• Journal of Practical Engineering Education
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• v.15 no.3
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• pp.625-633
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• 2023

In this paper, we will examine the theoretical background and educational methodological basis of Novel engineering class cases published to date. For this purpose, we selected and investigated 30 Novel engineering-related academic papers and dissertations published from 2016 to 2023. As a result, the theoretical background is Seymour Papert's constructionism and Vygotsky's socio-cultural constructivism, and the educational methodological basis is creative problem-solving learning, problem-based learning, interdisciplinary convergence class, action learning, associating reading and writing education, possibility with integrated curriculum. We hope that this study will solidify the theoretical value of the Nobel Engineering convergence teaching model and serve as an alternative for teachers preparing for future education.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2175-2178
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• 2012

Purpose: Definite diagnosis of follicular thyroid carcinoma (FTC) is based on the presence of capsular or vascular invasion. To date, no reliable and practical method has been introduced to discriminate this malignant neoplasm from follicular thyroid adenoma (FTA) in fine needle aspiration biopsy material. Matrix metalloproteinase-2 (MMP-2), by degrading extracellular matrix, and caspase-3, by induction of apoptosis, have been shown to play important roles in carcinogenesis and aggressive behavior in many tumor types. The aim of this study was to examine expression of MMP-2 and caspase-3 in thyroid follicular neoplasms and to determine their usefulness for differential diagnosis. Method: Sixty FTAs and 41 FTCs were analysed immunohistochemically for MMP-2 and caspase-3. Result: MMP-2 was positive in 4 FTCs (9.8%), but in none of FTAs, with statistical significance (p= 0.025). Caspase-3 was positive in 30 (50%) of FTAs and in 27 (65.9%) of FTCs. Conclusion: Our results show MMP-2 expression only in FTCs and suggest that this protein may be a useful marker to confirm diagnosis of FTC versus FTA with 100% specificity and 100% predictive value of a positive test. We failed to show any differential diagnostic value for caspase-3 in thyroid follicular neoplasms.

• Journal of Microbiology and Biotechnology
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• v.30 no.10
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• pp.1574-1582
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• 2020

Flavonoids have diverse biological functions in human health. All flavonoids contain a common 2-phenyl chromone structure (C6-C3-C6) as a scaffold. Hence, in using such a scaffold, plenty of high-value-added flavonoids can be synthesized by chemical or biological catalyzation approaches. (2S)-Naringenin is one of the most commonly used flavonoid scaffolds. However, biosynthesizing (2S)-naringenin has been restricted not only by low production but also by the expensive precursors and inducers that are used. Herein, we established an induction-free system to de novo biosynthesize (2S)-naringenin in Escherichia coli. The tyrosine synthesis pathway was enhanced by overexpressing feedback inhibition-resistant genes (aroG^fbr and tyrA^fbr) and knocking out a repressor gene (tyrR). After optimizing the fermentation medium and conditions, we found that glycerol, glucose, fatty acids, potassium acetate, temperature, and initial pH are important for producing (2S)-naringenin. Using the optimum fermentation medium and conditions, our best strain, Nar-17LM1, could produce 588 mg/l (2S)-naringenin from glucose in a 5-L bioreactor, the highest titer reported to date in E. coli.

• Journal of Korean Society of Forest Science
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• v.107 no.3
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• pp.237-244
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• 2018

This study was carried out in order to secure basic data of seedling mass propagation technique of Rhododendron mucronulatum which is the native tree species of Korea by surveying the characteristics of its fruit and seed. The fruits were collected at Mt. Goryeo in Ganghwa-gun on different dates in 2013; August 26th, September 5th, September 12th, October 4th. The seed germination test was carried out at 5, 10, 15, 20, 25 and $30^{\circ}C$. Moisture content of the fruit was highest (54.5%) in the fruit collected on September 5th. Number of the seeds in a fruit was 91.3 to 116.3, regardless of the collection date. Seed length was highest ($1947.4{\mu}m$) in the seeds collected on October 4th and seed width was highest ($727.3{\mu}m$) in the seeds collected on September 12th. Germination rate of the seeds was highest at $25^{\circ}C$ regardless of the seed collection date, which showed the highest value(27.3%) in the seeds collected September 12th. Meanwhile, the seeds were not germinated not at all at 5, 10 and $30^{\circ}C$. $T_{50}$ and mean germination time of the seeds got shorter at the higher temperature. Germination uniformity got lower when the collection date got later. Germination speed of the seeds was fastest at $25^{\circ}C$. According to the results of this study, it seems that the appropriate time to collect fruit and seed is between September 12th and October 4th, and the appropriate temperature for the seed germination is $25^{\circ}C$.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.6 no.2
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• pp.282-287
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• 2002

This paper action tracing by techniques to do image sequence component to watch invader based on Mobile internet use. First, detect frame in animation that film fixed area, and make use of image subtraction between two frame that adjoin, segment fixed backing and target who move. Segmentalized foreground object detected and did so that can presume middle value of gouge that is abstracted to position that is specified and watch invader by analyzing action gouge. Those watch information is stored, and made Mobile client send out SMS Message about situation of watch place to server being stored to sensed serial numbers, date, Image file with recording of time.

