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Protective Effect of Genistein and Korean Fermented Soybean (Chungkookjang) Extract against Benzo(a)pyrene Induced DNA Damage in HepG2 Cells (Benzo(a)pyrene 유도 DNA 손상에 대한 Genistein과 청국장추출물의 보호효과)

  • Song, Eun-Jeong;Kim, Hyun-Pyo;Heo, Moon-Young
    • YAKHAK HOEJI
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    • v.52 no.5
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    • pp.376-383
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    • 2008
  • Chungkookjang (CKJ) is a fermented soybean product and one of favorite traditional foods in Korea. In this study, the alcoholic extract from Korean fermented soybean (CKJ) and its one of major flavonoids, genistein were evaluated for their protective effect against B(a)P induced cytotoxicity and DNA damage in HepG2 cells. CKJ extract and genistein decreased B(a)P-induced cell cytotoxicity. CKJ extract inhibited DNA single strand breaks evaluated by single cell gel electrophoresis. From RT-PCR study, it was revealed that CKJ extract decrease DNA damage induced in HepG2 cells expressing CYP1A1 and 1A2 by B(a)P. The metabolizing activities of CYP1A1 and CYP1A2, as measured by the 7-alkoxy resorufin O-deethylation (AROD) assay, showed that CKJ extract and genistein inhibited CYP1A1 and CYP1A2 activities. Genistein may contribute to these biological effects of CKJ extract at least in part. All these results indicate that CKJ extract and genistein may be useful for protection against B(a)P-induced cytotoxicity and DNA damage. Therefore, the alcoholic extract of Korean fermented soybean (CKJ) is suggested to be promising functional food which can prevent the cellular genotoxicity of dietary and lifestyle related carcinogens.

Effect of Wood Charcoal and Pyroligneous Acid on Soil Microbiology and Growth of Red Pepper (탄화물이 토양미생물 및 고추 생육에 미치는 영향)

  • 안병준;조성택;조태수;이성재;이윤수
    • Journal of Korea Foresty Energy
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    • v.22 no.3
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    • pp.49-56
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    • 2003
  • As a part of agricultural utilization of charcoal and pyroligneous acid, the effect of wood carbonization products on the growth of red pepper and soil microorganisms was investigated. The treatment of charcoal and pyroligneous acid provided good growth conditions to microorganisms through neutralizing soil acidity and improving the physicochemical properties of soil. Therefore the density of useful microorganism in the soil has been increased. In the growth of red pepper, the length, diameter, and the fruit numbers of red pepper have been increased by treating with wood carbonization products. It was especially shown that yield has increased about 50% in the fruit number, by treating charcoal 1kg, 1000 time-diluted solution of pyroligneous acid and bacteria, compared with the control. It was estimated that increasing the length of seedling and the diameter of red pepper stem contributed to the resistance against the prerequisites of various environmental changes in open field. Therefore, the final yield would be increased. In the antagonism experiment of red pepper mold (Colletotrichum gloeosporioides), the mold became extinct in the 2- and 10-time diluted solution of pyroligneous acid, compared with the control. On the other hand, their growth speed was delayed in the 100- and 1000 time-diluted solution.

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3D Panoramic Mosaiciking to Silppress the Ghost Effect at Long Distance Scene for Urban Area Visualization (도심영상 입체 가시화 중 발생하는 원거리 환영현상 해소를 위한 3차원 파노라믹 모자이크)

  • Chon, Jae-Choon;Kim, Hyong-Suk
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.42 no.4 s.304
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    • pp.87-94
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    • 2005
  • 3D image mosaicking is useful for 3D visualization of the roadside scene of urban area by projecting 2D images to the 3D planes. When a sequence of images are filmed from a side-looking video camera passing long distance areas, the ghost effect in which same objects appear repeatively occurs. To suppress such ghost effect, the long distance range areas are detected by using the distance between the image frame and the 3D coordinate of tracked optical flows. The ghost effects are suppressed by projecting the part of image frames onto 3D multiple planes utilizing vectors passing the focal point of frames and a virtual focal point. The virtual focal point is calculated by utilizing the first and last frames of the long distance range areas. We demonstrate algorithm that creates efficient 3D Panoramic mosaics without the ghost effect at the long distance area.

Effects of Bee Venom Acopuncture at Sinsu($BL_{23}$) and Daejangsu($BL_{25}$) in Different Concentration on Neuropathic Pain Induced by Tibial and Sural Nerve Injury in Rats (농도 차이에 따른 신수(腎兪)($BL_{23}$).대장수(大腸兪)($BL_{25}$) 봉독약침이 백서의 신경병리성 동통모델에 미치는 영향)

