• 제목/요약/키워드: V-128

검색결과 314건 처리시간 0.031초

취성파괴수준과 파괴개시시점에 관한 진삼축 모형실험연구 (True Triaxial Physical Model Experiment on Brittle Failure Grade and Failure Initiation Stress)

  • 천대성;박찬;박철환;전석원
    • 터널과지하공간
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    • 제17권2호
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    • pp.128-138
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    • 2007
  • 상대적으로 저심도에 건설되는 암반구조물의 경우 단층이나 절리 등 암반 내 존재하는 불연속면이 굴착 후 생성된 경계면과의 교차에 의해 구조적인 형태의 파괴가 지배적으로 발생하나, 고심도에 건설되는 경우 높은 현지응력과 굴착에 따른 유도응력으로 인해 공동 경계면에서 스폴링이나 슬래빙과 같은 취성파괴가 발생할 수 있다. 취성파괴는 암반구조물의 안정성을 약화시키는 주된 원인으로, 고심도 영역에서 암반구조물의 안정성을 확보하기 위하여 응력조건에 따라 발생하는 취성파괴의 개시시점, 파괴수준 및 파괴범위 등과 같은 파괴특성이 규명되어야 한다. 본 연구에서는 고심도의 암반구조물에서 발생할 수 있는 취성파괴의 파괴수준 및 개시시점과 재하응력사이의 관계를 정량적으로 평가하고자 진삼축 응력조건을 구현할 수 있는 모형실험장치를 설계, 제작하여 여러 응력조건에서 모형실험을 수행하였다. 공동주변에서 발생한 파괴수준을 육안관찰과 미소파괴음 발생양상에 의해 3단계로 구분하고, 진삼축 응력조건에 따라 제시하였다. 그 결과 파괴수준은 공동단면에 작용하는 재하응력$(S_v,\;S_{H2})$ 뿐 아니라 공동 축에 평행한 재하응력 $S_{H1}$에 영향을 받으며, $S_{H1}$$S_{H2}$의 크기가 증가할수록 동일한 $S_v$에서 파괴수준은 감소하였다. 파괴개시점 역시 $S_{H1}$$S_{H2}$의 증가에 따라 파괴개시를 위한 응력수준은 증가하였으며, 다중회귀분석을 통해 파괴개시시점과 진삼축 응력조건의 관계식을 도출하였다.

Deep Learning-Based Computed Tomography Image Standardization to Improve Generalizability of Deep Learning-Based Hepatic Segmentation

  • Seul Bi Lee;Youngtaek Hong;Yeon Jin Cho;Dawun Jeong;Jina Lee;Soon Ho Yoon;Seunghyun Lee;Young Hun Choi;Jung-Eun Cheon
    • Korean Journal of Radiology
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    • 제24권4호
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    • pp.294-304
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    • 2023
  • Objective: We aimed to investigate whether image standardization using deep learning-based computed tomography (CT) image conversion would improve the performance of deep learning-based automated hepatic segmentation across various reconstruction methods. Materials and Methods: We collected contrast-enhanced dual-energy CT of the abdomen that was obtained using various reconstruction methods, including filtered back projection, iterative reconstruction, optimum contrast, and monoenergetic images with 40, 60, and 80 keV. A deep learning based image conversion algorithm was developed to standardize the CT images using 142 CT examinations (128 for training and 14 for tuning). A separate set of 43 CT examinations from 42 patients (mean age, 10.1 years) was used as the test data. A commercial software program (MEDIP PRO v2.0.0.0, MEDICALIP Co. Ltd.) based on 2D U-NET was used to create liver segmentation masks with liver volume. The original 80 keV images were used as the ground truth. We used the paired t-test to compare the segmentation performance in the Dice similarity coefficient (DSC) and difference ratio of the liver volume relative to the ground truth volume before and after image standardization. The concordance correlation coefficient (CCC) was used to assess the agreement between the segmented liver volume and ground-truth volume. Results: The original CT images showed variable and poor segmentation performances. The standardized images achieved significantly higher DSCs for liver segmentation than the original images (DSC [original, 5.40%-91.27%] vs. [standardized, 93.16%-96.74%], all P < 0.001). The difference ratio of liver volume also decreased significantly after image conversion (original, 9.84%-91.37% vs. standardized, 1.99%-4.41%). In all protocols, CCCs improved after image conversion (original, -0.006-0.964 vs. standardized, 0.990-0.998). Conclusion: Deep learning-based CT image standardization can improve the performance of automated hepatic segmentation using CT images reconstructed using various methods. Deep learning-based CT image conversion may have the potential to improve the generalizability of the segmentation network.

