• Title/Summary/Keyword: VP1-2A

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The Multi-Case Self-Healing Algorithm with QoS Guarantee in ATM Networks (ATM망에서 클래스별 QoS 보장을 위한 Multi Case Self-healing방법)

  • Lee, Dong-Wook;Hong, Choong-Seon;Lee, Dae-Young
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.27 no.2C
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    • pp.131-142
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    • 2002
  • It is Proposed thatthe Algorithm for Self healing to restoration the backup VP Occurrence Error in ATM Network. This study focuses on self-healing algorithm to restore failed VP. and backup-VP algorithm, one of the popular self-healing algorithm, is applied in this study. The problem with the existing algorithm is that when backup-VP is failed, there is no solution. This study proposes backup-VP algorithm to guarantee QoS in accordance with class. This study evaluates the effect of failure and proposes two algorithms. One is a disjointed path group to node pair class, and the other is one that applied different backup-VP case by case. Through simulation network restoring ability is compared, analyzed and synthesized.

Anti-herpes Activity of Vinegar-processed Daphne genkwa Flos Via Enhancement of Natural Killer Cell Activity

  • Uyangaa, Erdenebileg;Choi, Jin Young;Ryu, Hyung Won;Oh, Sei-Ryang;Eo, Seong Kug
    • IMMUNE NETWORK
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    • v.15 no.2
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    • pp.91-99
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    • 2015
  • Herpes simplex virus (HSV) is a common causative agent of genital ulceration and can lead to subsequent neurological disease in some cases. Here, using a genital infection model, we tested the efficacy of vinegar-processed flos of Daphne genkwa (vp-genkwa) to modulate vaginal inflammation caused by HSV-1 infection. Our data revealed that treatment with optimal doses of vp-genkwa after, but not before, HSV-1 infection provided enhanced resistance against HSV-1 infection, as corroborated by reduced mortality and clinical signs. Consistent with these results, treatment with vp-genkwa after HSV-1 infection reduced viral replication in the vaginal tract. Furthermore, somewhat intriguingly, treatment of vp-genkwa after HSV-1 infection increased the frequency and absolute number of $CD3^-NK1.1^+NKp46^+$ natural killer (NK) cells producing interferon (IFN)-${\gamma}$ and granyzme B, which indicates that vp-genkwa treatment induces the activation of NK cells. Supportively, secreted IFN-${\gamma}$ was detected at an increased level in vaginal lavages of mice treated with vp-genkwa after HSV-1 infection. These results indicate that enhanced resistance to HSV-1 infection by treatment with vp-genkwa is associated with NK cell activation. Therefore, our data provide a valuable insight into the use of vp-genkwa to control clinical severity in HSV infection through NK cell activation.

The unique role of domain 2A of the hepatitis A virus precursor polypeptide P1-2A in viral morphogenesis

  • Morace, Graziella;Kusov, Yuri;Dzagurov, Georgy;Beneduce, Francesca;Gauss-Muller, Verena
    • BMB Reports
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    • v.41 no.9
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    • pp.678-683
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    • 2008
  • The initial step during assembly of the hepatitis A virus particle is driven by domain 2A of P1-2A, which is the precursor of the structural proteins. The proteolytic removal of 2A from particulate VP1-2A by an as yet unknown host enzyme presumably terminates viral morphogenesis. Using a genetic approach, we show that a basic amino acid residue at the C-terminus of VP1 is required for efficient particle assembly and that host proteases trypsin and cathepsin L remove 2A from hepatitis A virus particles in vitro. Analyses of insertion mutants in the C-terminus of 2A reveal that this part of 2A is important for liberation of P1-2A from the polyprotein. The data provide the first evidence that the VP1/2A junction is involved in both viral particle assembly and maturation and, therefore, seems to coordinate the first and last steps in viral morphogenesis.

Evaluation of Image Quality and dose with the Change of kVp and BMI in the Liver CT (CT 검사 시 관전압과 BMI 변화에 따른 화질 및 피폭평가)

  • Kim, Dong-Hyun;Ko, Sung-Jin;Kang, Se-Sik;Kim, Jung-Hoon;Choi, Seok-Yoon;Kim, Changsoo
    • The Journal of the Korea Contents Association
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    • v.13 no.6
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    • pp.331-338
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    • 2013
  • CT for follow-up visits because of liver disease, body mass index (BMI) and kVp according to the change of the image quality and radiation dose to evaluate for changes. March 2010 to June 2011 at Pusan P University Hospital, abdominal CT scans a patient BMI (Body Mass Index. Less BMI) index was less than 25 in the treatment of subjects had a 48-person Noise and SNR at 100kVp abdominal image is lager than the 120kVp image. CTDI volume value at by the analysis of the radiation dose is 4.47mGy(100kVp) and 9.01mGy(120kVp). So CTDIvol in 100kVp is smaller than CTDIvol in 120kVp(decrease by 44.1%). And, effective dose is 7.1mSv(100kVp) and 12.51mSv(120kVp). So effective dose in 100kVp is smaller than effective dose in 120kVp(decrease by 43%). Evaluation of image quality is that Unacceptable 0 person, Suboptimal 0 person, Adequate 0 person, Good 1 person, Excellent 47 person. In case of repeatly patient, we examinate abdomianl CT scan by using low kVp and body mass index less than 25. We can has good quality image and benefit of low radiation dose.

