• Biomolecules & Therapeutics
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• v.6 no.3
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• pp.317-327
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• 1998

The subchronic toxicity study of rHuEPO, a newly developed recombinant erythropoietin, was investigated for 13 weeks in Beagle dogs intravenously treated with doses of 100, 500 and 2,500 lU/kg/day. There were no significant changes in body weight, food intake, physical and opthalmic examination, urine analysis, etc. Any toxic response was not observed except for enlarged spleen and extramedullary hematopoiesis. These results indicate that the no-observed adverse effect level (NOAEL) of rHuEPO is 100 lU/kg in Beagle dogs.

• Proceedings of the IEEK Conference
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• 2006.06a
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• pp.865-866
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• 2006

The aim of this study was to implement the system that could evaluate the function of urinary tract with noninvasive and comfort methods. There for in this study hardware device and computer software have been developed that enables the analysis of the urine flow rate and vesical pressure signal measured during voiding. These signals were recorded simultaneously and transmitted to the PC. For the measurement system evaluation, the model system for the lower urinary system of men was designed. From the evaluation of the model system, vesical pressure was correlated with the occlusion degree. In a pilot study on 5 male subjects, means of standard deviation was 1.06, average error rate was 2.09 and coefficient variation was 2.09.

• Korean Journal of Oriental Medicine
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• v.11 no.1
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• pp.109-118
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• 2005

In a field of oriental medicine, it is necessary to collect systemically clinical data and integrate. Input data items was decided, then categorized by the modules through discussion of the institute and hospitals. Items are information of patient, history, aspects of occurrence, pattern identification, prescriptions of herbal medicine, the results of biochemical serum examination, blood cell count, urine analysis, CT, MRI, Chest PA, EKG etc. Factors in oriental medicine are Sasang constitution, Stroke-Pattern-Identification(china), differentiation of cold and heat syndrome. This tool was constructed by using Microsoft-Access 2000 and Microsoft Visual Basic 6.0. Furthermore this web-based system could be applied to multi-center clinical investigation.

• Proceedings of the Korea Society for Simulation Conference
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• 2000.11a
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• pp.186-191
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• 2000

요에 함유된 여러 성분들의 영향에 의해 다양한 정적 특성을 나타내는 요분석용 스트립의 화학적인 변화 양상을 요분석 시스템을 사용하여 요분석용 스트립의 각 항목별 각 등급별을 정성적 및 반정량적 분석을 하기 위하여 퍼지 알고리듬을 제안하고, 퍼지 분류기를 구현한 후 구현된 분류기를 검증하기 위하여 시뮬레이션 하였다. 이를 위하여 다음과 같은 연구를 수행하였다. 표준시료를 사용하여 요분석용 스트립의 분광학적 분석에 의한 퍼지 입력 변수, 퍼지 멤버쉽함수 및 퍼지규칙을 생성하였다. 그리고 구현된 분류기를 사용하여 각 항목별과 각 등급별로 평가하였다. 평가 결과 요분석용 스트립의 항목별 음성과 양성의 판별에서는 우수한 결과가 나왔으나, 정량적 분석을 위한 각 항목별 등급의 분류에서는 측정값의 오차로 인해 최고 8%의 오차가 발생하였다.

• Mycobiology
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• v.45 no.4
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• pp.426-429
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• 2017

A yeast-like organism was isolated from a urine sample of a 6-year-old neutered male miniature poodle dog with urinary tract infection, diabetes ketoacidosis, and acute pancreatitis. We identified the yeast-like organism to be Candida glabrata and found that this fungus was highly resistant to azole antifungal drugs. To understand the mechanism of azole resistance in this isolate, the sequences and expression levels of the genes involved in drug resistance were analyzed. The results of our analysis showed that increased drug efflux, mediated by overexpression of ATP transporter genes CDR1 and PDH1, is the main cause of azole resistance of the C. glabrata isolated here.

