• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7071-7076
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• 2015

Epidermal growth factor receptor (EGFR) is one of the targeted molecular markers in many cancers including lung malignancies. Gefitinib and erlotinib are two available therapeutics that act as specific inhibitors of tyrosine kinase (TK) domains. We performed a case-control study with formalin-fixed paraffin-embedded tissue blocks (FFPE) from tissue biopsies of 167 non-small cell lung carcinoma (NSCLC) patients and 167 healthy controls. The tissue biopsies were studied for mutations in exons 18-21 of the EGFR gene. This study was performed using PCR followed by DNA sequencing. We identified 63 mutations in 33 men and 30 women. Mutations were detected in exon 19 (delE746-A750, delE746-T751, delL747-E749, delL747-P753, delL747-T751) in 32 patients, exon 20 (S786I, T790M) in 16, and exon 21 (L858R) in 15. No mutations were observed in exon 18. The 63 patients with EFGR mutations were considered for upfront therapy with oral tyrosine kinase inhibitor (TKI) drugs and have responded well to therapy over the last 15 months. The control patients had no mutations in any of the exons studied. The advent of EGFR TKI therapy has provided a powerful new treatment modality for patients diagnosed with NSCLC. The study emphasizes the frequency of EGFR mutations in NSCLC patients and its role as an important predictive marker for response to oral TKI in the south Indian population.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.39 no.1
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• pp.93-103
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• 2019

In metropolitan cities have been reorganizing the routes of the city buses periodically due to changes in the spatial structure and traffic pattern and the lack of supply due to new developments. However, there is a lack of system to comprehensively evaluate the routes. Even if the evaluation index is not clearly defined, it may not be reasonable. Therefore, it is difficult to set the improvement direction when the bus route is reorganized. In this study, the existing evaluation indexes were reviewed and further investigation was conducted on the problematic indexes. In particular, the degree of curvature has been used as a very important index in the evaluation of the route system, but the existing curvature based curvature has a limitation in considering the traffic characteristics of individual users. For this purpose, a virtual city bus network was set up and the degree of curvature was calculated and compared based on the point - based curvature and stopping point based on individual user O/D. In this study, it is considered that more efficient and practical analysis and evaluation are possible in the evaluation of the city bus route system through the curvature considering the individual user O/D based on the stopping point. It is expected that it will be used at the time of reorganization of city bus route performed by individual local governments in the future.

• Fisheries and Aquatic Sciences
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• v.26 no.3
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• pp.204-215
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• 2023

The thermolabile haemolysin (tlh) of Vibrio parahaemolyticus (Vptlh) from V. parahaemolyticus is a multiple-function enzyme, initially describes as a haemolytic factor activated by lecithin and phospholipase A2 enzymatic activity (Shinoda, 1991; Vazquez-Morado, 2021; Yanagase et al., 1970). Until now, the tlh structure has hypothesized including N-terminal and C-terminal domain, but what domain of the Vptlh structure does the haemolytic activity has not been refined yet. In this study, a 450-bp VpTLH nucleotide sequence of the entire Vptlh gene encoded the C-terminal domain cloned firstly to examine its responsibility in the activity of the Vptlh. The C-terminal domain fused with a 6-His-tag named the His-tag-VpC-terminal domain was expressed successfully in soluble form in the BL21 (DE3) PlysS cell. Remarkably, both expression and purification results confirmed a high agreement in the molecular weight of the His-tag-VpC-terminal domain was 47 kDa. This work showed the His-tag-VpC-terminal domain lysed the erythrocyte membranes in the blood agar and the phosphate buffered saline (0.9%) media without adding the lecithin substrate of the phospholipase enzyme. Haemolysis occurred at all tested diluted concentrations of His-tag-VpC-terminal domain (p < 0.05), providing evidence for the independent haemolytic activity of the His-tag-VpC-terminal domain. The content of 100 ㎍ of the His-tag-VpC-terminal domain brought the highest haemolytic activity of 80% compared to that in the three remaining contents. Significantly, the His-tag-VpC-terminal domain demonstrated not to involve the phospholipase activity in Luria-Bertani agar supplemented with 1% (vol/vol) egg yolk emulsion. All results proved the vital responsibility of the His-tag-VpC-terminal domain in causing the haemolytic activity without the required activation by the phospholipase enzyme. Raw extracts of Phellinus igniarus and Phellinus pipi at 10^-1 mg/mL inhibited the haemolytic activity of the His-tag-VpC-terminal domain from 67.7% to 87.42%, respectively. Hence applying the His-tag-VpC-terminal domain as a simple biological material to evaluate quickly potential derivatives against the Vptlh in vivo conditions will accessible and more advantageous than using the whole of the Vptlh.