  • Chiang, Suo-Yue;Bang, Sung-Pil;Kim, Jae-Hong;Wei, Tung-Sheun;Yun, Yeo-Choong
    • Journal of Acupuncture Research
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    • v.27 no.5
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    • pp.13-24
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    • 2010
  • Objectives : This study was designed to investigate the effects of bee venom acupuncture at Shinsu($BL_{23}$) and Daejangsu($BL_{25}$) on neuropathic pain induced by tibial and sural nerve injury in rats. Methods : Neuropathic pain model was made by partial resection of tibial and sural nerve. Three weeks after the neuropathic surgery, bee venom acupuncture was firstly injected at $BL_{23}$ and $BL_{25}$, then we measured withdrawal responses induced by von Frey filament and acetone stimulation. Bee venom acupunctures were injected 6times on every 2days. Measurement of withdrawal responses were conducted on the same days. After bee venom acupuncture injection, expression levels of c-Fos, nocieptin and KOR-3 were observed through using immunohistochemistry. Results : In this experiment, bee venom acupunctures at $BL_{23}$ and $BL_{25}$ decreased levels of withdrawal responses induced by von Frey filament and acetone stimulation respectively. In addtion, expression levels of c-Fos, nociceptin and KOR-3 in central gray part of brain in rats were decreased by bee venom acupuncture. Conclusions : These results imply that bee venom acupuncture was useful to treat patients with neuropathic pain, and related mechanisms were involved in opioid and their receptors such as nociceptin and KOR-3.

Shifting of Centricity: Qualitative Meta Synthetic Approach on Caring Experience of Family Members of Patients with Dementia (중심성의 이동: 치매 환자 가족의 돌봄 경험에 대한 질적 합성 접근)

  • Ryu, Young Mi;Yu, Mi;Oh, Seieun;Lee, Haeyoung;Kim, Haejin
    • Journal of Korean Academy of Nursing
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    • v.48 no.5
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    • pp.601-621
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    • 2018
  • Purpose: This study aimed to synthesize the caring experiences of Korean family members of patients with dementia through a qualitative meta-synthesis method. Methods: By searching through nine Korean and English databases, we compared 37 qualitative studies on caring experiences of family members of patients with dementia. The selected studies were synthesized through meta-synthesis, proposed by Sandelowski and Barroso (2007). Results: The meta-synthesis elicited four themes: tough life due to care for patients, changes in relationships, adaptation to caregiver's roles, and new perspectives of life through personal growth. Caregivers were shocked when a sudden diagnosis of dementia was made prior to any preparation on their part. They were tied to their patients all the time and their mind and body got exhausted. Their relationship with patients began to change and they looked at them differently. They experienced conflicts with the other non-caring family members and were alienated from them. They were also socially isolated. However, by building their own care strategies and utilizing social resources, they gradually adapted to their caregiver roles. Finally, they experienced personal growth and acquired a new perspective toward life by accepting their roles and finding meaning in their lives. Shifting the caregiver's centricity from themselves to the patient was the process of becoming human beings who actively constructed their realities while giving meaning to their painful lives and interacting with the environment. Conclusion: The results of the study can be useful for nurses in understanding the experiences of caregivers of the patients with dementia and in providing them with practical interventions.

Design of Carrier Recovery Circuit for High-Order QAM - Part II : Performance Analysis and Design of the Gear-shift PLL with ATC(Automatic Transfer-mode Controller) and Average-mode-change Circuit (High-Order QAM에 적합한 반송파 동기회로 설계 - II부. 자동모드전환시점 검출기 및 평균모드전환회로를 적용한 Gear-Shift PLL 설계 및 성능평가)

  • Kim, Ki-Yun;Kim, Sin-Jae;Choi, Hyung-Jin
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.38 no.4
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    • pp.18-26
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    • 2001
  • In this paper, we propose an ATC(Automatic Transfer mode Controller) algorithm and an average-mode-change method for use in Gear shift PLL which can automatically change loop gain. The proposed ATC algorithm accurately detects proper timing or the mode change and has a very simpler structure - than the conventional lock detector algorithm often used in QPSK. And the proposed average mode change method can obtain low errors of estimated frequency offset by averaging the loop filter output of frequency component in shift register. These algorithms are also useful in designing ASIC, since these algorithms occupy small circuit area and are adaptable for high speed digital processing. We also present phase tracking performance of proposed Gear-shift PLL, which is composed of polarity decision PD, ATC and average mode change circuit, and analyze the results by examining constellation at each mode.

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Civil-Military Relations and Military Leadership (민군관계와 국방리더십의 발전방향)

  • Son, Su-Tae
    • Journal of National Security and Military Science
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    • s.4
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    • pp.119-156
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    • 2006
  • Now it is not useful the theory about civil-military relationship that have been analysed for power games between military and civilians Korean society is going on governance society managed by cooperating network of government, civilian society and business market These social change require for new context about civil-Military relationship. Military leadership must contribute desirable civil-military relationship This study will suggest the direction about military leadership for desirable civil-military relationship. Now political issues about military intervention to the government are almost settled, but the worry about complications between military and civilians exist in the part of low issues like policy-making. Another important issues is military leadership about the style of social-being. In recent years, social change is very complex and speedy like global networking and diversity, leadership environment also, changed like leadership paradigm shift. Military leadership must be examined from the principle to the context of social integration At the present age, individual soldier is citizen in uniformed. Also military leadership must to seek the principle in the citizen mind like citizenship. Another charactristics of present day military is influence of high technogy. For the high-tech war military need the transition about science and technology from the whole society. In the context of above the development of military leadership are suggested as follows. First, the development of military control leadership must besought to the context of cooperation between government and military. Government must provide the system to strengthen military professionals in the process of policy-making about national security Second, military leadership must embody the important social values through the advanced military making, Third, military leadership must provide the adaptability to the society through the military education of their soldiers Forth, military leadership must be contributed to the social integration and to the growing up individual soldiers like their socialization and their achievement. Five, an important subject of military leadership is the creation of desirable military culture through the harmony of social culture and military culture.

