolate and perform RT-PCR and sequencing. Results: A variant of polymerase beta (deletion of exon 4-6 and 11-13, comprising of amino acid 63-123, and 208-304) is detected in heterozygous condition. The product size of this variant is 532 bp while wild type pol beta is 1 kb. Our study of association between the variant and the endometrioid type shows that it is a statistically significant factor for ovarian cancer [OR=31.9 (4.12-246.25) with p<0.001]. The association between variant and stage IV patients further indicated risk (${\chi}^2$ value of 29.7, and OR value 6.77 with 95% CI values 3.3-13.86). The correlation study also confirms the association data (Pearson correlation values for variant/stage IV and variant/endometrioid of 0.44 and 0.39). Conclusion: Individuals from this part of India with this type of variant may be at risk of stage IV, endometrioid type ovarian carcinoma.

• 한국자원식물학회지
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• 제25권3호
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• pp.308-316
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• 2012

The purpose of this study was to identify the variant of Platanus occidentalis, whose bark looks white, also can be classified as P. occidentalis and to examine its genetic difference from the general P. occidentalis. For the variant identification of P. occidentalis, SNP and ISSR analysis were used in this study. Thirteen samples of P. occidentalis white variant were collected in Cheongju and 24 samples of normal P. occidentalis obtained in Cheongju, Pyongtaek, Ansan, Suwon, Osan and Jincheon area. ITS 1 and ITS 2 sequences of white variants were identical with those of P. occidentalis. We could not find any sequence difference between normal and white P. occidentalis. So we concluded that the white variant belongs to normal P. occidentalis even their bark is white and peeled easily. By ISSR test, 98 amplicons were acquired using 10 primers. P. occidentalis and white P. occidentalis showed different band patterns from the UBC #834. According to the result of Nei (1979)'s genetic distance analysis, the members of white P. occidentalis were grouped more tightly than the members of normal P. occidentalis. The UPGMA dendrogram shows that the variant and P. occidentalis divided widely into two groups. These results show that the phenotype of P. occidentalis white variant is caused by genetic factors rather than by environmental factors.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제5권1호
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• pp.7-16
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• 2016

이 논문은 인터넷 최상위 한자 도메인의 국제 생성 규칙(LGR)을 위하여 검토 대상 이체자 묶음 선정 방안을 연구한다. 한자 도메인의 국제 생성 규칙을 정하는데 있어 가장 어려운 점은 한자 이체자를 어떻게 처리할 것인가이다. 만일 이체자가 들어간 도메인들(보기: 동해국(東海國), 동해국)이 각각 다른 주소로 접속된다면 혼란이 일어나므로 같은 주소로 접속되는 것이 바람직하다. 그런데 한중의 이체자 묶음이 같지 않으므로 한중의 이체자 묶음을 통합할 필요가 있다. 이런 이유로 저자는 중국 이체자 묶음 3093개에 대한 검토 작업을 진행하다가 한국 한자가 전혀 없거나 한 글자만 있는 중국 이체자 묶음은 한국이 검토할 필요가 없음을 발견하였다. 한국은 중국 이체자 묶음 가운데 한국 한자가 2자 이상 있는 것만 검토하면 된다. 이렇게 함으로써 저자는 한국이 검토해야 할 중국 이체자 묶음의 개수를 3093개에서 303개로 줄일 수 있었는데, 이는 원래 중국 이체자 묶음 개수의 1/10 이다. 본 논문에서 제안한 방법에 따라 중국 이체자 묶음 303개에 대한 검토가 마무리되면 중국과의 협의를 통해 인터넷 최상위 한자 도메인의 국제 생성 규칙을 정하는 작업이 가속화될 것이다.

• Preventive Nutrition and Food Science
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• 제9권1호
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• pp.71-78
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• 2004

Adrenergic receptors play a major role in thermogenesis and lipolysis in brown and visceral adipose tissues, and have been implicated in the pathogenesis of obesity and metabolic disorders. The purpose of this study was to estimate the effects of $\beta$2-adrenergic receptor ($\beta$2AR) and $\beta$3-adrenergic receptor ($\beta$3AR) genotypes on hyperglycemia and obesity in the Korean population. A representative sample consisting of 530 Korean men and women were measured for height, weight, BMI, WHR, obesity index and body composition. The genotypes of $\beta$2AR polymorphism in codon 27 and $\beta$3AR polymorphism in codon 64 were analyzed by the PCR RFLP method. Serum concentrations of fasting glucose, total cholesterol, HDL cholesterol and triglyceride were determined. The frequencies of $\beta$2AR and $\beta$3AR genotype were: both wild type, 62.5% ; only $\beta$2AR variant type, 12.8% ; only $\beta$3AR variant type, 18.8% ; and both variant type, 5.8% ; the frequency of E and R alleles were 0.098 and 0.137, respectively. Among the physiological parameters, fasting glucose level was significantly higher in subjects with both variant type compared with the three other types (p <0.05), Subjects with both variant type had 12%, 12% and 9.3% increases in serum glucose levels compared with wild type, only $\beta$2AR variant type, and only $\beta$3AR variant type, respectively. When logistic regression analysis was conducted to estimate the risk for hyperglycemia, the subjects were selected for fasting blood glucose concentrations of more than 6.105 m㏖/L (110 mg/dL), and the odds ratios were 1.215 (p=0.636) for only $\beta$2AR variant type,1.659 (p=0.089) for only $\beta$3AR variant type, and 3.078 (p=0.011) for both variant type. These results suggest that the interaction of $\beta$2AR and $\beta$3AR variant genotypes has a strong association with increased glucose levels, and might be a significant risk factor for hyperglycemia among Korean subjects.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.1758-1763
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• 2004

This paper focuses on congestion control for ATM network with uncertain time-variant delays. The time-variant delays can be distinguished into two distinct components. The first one is represented by time-variant queueing delays in the intermediate switches that are occurred in the return paths of RM cells. The next one is a forward path delay. It is solved by the VBR model which quantifies the data propagation from the sources to the switch. Robust $H_8$ control is studied for solving congestion problem with norm-bounded time-varying uncertain parameters. The suitable robust $H_8$ controller is obtained from the solution of a convex optimization problem through LMI technique.