• The Korean Journal of Pain
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• v.35 no.1
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• pp.59-65
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• 2022

Background: There is still unmet need in treating neuropathic pain and increasing awareness regarding the use of drug combinations to increase the effectiveness of treatment and reduce adverse effects in patients with neuropathic pain. Methods: This study was performed to determine the individual and combined effects of pregabalin, tianeptine, and clopidogrel in a rat model of neuropathic pain. The model was created by ligation of the L5-L6 spinal nerve in male Sprague-Dawley rats; mechanical allodynia was confirmed using von Frey filaments. Drugs were administered to the intrathecal space and mechanical allodynia was assessed; drug interactions were estimated by isobolographic or fixed-dose analyses. Results: Intrathecal pregabalin and tianeptine increased the mechanical withdrawal threshold in a dose-dependent manner, but intrathecal clopidogrel had little effect on the mechanical withdrawal threshold. An additive effect was noted between pregabalin and tianeptine, but not between pregabalin and clopidogrel. Conclusions: These findings suggest that intrathecal coadministration of pregabalin and tianeptine effectively attenuated mechanical allodynia in the rat model of neuropathic pain. Thus, pregabalin plus tianeptine may be a valid option to enhance the efficacy of neuropathic pain treatment.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.1
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• pp.22-32
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• 2021

Fluorine-18 is by far the most widely exploited radionuclide in PET (positron emission tomography) radiochemistry. The physical half-life of fluorine-18 allows for chemical manipulation within a restricted timeframe, and cyclotron-produced fluoride ion has been widely applied in aliphatic and aromatic nucleophilic radiofluorinations to produce a variety of established radiotracers. Radiotracers have become more structurally complicated to address diverse targets in physiobiological systems. There is therefore an unmet need to complement traditional C-¹⁸F bond-forming radiofluorination with new and efficient radiolabeling techniques to tackle the myriad of possible chemical environments. This review discusses recent advances in organometallic fluorine-18 bond creation in ¹⁸F-radiochemistry. Although not widely employed, new radiolabeling strategies for constructing boron-¹⁸F, silicon-¹⁸F, aluminum-¹⁸F, and other metal-¹⁸F bonds are described in view of their potential use in the development of novel radiopharmaceuticals.

• Journal of Korean Academy of Dental Administration
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• v.11 no.1
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• pp.1-7
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• 2023

The purpose of this study was to identify chronic diseases and oral health care behaviors in 65-year-old individuals and to determine the factors that influence masticatory mobility. The raw data from the 8th National Health and Nutrition Examination Survey in 2020 were utilized to analyze factors associated with chewing discomfort in 1,278 elderly Koreans. Using IBM SPSS Statistics 27.0, we conducted complex sample cross-analysis to examine the difference in chewing discomfort based on general characteristics, chronic diseases, and oral health care behaviors. Additionally, we performed complex sample multiple logistic regression analysis to identify the factors associated with chewing discomfort. As a factor influencing chewing discomfort, unmet dental care was 3.33 times higher (p<0.001), and subjective oral health was 0.18 times more likely to be moderate (p<0.001) and 0.48 times more likely to be good (p<0.001) lower. In the case of arthritis, the level of chewing discomfort was high (OR=1.08, p=0.694), but there was no significant difference. As a result of the aforementioned factors, it is believed that there is a need for policies and systems to provide dental care to the elderly before their oral health deteriorates. Additionally, tailored oral health promotion programs should be implemented.

• Research in Community and Public Health Nursing
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• v.27 no.4
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• pp.358-369
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• 2016

Purpose: This study was to identify health-related quality of life of Korean young adults and elderly with multimorbidity and to examine factors influencing their health-related quality of life. Methods: Health-related quality of life was measured by the Korean version of the EQ-5D. Using a descriptive study, the study incorporated a secondary analysis of the Korean version of the EQ-5D data from the 8th wave of the Korea Health Panel Survey in 2013. Selected demographic data and the Korean version of the EQ-5D were analyzed using ${\chi}^2$-test, t-test, ANOVA and multiple regression analysis. Results: Education, drinking, type of health insurance, and number of chronic disease significantly affected the health-related quality of life in the young adults with multimorbidity. Educational level, occupational type, drinking, physical activity, number of chronic disease, unmet healthcare need and the type of multimorbidity significantly affected the health-related quality of life in the elderly with multimorbidity. Conclusion: The factors influencing health-related quality of life were different for young adults versus elderly with multimorbidity. Therefore, there is a need for age-specific health care programs that may improve health-related quality of life of adults with multimorbidity.