• Geophysics and Geophysical Exploration
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• v.11 no.3
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• pp.230-241
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• 2008

Characteristics of transfer responses for arrays like triangle, hexagon and semicircle were investigated. To characterize the site near Izmit city with ambient noise measurement, dispersion curves of surface waves were derived with using array technique like F-K, High resolution F-K, MSPAC and H/V ratio was calculated. Also, MASW was surveyed to get the high frequency part of dispersion curves. The transition from fundamental mode to first high mode of surface waves for dispersion curve was observed. Dispersion curve of fundamental mode of ambient noise and first higher mode of MASW was used in inversion to get S-wave velocity structure of subsurface. None-unique problem of results of surface wave inversion was solved with comparison of result of refraction tomography performed with first arrivals of MASW data.

• The Journal of Asian Finance, Economics and Business
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• v.6 no.3
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• pp.295-304
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• 2019

The study aims to investigate the determinant factors in the organisation of a firm's innovative activities, and the impact of innovation capability on firm's performance of electronic firms in Ho Chi Minh city, Vietnam. How is the performance of electronic companies after delivering an innovation project? How will innovation capability affect firm's performance in electronic companies? This study aims to seek the answer of these questions. We employ a Structural Equation Model and the PLS technique in order to validate the theoretical model proposed in this study. With observation of 374 valid firms, based on Cronbach's Alpha analysis, EFA analysis, CFA analysis and SEM analysis, this study discovers 5 groups of factors including: (i) Institution factors; (ii) Attitude of leadership factors; (iii) Marketing factors; (iv) Technological resources factors; (v) Combination factors, which have direct impact on innovation capability of firms. There are 4 groups of factors that have positive impacts on financial performance of electronic firms, with descending order of importance as follows: (1) Attitude of leadership factors; (2) Quality of human resources factors; (3) Innovation capability; (4) Marketing activities factors. Research results are important implications for Government administrative agencies for business to consult and introduce effective support policies.

• The Journal of Korean Society for School & Community Health Education
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• v.16 no.2
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• pp.1-15
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• 2015

Objectives: This study purposed to identify the factors influencing cardiopulmonary resuscitation(CPR) skills in nursing students. Methods: The research design was descriptive study. Data were collected through structured questionnaires. The participants of this study were 202 nursing students in B & U metropolitan city, and C city. Data were collected from November 15 to November 30, 2013. The data were analyzed using t-test, ANOVA, Scheffe's test, Pearson's correlation coefficients, and Multiple stepwise regression with SPSS WIN v 20.0. Results: CPR knowledge(r=0.51, p<0.001), critical thinking disposition(r=0.43, p<0.001), CPR attitude(r=0.56, p<0.001). self efficacy(r=0.74, p<0.001), and CPR skills were significantly correlated with each other. Predictors of CPR skills were self efficacy, CPR knowledge, critical thinking disposition, grade, and CPR attitude. These variables explained 60% of CPR skills. Multiple regression analysis showed that most powerful factors influencing CPR skills among nursing students was self efficacy. Conclusions: Based on this study, it is required to develop nursing education program to improve self efficacy of nursing students for increasing CPR skills.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.1
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• pp.101-110
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• 2020