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Impact of a "TED-Style" presentation on potential patients' willingness to accept dental implant therapy: a one-group, pre-test post-test study

  • Ghanem, Henry;Afrashtehfar, Kelvin Ian;Abi-Nader, Samer;Tamimi, Faleh
    • The Journal of Advanced Prosthodontics
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    • v.7 no.6
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    • pp.437-445
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    • 2015
  • PURPOSE. A survey was conducted to assess the impact of a TED-like educational session on participants' willingness to accept dental implant therapy. MATERIALS AND METHODS. Volunteers interested in having information about dental implant therapies were recruited and asked to complete a two-part survey before and after an educational session. The initial survey elicited demographic information, self-perceived knowledge on dental implants and willingness to this kind of treatment. A "TED-style" presentation that provided information about dental implant treatments was conducted before asking the participants to complete a second set of questions assessing the impact of the session. RESULTS. The survey was completed by 104 individuals, 78.8% were women and the mean age was $66.5{\pm}10.8$. Before the educational session, 76.0% of the participants refused dental implants mainly due to lack of knowledge. After the educational session, the rejection of dental implants decreased by almost four folds to 20.2%. CONCLUSION. This study proved that an educational intervention can significantly increase willingness to accept treatment with dental implants in a segment of the population who is interested in having information about dental implant therapy. Furthermore, educational interventions, such as TED-like talks, might be useful to increase popular awareness on dental implant therapy.

Radionuclide Tubal Function Test (방사핵을 이용한 난관기능검사)

  • Roh, T.S.;Kim, J.G.;Yoon, B.H.;Moon, S.Y.;Lee, J.Y.;Chang, Y.S.;Chung, J.K.
    • Clinical and Experimental Reproductive Medicine
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    • v.14 no.1
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    • pp.1-6
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    • 1987
  • The Radionuclide test (RN test) using radioactively labelled human albumin microspheres was developed recently to evaluate the patency and functional capacity of the fallopian tubes. 57 infertile women underwent this procedure as a part of their infertility work up. The results of the radionuclide evaluation were compared with those of the hysterosalpingography (HSG) and further the surgical findings of the laparoscopy and laparotomy. In 64.9%(37/57) of the cases, there was complete agreement between radionuclide test (RN test), hysterosalpingography(HSG) and surgical findings. In comparison with surgical findings, RN test showed a complete agreement rate of 89.4%(51/57), a partial agreement rate of 5.3%(3/57) and no agreement rate of 5.3%(3/57), respectively. Likewise, HSG revealed a complete agreement rate of 80.7%(46/57), a partial agreement rate of 10.5%(6/57) and no agreement 8.8%(5/57), respectively. It would appear that as opposed to the traditional HSG, RN test may give a better understanding of the functional capacity of the tube and may prove a useful method before and after tubal surgery.

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Effect of corrosion on the ultimate strength of double hull oil tankers - Part I: stiffened panels

  • Kim, Do Kyun;Park, Dae Kyeom;Kim, Jeong Hwan;Kim, Sang Jin;Kim, Bong Ju;Seo, Jung Kwan;Paik, Jeom Kee
    • Structural Engineering and Mechanics
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    • v.42 no.4
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    • pp.507-530
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    • 2012
  • Age-related problems especially corrosion and fatigue are normally suffered by weatherworn ships and aging offshore structures. The effect of corrosion is one of the important factors in the Common Structural Rule (CSR) guideline of the ship design based on a 20 or 25 years design life. The aim of this research is the clarification of the corrosion effect on ultimate strength of stiffened panels on various types of double hull oil tankers. In the case of ships, corrosion is a phenomenon caused by the ambient environment and it has different characteristics depending on the parts involved. Extensive research considering these characteristic have already done by previous researchers. Based on this data, the ultimate strength behavior of stiffened panels for four double hull oil tankers such as VLCC, Suezmax, Aframax, and Panamax classes are compared and analyzed. By considering hogging and sagging bending moments, the stiffened panels of the deck, inner bottom and outer bottom located far away from neutral axis of ship are assessed. The results of this paper will be useful in evaluating the ultimate strength of an oil tanker subjected to corrosion. These results will be an informative example to check the effect of ultimate strength of a stiffened panel according to corrosion addition from CSR for a given type of ship.