석회암지대인 덕항산 (강원)의 관속식물상과 식물지리 (Flora and Phytogeography on Mt. Deokhang (Gangwon-do), Limestone area in Korea)

  • 김진석;이병천;정재민;박재홍
    • 식물분류학회지
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    • 제35권4호
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    • pp.337-364
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    • 2005
  • 석회암지대인 강원도 덕항산 일대에 자생하는 관속식물상을 밝히고, 이를 바탕으로 본 지역의 식물지리학적 특성을 논의하였다. 덕항산은 해발 1072.5m에 이르는 석회암지대로서, 지리적으로는 북위 $37^{\circ}17^{\prime}{\sim}37^{\circ}20^{\prime}$, 동경 $128^{\circ}09^{\prime}{\sim}129^{\circ}03^{\prime}$에 위치하며, 행정구역상으로 강원도 삼척시 신기면 대이리에서 태백시 하사미동에 걸쳐 있다. 2003년 10월 10일부터 2005년 10월 4일에 까지 총 10회 조사를 실시한 결과 덕항산 일대의 관속식물은 총 90과 337속 537종 4아종 46변종 3품종의 총 590종류로 분류되었다. 그 중 우리나라 특산식물은 30종이며, 법정 보호종 4종과 희귀 및 멸종위기식물 17종이 분포하였다. 또한 환경부 특정식물종으로는 VI등급 17종, V등급 6종이 조사되었다. 결론적으로 덕항산 일대는 특산식물 및 희귀식물들이 다수가 분포하며, 여러 북방계 식물의 남한계가 되는 곳으로 나타나 식물지리학적으로 중요한 곳으로 평가되었다.

Software development for the visualization of brain fiber tract by using 24-bit color coding in diffusion tensor image

  • Oh, Jung-Su;Song, In-Chan;Ik hwan Cho;Kim, Jong-Hyo;Chang, Kee-Hyun;Park, Kwang-Suk
    • 대한자기공명의과학회:학술대회논문집
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    • 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
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    • pp.133-133
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    • 2002
  • Purpose: The purpose of paper is to implement software to visualize brain fiber tract using a 24-bit color coding scheme and to test its feasibility. Materials and Methods: MR imaging was performed on GE 1.5 T Signa scanner. For diffusion tensor image, we used a single shot spin-echo EPI sequence with 7 non-colinear pulsed-field gradient directions: (x, y, z):(1,1,0),(-1,1,0),(1,0,1),(-1,0,1),(0,1,1),(0,1,-1) and without diffusion gradient. B-factor was 500 sec/$\textrm{mm}^2$. Acquisition parameters are as follows: TUTE=10000ms/99ms, FOV=240mm, matrix=128${\times}$128, slice thickness/gap=6mm/0mm, total slice number=30. Subjects consisted of 10 normal young volunteers (age:21∼26 yrs, 5 men, 5 women). All DTI images were smoothed with Gaussian kernel with the FWHM of 2 pixels. Color coding schemes for visualization of directional information was as follows. HSV(Hue, Saturation, Value) color system is appropriate for assigning RGB(Red, Green, and Blue) value for every different directions because of its volumetric directional expression. Each of HSV are assigned due to (r,$\theta$,${\Phi}$) in spherical coordinate. HSV calculated by this way can be transformed into RGB color system by general HSV to RGB conversion formula. Symmetry schemes: It is natural to code the antipodal direction to be same color(antipodal symmetry). So even with no symmetry scheme, the antipodal symmetry must be included. With no symmetry scheme, we can assign every different colors for every different orientation.(H =${\Phi}$, S=2$\theta$/$\pi$, V=λw, where λw is anisotropy). But that may assign very discontinuous color even between adjacent yokels. On the other hand, Full symmetry or absolute value scheme includes symmetry for 180$^{\circ}$ rotation about xy-plane of color coordinate (rotational symmetry) and for both hemisphere (mirror symmetry). In absolute value scheme, each of RGB value can be expressed as follows. R=λw|Vx|, G=λw|Vy|, B=λw|Vz|, where (Vx, Vy, Vz) is eigenvector corresponding to the largest eigenvalue of diffusion tensor. With applying full symmetry or absolute value scheme, we can get more continuous color coding at the expense of coding same color for symmetric direction. For better visualization of fiber tract directions, Gamma and brightness correction had done. All of these implementations were done on the IDL 5.4 platform.