Energy and energy consumption play an important role in strategies for socio-economic development of the country. In 1995, Vietnam officially entered the 500 kV North-South transmission power line exploits, with a full length of 1,487 km. The purpose of this study is to investigate the breakpoint and the transition effect of energy consumption to economic growth in Vietnam during the period of 1980-1994, and 1995-2016. The Autoregressive Distributed Lag (ARDL) approach and the Bounds test are used to test for the presence of cointegration, whereas the Toda and Yamamoto procedure Granger causality test is used for the direction of causality. The result of the Bounds test validates the existence of cointegration among the included variables. The empirical results provide evidence that energy consumption has a positive impact on the economic growth of Vietnam in the long run. The causality test shows that there is bi-directional causality between energy consumption and economic growth, supported feedback hypothesis. There is a breakpoint in 1995 and the contribution of energy consumption in economic growth in the period of 1995-2016 is lower than the stage 1980-1994. This study suggests Government authorities explore new sources of energy to achieve sustainable economic development in the long run.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.25 no.7
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• pp.49-54
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• 2011

Now the world will regulate the CO2 emission due to environmental issues. For an alternative plan photovoltaic system is watched. So, photovoltaic system is trend of big city and it is mandatory for renovation of construction. Oil & gas filling station existed in city is suitable to found the photovoltaic system. But the general photovoltaic system in oil & gas filling station is difficult to found because it is classified into hazardous area. This paper evaluates intrinsic safety evaluation of solar cell for making basic data to found for the photovoltaic system on hazardous area. The intrinsic safety characteristic is evaluated by short-circuit ignition test using IEC type spark ignition test apparatus and temperature rising test. The result of short-circuit ignition test, propane-air mixture gas is exploded on condition that 4 solar cells(9[V], 90[mA]) are connected serially under insolation 800[W/$m^2$]. So, if a larger solar module will be used at oil & gas filling station than we were tested, it needs explosion proof. As the result of rising temperature test, the temperature rising due to short circuit is not so much, but when the temperature rises due to radiant heat, it demands careful consideration for environmental influence.

• Journal of Ecology and Environment
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• v.38 no.2
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• pp.123-131
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• 2015

During several visits to the Cebu City landfill in the Philippines, plants were observed growing within the area, including on top of the garbage piles. Studying the response of these plants is important in assessing which can be used in remediating metal contaminated soils. This study aimed to determine whether the plants in the Cebu City landfill excluded or accumulated cadmium (Cd) and chromium (Cr) in the plant tissues. The floristic composition of the landfill was analyzed prior to the sample collection. The samples were acid-digested before the desired elements were measured using atomic absorption spectrophotometry (AAS). The Cd and Cr concentrations in the plant root-zone soil were also measured using AAS. The results indicated that the landfill substrate was generally acidic based on the results of the pH measurement. Of the 32 plant species sampled, Cyperus odoratus showed potential for Cd uptake and internal transfer; Cenchrus echinatus, Vernonia cinerea and Terminalia catappa for Cr uptake, and Cynodon dactylon for Cr internal transfer. The plants in the landfill differed in their response towards the heavy metals. To confirm the behavior of C. odoratus towards Cd, and C. echinatus, C. dactylon, V. cinerea, and T. catappa towards Cr, controlled experiments are recommended, as the plant samples analyzed were collected from the field.

• Journal of Environmental Science International
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• v.12 no.10
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• pp.1043-1054
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• 2003

During the period from April to September 2002, the size distributions of ambient aerosol were measured at the coastal site at Hamduk in Jeju Island. Na$\^$+/, K$\^$+/, Mg$\^$2+/, Ca$\^$2+/and Cl$\^$-/ exhibited mostly a bimodal coarse mode size distribution, while ammonium and sulfate were mainly in the fine size range, with maximum at around 0.54$\mu\textrm{m}$. The average molar concentration ratio of ammonium to sulfate for fine particles was equal to 2.0${\pm}$0.9. Nitrate was evenly found in both the coarse and fine modes. Elements like Al, Fe, Cu, Mg, Na, Ti, Sr and Mn were dominant in coarse particles, with the maximum at around 5.25$\mu\textrm{m}$. S and Pb were mainly in the submicrometer size range. Other elements with a fine and coarse modes were V, Ni, Cu, Ba and Mo. The patterns of the size distributions of trace elements measured at the downtown in Jeju City were very similar to those at the coastal site in Hamduk. However, the amplitude of size fractional concentrations at Jeju City was narrower than that at Hamduk. While the mass median diameters for the chemical species originated from the natural origin such as marine and crust were relatively large, those for ammonium, sulfate, S and Pb were very small.