• Journal of Veterinary Clinics
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• v.20 no.4
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• pp.501-503
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• 2003

Urolithiasis (UL) is a common disease of canine. Analysis of urinary stone is an essential step in the examination and initial treatment of the patient with UL. The dead maned wolf (Chrysocyon brachyurus), male, was introduced to the Veterinary Teaching Hospital, Chungbuk National University. The maned wolf was imported from USA to Cheong-ju zoo. Postmortem sign of maned wolf was hemorrhage of bladder with a many stones. No bacteria was shown with bacterial culture of urine. But in feces, Clostridium perfringens were overgrown. Bladder stone from maned wolf was composed of calcium oxalate. Calcium oxalate was formed with excess calcium from diet mainly meat base.

• Acta Via Serica
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• v.5 no.1
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• pp.57-86
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• 2020

This article is an analysis of the tale Munhŭi who bought a dream which has been reported, with few variants, both in Samguk sagi and Samguk yusa. As the tale narrates a very particular and old dream, in which a urine flood forecasts kingship and royalty, it has not been investigated here on the basis of a modern psycho-analytical approach, but within eastern and western ancient cultural patterns regarding humans' consideration for excreta and criteria of dreams interpretation. The research led the author to propose for Munhŭi's dream an archaic (and today lost) archetype of interpretation, whose origin is perhaps to be found in the Ancient Middle-East.

• Journal of Interdisciplinary Genomics
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• v.5 no.1
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• pp.5-11
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• 2023

β-ureidopropionase (β-UP) is an enzyme that catalyzes the final step in the pyrimidine degradation pathway, which converts β-ureidopropionate and β-ureidoisobutyrate into β-alanine and β-aminoisobutyrate, respectively. β-UP deficiency (UPB1D; OMIM # 613161) is an extremely rare autosomal recessive inborn error disease caused by a mutation in the UPB1 gene on chromosome 22q11. To date, approximately 40 cases of UPB1D have been reported worldwide, including one case in Korea. The clinical manifestations of patients with UPB1D are known to be diverse, with a very wide range of manifestations being previously reported; these manifestations include completely asymptomatic, urogenital and colorectal anomalies, or severe neurological involvement, including global developmental delay, microcephaly, early onset psychomotor retardation with dysmorphic features, epilepsy, optic atrophy, retinitis pigmentosa, severely delayed myelination, and cerebellar hypoplasia. Currently, diagnosis of UPB1D is challenging as neurological manifestations, MRI abnormalities, and biochemical analysis for pyrimidine metabolites in the urine, plasma, and cerebrospinal fluid also need to be confirmed by UPB1 gene mutations. Overall, treatment of patients with UPB1D is palliative as there is still no definitive curative treatment available.

• Journal of Digestive Cancer Research
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• v.8 no.1
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• pp.56-60
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• 2020

In recent years, liquid biopsy has received immense attention. Liquid biopsy is a minimally invasive method used for obtaining biological fluids including urine, pleural fluid and, mostly, peripheral blood. Liquid biopsy involves various targets including circulating tumors cells (CTCs), circulating cell-free tumor DNA (ctDNA), and microRNA (miRNA). Colorectal cancer (CRC), like other solid tumors, shed tumor cells into the bloodstream. Analysis of these CTCs, as well as ctDNA is the primary objective of the liquid biopsy. Evaluation of CTC or ctDNA offers information about early tumor release, development of tumor metastasis and also about mechanisms involved in tumor resistance to treatment.

• Communications of the Korean Mathematical Society
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• v.39 no.3
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• pp.803-819
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• 2024

In our study, the integration of fuzzy graphs into classical graph theory gives rise to a novel concept known as "Fuzzy Super Subdivision." Let SS_f (G) be the fuzzy super subdivision graphs, by substituting a complete bipartite graph k_(2,m) (m = 1, 2, . . .) for each edge of a fuzzy graph. The attributes and properties of this newly proposed concept are briefly outlined, in addition to illustrative examples. Furthermore, significant findings are discussed on connectivity, size, degree and order of fuzzy super subdivision structures. To illustrate the practical implications of our approach, we present an application focused on analyzing the growth of infections in blood or urine samples using the Fuzzy Super Subdivision model.