Image Evaluation and Exposure Dose with the Application of Tube Voltage and Adaptive Statistical Iterative Reconstruction of Low Dose Computed Tomography (저 선량 전산화단층촬영의 관전압과 적응식 통계적 반복 재구성법 적용에 따른 영상평가 및 피폭선량)

  • Moon, Tae-Joon;Kim, Ki-Jeong;Lee, Hye-Nam
    • Journal of radiological science and technology
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    • v.40 no.2
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    • pp.261-267
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    • 2017
  • The study has attempted to evaluate and compare the image evaluation and exposure dose by respectively applying filter back projection (FBP), the existing test method, and adaptive statistical iterative reconstruction (ASIR) with different values of tube voltage during the low dose computed tomography (LDCT). With the image reconstruction method as basis, chest phantom was utilized with the FBP and ASIR set at 10%, 20% respectively, and the change of tube voltage (100 kVp, 120 kVp). For image evaluation, back ground noise, signal-noise ratio (SNR) and contrast-noise ratio (CNR) were measured, and, for dose assessment, CTDIvol and DLP were measured respectively. In terms of image evaluation, there was significant difference in ascending aorta (AA) SNR and inpraspinatus muscle (IM) SNR with the different amount of tube voltage (p < 0.05). In terms of CTDIvol, the measured values with the same tube voltage of 120 kVp were 2.6 mGy with no-ASIR and 2.17 mGy with 20%-ASIR respectively, decreased by 0.43 mGy, and the values with 100 kVp were 1.61 mGy with no-ASIR and 1.34 mGy with 20%-ASIR, decreased by 0.27 mGy. In terms of DLP, the measured values with 120 kVp were $103.21mGy{\cdot}cm$ with no-ASIR and $85.94mGy{\cdot}cm$ with 20%-ASIR, decreased by $17.27mGy{\cdot}cm$ (about 16.7%), and the values with 100 kVp were $63.84mGy{\cdot}cm$ with no-ASIR and $53.25mGy{\cdot}cm$ with 20%-ASIR, a decrease by $10.62mGy{\cdot}cm$ (about 16.7%). At lower tube voltage, the rate of dose significantly decreased, but the negative effects on image evaluation was shown due to the increase of noise.

VP7 Genotypes of Group A Rotavirus Isolated from Infants and Toddlers with Rotavirus Gastroenteritis in Jeju (제주지역 로타바이러스 위장관염 환아로부터 분리한 A군 로타바이러스의 VP7 Genotypes에 대한 연구)

  • Kang, Ki Soo;Shin, Kyung-Sue;Cui, Xiu Ji;Kim, Wonyong
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.9 no.2
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    • pp.147-152
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    • 2006
  • Purpose: Efficacy of the new rotavirus vaccines ($Rotarix^{(R)}$, $RotaTeq^{(R)}$) recently developed can be affected by the rotavirus genotypes prevalent in communities. We performed this study to identify the recent distribution of rotavirus genotypes prevalent in Jeju. Methods: Genotyping of human rotaviruses was performed using 81 samples collected from 154 inpatients and outpatients with rotavirus gastroenteritis at Cheju National University Hospital between July 2005 and June 2006. All six (1, 2, 3, 4, 8, 9) G serotypes were identified by amplification of segments of the gene for VP7 using the reverse transcription-polymerase reaction (RT-PCR). Results: The results of RT-PCR for 81 samples were all positive. G typing of the VP7 protein showed that G1 was the most dominant circulating genotype (65.5%) followed by G2 (14.8%), G3 (13.6%), G8 (1.2%), G9 (1.2%), G4 (0%), and a combination of G1/G3 (3.7%). Conclusion: This distribution of rotavirus VP7 genotypes in Jeju is different from that in other domestic areas; the most dominant circulating genotype was G1.

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The Sound Velocity and Attenuation Coefficient of the Marine Surface Seciments in the nearshore area, Korea (韓半島 沿近海底 表層堆積物에서의 音波傳達速度와 減衰係數)