• Korean Journal of Agricultural Science
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• v.50 no.3
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• pp.407-413
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• 2023

This experiment was carried out to breed a medium maturing variety of Italian ryegrass (Lolium multiflorum Lam.) in Grassland and Forage Crops Division, National Institute of Animal Science, Rural Development Administration (RDA), Cheonan from 2019 to 2020. An Italian ryegrass variety, IR 604 is a tetraploid variety with green in leaf color and has half-erect growth habit in late autumn and erect growth habit in early spring, IR 604 was on May 17 in heading date as a medium maturing variety. Also, IR 604 was longer by 11 cm in flag leaf length and longer by 1.3 cm in plant height than those of the control variety, Kowinner, respectively. IR 604 was also thicker by 1.0 mm in stem thickness and strong in winter hardness. Dry matter (DM) yield (11,036 kg/ha) of IR 604 was 16.6% higher than that of Kowinner. Total digestible nutrient (TDN), crude protein (CP) and relative feed value (RFV) of IR 604 were 60.4, 13.8% and 100.6 which are 1.4, 3.3%, 7.7 higher than those of Kowinner, respectively. Acid detergent fiber (ADF) and neutral detergent fiber (NDF) of IR 604 were 35.5 and 56.7% which are 1.3 and 3.6% lower than those of Kowinner, respectively.

• Journal of Korean Society of Forest Science
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• v.108 no.3
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• pp.322-328
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• 2019

The purpose of this study was to provide basic data for maintenance and repair of the forest road surfaces using the light drop weight test (LDWT), density test, and grain size analysis at four sites in Yeongyang-gun Mt. (2011y, 2014y, 2016y, and 2017y). In terms of the density test results, the opening density in 2011 was the highest at $2.0694g/cm^3$, and the opening density in 2017 was the lowest at $1.7443g/cm^3$. The grain size analysis showed that the proportion of large aggregates was highest at the opening in 2017, and the proportion of large aggregates decreased with the delay of opening date. From the LDWT results, $E_{vd}$ (the dynamic deformation coefficient) of the 2011y forest road was $35.7MN/m^2$, 2014y was $30.5MN/m^2$, 2016y was $28.6MN/m^2$, and 2017y was $23.5MN/m^2$. The $E_{vd}$ value for the oldest forests opened with the 2011y forest road was the highest, the average $E_{vd}$ value of the center portion was $21.45MN/m^2$, the average $E_{vd}$ value of the wheel portion of the banking part was $31.31MN/m^2$, and the average $E_{vd}$ value of the wheel portion of the cut part was $36.71MN/m^2$.

• Journal of Industrial Convergence
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• v.17 no.2
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• pp.9-14
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• 2019

This study was carried out to investigate how the basic plan of the Saemangeum development project that has been developed by the government since 1991 has been changed and to present a new development strategy by analyzing the future value and tourism resource value of Saemangeum development. The research methodology is based on the in - depth analysis methodology of the time series research materials and press releases published by the Saemangeum Development Administration, which oversees the development of Saemangeum. The government announced a plan to significantly reduce agricultural land and increase the proportion of non-agricultural land to 70% in order to create a multifunctional complex. After that, the government revised the basic plan of Saemangeum in 2014 and changed the plan to tailor the investment demand in order to cultivate investment demand, and introduced the special economic cooperation system for global economic cooperation. Therefore, the purpose of this paper is to analyze the process of Saemangeum development to date and to evaluate the value of Saemangeum development as a tourism resource, centered on the Master Plan of the Saemangeum Development Project changed by the government. Based on the results of this analysis, I would like to present the vision of Saemangeum tourism development considering Saemangeum 's environment and characteristics of the surrounding scenery by referring to trends and similar cases of international tourism.

• Journal of Internet Computing and Services
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• v.9 no.6
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• pp.127-139
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• 2008

The value of up-to-date Mobile PC such as UMPC (Ultra Mobile Personal Computer) is recognized greatly in learning environment that busywork such as characteristic of transfer easy and real time communication possibility etc. and conversation with a colleague student, free sending of studying data and public ownership etc. is required. Wish to recognize whether is acting relevant role in u - unfold learning that inflect UMPC in integration research model, and UMPC is u searching for relevant element at studying activity unfolding process u - integration Inquiry-Based Learning that present in Korean education & research information service (KERIS) at fifth-year student science time In primary school in this research. This research result could take charge role of UMPCs' studying-activity though there is persistent feedback with teacher among studying-activity although UMPC's role is utilized on constituent that can be related with studying-activity in learning process.

• Journal of Service Research and Studies
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• v.6 no.3
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• pp.29-40
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• 2016

Since the late 20th century, there has been much effort to improve the market value of media contents which are commercialized in a digital format, by fusing digital data of video, audio, numerals, characters with IT technology together. Then by what criteria and methodologies could the market value for the drama "Sons of the Sun" or the animated film 'Frozen', often referred to in the meida, be estimated? In the circumstances there has been little or no research on the valuation framework of media contents and the status of their valuation system development to date, we propose a practical valuation models for various purposes such as contents trading, review of investment adequacy, etc., by formalizing and presenting a contents valuation framework for the four types of media of movies, online games, and broadcasting commercials, and animations. Therefore, we develope computational methods of cash flows which includes production cost by media content types, provide reference databases associated with key variables of valuation (economic life cycle, discount rates, contents contribution and royalty rates), and finally propose the valuation framework of media contents based on both income approach and relief-from-royalty method which has been applied to valuation of intangible assets so far.