• Korean Journal of Health Education and Promotion
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• v.31 no.3
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• pp.109-117
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• 2014

Objectives: Although many cities have adopted Healthy Cities approach in Republic of Korea, few studies have been reported about city health profile. So we report a case of city health profile made of subjective indexes and objective indicators using available recent evidence. Methods: To assess subjective city health indexes, questionnaire survey was implemented to public officers and citizen adapting the 'Signs of progress, signs of caution of 12 stage tool from Ontario Healthy Community Coalition. Based on recent literature objective city health indicators were collected for time-series comparison and for the comparison with those of larger province mainly using Korean Statistical Information Service. Results: Subjective city health indexes were successfully constructed in four areas including human health, environment, social and economic area. The score was especially low in environmental area. Specific items in each area for improvement were identified. Objective city health indicators were collected for three year time-series comparison and for the compared with those of larger province. Conclusions: City health profile comprised of subjective city health indexes and objective city health indicators could successfully be made from primary survey and secondary data in a medium-sized Korean city. That City health profile was useful in subsequent city health planning through participatory process.

• Journal of Sensor Science and Technology
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• v.6 no.1
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• pp.63-71
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• 1997

The thin-film eletroluminescent (TFEL) device having the stacked structure of ZnS:Mn/$ZnS:TbF_{3}$ has been fabricated. Insulate layers used (Pb,La)$TiO_{3}$ and $SiO_{2}$ thin films. The emission color was white. The TFEL device employing ZnS:Mn/$ZnS:TbF_{3}(8000{\AA})$ stacked phosphor layers showed the threshold voltage of $78V_{rms}$. And the brightness of the TFEL device was $400{\mu}W/cm^{2}$ at the applied voltage of $100V_{rms}$. The emission spectrum of TFEL device had a wavelength from 450nm to 620nm. The manufactured devices can be a practical use as a TFEL devices of red, green and blue by using the color filters.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.1
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• pp.192-196
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• 2002

Traditionally, aqueous extracts of Puerariae radix had been used for the treatment of alcohol-related problems. In the present study, the effect of Puerariae radix on cell proliferation and expression of nitric oxide synthase (NOS) in the dentate gyrus of alcohol-intoxicated rats were investigated via 5-bromo-2' -deoxyuridine (BrdU) immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry, respectively. Sprague-Dawley rats weighing 150 ± 10 g were divided into four groups: the control group, the Puerarias radix-treated group, the alcohol-treated group, and the alcohol- and Puerariae radix-treated group. The numbers of both BrdU-positive and NADPH-d-positive cells in the dentate gyrus were inhibited significantly by alcohol administration, while Puerariae radix treatment was shown to increase those numbers. In this study, it was revealed that Puerariae radix possesses protective effect against alcohol-induced suppressed new cell formation and NOS expression in the dentate gyrus. Based on the results, it is possible that NO, which might play an important role in the regulation of cell proliferation, is a major target of the toxic effects of alcohol.

• Transactions of the Korean Society of Automotive Engineers
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• v.18 no.6
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• pp.130-137
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• 2010

Due to test facility and specialty, it is physically difficult to conduct the modal tests of large-sized structures such as truck, bus and airplane. So, in case of a large-sized truck, the mode analysis on a full vehicle model comprised of reliable cabin, frame, and deck has been generally performed. However, the reliability of overall vibrational characteristics of the analytic model has not been fairly guaranteed by the testified models of each subsystem owing to the existence of cab suspension and the nonlinear mounting between a chassis frame and a special deck system. In this paper, a method to find out the modal characteristics of a large-sized military truck is presented. New modal test equipment is developed to set the boundary conditions of three military truck variants as close as a free-free condition. And the mode analysis method using coupled structure and dynamic models is established to consider the above-mentioned dynamic non-linearities of the vehicle itself. The usefulness of the suggested method is verified by comparing with the modal test results. Finally, the modal parameters of the final variant are extracted using the proved analytic method.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.05a
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• pp.398-404
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• 2006

Recently in Korea, rocket technology is being taken a wide scope as government planning to build Oeinaro-do space center and to select First Korean astronaut. But compared to development in USA, there is a lack of safety rules in amateur rocket. So it is very essential to meet some powerful legal safety rules for keeping pace with increasing popularization of rocket technology. Herein we discuss, in the field of rocket design, making, launching and collecting stage with considering the rules of IRR, NURA and NAR-HIAA.