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열, 살균소독제, 항생제에 의한 분리 Cronobacter spp. (Enterobacter sakazakii) 제어 (Biocontrol of Isolated Cronobacter spp. (Enterobacter sakazakii) by Heat, Sanitizer, and Antibiotic)

  • 이은진;박종현
    • 한국축산식품학회지
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    • 제30권3호
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    • pp.479-486
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    • 2010
  • 국내의 건조분말 식품에서 분리한 Cronobacter spp.의 건조내성에 따른 열, 살균소독제, 항생제에 대한 내성특성 분석하여 Cronobacter spp.을 제어하는 효과적인 방법을 연구하고자 하였다. 분리된 37개의 건조저항 균주, 7개의 건조민감 균주, 그리고 68개의 중간그룹의 균주 총 112개에 대하여 분석한 결과 건조내성을 가지고 있는 Cronobacter spp.는 열에 대해서도 저항성이 큰 것으로 나타났다. 따라서 조제분유등의 건조 스트레스에 노출되어 살아남은 Cronobacter spp.는 열 스트레스에서도 높은 내성을 보일수 있을 것으로 사료된다. 살균소독제를 이용한 Cronobacter spp.의 제어효능은 sodium hypochlorite는 15-25 ppm와 benzalkonium chloride는 5-15 ppm 농도에서 5 log CFU/mL 살균 효과가 있었다. Albumin으로 3%(w/v)오염시킨 부유세균의 살균력은 건조내성 균주와 건조민감 균주 모두에서 오염전과 비슷하여 유기물 오염상태에서도 살균소독제 효능에는 큰 영향을 주고 있지 않음을 알 수가 있었다. 그리고 항생제 내성은 $\beta$-lactam 계열의 ampicillin에 대하여 약 90% 분리주가 64-128 ppm의 농도에서 최소저해 농도를 보여 주었다. Aminoglycoside 계열의 kanamycin과 Gram(-) spectrum의 nalidixic acid에서 4 ppm의 가장 낮은 내성을 보였다. 건조민감 균주과 건조내성 균주의 최소저해농도 경우 전반적으로 모든 항생제에 대해서 건조 내성이 높은 균주가 더 큰 항생제 내성을 지니고 있는 것으로 나타났다. 따라서 분리 Cronobacter spp.의 건조내성이 열과 항생제의 저항성과 관련이 있는 것으로 보인다. 그러므로 조제분유와 같은 분말식품과 그 원료의 오염 Cronobacter spp.의 살균제어에 더 강력한 처리가 필요할 것으로 보인다.

안면부에 발생한 기저세포암 137례의 임상적 고찰 (Clinical Consideration of 137 Cases of Basal Cell Carcinoma in Face)