• Journal of Preventive Medicine and Public Health
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• v.24 no.3 s.35
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• pp.328-338
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• 1991

To find out the state of illness, patterns of medical care utilization, and factors which determine medical care utilization for aged we surveyed 679 rural old persons who live in the Chungnam province from Jan. 10 1991 to Jan. 19. The major findings of this study were as follows : 1. The morbidity rate of chronic illness during last 3 months was 56.4% for all surveyed old persons ; 58.7% for female and 52.8% for male. 2. As expected, 80 years old or above group showed the highest morbidity rate, 60.2% and the 65-69 years age group was the lowest, 50.5%. 3. Old persons who are householder, whose family income is less than 290,000 won per month, and who receive benifits from the public medical assistance program had relative higher morbidity rate than other groups and the difference was statistically significant (p<0.05). 4. The most frequent chronic illness was musculoskeletal disease, 49.6% ; the disease from which the aged had suffered for the longest period was gastrointestinal, 11.6yrs : the cerebrovascular was the disease which inflicts the lowest level of physical ability. 5. 67.1% of 383 persons who were suffering from chronic illness were in need of medical care but unmet ; among the remaining 32.9% who utilized medical care, 19.2% utilized it in local clinics or hospital OPD and 15% in th health centers or subcenters. 6. Old person who are married, whose sons are householder and whose family income is 500,000 won or above per month showed relative higher utilization rate than other groups and the difference was statistically significant (p<0.05). 7. The most common reason why the aged did not utilize, in spite of, need medical care was economic problem, 35.4%. For the aged whose family income per month is 500,000 won or above, however the most common reason was tolerable symptom, 46.9% while persons who answered economic problem were 6.1% of them, the lowest frequency.

• BMB Reports
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• v.57 no.6
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• pp.287-292
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• 2024

Hepatocellular Carcinoma (HCC), the predominant primary hepatic malignancy, is the prime contributor to mortality. Despite the availability of multiple surgical interventions, patient outcomes remain suboptimal. Immunotherapies have emerged as effective strategies for HCC treatment with multiple clinical advantages. However, their curative efficacy is not always satisfactory, limited by the dysfunctional T cell status. Thus, there is a pressing need to discover novel potential biomarkers indicative of T cell exhaustion (Tex) for personalized immunotherapies. One promising target is Cyclin-dependent kinase inhibitor 2 (CDKN2) gene, a key cell cycle regulator with aberrant expression in HCC. However, its specific involvement remains unclear. Herein, we assessed the potential of CDKN2 expression as a promising biomarker for HCC progression, particularly for exhausted T cells. Our transcriptome analysis of CDKN2 in HCC revealed its significant role involving in HCC development. Remarkably, single-cell transcriptomic analysis revealed a notable correlation between CDKN2 expression, particularly CDKN2A, and Tex markers, which was further validated by a human cohort study using human HCC tissue microarray, highlighting CDKN2 expression as a potential biomarker for Tex within the intricate landscape of HCC progression. These findings provide novel perspectives that hold promise for addressing the unmet therapeutic need within HCC treatment.