  • 김성;석봉출
    • 한국해양학회지
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    • v.20 no.2
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    • pp.10-21
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    • 1985
  • The sound velocity (compressional wave) and attenuation coefficient in the marine surface sediments in the nearshore areas off the Pohang, Pusan, Yeosu and Kunsan were investigated in terms of the geotechnical properties of the marine surface sediments in the water depth range of 10-50 meters. The marine surface sediments in the study areas are variable, that is, sand to clay. Due to the various four different study area, the sound velocities and attenuation coefficients in the surface sediment facies vary 1,44m/sec to 1,510m/sec in velocity and 0.82dB/m to 3.70dB/m in coefficient respectively. In fact, the sound velocity increases with increasing of density and mean grain sizes of the sediments, and however, with decreasing of porosith. The correlation equations between the sound velocith and geotechnical properties of mean grain size, density, and porosity were expressed as the following: Vp=1512.28406-9.16083(Mz)+0.20795(Mz)$\^$2/, Vp=1876.15527-597.50397(d)+210.48375(d)$\^$2/, Vp=1559.47217-2.09266(n)$\^$2/. where Vp is sound velocity, Mz is mean grain size, d is density, and m is porosity, respectively. However, the relationship between the attenuation and geotechnical properties were different from that of sound velocity and geotchnical properties. Furthermore, the correlation equations between attenuation coefficient and geotechnical properties were expressed as the following: a=1.85217+0.67197(Mz)-0.09035 (Mz)$\^$2/, a=48.87859+58.21721(d)-16.3.143(d)$\^$2/, a=2.06765+0.07215(n)-0.00111(n)$\^$2/, where a is attenuation coefficient. The high attenuation appeared in the silty sand through fine sand facies in sediment and k values in these facies were in the range of 0.86 to 0.89 dB/m/KHz.

Genogroup position of aquabirnavirus GC-1 isolated from rockfish Sebastes schiegeli in Korea

  • Joh, Seong-Joon;Lee, Youn-Jeong;Song, Chang-Sun;Kang, Shien-Young;Mo, In-Pil;Heo, Gang-Jun
    • Korean Journal of Veterinary Research
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    • v.48 no.3
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    • pp.287-293
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    • 2008
  • The cDNA of the aquabirnavirus, GC-1 isolated from rockfish Sebastes schlegeli in Korea, was synthesized using the reverse transcriptase-polymerase chain reaction. The nucleotide and deduced amino acid sequences were determined from cDNA of the VP2-NS-VP3 coding region of genome segment A. The nucleotide sequences of the segment A were 3,086 base pairs (bp) in length and contained large open reading frame (ORF) and terminal sequences. The large ORF was comprised of 2,916 bp nucleotides and composed of 972 deduced amino acid sequences. Pairwise comparisons were made with other aquabirnavirus sequences published previously. The study of genetic relationships between GC-1 and aquabirnaviruses in the large ORF and VP2 coding regions demonstrated that the GC-1 has the nearest genetic relationship with the marine birnaviruses (MABV strains), and the GC-1 and MABV strains can be clustered as the same genogroup. GC-1 can be included in MABV, which is the 7th genogroup of family Aquabirnaviridae.

A Study for Reduction of Radiation Dose in the Field of Diagnostic Radiology - A Point of Tube Voltage and Filtration - (진단방사선 영역에서 피폭선량 감소를 위한 기술적 연구 - 관전압과 부가여과판을 중심으로 -)

  • Ha, Ho-Young
    • Journal of radiological science and technology
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    • v.15 no.1
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    • pp.89-97
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    • 1992
  • X-ray quality is identified numerically by half value layer(H.V.L) and the HVL is affected by the kVp and the amount of filtration in the useful beam. X-ray quality evaluated by H.L.D is influenced by kVp and filtration. Author had several experiments with phantom in diameter of 8 cm normal adult chest, for reduction of radiation dose of the patients in diagnostic radiology and got some results. 1. H.V.L is increased the thicker the filter and the higher the kVp. 2. If the kVp is increased from 60 to 120, the skin dose can be reduced as 34%(Skin dose of 60 kVp with 4 mmAl filter : 100%). 3. If the 4 mmAl filter with 60 kVp is added to x-ray tube, skin dose can be reduced as 23% than no filter. 4. Therefore high kVp and filtration can increase output to input dose ratio and 120 kVp and 4 mmAl filter were most effective for reduction of patient dose in chest radiography.

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Characterization of G9 genotype porcine rotavirus isolated in Korea (국내 양돈장에서 분리한 G9형 돼지로타바이러스의 특성)

  • Wang, Jun-Hui;Lee, Seung-Chul;Kang, Shien-Young
    • Korean Journal of Veterinary Service
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    • v.35 no.2
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    • pp.83-90
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    • 2012
  • Porcine rotaviruses are the most common causes of viral gastroenteritis in piglets around the world. The major G genotypes of porcine rotaviruses causing diarrhea were G4, G5 and G11 genotypes. Recently, G9 genotype rotaviruses were problemed at swine farms and frequently recognized from diarrheic piglets. In this study, a porcine rotavirus (PoRV-1) was isolated from piglet showing diarrhea using MA104 cells and confirmed as rotavirus by electron microscopy, genomic RNA electropherotyping and indirect immunofluorescence antibody tests. The nucleotide sequence of the VP7 gene of PoRV-1 was determined and compared with those of other genotype rotavirus strains from other parts of the world. Also, the nucleotide sequences of VP4, VP6 and NSP4 genes of PoRV-1 were determined and compared with those of other rotavirus strains from other countries. The results showed that the PoRV-1 isolate belonged to the G9 genotype and the P, I and E genotypes of PoRV-1 were P[23], I5 and E1, respectively. The Korean G9 PoRV-1 isolate and its nucleotide sequence data would be usefully used for the development of porcine rotavirus vaccines in near future.