  • 이봉무;심정수;김태섭;한동길;박대환
    • 대한두개안면성형외과학회지
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    • 제14권2호
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    • pp.107-110
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    • 2013
  • Background: Basal cell carcinoma (BCC) is the most common skin cancer. About 74% cases of basal cell cancer occur on the head and neck. Basal cell carcinoma on the face may have a higher degree of subclinical spread than tumors arising elsewhere. And incompletely excised BCCs become more aggressive when they recur. So the surgical removal and reconstruction of BCC located on the face are important to make perfect curing and cosmetic results. Methods: A retrospective study was done with 128 patients (137 cancers) who were treated with BCC on the face since 1987 to 2011. General data of these cases such as the primary site of cancer, age and sex of the patients, operative methods, and recurrence rate were reviewed. Results: The ratio of men to women was 1:1.4. And 86.9% of the patients with BCC were older than the age of 50 years with the mean age of 65.8 years. The distribution of facial basal cell carcinoma was on the nose, eyelids, cheek, and nasolabial fold. Surgical methods for treatment were local flap, full thickness skin graft, primary closure, and split thickness skin graft. Specifically, local flap consists of V-Y advancement flap, cheek advancement flap, limberg flap, forehead flap, nasolabial flap, rotation flap, transposition flap, bilobed flap, and island flap. Six cases recurred and all of them were treated with reoperation. Conclusion: The authors reviewed facial basal cell carcinoma cases in our hospital. This study might be helpful to choose appropriate operation method to manage BCC on face in Korea.

스트렙토조토신 유도 당뇨 흰쥐에서 전기자극이 상처치유와 피부 비만세포에 미치는 영향 (Effects of Electrical Stimulation on Wound Healing and Skin Mast Cells in Streptozotocin-Induced Diabetic Rats)

  • 제갈승주;이경선;정옥봉;이재형
    • 대한임상검사과학회지
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    • 제40권2호
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    • pp.118-128
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    • 2008
  • The aim of this study was to investigate the effect of electrical stimulation on healing of impaired wound and alteration of mast cells in experimental diabetic rats. Thirty male Sprague-Dawley rats were divided into three groups : incision (control), diabetes+incision (diabetes) and diabetes + incision + electrical stimulation (D/ES). Diabetes was induced in rats by streptozotocin (STZ) injection (60 mg/kg, one time) and 20 mm length incision wounds were created on the back after shaving hair. The electrical stimulation rats were treated with a current intensity of 30~50 V at 120 pps and $140{\mu}s$ for 10 days from 3 days after STZ injection. The lesion and adjacent skin tissues were fixed with 10% buffered formalin, embedded with paraffin. For wound healing analysis, hematoxylin-eosin (HE) and picrosirius red staining were performed. Mast cells (MC) were stained with toluidine blue (pH 0.5) and quantified at ${\times}200$ using a light microscope. The density of keratinocyte proliferation and microvessels in skin tissues were analyzed using a computerized image analysis system on sections immunostained with proliferative cell nuclear antigen (PCNA) and ${\alpha}$-smooth muscle actin (${\alpha}$-SMA), respectively. The results showed that the wound healing rate, collagen density and neoepidermis thickness, density of PCNA-positive cells and density of ${\alpha}$-SMA-positive vessels were significantly higher in D/ES rats than in diabetic rats. The density of MCs and degranulated MCs in D/ES rats were also significantly higher than those in diabetic rats. These findings suggest that the electrical stimulation may promote the tissue repair process by accelerating collagen production, keratinocyte proliferation and angiogenesis in the diabetic rats, and MCs are required for wound healing of skin in rats.

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PMF 모델을 이용한 대기 중 PM-10 오염원의 확인 (Source Identification of Ambient PM-10 Using the PMF Model)

  • 황인조;김동술
    • 한국대기환경학회지
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    • 제19권6호
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    • pp.701-717
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    • 2003
  • The objective of this study was to extensively estimate the air quality trends of the study area by surveying con-centration trends in months or seasons, after analyzing the mass concentration of PM-10 samples and the inorganic lements, ion, and total carbon in PM-10. Also, the study introduced to apply the PMF (Positive Matrix Factoriza-tion) model that is useful when absence of the source profile. Thus the model was thought to be suitable in Korea that often has few information about pollution sources. After obtaining results from the PMF modeling, the existing sources at the study area were qualitatively identified The PM-10 particles collected on quartz fiber filters by a PM-10 high-vol air sampler for 3 years (Mar. 1999∼Dec.2001) in Kyung Hee University. The 25 chemical species (Al, Mn, Ti, V, Cr, Fe, Ni, Cu, Zn, As, Se, Cd, Ba, Ce, Pb, Si, N $a^{#}$, N $H_4$$^{+}$, $K^{+}$, $Mg^{2+}$, $Ca^{2+}$, C $l^{[-10]}$ , N $O_3$$^{[-10]}$ , S $O_4$$^{2-}$, TC) were analyzed by ICP-AES, IC, and EA after executing proper pre - treatments of each sample filter. The PMF model was intensively applied to estimate the quantitative contribution of air pollution sources based on the chemical information (128 samples and 25 chemical species). Through a case study of the PMF modeling for the PM-10 aerosols. the total of 11 factors were determined. The multiple linear regression analysis between the observed PM-10 mass concentration and the estimated G matrix had been performed following the FPEAK test. Finally the regression analysis provided source profiles (scaled F matrix). So, 11 sources were qualitatively identified, such as secondary aerosol related source, soil related source, waste incineration source, field burning source, fossil fuel combustion source, industry related source, motor vehicle source, oil/coal combustion source, non-ferrous metal source, and aged sea- salt source, respectively.ively.y.