• Korean Journal of Health Education and Promotion
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• v.24 no.3
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• pp.99-118
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• 2007

There are little program and services that have been developed to address the health and health care needs of vulnerable women. The access for their timely and appropriate health care and health promotion services have been a increasing concern. The purpose of this study was to suggest health promotion program for vulnerable women with collaboration of women's NGOs. At the first part of this study, we reviewed a conceptual framework for identifying vulnerable population, and issues regarding health problems, unmet needs, policies and programs that have been developed to address their need. In second part, we focused on investigating the role, subjects and activities of women's NGOs and their capacity for health promotion program. The last part of this study proposed health promotion programme with integrating above two parts of study. In describing what type of health promotion program available in women's NCOs, eight major programs and services were summarized. 1. Direct health promotion program and collaborating program with other services. 2. Education and training for empowerment of vulnerable women 3. Organizing mutual support system such as self-help group 4. Community supports. Vulnerable women living at home may benefit from linkage to community services as much as women living in facility 5. Organizing collaboration system with program for economic support and job training, social rehabilitation 6. Trainer's training for practitioners in NGOs 7. Technical, informational support from professional groups 8. A national coordinating policies for vulnerable population should be established at the central level. National support for NGOs' health promotion program are needed hi solving unmet needs of vulnerable women.

• Korean Journal of Psychosomatic Medicine
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• v.32 no.1
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• pp.24-33
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• 2024

Objectives : The purpose of this study was to investigate individual- and community-level factors on suicidal ideation and suicide attempt among Korean adults. Methods : This study was conducted on 225,965 adults collected through data from the 2021 Community Health Survey and the Korean Statistical Information Service (KOSIS). The general characteristics, suicidal behavior (e.g., suicidal ideation, and suicide attempts), and community-level characteristics of the study subjects were analyzed using frequency (%) and mean (standard deviation). The effects on individual- and community-level factors on suicidal ideation and suicide attempts was analyzed using multilevel logistic regression models. Results : The community-level factor associated with suicidal ideation was unmet health care (Odds Ratio [OR]=1.053, 95% CI=1.035-1.071), and the community-level factor associated with suicide attempt was the aging rate (OR=1.015, 95% CI=1.001-1.030). Regarding health-related variables, the individual-level factors associated with suicidal ideation were stress status (OR=9.388, 95% CI=8.629-10.213), depressive experience in the past year (OR=6.737, 95% CI=6.454-7.032), and the predominantly individual-level factors associated with suicide attempt were also stress status (OR=5.213, 95% CI=3.699-7.347), and depressive experience in the last one year (OR=13.433, 95% CI: 11.247-16.044). Conclusions : We confirmed individual-level and community-level factors influencing suicidal ideation and suicide attempt. Through these findings, we need to establish suicide prevention policies, considering managing individual-level factors such as stress and depression as well as community-level factors such as unmet health care.

• Journal of Convergence for Information Technology
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• v.10 no.5
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• pp.177-187
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• 2020

The purpose of this study was to classify the care needs of the older adults aged 65 and over and to identify characteristics of care need groups. This was a secondary analysis study using data from 2017 National Survey of Older Persons in Seoul. There were 50.4% in the general group without any support needs, 17.9% in the medical needs group, 14.2% in the welfare needs group with support needs of daily living or social activity, and 17.5% in the complex needs group with both medical and welfare needs. Significant differences were shown in most variables of the general characteristics, grading of long-term care or disability, financial burden and caregiving, health behaviors, health status, and life satisfactions among groups (p<.001). The complex care need group should be provided with integrated care service for medical and welfare through multidisciplinary team approach.

• The Journal of Korean society of community based occupational therapy
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• v.1 no.2
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• pp.45-59
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• 2011

Objective : he aim of this study is to describe on the definition of the welfare state and scope of the social welfare and to analyze the development of the social welfare policy for the disabled in South Korea. Methods : We described on the definition of the welfare state and scope of the social welfare and analyzed the social welfare policy and welfare policy for the disabled among Korean Government through literature review. Finally, We also analyzed the welfare policy for the disabled in the Roh Moo-hyun Administration. Results : Welfare policy or welfare policy for the disabled was developed as economic growth from 'selective welfare' to 'universal welfare'. Scope of the social welfare was expanded from 'minimum guarantee' of the Lee seong-man administration to 'participatory welfare' of the Roh moo-hyun administration and that was similar to the welfare policy of administration for the disabled. Conclusion : We suggest that occupational therapist based community should find unmet health need and provide home-based rehabilitation services to the disabled and the elderly.