Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지

Effects of Bee Venom Acopuncture at Sinsu($BL_{23}$) and Daejangsu($BL_{25}$) in Different Concentration on Neuropathic Pain Induced by Tibial and Sural Nerve Injury in Rats

농도 차이에 따른 신수(腎兪)($BL_{23}$).대장수(大腸兪)($BL_{25}$) 봉독약침이 백서의 신경병리성 동통모델에 미치는 영향

  • Chiang, Suo-Yue (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Bang, Sung-Pil (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Kim, Jae-Hong (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Wei, Tung-Sheun (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University) ;
  • Yun, Yeo-Choong (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Dongshin University)
  • 강수우 (동신대학교 한의과대학 침구과교실) ;
  • 방성필 (동신대학교 한의과대학 침구과교실) ;
  • 김재홍 (동신대학교 한의과대학 침구과교실) ;
  • 위통순 (동신대학교 한의과대학 침구과교실) ;
  • 윤여충 (동신대학교 한의과대학 침구과교실)
  • Received : 2010.07.09
  • Accepted : 2010.10.11
  • Published : 2010.10.20
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Abstract

Objectives : This study was designed to investigate the effects of bee venom acupuncture at Shinsu($BL_{23}$) and Daejangsu($BL_{25}$) on neuropathic pain induced by tibial and sural nerve injury in rats. Methods : Neuropathic pain model was made by partial resection of tibial and sural nerve. Three weeks after the neuropathic surgery, bee venom acupuncture was firstly injected at $BL_{23}$ and $BL_{25}$, then we measured withdrawal responses induced by von Frey filament and acetone stimulation. Bee venom acupunctures were injected 6times on every 2days. Measurement of withdrawal responses were conducted on the same days. After bee venom acupuncture injection, expression levels of c-Fos, nocieptin and KOR-3 were observed through using immunohistochemistry. Results : In this experiment, bee venom acupunctures at $BL_{23}$ and $BL_{25}$ decreased levels of withdrawal responses induced by von Frey filament and acetone stimulation respectively. In addtion, expression levels of c-Fos, nociceptin and KOR-3 in central gray part of brain in rats were decreased by bee venom acupuncture. Conclusions : These results imply that bee venom acupuncture was useful to treat patients with neuropathic pain, and related mechanisms were involved in opioid and their receptors such as nociceptin and KOR-3.

Keywords

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