호알칼리성 Bacillus sp.의 Lactose 투과와 이용성 (Transport and Utilization of Lactose by Alkalophilic Bacillus sp.)

  • 윤성식;김창민;양융;유주현
    • 한국미생물·생명공학회지
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    • 제19권2호
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    • pp.128-134
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    • 1991
  • To study the reduced growth and synthesis, proeviously reported, of ${\beta}$-galactosidase of alkalophilic Bacillus sp. YS-309 at the higher lactose concentration of 0.5% (w/v) in the medium, lactose transport and utilization were examined. The results showed that lactose transport was influenced by the addition of four kinds of antibiotics, and tetracycline stimulated most but not valinomycin. PEP-potentials of the cells grown on lactose was estimated lower than the cells on glucose and on galactose. Thus, the transport of lactose was independent of intracellular PEP and phosphorylation reactions, and was thought to be uptaked directly or oxidized in part in the transport process. In the other hand, once lactose was uptaked into the cells, it was hydrolyzed by ${\beta}$-glactosidase to glucose and galactose. The former was metabolized fast but the latter was accumulated. Galactose and lactose were not utilized until glucose was mostly depleted in the medium. The ${\beta}$-galactosidase synthesis decreased in the presence of glucose over 0.2% and galactose over 0.05 to 0.1%, respectively. In conclusion, it was considered for glucose as a repressor and galactose as a inducer for ${\beta}$-galactosidase synthesis even though the mechanisms were not elucidated. Catabolite repression of glucose on the enzyme synthesis was not relieved by the addition of exogeneous cAMP.

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Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans

  • Lee, Eun Byeol;Kim, Jun Hyeong;Cha, Youn-Soo;Kim, Mina;Song, Seuk Bo;Cha, Dong Seok;Jeon, Hoon;Eun, Jae Soon;Han, Sooncheon;Kim, Dae Keun
    • Biomolecules & Therapeutics
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    • 제23권6호
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    • pp.582-589
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    • 2015
  • Several theories emphasize that aging is closely related to oxidative stress and disease. The formation of excess ROS can lead to DNA damage and the acceleration of aging. Vigna angularis is one of the important medicinal plants in Korea. We isolated vitexin from V. angularis and elucidated the lifespan-extending effect of vitexin using the Caenorhabditis elegans model system. Vitexin showed potent lifespan extensive activity and it elevated the survival rates of nematodes against the stressful environments including heat and oxidative conditions. In addition, our results showed that vitexin was able to elevate antioxidant enzyme activities of worms and reduce intracellular ROS accumulation in a dose-dependent manner. These studies demonstrated that the increased stress tolerance of vitexin-mediated nematode could be attributed to increased expressions of stress resistance proteins such as superoxide dismutase (SOD-3) and heat shock protein (HSP-16.2). In this work, we also studied whether vitexin-mediated longevity activity was associated with aging-related factors such as progeny, food intake, growth and movement. The data revealed that these factors were not affected by vitexin treatment except movement. Vitexin treatment improved the body movement of aged nematode, suggesting vitexin affects healthspan as well as lifespan of nematode. These results suggest that vitexin might be a probable candidate which could extend the human lifespan.