• Journal of Pharmaceutical Investigation
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• v.41 no.5
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• pp.309-315
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• 2011

A sensitive and specific liquid chromatographic method coupled with tandem mass spectrometry (LC-MS/MS) was developed for the analysis of ambroxol (active moiety of acebrophylline). After acetonitrile precipitation of proteins from plasma samples, ambroxol and the domperidone (internal standard, IS) were eluted on a C18 column. The isocratic mobile phase was consisted of 10 mM ammonium acetate and methanol (10 : 90, v/v), with flow rate at 0.2 mL/min. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z 379.2${\rightarrow}$264.0 and the m/z 426.2${\rightarrow}$175.1 transitions for ambroxol and the IS, respectively. Twenty four healthy Korean male subjects received two capsules (100 mg ${\times}$ 2) of either the test or the reference formulation of acebrophylline HCl in a 2 ${\times}$ 2 crossover study, this was followed by a 1week washout period between either formulation. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25 (e.g., log 0.8964 - log 0.9910 for $AUC_{0-t}$ log 0.8690 - log 1.0750 for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of Korea Food and Drug Administration for bioequivalence indicating that Acephyll$^{(R)}$ capsule (test) is bioequivalent to Surfolase$^{(R)}$ capsule (reference).

• Journal of Pharmaceutical Investigation
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• v.41 no.5
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• pp.289-294
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• 2011

A rapid and specific high performance liquid chromatography-tandem mass (LC/MS/MS) method for the analysis of montelukast in human plasma has been developed and validated. After cold acetonitrile-induced precipitation of the plasma samples, montelukast and glipizide (internal standard, IS) were eluted on a reverse-phase $C_{18}$ column by isocratic mobile phase consisted of 10 mM ammonium formate buffer (adjusted to pH 3.5 with formic acid) and acetonitrile (3:97, v/v). Acquisition was performed with multiple reaction monitoring (MRM) mode by monitoring the transitions: m/z 587.2${\rightarrow}$ 423.2 for montelukast and m/z 446.0${\rightarrow}$321.2 for IS. Ranges of concentration for calibration curves (10-1000 ng/mL) showed correlation coefficients ($r^2$) were better than 0.9948. Precision of intra- and inter-day ranged from 3.70 to 11.68% and from 3.04 to 12.95%, accuracy of intra-day and inter-day ranged from 93.34 to 102.75% and from 100.79 to 107.63%, respectively. The described method provides a fast and sensitive analytical tool for determining montelukast levels in plasma, and was successfully applied to a pharmacokinetic study in 16 healthy human subjects after oral administration of 10mg tablet formulation of montelukast sodium under fasting conditions.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.4
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• pp.143-148
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• 2008

Caveolin-1 (CAV1) is an integral membrane protein that may function as a scaffold for plasma membrane proteins and acts as a tumor suppressor protein. One causative factor of chemotherapy-resistant cancers is P-plycoprotein (P-gp), the product of the multidrug resistance-1 gene (MDR1), which is localized in the caveolar structure. Currently, the interactive roles of CAV1 and MDR1 expression in the death of cancer cells remain controversial. In this study, we investigated the effects of indomethacin on the cell viability and the expression levels of MDR1 mRNA and protein in a CAV1-siRNA-mediated gene knockdown hepatoma cell line (SK-Hep1). Cell viability was significantly decreased in CAV1-siRNA-transfected cells compared with that of control-siRNA-transfected cells. Furthermore, the viability of cells pretreated with CAV1 siRNA was markedly decreased by treatment with indomethacin (400${\mu}$M for 24 h). However, the protein and mRNA levels of MDR1 were unchanged in CAV1-siRNA-transfected cells. These results suggest that CAV1 plays an important role as a major survival enzyme in cancer cells, and indomethacin can sensitively induce cell death under conditions of reduced CAV1 expression, independent of MDR1 expression.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.05a
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• pp.353-358
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• 2008

Inha Rocket Research Institute has made the igniter that is combination of black powder and PVA polymer for ignition small rocket. But recent igniter is not satisfy because of the performance of igniter is not identified. So, we confirmed requirement of igniter by comparing of ratio of black powder and PVA through experimental method. Especially we studied with ignition temperature for propellant and stable combustion pressure that is requirements of propellant. We can know the tendency of combustion properties by ratio of oxidizer and combustion catalyst through changing of temperature and pressure of exhaust gas of igniter.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.43 no.10 s.352
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• pp.68-73
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• 2006

This, paper proposes a cosimulation methodology that results in an efficient SoC design as well as fast verification by integrating HDL, SystemC, and algorithm-level abstraction using the design tools Active-HDL and Matlab's Simulink. To demonstrate the proposed design methodology, we implemented the design technique on a serial connection multi-channel speaker system. We have demonstrated the proposed cosimulation method utilizing an ARM processor based SoC Master board with the AMBA bus interface and a Xilinx Vertex4 FPGA. The proposed method has the advantage of simultaneous simulation verification of both software and hardware parts in high levels of abstraction mixed with some performance critical parts in more concrete RTL codes. This allows relatively fast and easy design of a speaker connection system which typically requires significant amount of data processing for verification.